Chlamydia trachomatis ompA variants in trachoma: what do they tell us?

abstract：:The evolutionary history and age of Plasmodium vivax has been inferred as both recent and ancient by several studies, mainly using mitochondrial genome diversity. Here we address the age of P. vivax on the Indian subcontinent using selectively neutral housekeeping genes and tandem repeat loci. Analysis of ten housekee...

journal_title：PLoS neglected tropical diseases

authors： Prajapati SK,Joshi H,Carlton JM,Rizvi MA

更新日期：2013-09-19 00:00:00

abstract：:Benzimidazole anthelmintics have long been employed for the control of soil-transmitted helminth infections. Flubendazole (FBZ) was approved in 1980 for the treatment of gastrointestinal nematode infections in both veterinary and human medicine. It has also long been known that parenteral administration of FBZ can lea...

journal_title：PLoS neglected tropical diseases

authors： Geary TG,Mackenzie CD,Silber SA

更新日期：2019-01-16 00:00:00

abstract：BACKGROUND:Mapping of lymphatic filariasis (LF) caused by Wuchereria bancrofti largely relies on the detection of circulating antigen using ICT cards. Several studies have recently shown that this test can be cross-reactive with sera of subjects heavily infected with Loa loa and thus mapping results in loiasis endemic ...

journal_title：PLoS neglected tropical diseases

authors： Wanji S,Esum ME,Njouendou AJ,Mbeng AA,Chounna Ndongmo PW,Abong RA,Fru J,Fombad FF,Nchanji GT,Ngongeh G,Ngandjui NV,Enyong PI,Storey H,Curtis KC,Fischer K,Fauver JR,Lew D,Goss CW,Fischer PU

更新日期：2019-03-08 00:00:00

abstract：BACKGROUND:Melioidosis, a fatal infectious disease caused by Burkholderia pseudomallei, is increasingly diagnosed in tropical regions. However, data on risk factors and the geographic epidemiology of the disease are still limited. Previous studies have also largely been based on the analysis of case series data. Here, ...

journal_title：PLoS neglected tropical diseases

authors： Abu Hassan MR,Aziz N,Ismail N,Shafie Z,Mayala B,Donohue RE,Pani SP,Michael E

更新日期：2019-03-18 00:00:00

abstract：:Cystic echinococcosis is still a major concern in South America. While some regions show advances in the control of the disease, others have among the highest incidence in the world. To reverse this situation the Pan American Health Organization (PAHO) has launched a regional project on cystic echinococcosis control a...

journal_title：PLoS neglected tropical diseases

authors： Morel N,Lassabe G,Elola S,Bondad M,Herrera S,Marí C,Last JA,Jensen O,Gonzalez-Sapienza G

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the relationship between prior Anisakis infections and upper gastrointestinal bleeding (UGIB), and its interaction with non-steroidal anti-inflammatory drug (NSAID) intake. METHODS/PRINCIPAL FINDINGS:We conducted a hospital-based case-control study covering 215 UGIB ...

journal_title：PLoS neglected tropical diseases

authors： Ubeira FM,Anadón AM,Salgado A,Carvajal A,Ortega S,Aguirre C,López-Goikoetxea MJ,Ibanez L,Figueiras A

更新日期：2011-06-01 00:00:00

abstract：:Cysticercosis is caused by Taenia solium, a parasitic disease that affects humans and rurally bred pigs in developing countries. The cysticercus may localize in the central nervous system of the human, causing neurocysticercosis, the most severe and frequent form of the disease. There appears to be an association betw...

journal_title：PLoS neglected tropical diseases

authors： Morales J,Martínez JJ,Rosetti M,Fleury A,Maza V,Hernandez M,Villalobos N,Fragoso G,de Aluja AS,Larralde C,Sciutto E

更新日期：2008-01-01 00:00:00

abstract：:Mycobacterium tuberculosis complex (MTBC) comprises closely related species responsible for human and animal tuberculosis (TB). Efficient species determination is useful for epidemiological purposes, especially for the elucidation of the zoonotic contribution. In Algeria, data on MTBC genotypes are largely unknown. In...

journal_title：PLoS neglected tropical diseases

authors： Damene H,Tahir D,Diels M,Berber A,Sahraoui N,Rigouts L

更新日期：2020-11-30 00:00:00

abstract：:The tick-borne flavivirus, Powassan virus (POWV) causes life-threatening encephalitis in humans in North America and Europe. POWV is transmitted by ixodid tick vectors that feed on small to medium-sized mammals, such as Peromyscus leucopus mice, which may serve as either reservoir, bridge or amplification hosts. Intra...

journal_title：PLoS neglected tropical diseases

authors： Mlera L,Meade-White K,Saturday G,Scott D,Bloom ME

更新日期：2017-01-31 00:00:00

abstract：:Chikungunya virus (CHIKV) infection is characterized by rash, acute high fever, chills, headache, nausea, photophobia, vomiting, and severe polyarthralgia. There is evidence that arthralgia can persist for years and result in long-term discomfort. Neurologic disease with fatal outcome has been documented, although at ...

journal_title：PLoS neglected tropical diseases

authors： van den Doel P,Volz A,Roose JM,Sewbalaksing VD,Pijlman GP,van Middelkoop I,Duiverman V,van de Wetering E,Sutter G,Osterhaus AD,Martina BE

更新日期：2014-09-04 00:00:00

abstract：:The increasing use of immunosuppressants in areas where visceral leishmaniasis (VL) is endemic has increased the number of people susceptible to developing more severe forms of the disease. Few studies have examined the quality of the immune response in immunosuppressed patients or experimental animals with VL. The pr...

journal_title：PLoS neglected tropical diseases

authors： Bernardo L,Solana JC,Romero-Kauss A,Sánchez C,Carrillo E,Moreno J

更新日期：2021-02-01 00:00:00

abstract：:Chagas disease is a significant health problem in Latin America and the available treatments have significant issues in terms of toxicity and efficacy. There is thus an urgent need to develop new treatments either via a repurposing strategy or through the development of new chemical entities. A key first step is the i...

journal_title：PLoS neglected tropical diseases

authors： De Rycker M,Thomas J,Riley J,Brough SJ,Miles TJ,Gray DW

更新日期：2016-04-15 00:00:00

abstract：:Over the last years, there has been a remarkable increase in the number of unresponsive patients with anthroponotic cutaneous leishmaniasis (ACL) reported worldwide. The primary objective of this study was to explore the role of demographic, clinical and environmental risk related-factors in the development of treatme...

journal_title：PLoS neglected tropical diseases

authors： Bamorovat M,Sharifi I,Dabiri S,Shamsi Meymandi S,Karamoozian A,Amiri R,Heshmatkhah A,Borhani Zarandi M,Aflatoonian MR,Sharifi F,Kheirandish R,Hassanzadeh S

更新日期：2021-01-28 00:00:00

abstract：BACKGROUND:Ofloxacin is a fluoroquinolone (FQ) used for the treatment of leprosy. FQs are known to interact with both A and B subunits of DNA gyrase and inhibit supercoiling activity of this enzyme. Mutations conferring FQ resistance have been reported to be found only in the gene encoding A subunit of this enzyme (gyr...

journal_title：PLoS neglected tropical diseases

authors： Yokoyama K,Kim H,Mukai T,Matsuoka M,Nakajima C,Suzuki Y

更新日期：2012-01-01 00:00:00

abstract：:All of our current knowledge of African trypanosome metabolism is based on results from trypanosomes grown in culture or in rodents. Drugs against sleeping sickness must however treat trypanosomes in humans. We here compare the transcriptomes of Trypanosoma brucei rhodesiense from the blood and cerebrospinal fluid of ...

journal_title：PLoS neglected tropical diseases

authors： Mulindwa J,Leiss K,Ibberson D,Kamanyi Marucha K,Helbig C,Melo do Nascimento L,Silvester E,Matthews K,Matovu E,Enyaru J,Clayton C

更新日期：2018-02-23 00:00:00

abstract：BACKGROUND:In view of the current widespread use of and reliance on a single schistosomicide, praziquantel, there is a pressing need to discover and develop alternative drugs for schistosomiasis. One approach to this is to develop High Throughput in vitro whole organism screens (HTS) to identify hits amongst large comp...

journal_title：PLoS neglected tropical diseases

authors： Mansour NR,Bickle QD

更新日期：2010-08-10 00:00:00

abstract：:Accumulating evidences have assigned a central role to parasite-derived proteins in immunomodulation. Here, we report on the proteomic identification and characterization of immunomodulatory excretory-secretory (ES) products from the metacestode larva (tetrathyridium) of the tapeworm Mesocestoides corti (syn. M. vogae...

journal_title：PLoS neglected tropical diseases

authors： Vendelova E,Camargo de Lima J,Lorenzatto KR,Monteiro KM,Mueller T,Veepaschit J,Grimm C,Brehm K,Hrčková G,Lutz MB,Ferreira HB,Nono JK

更新日期：2016-10-13 00:00:00

abstract：BACKGROUND:A majority infections caused by dengue virus (DENV) are asymptomatic, but a higher incidence of severe illness, such as dengue hemorrhagic fever, is associated with secondary infections, suggesting that pre-existing immunity plays a central role in dengue pathogenesis. Primary infections are typically associ...

journal_title：PLoS neglected tropical diseases

authors： Chaudhury S,Gromowski GD,Ripoll DR,Khavrutskii IV,Desai V,Wallqvist A

更新日期：2017-02-21 00:00:00

abstract：BACKGROUND:The diagnosis of canine echinococcosis can be a challenge in surveillance studies because there is no perfect gold standard that can be used routinely. However, unknown test specificities and sensitivities can be overcome using latent-class analysis with appropriate data. METHODOLOGY:We utilised a set of fa...

journal_title：PLoS neglected tropical diseases

authors： Hartnack S,Budke CM,Craig PS,Jiamin Q,Boufana B,Campos-Ponce M,Torgerson PR

更新日期：2013-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0004470.]. ...

journal_title：PLoS neglected tropical diseases

authors： Decuypere S,Meehan CJ,Van Puyvelde S,De Block T,Maltha J,Palpouguini L,Tahita M,Tinto H,Jacobs J,Deborggraeve S

更新日期：2017-07-28 00:00:00

abstract：BACKGROUND:Contacts of leprosy patients are at increased risk of developing leprosy and need to be targeted for early diagnosis. Seropositivity to the phenolic glycolipid I (PGL-I) antigen of Mycobacterium leprae has been used to identify contacts who have an increased risk of developing leprosy. In the present study, ...

journal_title：PLoS neglected tropical diseases

authors： Düppre NC,Camacho LA,Sales AM,Illarramendi X,Nery JA,Sampaio EP,Sarno EN,Bührer-Sékula S

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Leptospirosis, a spirochaetal zoonotic disease, is the cause of epidemics associated with high mortality in urban slum communities. Infection with pathogenic Leptospira occurs during environmental exposures and is traditionally associated with occupational risk activities. However, slum inhabitants reside in...

journal_title：PLoS neglected tropical diseases

authors： Maciel EA,de Carvalho AL,Nascimento SF,de Matos RB,Gouveia EL,Reis MG,Ko AI

更新日期：2008-01-30 00:00:00

abstract：BACKGROUND:Zika virus (ZIKV) is an important flavivirus infection. Although ZIKV infection is rarely fatal, risk for severe disease in adults is not well described. Our objective was to describe the spectrum of illness in U.S. Veterans with ZIKV infection. METHODOLOGY:Case series study including patients with laborato...

journal_title：PLoS neglected tropical diseases

authors： Schirmer PL,Wendelboe A,Lucero-Obusan CA,Ryono RA,Winters MA,Oda G,Martinez M,Saavedra S,Holodniy M

更新日期：2018-05-24 00:00:00

abstract：:We recently developed a superhydrophobic cone-based method for the collection of mosquito excreta/feces (E/F) for the molecular xenomonitoring of vector-borne parasites showing higher throughput compared to the traditional approach. To test its field applicability, we used this platform to detect the presence of filar...

journal_title：PLoS neglected tropical diseases

authors： Minetti C,Pilotte N,Zulch M,Canelas T,Tettevi EJ,Veriegh FBD,Osei-Atweneboana MY,Williams SA,Reimer LJ

更新日期：2020-04-08 00:00:00

abstract：BACKGROUND:In the roadmap on the neglected tropical diseases (NTD) the World Health Organization (WHO) aims at attaining at least 75% coverage of preventive chemotherapy in pre-school and school-age children by 2020. A randomized controlled trial was used to compare the effectiveness of praziquantel in treating Schisto...

journal_title：PLoS neglected tropical diseases

authors： Wang XY,He J,Juma S,Kabole F,Guo JG,Dai JR,Li W,Yang K

更新日期：2019-04-10 00:00:00

abstract：:The human mutilating disease chromoblastomycosis is caused by melanized members of the order Chaetothyriales. To assess population diversity among 123 clinical strains of agents of the disease in Brazil we applied sequencing of the rDNA internal transcribed spacer region, and partial cell division cycle and β-tubulin ...

journal_title：PLoS neglected tropical diseases

authors： Gomes RR,Vicente VA,Azevedo CM,Salgado CG,da Silva MB,Queiroz-Telles F,Marques SG,Santos DW,de Andrade TS,Takagi EH,Cruz KS,Fornari G,Hahn RC,Scroferneker ML,Caligine RB,Ramirez-Castrillon M,de Araújo DP,Heidrich D,Co

更新日期：2016-11-28 00:00:00

abstract：BACKGROUND:A family of hydrophilic acylated surface (HASP) proteins, containing extensive and variant amino acid repeats, is expressed at the plasma membrane in infective extracellular (metacyclic) and intracellular (amastigote) stages of Old World Leishmania species. While HASPs are antigenic in the host and can induc...

journal_title：PLoS neglected tropical diseases

authors： Depledge DP,MacLean LM,Hodgkinson MR,Smith BA,Jackson AP,Ma S,Uliana SR,Smith DF

更新日期：2010-09-28 00:00:00

abstract：INTRODUCTION:Between 1998 and 2010, S. Typhi was an uncommon cause of bloodstream infection (BSI) in Blantyre, Malawi and it was usually susceptible to first-line antimicrobial therapy. In 2011 an increase in a multidrug resistant (MDR) strain was detected through routine bacteriological surveillance conducted at Queen...

journal_title：PLoS neglected tropical diseases

authors： Feasey NA,Gaskell K,Wong V,Msefula C,Selemani G,Kumwenda S,Allain TJ,Mallewa J,Kennedy N,Bennett A,Nyirongo JO,Nyondo PA,Zulu MD,Parkhill J,Dougan G,Gordon MA,Heyderman RS

更新日期：2015-04-24 00:00:00

abstract：:In most low-resource settings, microscopy still is the standard method for diagnosis of cutaneous leishmaniasis, despite its limited sensitivity. In Ethiopia, the more sensitive molecular methods are not yet routinely used. This study compared five PCR methods with microscopy on two sample types collected from patient...

journal_title：PLoS neglected tropical diseases

authors： Merdekios B,Pareyn M,Tadesse D,Eligo N,Kassa M,Jacobs BKM,Leirs H,Van Geertruyden JP,van Griensven J,Caljon G,Cnops L

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND:Viral hemorrhagic fevers (VHF) are acute diseases associated with bleeding, organ failure, and shock. VHF may hardly be distinguished clinically from other diseases in the African hospital, including viral hepatitis. This study was conducted to determine if VHF and viral hepatitis contribute to hospital morb...

journal_title：PLoS neglected tropical diseases

authors： Bonney JH,Osei-Kwasi M,Adiku TK,Barnor JS,Amesiya R,Kubio C,Ahadzie L,Olschläger S,Lelke M,Becker-Ziaja B,Pahlmann M,Günther S

更新日期：2013-09-19 00:00:00