Proteomics profiling of chikungunya-infected Aedes albopictus C6/36 cells reveal important mosquito cell factors in virus replication.

abstract：BACKGROUND:The diagnosis of Human African Trypanosomiasis relies mainly on the Card Agglutination Test for Trypanosomiasis (CATT). While this test is successful, it is acknowledged that there may be room for improvement. Our aim was to develop a prototype lateral flow test based on the detection of antibodies to trypan...

journal_title：PLoS neglected tropical diseases

authors： Sullivan L,Wall SJ,Carrington M,Ferguson MA

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Leptospirosis occurs worldwide, but the global incidence of human disease and its mortality are not well understood. Many patients are undiagnosed and untreated due to its non-specific symptoms and a lack of access to diagnostics. This study systematically reviews the literature to clarify the mortality from...

journal_title：PLoS neglected tropical diseases

authors： Taylor AJ,Paris DH,Newton PN

更新日期：2015-06-25 00:00:00

abstract：:Mycetoma is a chronic infectious disease of the subcutaneous tissue with a high morbidity. This disease has been reported from countries between 30°N and 15°S since 1840 but the exact burden of disease is not known. It is currently unknown what the incidence, prevalence and the number of reported cases per year per co...

journal_title：PLoS neglected tropical diseases

authors： van de Sande WW

更新日期：2013-11-07 00:00:00

abstract：:Dengue virus transmission is endemic in Makassar, Indonesia, with the majority of cases reported soon after the start of the annual rainy season. Before 2006, larval source reduction, larvaciding, and reactive routine, outdoor, insecticide fogging campaigns did not result in a reduction in seasonal dengue incidence. B...

journal_title：PLoS neglected tropical diseases

authors： Wahid I,Ishak H,Hafid A,Fajri M,Sidjal S,Nurdin A,Azikin NT,Sudirman R,Hasan H,Yusuf M,Bachtiar I,Hawley WA,Rosenberg R,Lobo NF

更新日期：2019-08-05 00:00:00

abstract：:Pathogens originating from wildlife (zoonoses) pose a significant public health burden, comprising the majority of emerging infectious diseases. Efforts to control and prevent zoonotic disease have traditionally focused on animal-to-human transmission, or "spillover." However, in the modern era, increasing internation...

journal_title：PLoS neglected tropical diseases

authors： Guth S,Hanley KA,Althouse BM,Boots M

更新日期：2020-08-13 00:00:00

abstract：BACKGROUND:With few studies conducted to date, very little is known about the epidemiology of rickettsioses in Bhutan. Due to two previous outbreaks and increasing clinical cases, scrub typhus is better recognized than other rickettsial infections and Q fever. METHODOLOGY:A descriptive cross-sectional serosurvey was c...

journal_title：PLoS neglected tropical diseases

authors： Tshokey T,Stenos J,Durrheim DN,Eastwood K,Nguyen C,Graves SR

更新日期：2017-11-27 00:00:00

abstract：:The global spread of vector-borne diseases remains a worrying public health threat, raising the need for development of new combat strategies for vector control. Knowledge of vector ecology can be exploited in this regard, including plant feeding; a critical resource that mosquitoes of both sexes rely on for survival ...

journal_title：PLoS neglected tropical diseases

authors： Nyasembe VO,Tchouassi DP,Pirk CWW,Sole CL,Torto B

更新日期：2018-02-20 00:00:00

abstract：BACKGROUND:Schistosomiasis (or bilharzia), a major parasitic disease, affects more than 260 million people worldwide. In chronic cases of intestinal schistosomiasis caused by trematodes of the Schistosoma genus, hepatic fibrosis develops as a host immune response to the helminth eggs, followed by potentially lethal por...

journal_title：PLoS neglected tropical diseases

authors： Masi B,Perles-Barbacaru TA,Laprie C,Dessein H,Bernard M,Dessein A,Viola A

更新日期：2015-09-22 00:00:00

abstract：BACKGROUND:The frequency of accidental spider bites in Brazil is growing, and poisoning due to bites from the spider genus Phoneutria nigriventer is the second most frequent source of such accidents. Intense local pain is the major symptom reported after bites of P. nigriventer, although the mechanisms involved are sti...

journal_title：PLoS neglected tropical diseases

authors： Gewehr C,Oliveira SM,Rossato MF,Trevisan G,Dalmolin GD,Rigo FK,de Castro Júnior CJ,Cordeiro MN,Ferreira J,Gomez MV

更新日期：2013-04-25 00:00:00

abstract：:To obtain further insight into geographic distribution of Leishmania species in Peru, a countrywide survey, including central to southern rainforest areas where information on causative parasite species is limited, was performed based on cytochrome b (cyt b) and mannose phosphate isomerase (mpi) gene analyses. A total...

journal_title：PLoS neglected tropical diseases

authors： Kato H,Cáceres AG,Seki C,Silupu García CR,Holguín Mauricci C,Castro Martínez SC,Moreno Paico D,Castro Muniz JL,Troyes Rivera LD,Villegas Briones ZI,Guerrero Quincho S,Sulca Jayo GL,Tineo Villafuerte E,Manrique de Lara Estrada C

更新日期：2019-06-20 00:00:00

abstract：:The metacestode (larval) stage of the tapeworm Echinococcus multilocularis causes alveolar echinococcosis (AE), a very severe and in many cases incurable disease. To date, benzimidazoles such as albendazole and mebendazole are the only approved chemotherapeutical treatment options. Benzimidazoles inhibit metacestode p...

journal_title：PLoS neglected tropical diseases

authors： Stadelmann B,Rufener R,Aeschbacher D,Spiliotis M,Gottstein B,Hemphill A

更新日期：2016-03-11 00:00:00

abstract：BACKGROUND:The treatment of Leishmaniasis caused by Leishmania (Viannia) guyanensis is based on a weak strength of evidence from very few clinical trials and some case series reports. Current treatment guidelines recommend pentamidine isethionate or meglumine antimoniate (Glucantime) as the first-line choices. Both are...

journal_title：PLoS neglected tropical diseases

authors： Francesconi VA,Francesconi F,Ramasawmy R,Romero GAS,Alecrim MDGC

更新日期：2018-02-26 00:00:00

abstract：:Chromoblastomycosis (CBM) is a chronic, progressive, cutaneous and subcutaneous fungal infection following the traumatic implantation of certain dematiaceous fungi. The disease has worldwide prevalence with predominant cases reported from humid tropical and subtropical regions of America, Asia, and Africa. Diagnosis i...

journal_title：PLoS neglected tropical diseases

authors： Agarwal R,Singh G,Ghosh A,Verma KK,Pandey M,Xess I

更新日期：2017-08-03 00:00:00

abstract：BACKGROUND:Plasmodium vivax and Hepatitis B virus (HBV) are globally outspread in similar geographic regions. The concurrence of both infections and its association with some degree of protection against symptomatic and/or severe vivax malaria has been already described. Nevertheless, data on how host response to both ...

journal_title：PLoS neglected tropical diseases

authors： Cruz LAB,Moraes MOA,Queiroga-Barros MR,Fukutani KF,Barral-Netto M,Andrade BB

更新日期：2019-06-24 00:00:00

abstract：BACKGROUND:Our earlier genome-wide expression study revealed up-regulation of a tryptophan-catabolizing enzyme, indoleamine 2,3-dioxygenase (IDO1), in patients with scrub typhus. This gene has been previously reported to have anti-microbial activity in a variety of infectious diseases; therefore, we aimed to prove whet...

journal_title：PLoS neglected tropical diseases

authors： Prachason T,Konhan K,Pongnarin P,Chatsiricharoenkul S,Suputtamongkol Y,Limwongse C

更新日期：2012-01-01 00:00:00

abstract：:Most studies evaluating epidemiologic relationships between helminths and HIV have been conducted in the pre-ART era, and evidence of the impact of helminth infections on HIV disease progression remains conflicting. Less is known about helminth infection and clinical outcomes in HIV-infected adults receiving antiretro...

journal_title：PLoS neglected tropical diseases

authors： Morawski BM,Yunus M,Kerukadho E,Turyasingura G,Barbra L,Ojok AM,DiNardo AR,Sowinski S,Boulware DR,Mejia R

更新日期：2017-05-25 00:00:00

abstract：BACKGROUND:Traditional faecal-based methods have poor sensitivity for the detection of S. stercoralis, therefore are inadequate for post-treatment evaluation of infected patients who should be carefully monitored to exclude the persistence of the infection. In a previous study, we demonstrated high accuracy of five ser...

journal_title：PLoS neglected tropical diseases

authors： Buonfrate D,Sequi M,Mejia R,Cimino RO,Krolewiecki AJ,Albonico M,Degani M,Tais S,Angheben A,Requena-Mendez A,Muñoz J,Nutman TB,Bisoffi Z

更新日期：2015-02-10 00:00:00

abstract：BACKGROUND:Standard diagnosis of human soil-transmitted helminth (STH) infections is based on the microscopic detection of helminth eggs in stool and supports programmatic decision making in control programs. However, the current standard diagnostic techniques still show a number of limitations. Recently, the FECPAKG2 ...

journal_title：PLoS neglected tropical diseases

authors： Ayana M,Vlaminck J,Cools P,Ame S,Albonico M,Dana D,Keiser J,Manly H,Matoso LF,Mekonnen Z,Montresor A,Correa-Oliveira R,Rinaldi L,Sayasone S,Sowersby SJ,Tesfaye L,Vercruysse J,Mirams G,Levecke B

更新日期：2018-10-15 00:00:00

abstract：:Soil-transmitted helminths (STH) are a major cause of morbidity in tropical developing countries with a global infection prevalence of more than one billion people and disease burden of around 3.4 million disability adjusted life years. Infection prevalence directly correlates to inadequate sanitation, impoverished co...

journal_title：PLoS neglected tropical diseases

authors： Stracke K,Clarke N,Awburn CV,Vaz Nery S,Khieu V,Traub RJ,Jex AR

更新日期：2019-06-17 00:00:00

abstract：BACKGROUND:The possible emergence of resistance to the only available drug for schistosomiasis spurs drug discovery that has been recently incentivized by the availability of improved transcriptome and genome sequence information. Transient RNAi has emerged as a straightforward and important technique to interrogate th...

journal_title：PLoS neglected tropical diseases

authors： Stefanić S,Dvořák J,Horn M,Braschi S,Sojka D,Ruelas DS,Suzuki B,Lim KC,Hopkins SD,McKerrow JH,Caffrey CR

更新日期：2010-10-19 00:00:00

abstract：BACKGROUND:The World Health Organization now recommends semiannual mass drug administration (MDA) of albendazole with integrated vector management as an option for eliminating lymphatic filariasis (LF) in areas of loiasis-endemic countries where it may not be safe to use diethylcarbamazine or ivermectin in MDA programs...

journal_title：PLoS neglected tropical diseases

authors： Pion SDS,Chesnais CB,Awaca-Uvon NP,Vlaminck J,Abdou A,Kunyu-Shako B,Kuyangisa Simuna G,Tambwe JP,Weil GJ,Boussinesq M

更新日期：2020-06-23 00:00:00

abstract：BACKGROUND:The Asian tiger mosquito, Aedes albopictus, is an important vector of dengue, chikungunya and Zika viruses and is a highly invasive and aggressive biter. Established populations of this species were first recognised in Australia in 2005 when they were discovered on islands in the Torres Strait, between mainl...

journal_title：PLoS neglected tropical diseases

authors： Muzari MO,Devine G,Davis J,Crunkhorn B,van den Hurk A,Whelan P,Russell R,Walker J,Horne P,Ehlers G,Ritchie S

更新日期：2017-02-13 00:00:00

abstract：BACKGROUND:Junín virus (JUNV), the etiologic agent of Argentine hemorrhagic fever (AHF), is classified by the NIAID and CDC as a Category A priority pathogen. Presently, antiviral therapy for AHF is limited to immune plasma, which is readily available only in the endemic regions of Argentina. T-705 (favipiravir) is a b...

journal_title：PLoS neglected tropical diseases

authors： Gowen BB,Juelich TL,Sefing EJ,Brasel T,Smith JK,Zhang L,Tigabu B,Hill TE,Yun T,Pietzsch C,Furuta Y,Freiberg AN

更新日期：2013-12-26 00:00:00

abstract：:The N-linked glycosylation motif at amino acid position 154-156 of the envelope (E) protein of West Nile virus (WNV) is linked to enhanced murine neuroinvasiveness, avian pathogenicity and vector competence. Naturally occurring isolates with altered E protein glycosylation patterns have been observed in WNV isolates; ...

journal_title：PLoS neglected tropical diseases

authors： Maharaj PD,Langevin SA,Bolling BG,Andrade CC,Engle XA,Ramey WN,Bosco-Lauth A,Bowen RA,Sanders TA,Huang CY,Reisen WK,Brault AC

更新日期：2019-07-15 00:00:00

abstract：:The leptospiral LigA protein consists of 13 bacterial immunoglobulin-like (Big) domains and is the only purified recombinant subunit vaccine that has been demonstrated to protect against lethal challenge by a clinical isolate of Leptospira interrogans in the hamster model of leptospirosis. We determined the minimum nu...

journal_title：PLoS neglected tropical diseases

authors： Coutinho ML,Choy HA,Kelley MM,Matsunaga J,Babbitt JT,Lewis MS,Aleixo JA,Haake DA

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:The activities of the Global Programme for the Elimination of Lymphatic Filariasis have been in operation since the year 2000, with Mass Drug Administration (MDA) undertaken yearly in disease endemic communities. Information collected during MDA-such as population demographics, age, sex, drugs used and remai...

journal_title：PLoS neglected tropical diseases

authors： de Souza DK,Yirenkyi E,Otchere J,Biritwum NK,Ameme DK,Sackey S,Ahorlu C,Wilson MD

更新日期：2016-03-30 00:00:00

abstract：OBJECTIVE:In some Pacific Island countries, such as Solomon Islands and Fiji, active trachoma is common, but ocular Chlamydia trachomatis (Ct) infection and trachomatous trichiasis (TT) are rare. On Tarawa, the most populous Kiribati island, both the active trachoma sign "trachomatous inflammation-follicular" (TF) and ...

journal_title：PLoS neglected tropical diseases

authors： Cama A,Müller A,Taoaba R,Butcher RMR,Itibita I,Migchelsen SJ,Kiauea T,Pickering H,Willis R,Roberts CH,Bakhtiari A,Le Mesurier RT,Alexander NDE,Martin DL,Tekeraoi R,Solomon AW,Global Trachoma Mapping Project.

更新日期：2017-09-12 00:00:00

abstract：:One of the stated goals of the London Declaration on Neglected Tropical Diseases is the interruption of domiciliary transmissions of Chagas disease in the region of the Americas. We used a game-theoretic approach to assess the voluntary use of insecticide treated nets (ITNs) in the prevention of the spread of infectio...

journal_title：PLoS neglected tropical diseases

authors： Han CY,Issa H,Rychtář J,Taylor D,Umana N

更新日期：2020-11-03 00:00:00

abstract：:The main consequence of oxidative stress is the formation of DNA lesions, which can result in genomic instability and lead to cell death. Guanine is the base that is most susceptible to oxidation, due to its low redox potential, and 8-oxoguanine (8-oxoG) is the most common lesion. These characteristics make 8-oxoG a g...

journal_title：PLoS neglected tropical diseases

authors： Aguiar PH,Furtado C,Repolês BM,Ribeiro GA,Mendes IC,Peloso EF,Gadelha FR,Macedo AM,Franco GR,Pena SD,Teixeira SM,Vieira LQ,Guarneri AA,Andrade LO,Machado CR

更新日期：2013-06-13 00:00:00

abstract：BACKGROUND:Leptospira (L.) interrogans are bacteria responsible for a worldwide reemerging zoonosis. Rodents carry L. interrogans asymptomatically in their kidneys and excrete bacteria in the urine, contaminating the environment. Humans get infected through skin contact and develop a mild or severe leptospirosis that m...

journal_title：PLoS neglected tropical diseases

authors： Fanton d'Andon M,Quellard N,Fernandez B,Ratet G,Lacroix-Lamandé S,Vandewalle A,Boneca IG,Goujon JM,Werts C

更新日期：2014-01-30 00:00:00