Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis.

abstract：:Over 200,000 new cases of leprosy are detected each year, of which approximately 7% are associated with grade-2 disabilities (G2Ds). For achieving leprosy elimination, one of the main challenges will be targeting higher risk groups within endemic communities. Nevertheless, the socioeconomic risk markers of leprosy rem...

journal_title：PLoS neglected tropical diseases

authors： Pescarini JM,Strina A,Nery JS,Skalinski LM,Andrade KVF,Penna MLF,Brickley EB,Rodrigues LC,Barreto ML,Penna GO

更新日期：2018-07-09 00:00:00

abstract：BACKGROUND:Aedes albopictus, the Asian tiger mosquito, is a vector of several arboviruses including dengue and chikungunya, and is also a significant nuisance mosquito. It is one of the most invasive of mosquitoes with a relentlessly increasing geographic distribution. Conventional control methods have so far failed to...

journal_title：PLoS neglected tropical diseases

authors： Labbé GM,Scaife S,Morgan SA,Curtis ZH,Alphey L

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Transmission of Yersinia pestis by flea bite can occur by two mechanisms. After taking a blood meal from a bacteremic mammal, fleas have the potential to transmit the very next time they feed. This early-phase transmission resembles mechanical transmission in some respects, but the mechanism is unknown. Ther...

journal_title：PLoS neglected tropical diseases

authors： Hinnebusch BJ,Bland DM,Bosio CF,Jarrett CO

更新日期：2017-01-12 00:00:00

abstract：:Konzo is a distinct neurological entity with selective upper motor neuron damage, characterized by an abrupt onset of an irreversible, non-progressive, and symmetrical spastic para/tetraparesis. Despite its severity, konzo remains a neglected disease. The disease is associated with high dietary cyanogen consumption fr...

journal_title：PLoS neglected tropical diseases

authors： Nzwalo H,Cliff J

更新日期：2011-06-01 00:00:00

abstract：:Response to Zika virus (ZIKV) invasion in Brazil lagged a year from its estimated February 2014 introduction, and was triggered by the occurrence of severe congenital malformations. Dengue (DENV) and chikungunya (CHIKV) invasions tend to show similar response lags. We analyzed geo-coded symptomatic case reports from t...

journal_title：PLoS neglected tropical diseases

authors： Bisanzio D,Dzul-Manzanilla F,Gomez-Dantés H,Pavia-Ruz N,Hladish TJ,Lenhart A,Palacio-Vargas J,González Roldan JF,Correa-Morales F,Sánchez-Tejeda G,Kuri Morales P,Manrique-Saide P,Longini IM,Halloran ME,Vazquez-Prokopec GM

更新日期：2018-03-15 00:00:00

abstract：:The main consequence of oxidative stress is the formation of DNA lesions, which can result in genomic instability and lead to cell death. Guanine is the base that is most susceptible to oxidation, due to its low redox potential, and 8-oxoguanine (8-oxoG) is the most common lesion. These characteristics make 8-oxoG a g...

journal_title：PLoS neglected tropical diseases

authors： Aguiar PH,Furtado C,Repolês BM,Ribeiro GA,Mendes IC,Peloso EF,Gadelha FR,Macedo AM,Franco GR,Pena SD,Teixeira SM,Vieira LQ,Guarneri AA,Andrade LO,Machado CR

更新日期：2013-06-13 00:00:00

abstract：BACKGROUND:A majority infections caused by dengue virus (DENV) are asymptomatic, but a higher incidence of severe illness, such as dengue hemorrhagic fever, is associated with secondary infections, suggesting that pre-existing immunity plays a central role in dengue pathogenesis. Primary infections are typically associ...

journal_title：PLoS neglected tropical diseases

authors： Chaudhury S,Gromowski GD,Ripoll DR,Khavrutskii IV,Desai V,Wallqvist A

更新日期：2017-02-21 00:00:00

abstract：:The bacterium Burkholderia ubonensis is commonly co-isolated from environmental specimens harbouring the melioidosis pathogen, Burkholderia pseudomallei. B. ubonensis has been reported in northern Australia and Thailand but not North America, suggesting similar geographic distribution to B. pseudomallei. Unlike most o...

journal_title：PLoS neglected tropical diseases

authors： Price EP,Sarovich DS,Webb JR,Hall CM,Jaramillo SA,Sahl JW,Kaestli M,Mayo M,Harrington G,Baker AL,Sidak-Loftis LC,Settles EW,Lummis M,Schupp JM,Gillece JD,Tuanyok A,Warner J,Busch JD,Keim P,Currie BJ,Wagner DM

更新日期：2017-09-14 00:00:00

abstract：BACKGROUND:Schistosomiasis has been reported in 78 endemic countries and affects 240 million people worldwide. The digenetic parasite Schistosoma mansoni needs fresh water to compete its life cycle. There, it is susceptible to soluble compounds that can affect directly and/or indirectly the parasite's biology. The cerc...

journal_title：PLoS neglected tropical diseases

authors： Augusto RC,Tetreau G,Chan P,Walet-Balieu ML,Mello-Silva CC,Santos CP,Grunau C

更新日期：2017-07-28 00:00:00

abstract：BACKGROUND:The parasitic protozoan Trypanosoma brucei utilizes glycolysis exclusively for ATP production during infection of the mammalian host. The first step in this metabolic pathway is mediated by hexokinase (TbHK), an enzyme essential to the parasite that transfers the gamma-phospho of ATP to a hexose. Here we des...

journal_title：PLoS neglected tropical diseases

authors： Sharlow ER,Lyda TA,Dodson HC,Mustata G,Morris MT,Leimgruber SS,Lee KH,Kashiwada Y,Close D,Lazo JS,Morris JC

更新日期：2010-04-13 00:00:00

abstract：:Burkholderia pseudomallei, the bacterial agent of melioidosis, causes disease through inhalation of infectious particles, and is classified as a Tier 1 Select Agent. Optical diagnostic imaging has demonstrated that murine respiratory disease models are subject to significant upper respiratory tract (URT) colonization....

journal_title：PLoS neglected tropical diseases

authors： Gutierrez MG,Pfeffer TL,Warawa JM

更新日期：2015-01-08 00:00:00

abstract：:The area of Walikale in North Kivu, Democratic Republic of Congo, is intensely affected by conflict and population displacement. Médecins-Sans-Frontières (MSF) returned to provide primary healthcare in July 2012. To better understand the impact of the ongoing conflict and displacement on the population, a retrospectiv...

journal_title：PLoS neglected tropical diseases

authors： Carrión Martín AI,Bil K,Salumu P,Baabo D,Singh J,Kik C,Lenglet A

更新日期：2014-09-18 00:00:00

abstract：BACKGROUND:Mosquito-borne viral diseases cause significant burden in much of the developing world. Although host-virus interactions have been studied extensively in the vertebrate host, little is known about mosquito responses to viral infection. In contrast to mosquitoes of the Aedes and Culex genera, Anopheles gambia...

journal_title：PLoS neglected tropical diseases

authors： Waldock J,Olson KE,Christophides GK

更新日期：2012-01-01 00:00:00

abstract：:Endemic mycoses are systemic fungal infections. Histoplasmosis is endemic in all temperate areas of the world; coccidioidomycosis and paracoccidioidomycosis are only present in the American continent. These pathogens are not present in Spain, but in the last years there has been an increase of reported cases due to mi...

journal_title：PLoS neglected tropical diseases

authors： Molina-Morant D,Sánchez-Montalvá A,Salvador F,Sao-Avilés A,Molina I

更新日期：2018-02-15 00:00:00

abstract：BACKGROUND:Buruli ulcer (BU) is a chronic necrotizing infectious skin disease caused by Mycobacterium ulcerans. The treatment with BU-specific antibiotics is initiated after clinical suspicion based on the WHO clinical and epidemiological criteria. This study aimed to estimate the predictive values of these criteria an...

journal_title：PLoS neglected tropical diseases

authors： Ayelo GA,Sopoh GE,Houezo JG,Fiodessihoue R,Affolabi D,Dossou AD,Barogui YT,Wadagni AAC,Agossadou DC,Hasker E,Portaels F,de Jong BC,Eddyani M

更新日期：2018-08-06 00:00:00

abstract：BACKGROUND:Amebic colitis, caused by intestinal infection with the parasite, Entamoeba histolytica, is a common cause of diarrhea worldwide. Fulminant amebic colitis is the most devastating complication of this infection, associated with both high mortality and morbidity. We conducted a review of the English literature...

journal_title：PLoS neglected tropical diseases

authors： Shirley DA,Moonah S

更新日期：2016-07-28 00:00:00

abstract：:The major arboviral diseases in mainland China include Japanese encephalitis, dengue fever, Crimean-Congo hemorrhagic fever (also known as Xinjiang hemorrhagic fever), and tick-borne encephalitis. These and other newly found arbovirus infections due to Banna virus and Tahyna virus contribute to a large and relatively ...

journal_title：PLoS neglected tropical diseases

authors： Gao X,Nasci R,Liang G

更新日期：2010-04-27 00:00:00

abstract：:Buruli ulcer (BU), caused by Mycobacterium ulcerans, is currently treated with a daily combination of rifampin and either injectable streptomycin or oral clarithromycin. An intermittent oral regimen would facilitate treatment supervision. We first evaluated the bactericidal activity of newer antimicrobials against M. ...

journal_title：PLoS neglected tropical diseases

authors： Chauffour A,Robert J,Veziris N,Aubry A,Pethe K,Jarlier V

更新日期：2020-08-31 00:00:00

abstract：:We present a general framework which describes the systematic (binary) scenario of individuals either taking treatment or not for any reason, over the course of mass drug administration (MDA)-which we refer to as 'adherence' and 'non-adherence'. The probability models developed can be informed by observed adherence be...

journal_title：PLoS neglected tropical diseases

authors： Hardwick RJ,Truscott JE,Oswald WE,Werkman M,Halliday KE,Pullan RL,Anderson RM

更新日期：2021-01-22 00:00:00

abstract：:The complement cascade in mammalian blood can damage the alimentary tract of haematophagous arthropods. As such, these animals have evolved their own repertoire of complement-inactivating factors, which are inadvertently exploited by blood-borne pathogens to escape complement lysis. Unlike the bloodstream stages, the ...

journal_title：PLoS neglected tropical diseases

authors： Ooi CP,Haines LR,Southern DM,Lehane MJ,Acosta-Serrano A

更新日期：2015-01-08 00:00:00

abstract：:Eukaryotes, protozoan, and helminth parasites make extensive use of protein kinases to control cellular functions, suggesting that protein kinases may represent novel targets for the development of anti-parasitic drugs. Because of their central role in intracellular signaling pathways, cyclic nucleotide-dependent kina...

journal_title：PLoS neglected tropical diseases

authors： Swierczewski BE,Davies SJ

更新日期：2009-08-25 00:00:00

abstract：BACKGROUND:The activities of the Global Programme for the Elimination of Lymphatic Filariasis have been in operation since the year 2000, with Mass Drug Administration (MDA) undertaken yearly in disease endemic communities. Information collected during MDA-such as population demographics, age, sex, drugs used and remai...

journal_title：PLoS neglected tropical diseases

authors： de Souza DK,Yirenkyi E,Otchere J,Biritwum NK,Ameme DK,Sackey S,Ahorlu C,Wilson MD

更新日期：2016-03-30 00:00:00

abstract：BACKGROUND:Dengue has become a major concern for international public health. Frequent epidemic outbreaks are believed to be driven by a complex interplay of immunological interactions between its four co-circulating serotypes and large fluctuations in mosquito densities. Viral lineage replacement events, caused for ex...

journal_title：PLoS neglected tropical diseases

authors： Lourenço J,Recker M

更新日期：2010-11-23 00:00:00

abstract：:Trypanosoma cruzi is exposed during its life to exogenous and endogenous oxidative stress, leading to damage of several macromolecules such as DNA. There are many DNA repair pathways in the nucleus and mitochondria (kinetoplast), where specific protein complexes detect and eliminate damage to DNA. One group of these p...

journal_title：PLoS neglected tropical diseases

authors： Rojas DA,Urbina F,Moreira-Ramos S,Castillo C,Kemmerling U,Lapier M,Maya JD,Solari A,Maldonado E

更新日期：2018-02-12 00:00:00

abstract：BACKGROUND:In mass vaccination campaigns, large volumes of data must be managed efficiently and accurately. In a reactive oral cholera vaccination (OCV) campaign in rural Haiti during an ongoing epidemic, we used a mobile health (mHealth) system to manage data on 50,000 participants in two isolated communities. METHOD...

journal_title：PLoS neglected tropical diseases

authors： Teng JE,Thomson DR,Lascher JS,Raymond M,Ivers LC

更新日期：2014-07-31 00:00:00

abstract：:We recently reported the medicinal chemistry re-optimization of a series of compounds derived from the human tyrosine kinase inhibitor, lapatinib, for activity against Plasmodium falciparum. From this same library of compounds, we now report potent compounds against Trypanosoma brucei brucei (which causes human Africa...

journal_title：PLoS neglected tropical diseases

authors： Ferrins L,Sharma A,Thomas SM,Mehta N,Erath J,Tanghe S,Leed SE,Rodriguez A,Mensa-Wilmot K,Sciotti RJ,Gillingwater K,Pollastri MP

更新日期：2018-11-26 00:00:00

abstract：BACKGROUND:The IAEA colony is the only one available for mass rearing of Glossina pallidipes, a vector of human and animal African trypanosomiasis in eastern Africa. This colony is the source for Sterile Insect Technique (SIT) programs in East Africa. The source population of this colony is unclear and its genetic dive...

journal_title：PLoS neglected tropical diseases

authors： Ciosi M,Masiga DK,Turner CM

更新日期：2014-02-13 00:00:00

abstract：:This study focused on Oeosophagostomum sp., and more especially on O. bifurcum, as a parasite that can be lethal to humans and is widespread among humans and monkeys in endemic regions, but has not yet been documented in apes. Its epidemiology and the role played by non-human primates in its transmission are still poo...

journal_title：PLoS neglected tropical diseases

authors： Krief S,Vermeulen B,Lafosse S,Kasenene JM,Nieguitsila A,Berthelemy M,L'hostis M,Bain O,Guillot J

更新日期：2010-03-16 00:00:00

abstract：BACKGROUND:Venom recurrence or persistence in the circulation after antivenom treatment has been documented many times in viper envenoming. However, it has not been associated with clinical recurrence for many snakes, including Russell's viper (Daboia spp.). We compare the recovery of coagulopathy to the recurrence or ...

journal_title：PLoS neglected tropical diseases

authors： Maduwage K,O'Leary MA,Scorgie FE,Shahmy S,Mohamed F,Abeysinghe C,Karunathilake H,Lincz LF,Gnanathasan CA,Isbister GK

更新日期：2014-12-18 00:00:00

abstract：:The global spread of vector-borne diseases remains a worrying public health threat, raising the need for development of new combat strategies for vector control. Knowledge of vector ecology can be exploited in this regard, including plant feeding; a critical resource that mosquitoes of both sexes rely on for survival ...

journal_title：PLoS neglected tropical diseases

authors： Nyasembe VO,Tchouassi DP,Pirk CWW,Sole CL,Torto B

更新日期：2018-02-20 00:00:00