Improved reliability of serological tools for the diagnosis of West Nile fever in horses within Europe.

abstract：:The leptospiral LigA protein consists of 13 bacterial immunoglobulin-like (Big) domains and is the only purified recombinant subunit vaccine that has been demonstrated to protect against lethal challenge by a clinical isolate of Leptospira interrogans in the hamster model of leptospirosis. We determined the minimum nu...

journal_title：PLoS neglected tropical diseases

authors： Coutinho ML,Choy HA,Kelley MM,Matsunaga J,Babbitt JT,Lewis MS,Aleixo JA,Haake DA

更新日期：2011-12-01 00:00:00

abstract：:Vector control is still our primary intervention for both prevention and mitigation of epidemics of many vector-borne diseases. Efficiently targeting control measures is important since control can involve substantial economic costs. Targeting is not always straightforward, as transmission of vector-borne diseases is ...

journal_title：PLoS neglected tropical diseases

authors： Stone CM,Schwab SR,Fonseca DM,Fefferman NH

更新日期：2019-07-03 00:00:00

abstract：:Buruli ulcer (BU), caused by Mycobacterium ulcerans, is currently treated with a daily combination of rifampin and either injectable streptomycin or oral clarithromycin. An intermittent oral regimen would facilitate treatment supervision. We first evaluated the bactericidal activity of newer antimicrobials against M. ...

journal_title：PLoS neglected tropical diseases

authors： Chauffour A,Robert J,Veziris N,Aubry A,Pethe K,Jarlier V

更新日期：2020-08-31 00:00:00

abstract：BACKGROUND:Despite the known burden of neglected tropical diseases (NTDs) on child health, there is limited information on current efforts to increase pediatric therapeutic options. Our objective was to quantify and characterize research activity and treatment availability for NTDs in children in order to inform the pr...

journal_title：PLoS neglected tropical diseases

authors： Rees CA,Hotez PJ,Monuteaux MC,Niescierenko M,Bourgeois FT

更新日期：2019-01-29 00:00:00

abstract：BACKGROUND:Typhoid fever, caused by the Gram-negative bacterium Salmonella enterica serovar Typhi, is a major cause of community-acquired bacteremia and death worldwide. S100A8 (MRP8) and S100A9 (MRP14) form bioactive antimicrobial heterodimers (calprotectin) that can activate Toll-like receptor 4, promoting lethal, en...

journal_title：PLoS neglected tropical diseases

authors： De Jong HK,Achouiti A,Koh GC,Parry CM,Baker S,Faiz MA,van Dissel JT,Vollaard AM,van Leeuwen EM,Roelofs JJ,de Vos AF,Roth J,van der Poll T,Vogl T,Wiersinga WJ

更新日期：2015-04-10 00:00:00

abstract：:Animal African Trypanosomosis (AAT) presents a severe problem for agricultural development in sub-Saharan Africa. It is caused by several trypanosome species and current means of diagnosis are expensive and impractical for field use. Our aim was to discover antigens for the detection of antibodies to Trypanosoma congo...

journal_title：PLoS neglected tropical diseases

authors： Fleming JR,Sastry L,Crozier TW,Napier GB,Sullivan L,Ferguson MA

更新日期：2014-06-12 00:00:00

abstract：BACKGROUND:Few studies have assessed the burden of Chagas disease in non-endemic countries and most of them are based on prevalence estimates from Latin American (LA) countries that likely differ from the prevalence in migrants living in Europe. The aim of this study was to systematically review the existing data infor...

journal_title：PLoS neglected tropical diseases

authors： Requena-Méndez A,Aldasoro E,de Lazzari E,Sicuri E,Brown M,Moore DA,Gascon J,Muñoz J

更新日期：2015-02-13 00:00:00

abstract：:Trypanosoma brucei are unicellular parasites endemic to Sub-Saharan Africa that cause fatal disease in humans and animals. Infection with these parasites is caused by the bite of the tsetse fly vector, and parasites living extracellularly in the blood of infected animals evade the host immune system through antigenic ...

journal_title：PLoS neglected tropical diseases

authors： Walsh ME,Naudzius EM,Diaz SJ,Wismar TW,Martchenko Shilman M,Schulz D

更新日期：2020-03-13 00:00:00

abstract：BACKGROUND:Among the different faces of immune reconstitution inflammatory syndrome (IRIS) developing in HIV-patients, no clinical definition has been reported for Schistosomiasis-IRIS (Schisto-IRIS). Although Schisto-IRIS remains largely uninvestigated, matrix metalloproteinases (MMP) and tissue inhibitors of metallop...

journal_title：PLoS neglected tropical diseases

authors： Goovaerts O,Mwinzi PNM,Muok EMO,Ceulemans A,Colebunders R,Kestens L

更新日期：2018-08-08 00:00:00

abstract：BACKGROUND:Trachoma, caused by Chlamydia trachomatis (Ct), is the leading infectious cause of blindness. Sequence-based analysis of the multiple strains typically present in endemic communities may be informative for epidemiology, transmission, response to treatment, and understanding the host response. METHODS:Conjun...

journal_title：PLoS neglected tropical diseases

authors： Andreasen AA,Burton MJ,Holland MJ,Polley S,Faal N,Mabey DC,Bailey RL

更新日期：2008-09-24 00:00:00

abstract：BACKGROUND:Pathogenesis of severe fever with thrombocytopenia syndrome (SFTS) has not been well described yet. Recent studies indicate that SFTSV could replicate in endothelial cells. Here we performed a case-control study to determine whether endothelial activation/dysfunction occurred in SFTSV infection and to identi...

journal_title：PLoS neglected tropical diseases

authors： Li XK,Yang ZD,Du J,Xing B,Cui N,Zhang PH,Li H,Zhang XA,Lu QB,Liu W

更新日期：2017-08-14 00:00:00

abstract：BACKGROUND:The liver fluke Opisthorchis viverrini is classified as a class I carcinogen due to the association between cholangiocarcinoma and chronic O. viverrini infection. During its feeding activity within the bile duct, the parasite secretes several cathepsin F cysteine proteases that may induce or contribute to th...

journal_title：PLoS neglected tropical diseases

authors： Pinlaor P,Kaewpitoon N,Laha T,Sripa B,Kaewkes S,Morales ME,Mann VH,Parriott SK,Suttiprapa S,Robinson MW,To J,Dalton JP,Loukas A,Brindley PJ

更新日期：2009-01-01 00:00:00

abstract：:Yellow fever virus (YFV) is a mosquito-borne flavivirus that is a major public health problem in tropical areas of Africa and South America. There have been detailed studies on YFV ecology in West Africa and South America, but current understanding of YFV circulation on the African continent is incomplete. This inadeq...

journal_title：PLoS neglected tropical diseases

authors： Beck A,Guzman H,Li L,Ellis B,Tesh RB,Barrett AD

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:In the Old World, sandfly species of the genus Phlebotomus are known vectors of Leishmania, Bartonella and several viruses. Recent sandfly catches and autochthonous cases of leishmaniasis hint on spreading tendencies of the vectors towards Central Europe. However, studies addressing potential future distribu...

journal_title：PLoS neglected tropical diseases

authors： Fischer D,Moeller P,Thomas SM,Naucke TJ,Beierkuhnlein C

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Traditional faecal-based methods have poor sensitivity for the detection of S. stercoralis, therefore are inadequate for post-treatment evaluation of infected patients who should be carefully monitored to exclude the persistence of the infection. In a previous study, we demonstrated high accuracy of five ser...

journal_title：PLoS neglected tropical diseases

authors： Buonfrate D,Sequi M,Mejia R,Cimino RO,Krolewiecki AJ,Albonico M,Degani M,Tais S,Angheben A,Requena-Mendez A,Muñoz J,Nutman TB,Bisoffi Z

更新日期：2015-02-10 00:00:00

abstract：:Rift Valley fever virus is an arbovirus that affects both livestock and humans throughout Africa and in the Middle East. Despite its endemicity throughout Africa, it is a rare event to identify an infected individual during the acute phase of the disease and an even rarer event to collect serial blood samples from the...

journal_title：PLoS neglected tropical diseases

authors： de St Maurice A,Harmon J,Nyakarahuka L,Balinandi S,Tumusiime A,Kyondo J,Mulei S,Namutebi A,Knust B,Shoemaker T,Nichol ST,McElroy AK,Spiropoulou CF

更新日期：2018-05-04 00:00:00

abstract：UNLABELLED:/ BACKGROUND:Dengue is the most important arthropod borne viral disease worldwide in terms of morbidity and mortality and is caused by any of the four serotypes of dengue virus (DENV-1 to 4). Brazil is responsible for approximately 80% of dengue cases in the Americas, and since the introduction of dengue in...

journal_title：PLoS neglected tropical diseases

authors： Lima Mda R,Nogueira RM,Schatzmayr HG,de Filippis AM,Limonta D,dos Santos FB

更新日期：2011-05-03 00:00:00

abstract：BACKGROUND:Large-scale deworming programs have, to date, mostly targeted preschool- and school-age children. As community-based deworming programs become more common, deworming will be offered to women of reproductive age. The World Health Organization recommends preventive chemotherapy be administered to pregnant wome...

journal_title：PLoS neglected tropical diseases

authors： St-Denis K,Blouin B,Rahme E,Casapia M,Montresor A,Mupfasoni D,Mbabazi PS,Gyorkos TW

更新日期：2020-01-30 00:00:00

abstract：BACKGROUND:Standard diagnosis of human soil-transmitted helminth (STH) infections is based on the microscopic detection of helminth eggs in stool and supports programmatic decision making in control programs. However, the current standard diagnostic techniques still show a number of limitations. Recently, the FECPAKG2 ...

journal_title：PLoS neglected tropical diseases

authors： Ayana M,Vlaminck J,Cools P,Ame S,Albonico M,Dana D,Keiser J,Manly H,Matoso LF,Mekonnen Z,Montresor A,Correa-Oliveira R,Rinaldi L,Sayasone S,Sowersby SJ,Tesfaye L,Vercruysse J,Mirams G,Levecke B

更新日期：2018-10-15 00:00:00

abstract：UNLABELLED:CELADEN was a randomized placebo-controlled trial of 50 patients with confirmed dengue fever to evaluate the efficacy and safety of celgosivir (A study registered at ClinicalTrials.gov, number NCT01619969). Celgosivir was given as a 400 mg loading dose and 200 mg bid (twice a day) over 5 days. Replication co...

journal_title：PLoS neglected tropical diseases

authors： Sung C,Wei Y,Watanabe S,Lee HS,Khoo YM,Fan L,Rathore AP,Chan KW,Choy MM,Kamaraj US,Sessions OM,Aw P,de Sessions PF,Lee B,Connolly JE,Hibberd ML,Vijaykrishna D,Wijaya L,Ooi EE,Low JG,Vasudevan SG

更新日期：2016-08-10 00:00:00

abstract：BACKGROUND:Health promotion is essential to the SAFE strategy for trachoma elimination. Schools are a valuable venue for health promotion. However, there is little literature about the impact of health education and water infrastructure in schools on facial cleanliness and trachoma in the community. Our study aimed to ...

journal_title：PLoS neglected tropical diseases

authors： Chen X,Munoz B,Mkocha H,Wolle MA,K West S

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Control of onchocerciasis as a public health problem in Africa relies on annual mass ivermectin distribution. New tools are needed to achieve elimination of infection. This study determined in a small number of Onchocerca volvulus infected individuals whether moxidectin, a veterinary anthelminthic, is safe e...

journal_title：PLoS neglected tropical diseases

authors： Awadzi K,Opoku NO,Attah SK,Lazdins-Helds J,Kuesel AC

更新日期：2014-06-26 00:00:00

abstract：BACKGROUND:Lymphatic filariasis (LF) is targeted for elimination by the year 2020. As of 2017, 67 of the 72 endemic countries have implemented annual Mass Drug Administration (MDA) for interrupting LF transmission. Transmission Assessment Survey (TAS) is the recommended protocol to evaluate the impact of MDA and to dec...

journal_title：PLoS neglected tropical diseases

authors： Subramanian S,Jambulingam P,Krishnamoorthy K,Sivagnaname N,Sadanandane C,Vasuki V,Palaniswamy C,Vijayakumar B,Srividya A,Raju HKK

更新日期：2020-01-24 00:00:00

abstract：:Schistosomiasis control and elimination has priority in public health agendas in several sub-Saharan countries. However, achieving these goals remains a substantial challenge. In order to assess progress of interventions and treatment efficacy it is pertinent to have accurate, feasible and affordable diagnostic tools....

journal_title：PLoS neglected tropical diseases

authors： Kildemoes AO,Vennervald BJ,Tukahebwa EM,Kabatereine NB,Magnussen P,de Dood CJ,Deelder AM,Wilson S,van Dam GJ

更新日期：2017-11-13 00:00:00

abstract：BACKGROUND:In 2010 and 2011, Haiti was heavily affected by a large cholera outbreak that spread throughout the country. Although national health structure-based cholera surveillance was rapidly initiated, a substantial number of community cases might have been missed, particularly in remote areas. We conducted a commun...

journal_title：PLoS neglected tropical diseases

authors： Page AL,Ciglenecki I,Jasmin ER,Desvignes L,Grandesso F,Polonsky J,Nicholas S,Alberti KP,Porten K,Luquero FJ

更新日期：2015-03-26 00:00:00

abstract：INTRODUCTION:Most of the studies related to rickettsial infection in Colombia are cross-sectional because of the challenge in conducting prospective studies on infectious disease that may have a difficult diagnosis. Although cross-sectional studies are essential to detect people exposed to rickettsiae, they are not sui...

journal_title：PLoS neglected tropical diseases

authors： Quintero Vélez JC,Aguirre-Acevedo DC,Rodas JD,Arboleda M,Troyo A,Vega Aguilar F,Osorio Quintero L,Rojas Arbeláez C

更新日期：2018-10-31 00:00:00

abstract：:Clonorchiasis is one of the most important food-borne trematodiases affecting millions of people. Strategies were recommended by different organizations and control programmes were implemented but mostly in short-time periods. It's important to assess the long-term benefits and sustainability of possible control strat...

journal_title：PLoS neglected tropical diseases

authors： Huang XH,Qian MB,Zhu GH,Fang YY,Hao YT,Lai YS

更新日期：2020-03-27 00:00:00

abstract：BACKGROUND:Mycobacterium tuberculosis causes the majority of tuberculosis (TB) cases in humans; however, in developing countries, human TB caused by M. bovis may be frequent but undetected. Human TB caused by M. bovis is considered a zoonosis; transmission is mainly through consumption of unpasteurized dairy products, ...

journal_title：PLoS neglected tropical diseases

authors： Bobadilla-del Valle M,Torres-González P,Cervera-Hernández ME,Martínez-Gamboa A,Crabtree-Ramirez B,Chávez-Mazari B,Ortiz-Conchi N,Rodríguez-Cruz L,Cervantes-Sánchez A,Gudiño-Enríquez T,Cinta-Severo C,Sifuentes-Osornio J,Ponce de L

更新日期：2015-09-30 00:00:00

abstract：:Japanese encephalitis virus (JEV) is a mosquito-borne, zoonotic flavivirus causing encephalitis in humans and reproductive disorder in pigs. JEV is present in large parts of Asia, where urbanization is high. Households within and outside Can Tho city, South Vietnam, were selected to monitor circulation of JEV. A neste...

journal_title：PLoS neglected tropical diseases

authors： Lindahl JF,Ståhl K,Chirico J,Boqvist S,Thu HT,Magnusson U

更新日期：2013-04-04 00:00:00

abstract：BACKGROUND:Taenia solium is a neglected zoonotic parasite endemic throughout many low-income countries worldwide, including Zambia, where it causes human and pig diseases with high health and socioeconomic burdens. Lack of knowledge is a recognized risk factor, and consequently targeted health educational programs can ...

journal_title：PLoS neglected tropical diseases

authors： Hobbs EC,Mwape KE,Devleesschauwer B,Van Damme I,Krit M,Berkvens D,Zulu G,Mambwe M,Chembensofu M,Trevisan C,Baauw J,Phiri IK,Speybroeck N,Ketzis J,Dorny P,Willingham AL,Gabriël S

更新日期：2019-05-20 00:00:00