Differential regional immune response in Chagas disease.

abstract：INTRODUCTION:This paper discusses the presence of Aedes aegypti pupae in different types of containers considering: volume, pH of the container, among other variables. METHODS:A nonlinear method for selection was applied, based on Mutual Information, by placing in order of importance the most appropriate variables for...

journal_title：PLoS neglected tropical diseases

authors： Medronho RA,Câmara VM,Macrini L

更新日期：2018-07-23 00:00:00

abstract：BACKGROUND:The Brugia malayi Bm-103 and Bm-RAL-2 proteins are orthologous to Onchocerca volvulus Ov-103 and Ov-RAL-2, and which were selected as the best candidates for the development of an O. volvulus vaccine. The B. malayi gerbil model was used to confirm the efficacy of these Ov vaccine candidates on adult worms an...

journal_title：PLoS neglected tropical diseases

authors： Arumugam S,Wei J,Liu Z,Abraham D,Bell A,Bottazzi ME,Hotez PJ,Zhan B,Lustigman S,Klei TR

更新日期：2016-04-05 00:00:00

abstract：BACKGROUND:Chikungunya virus (CHIKV), a reemerging pathogen causes a self limited illness characterized by fever, headache, myalgia and arthralgia. However, 10-20% affected individuals develop persistent arthralgia which contributes to considerable morbidity. The exact molecular mechanisms underlying these manifestatio...

journal_title：PLoS neglected tropical diseases

authors： Reddy V,Desai A,Krishna SS,Vasanthapuram R

更新日期：2017-01-26 00:00:00

abstract：BACKGROUND:The role of the immune response in influencing leptospirosis clinical outcomes is not yet well understood. We hypothesized that acute-phase serum cytokine responses may play a role in disease progression, risk for death, and severe pulmonary hemorrhage syndrome (SPHS). METHODOLOGY/PRINCIPAL FINDINGS:We perf...

journal_title：PLoS neglected tropical diseases

authors： Reis EA,Hagan JE,Ribeiro GS,Teixeira-Carvalho A,Martins-Filho OA,Montgomery RR,Shaw AC,Ko AI,Reis MG

更新日期：2013-09-19 00:00:00

abstract：INTRODUCTION:Individuals exposed to malaria infections for a long time develop immune responses capable of blocking Plasmodium transmission to mosquito vectors, potentially limiting parasite spreading in nature. Development of a malaria TB vaccine requires a better understanding of the mechanisms and main effectors res...

journal_title：PLoS neglected tropical diseases

authors： Vallejo AF,Rubiano K,Amado A,Krystosik AR,Herrera S,Arévalo-Herrera M

更新日期：2016-06-29 00:00:00

abstract：:Medical staff treating Coronavirus Disease 2019 (COVID-19) patients are at high risk for exposure to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), and many have been infected, which may cause panic among medical workers, their relatives, health professionals, and government leaders. We report the epide...

journal_title：PLoS neglected tropical diseases

authors： Li J,Long X,Zhang Q,Fang X,Li N,Lin Z,Li J,Xiong N

更新日期：2020-12-22 00:00:00

abstract：BACKGROUND:There is a pressing need for drug discovery against visceral leishmaniasis, a life-threatening protozoal infection, as the available chemotherapy is antiquated and not bereft of side effects. Plants as alternate drug resources has rewarded mankind in the past and aimed in this direction, we investigated the ...

journal_title：PLoS neglected tropical diseases

authors： Afrin F,Chouhan G,Islamuddin M,Want MY,Ozbak HA,Hemeg HA

更新日期：2019-05-09 00:00:00

abstract：:While the incidence of Human African Trypanosomiasis (HAT) is decreasing, the control approach is shifting from active population screening by mobile teams to passive case detection in primary care centers. We conducted a systematic review of the literature between 1970 and 2011 to assess which diagnostic tools are mo...

journal_title：PLoS neglected tropical diseases

authors： Mitashi P,Hasker E,Lejon V,Kande V,Muyembe JJ,Lutumba P,Boelaert M

更新日期：2012-01-01 00:00:00

abstract：:Schistosomiasis affects approximately 240 million people in the world. Schistosoma mansoni eggs in the liver induce periportal fibrosis and hepatic failure driven by monocyte recruitment and macrophage activation, resulting in robust Th2 response. Here, we suggested a possible involvement of Galectin-3 (Gal-3), histon...

journal_title：PLoS neglected tropical diseases

authors： de Oliveira FL,Carneiro K,Brito JM,Cabanel M,Pereira JX,Paiva LA,Syn W,Henderson NC,El-Cheikh MC

更新日期：2017-02-23 00:00:00

abstract：:Aedes aegypti is the major vector of yellow and dengue fevers. After 10 generations of adult selection, an A. aegypti strain (SP) developed 1650-fold resistance to permethrin, which is one of the most widely used pyrethroid insecticides for mosquito control. SP larvae also developed 8790-fold resistance following sele...

journal_title：PLoS neglected tropical diseases

authors： Kasai S,Komagata O,Itokawa K,Shono T,Ng LC,Kobayashi M,Tomita T

更新日期：2014-06-19 00:00:00

abstract：:Hansen's disease (HD) belongs to the group of neglected diseases and can cause physical deformities and disabilities, in addition to leading to social discrimination. Ocular involvement in HD is estimated at 70-75% worldwide. About 10-50% suffer from severe ocular symptoms and loss of vision occurs in approximately 5%...

journal_title：PLoS neglected tropical diseases

authors： Pavezzi PD,do Prado RB,Boin Filho PÂ,Gon ADS,Tuma B,Fornazieri MA,Scalone FM,Alves LRM,Montero RH,Casella AMB

更新日期：2020-09-21 00:00:00

abstract：:Orientia tsutsugamushi (Ots) frequently causes severe scrub typhus infections in the Asia-Pacific region. Korean investigators have demonstrated that Ots encodes five different autotransporter domain (ATD) proteins (ScaA-ScaE). ScaA functions as an adhesin and confers protective immunity in a lethal mouse model of Ots...

journal_title：PLoS neglected tropical diseases

authors： Koralur MC,Ramaiah A,Dasch GA

更新日期：2018-09-20 00:00:00

abstract：:Most statistical and mechanistic models used to predict mosquito-borne disease transmission incorporate climate drivers of disease transmission by utilizing environmental data collected at geographic scales that are potentially coarser than what mosquito populations may actually experience. Temperature and relative hu...

journal_title：PLoS neglected tropical diseases

authors： Murdock CC,Evans MV,McClanahan TD,Miazgowicz KL,Tesla B

更新日期：2017-05-30 00:00:00

abstract：BACKGROUND:Giardiasis is an intestinal infection correlated with poverty and poor drinking water quality, and treatment options are limited. According to the Center for Disease Control and Prevention, Giardia infections afflict nearly 33% of people in developing countries, and 2% of the adult population in the develope...

journal_title：PLoS neglected tropical diseases

authors： Kunz S,Balmer V,Sterk GJ,Pollastri MP,Leurs R,Müller N,Hemphill A,Spycher C

更新日期：2017-09-15 00:00:00

abstract：INTRODUCTION:While we lack a complete understanding of the molecular mechanisms by which parasites establish and achieve protection from host immune responses, it is accepted that many of these processes are mediated by products, primarily proteins, released from the parasite. Parasitic nematodes occur in different lif...

journal_title：PLoS neglected tropical diseases

authors： Moreno Y,Geary TG

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Epilepsy is one of the most common signs of Neurocysticercosis (NCC). In this study, spatial and temporal variations in the incidence of hospitalized cases (IHC) of epilepsy and NCC in Ecuadorian municipalities were analyzed. Additionally, potential socio-economic and landscape indicators were evaluated in o...

journal_title：PLoS neglected tropical diseases

authors： Ron-Garrido L,Coral-Almeida M,Gabriël S,Benitez-Ortiz W,Saegerman C,Dorny P,Berkvens D,Abatih EN

更新日期：2015-11-18 00:00:00

abstract：BACKGROUND:Rift Valley fever (RVF) is a zoonotic arbovirosis for which the primary hosts are domestic livestock (cattle, sheep and goats). RVF was first described in South Africa in 1950-1951. Mechanisms for short and long distance transmission have been hypothesised, but there is little supporting evidence. Here we de...

journal_title：PLoS neglected tropical diseases

authors： Métras R,Porphyre T,Pfeiffer DU,Kemp A,Thompson PN,Collins LM,White RG

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Cotrimoxazole prevents opportunistic infections including falciparum malaria in HIV-infected individuals but there are concerns of cross-resistance to other antifolate drugs such as sulphadoxine-pyrimethamine (SP). In this study, we investigated the prevalence of antifolate-resistance mutations in Plasmodium ...

journal_title：PLoS neglected tropical diseases

authors： Juma DW,Muiruri P,Yuhas K,John-Stewart G,Ottichilo R,Waitumbi J,Singa B,Polyak C,Kamau E

更新日期：2019-03-21 00:00:00

abstract：BACKGROUND:Most commonly used malaria diagnostic tests, including microscopy and antigen-detecting rapid tests, cannot reliably detect low-density infections which are frequent in low transmission settings. Molecular methods such as polymerase chain reaction (PCR) are highly sensitive but remain too laborious for field...

journal_title：PLoS neglected tropical diseases

authors： Vallejo AF,Martínez NL,González IJ,Arévalo-Herrera M,Herrera S

更新日期：2015-01-08 00:00:00

abstract：BACKGROUND:Loiasis, a filarial infection caused by Loa loa usually thought to cause relatively minor morbidity, can cause serious and often fatal reactions in patients carrying very high levels of circulating Loa loa microfilariae (mf) following administration of microfilaricidal drugs. An experimental model of this co...

journal_title：PLoS neglected tropical diseases

authors： Wanji S,Eyong EE,Tendongfor N,Ngwa C,Esuka E,Kengne-Ouafo A,Datchoua-Poutcheu F,Enyong P,Hopkins A,Mackenzie CD

更新日期：2015-11-10 00:00:00

abstract：:The 2015-2017 epidemics of Zika virus (ZIKV) in the Americas caused widespread infection, followed by protective immunity. The timing and burden of the next Zika virus outbreak remains unclear. We used an agent-based model to simulate the dynamics of age-specific immunity to ZIKV, and predict the future age-specific r...

journal_title：PLoS neglected tropical diseases

authors： Counotte MJ,Althaus CL,Low N,Riou J

更新日期：2019-12-26 00:00:00

abstract：BACKGROUND:In the past decade, research on neglected tropical diseases (NTDs) has intensified in response to the need to enhance community participation in health delivery, establish monitoring and surveillance systems, and integrate existing disease-specific treatment programs to control overlapping NTD burdens and de...

journal_title：PLoS neglected tropical diseases

authors： Armah FA,Quansah R,Luginaah I,Chuenpagdee R,Hambati H,Campbell G

更新日期：2015-08-04 00:00:00

abstract：BACKGROUND:Human brucellosis (HB) is a bacterial zoonosis that is more frequent in low income and middle-income countries; it is sometimes associated with outbreaks. The aim of this study was to describe the largest outbreak of HB in Brazil. METHODS:A retrospective cohort study of patients suspected of having contract...

journal_title：PLoS neglected tropical diseases

authors： Lemos TS,Cequinel JC,Costa TP,Navarro AB,Sprada A,Shibata FK,Gondolfo R,Tuon FF

更新日期：2018-09-18 00:00:00

abstract：BACKGROUND:Enterotoxigenic Escherichia coli (ETEC) encoding heat-stable enterotoxin (ST) alone or with heat-labile enterotoxin (LT) cause moderate-to-severe diarrhea (MSD) in developing country children. The Global Enteric Multicenter Study (GEMS) identified ETEC encoding ST among the top four enteropathogens. Since th...

journal_title：PLoS neglected tropical diseases

authors： Vidal RM,Muhsen K,Tennant SM,Svennerholm AM,Sow SO,Sur D,Zaidi AKM,Faruque ASG,Saha D,Adegbola R,Hossain MJ,Alonso PL,Breiman RF,Bassat Q,Tamboura B,Sanogo D,Onwuchekwa U,Manna B,Ramamurthy T,Kanungo S,Ahmed S,Q

更新日期：2019-01-04 00:00:00

abstract：BACKGROUND:Chagas disease is one of the most important neglected tropical diseases in the Americas. Vectorborne transmission of Chagas disease has been historically rare in urban settings. However, in marginal communities near the city of Arequipa, Peru, urban transmission cycles have become established. We examined th...

journal_title：PLoS neglected tropical diseases

authors： Bayer AM,Hunter GC,Gilman RH,Cornejo Del Carpio JG,Naquira C,Bern C,Levy MZ

更新日期：2009-12-15 00:00:00

abstract：:Greece was declared malaria-free in 1974 after a long antimalarial fight. In 2011-2012, an outbreak of P. vivax malaria was reported in Evrotas, an agricultural area in Southern Greece, where a large number of immigrants from endemic countries live and work. A total of 46 locally acquired and 38 imported malaria cases...

journal_title：PLoS neglected tropical diseases

authors： Tseroni M,Baka A,Kapizioni C,Snounou G,Tsiodras S,Charvalakou M,Georgitsou M,Panoutsakou M,Psinaki I,Tsoromokou M,Karakitsos G,Pervanidou D,Vakali A,Mouchtouri V,Georgakopoulou T,Mamuris Z,Papadopoulos N,Koliopoulos G,

更新日期：2015-11-19 00:00:00

abstract：BACKGROUND:The global burden of diarrhea is a leading cause of morbidity and mortality worldwide. In montane areas of South-East Asia such as northern Laos, recent changes in land use have induced increased runoff, soil erosion and in-stream suspended sediment loads, and potential pathogen dissemination. To our knowled...

journal_title：PLoS neglected tropical diseases

authors： Boithias L,Choisy M,Souliyaseng N,Jourdren M,Quet F,Buisson Y,Thammahacksa C,Silvera N,Latsachack K,Sengtaheuanghoung O,Pierret A,Rochelle-Newall E,Becerra S,Ribolzi O

更新日期：2016-12-09 00:00:00

abstract：BACKGROUND:Lymphatic filariasis (LF) is targeted for elimination in Sierra Leone. Epidemiological coverage of mass drug administration (MDA) with ivermectin and albendazole had been reported >65% in all 12 districts annually. Eight districts qualified to implement transmission assessment survey (TAS) in 2013 but were d...

journal_title：PLoS neglected tropical diseases

authors： Bah YM,Paye J,Bah MS,Conteh A,Redwood-Sawyerr V,Sonnie M,Veinoglou A,Koroma JB,Hodges MH,Zhang Y

更新日期：2020-12-28 00:00:00

abstract：BACKGROUND:Tick feeding causes extreme morbidity and mortality to humans through transmission of pathogens and causes severe economic losses to the agricultural industry by reducing livestock yield. Salivary gland secretions are essential for tick feeding and thus, reducing or preventing saliva secretions into the vert...

journal_title：PLoS neglected tropical diseases

authors： Li Z,Macaluso KR,Foil LD,Swale DR

更新日期：2019-02-07 00:00:00

abstract：:Hand, foot and mouth disease (HFMD) continues to challenge Asia with pandemic potential. In Vietnam, there have been two major outbreaks occurring during 2011-2012 (>200,000 hospitalizations and >200 deaths) and more recently in 2018 (>130,000 hospitalizations and 17 deaths). Given the high burden and the complex epid...

journal_title：PLoS neglected tropical diseases

authors： Nhan LNT,Khanh TH,Hong NTT,Van HMT,Nhu LNT,Ny NTH,Nguyet LA,Thanh TT,Anh NT,Hang VTT,Qui PT,Viet HL,Tung TH,Ha DQ,Tuan HM,Thwaites G,Chau NVV,Thwaites L,Hung NT,van Doorn HR,Tan LV

更新日期：2020-08-17 00:00:00