Abstract:
:Malaria and schistosomiasis are major parasitic diseases causing morbidity and mortality in the tropics. Epidemiological surveys have revealed coinfection rates of up to 30% among children in Sub-Saharan Africa. To investigate the impact of coinfection of these two parasites on disease epidemiology and pathology, we carried out coinfection studies using Plasmodium yoelii and Schistosoma mansoni in mice. Malaria parasite growth in the liver following sporozoite inoculation is significantly inhibited in mice infected with S. mansoni, so that when low numbers of sporozoites are inoculated, there is a large reduction in the percentage of mice that go on to develop blood stage malaria. Furthermore, gametocyte infectivity is much reduced in mice with S. mansoni infections. These results have profound implications for understanding the interactions between Plasmodium and Schistosoma species, and have implications for the control of malaria in schistosome endemic areas.
journal_name
PLoS Negl Trop Disjournal_title
PLoS neglected tropical diseasesauthors
Moriyasu T,Nakamura R,Deloer S,Senba M,Kubo M,Inoue M,Culleton R,Hamano Sdoi
10.1371/journal.pntd.0006197subject
Has Abstractpub_date
2018-01-26 00:00:00pages
e0006197issue
1eissn
1935-2727issn
1935-2735pii
PNTD-D-17-01599journal_volume
12pub_type
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