Thalidomide in the treatment of erythema nodosum leprosum (ENL) in an outpatient setting: A five-year retrospective analysis from a leprosy referral centre in India.

abstract：:Aedes aegypti is the major vector of yellow and dengue fevers. After 10 generations of adult selection, an A. aegypti strain (SP) developed 1650-fold resistance to permethrin, which is one of the most widely used pyrethroid insecticides for mosquito control. SP larvae also developed 8790-fold resistance following sele...

journal_title：PLoS neglected tropical diseases

authors： Kasai S,Komagata O,Itokawa K,Shono T,Ng LC,Kobayashi M,Tomita T

更新日期：2014-06-19 00:00:00

abstract：BACKGROUND:Cryptosporidium is a protozoan parasite that causes mild to severe diarrhoeal disease in humans. To date, several commercial companies have developed rapid immunoassays for the detection of Cryptosporidium infection. However, the challenge is to identify an accurate, simple and rapid diagnostic tool for the ...

journal_title：PLoS neglected tropical diseases

authors： Manouana GP,Lorenz E,Mbong Ngwese M,Nguema Moure PA,Maiga Ascofaré O,Akenten CW,Amuasi J,Rakotozandrindrainy N,Rakotozandrindrainy R,Mbwana J,Lusingu J,Byrne N,Melhem S,Zinsou JF,Adegbite RB,Hogan B,Winter D,May J,Kre

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:New therapeutics are needed for neglected tropical diseases including Human African trypanosomiasis (HAT), a progressive and fatal disease caused by the protozoan parasites Trypanosoma brucei gambiense and T. b. rhodesiense. There is a need for simple, efficient, cost effective methods to identify new molecu...

journal_title：PLoS neglected tropical diseases

authors： Swinney ZT,Haubrich BA,Xia S,Ramesha C,Gomez SR,Guyett P,Mensa-Wilmot K,Swinney DC

更新日期：2016-03-04 00:00:00

abstract：:Chikungunya virus (CHIKV), an alphavirus that causes fever and severe polyarthralgia, swept through the Americas in 2014 with almost 2 million suspected or confirmed cases reported by April 2016. In this study, we estimate the direct medical costs, cost of lost wages due to absenteeism, and years lived with disability...

journal_title：PLoS neglected tropical diseases

authors： Feldstein LR,Ellis EM,Rowhani-Rahbar A,Hennessey MJ,Staples JE,Halloran ME,Weaver MR

更新日期：2019-07-19 00:00:00

abstract：:Buruli ulcer (BU), caused by Mycobacterium ulcerans, is currently treated with a daily combination of rifampin and either injectable streptomycin or oral clarithromycin. An intermittent oral regimen would facilitate treatment supervision. We first evaluated the bactericidal activity of newer antimicrobials against M. ...

journal_title：PLoS neglected tropical diseases

authors： Chauffour A,Robert J,Veziris N,Aubry A,Pethe K,Jarlier V

更新日期：2020-08-31 00:00:00

abstract：BACKGROUND:Envenoming by viper snakes constitutes an important public health problem in Brazil and other developing countries. Local hemorrhage is an important symptom of these accidents and is correlated with the action of snake venom metalloproteinases (SVMPs). The degradation of vascular basement membrane has been p...

journal_title：PLoS neglected tropical diseases

authors： Baldo C,Jamora C,Yamanouye N,Zorn TM,Moura-da-Silva AM

更新日期：2010-06-29 00:00:00

abstract：BACKGROUND:Schistosomiasis japonica is a zoonotic parasitic disease. After nearly 70 years of control efforts in China, Schistosomiasis transmission has been reduced to a much lower level. The absence or near absence of infections in humans or livestock, based on traditional fecal and serological tests, has made the ta...

journal_title：PLoS neglected tropical diseases

authors： Qiu C,Zou HY,Deng Y,Liang YS,Lu DB

更新日期：2019-06-07 00:00:00

abstract：:Rift Valley fever (RVF) is endemic in most parts of Africa and has also been reported to occur in the Arabian Peninsula. It is responsible for significant morbidity and mortality, particularly in livestock, but also in humans. During the last two decades several outbreaks of RVF have been reported in countries in Sout...

journal_title：PLoS neglected tropical diseases

authors： Fafetine J,Neves L,Thompson PN,Paweska JT,Rutten VP,Coetzer JA

更新日期：2013-01-01 00:00:00

abstract：:Phlebotomine sand flies are insects that are highly relevant in medicine, particularly as the sole proven vectors of leishmaniasis. Accurate identification of sand fly species is an essential prerequisite for eco-epidemiological studies aiming to better understand the disease. Traditional morphological identification ...

journal_title：PLoS neglected tropical diseases

authors： Chavy A,Nabet C,Normand AC,Kocher A,Ginouves M,Prévot G,Vasconcelos Dos Santos T,Demar M,Piarroux R,de Thoisy B

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Burkholderia pseudomallei, a Tier 1 Select Agent and the cause of melioidosis, is a Gram-negative bacillus present in the environment in many tropical countries. Defining the global pattern of B. pseudomallei distribution underpins efforts to prevent infection, and is dependent upon robust environmental samp...

journal_title：PLoS neglected tropical diseases

authors： Limmathurotsakul D,Dance DA,Wuthiekanun V,Kaestli M,Mayo M,Warner J,Wagner DM,Tuanyok A,Wertheim H,Yoke Cheng T,Mukhopadhyay C,Puthucheary S,Day NP,Steinmetz I,Currie BJ,Peacock SJ

更新日期：2013-01-01 00:00:00

abstract：:Approximately 300,000 persons in the United States (US) are infected with Trypanosoma cruzi, the protozoan that causes Chagas disease, but less than 1% are estimated to have received antiparasitic treatment. Benznidazole was approved by the US Food and Drug Administration (FDA) for treatment of T. cruzi infection in 2...

journal_title：PLoS neglected tropical diseases

authors： Yoshioka K,Manne-Goehler J,Maguire JH,Reich MR

更新日期：2020-06-22 00:00:00

abstract：:Rift Valley fever (RVF), a re-emerging mosquito-borne disease of ruminants and man, was endemic in Africa but spread to Saudi Arabia and Yemen, meaning it could spread even further. Little is known about innate and cell-mediated immunity to RVF virus (RVFV) in ruminants, which is knowledge required for adequate vaccin...

journal_title：PLoS neglected tropical diseases

authors： Nfon CK,Marszal P,Zhang S,Weingartl HM

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Yersinia pestis, the agent of plague, is considered a potential bioweapon due to rapid lethality when delivered as an aerosol. Levofloxacin was tested for primary pneumonic plague treatment in a nonhuman primate model mimicking human disease. METHODS AND RESULTS:Twenty-four African Green monkeys (AGMs, Chlo...

journal_title：PLoS neglected tropical diseases

authors： Layton RC,Mega W,McDonald JD,Brasel TL,Barr EB,Gigliotti AP,Koster F

更新日期：2011-02-08 00:00:00

abstract：BACKGROUND:Leishmaniasis is a serious multifactorial parasitic disease with limited treatment options. Current chemotherapy is mainly consisted of drugs with serious drawbacks such as toxicity, variable efficacy and resistance. Alternative bioactive phytocompounds may provide a promising source for discovering new anti...

journal_title：PLoS neglected tropical diseases

authors： Karampetsou K,Koutsoni OS,Gogou G,Angelis A,Skaltsounis LA,Dotsika E

更新日期：2021-01-11 00:00:00

abstract：BACKGROUND:Leishmania uses the amino acid L-arginine as a substrate for arginase, enzyme that produces urea and ornithine, last precursor of polyamine pathway. This pathway is used by the parasite to replicate and it is essential to establish the infection in the mammalian host. L-arginine is not synthesized by the par...

journal_title：PLoS neglected tropical diseases

authors： Aoki JI,Muxel SM,Zampieri RA,Acuña SM,Fernandes JCR,Vanderlinde RH,Sales MCOP,Floeter-Winter LM

更新日期：2017-10-26 00:00:00

abstract：INTRODUCTION:The agents of paracoccidioidomycosis, historically identified as Paracoccidioides brasiliensis, are in fact different phylogenetic species. This study aims to evaluate associations between Paracoccidioides phylogenetic species and corresponding clinical data. METHODS:Paracoccidioides strains from INI/Fioc...

journal_title：PLoS neglected tropical diseases

authors： de Macedo PM,Teixeira MM,Barker BM,Zancopé-Oliveira RM,Almeida-Paes R,Francesconi do Valle AC

更新日期：2019-04-15 00:00:00

abstract：:Zika virus (ZIKV) emerged as a global public health threat throughout the Americas since 2014. Phylogenetically, the virus is composed of three main lineages, an African, Asian, and American lineage. The recent emergence and spread of ZIKV has raised questions regarding the breadth and potency of human primary ZIKV im...

journal_title：PLoS neglected tropical diseases

authors： Nix CD,Salberg J,Coulter FJ,Kareko BW,Lyski ZL,Booty BL,Messer WB

更新日期：2020-04-13 00:00:00

abstract：BACKGROUND:Zika virus (ZIKV) is a mosquito-borne flavivirus distributed throughout much of Africa and Asia. Infection with the virus may cause acute febrile illness that clinically resembles dengue fever. A recent study indicated the existence of three geographically distinct viral lineages; however this analysis utili...

journal_title：PLoS neglected tropical diseases

authors： Haddow AD,Schuh AJ,Yasuda CY,Kasper MR,Heang V,Huy R,Guzman H,Tesh RB,Weaver SC

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Hantaan virus (HTNV; family Hantaviridae, order Bunyavirales) causes hemorrhagic fever with renal syndrome (HFRS), which has raised serious concerns in Eurasia, especially in China, Russia, and South Korea. Previous studies reported genetic diversity and phylogenetic features of HTNV in different parts of Ch...

journal_title：PLoS neglected tropical diseases

authors： Li N,Li A,Liu Y,Wu W,Li C,Yu D,Zhu Y,Li J,Li D,Wang S,Liang M

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:Praziquantel-based mass treatment is the main approach to controlling schistosomiasis mansoni in endemic areas. Interventions such as provision and use of safe water, minimising contact with infested water, disposal of stool in latrines and snail control provide key avenues to break the transmission cycle an...

journal_title：PLoS neglected tropical diseases

authors： Sanya RE,Tumwesige E,Elliott AM,Seeley J

更新日期：2017-10-02 00:00:00

abstract：BACKGROUND:Hookworm disease is one of the most common infections and cause of a high disease burden in the tropics and subtropics. Remotely sensed ecological data and model-based geostatistics have been used recently to identify areas in need for hookworm control. METHODOLOGY:Cross-sectional interview data and stool s...

journal_title：PLoS neglected tropical diseases

authors： Riess H,Clowes P,Kroidl I,Kowuor DO,Nsojo A,Mangu C,Schüle SA,Mansmann U,Geldmacher C,Mhina S,Maboko L,Hoelscher M,Saathoff E

更新日期：2013-09-05 00:00:00

abstract：BACKGROUND:Hydatidosis is a zoonotic disease of worldwide distribution caused by Echinococcus granulosus. Our study aimed to determine the prevalence of human and canine echinococcosis as well as the associated risk factors in a rural area of the Limarí province in northern Chile. METHODOLOGY/PRINCIPAL FINDINGS:A cros...

journal_title：PLoS neglected tropical diseases

authors： Acosta-Jamett G,Weitzel T,Boufana B,Adones C,Bahamonde A,Abarca K,Craig PS,Reiter-Owona I

更新日期：2014-08-28 00:00:00

abstract：:The disease burden of Wuchereria bancrofti and Plasmodium falciparum malaria is high, particularly in Africa, and co-infection is common. However, the effects of filarial infection on the risk of severe malaria are unknown. We used the remaining serum samples from a large cohort study in Muheza, Tanzania to describe v...

journal_title：PLoS neglected tropical diseases

authors： Kwan JL,Seitz AE,Fried M,Lee KL,Metenou S,Morrison R,Kabyemela E,Nutman TB,Prevots DR,Duffy PE

更新日期：2018-03-26 00:00:00

abstract：:Accumulating evidences have assigned a central role to parasite-derived proteins in immunomodulation. Here, we report on the proteomic identification and characterization of immunomodulatory excretory-secretory (ES) products from the metacestode larva (tetrathyridium) of the tapeworm Mesocestoides corti (syn. M. vogae...

journal_title：PLoS neglected tropical diseases

authors： Vendelova E,Camargo de Lima J,Lorenzatto KR,Monteiro KM,Mueller T,Veepaschit J,Grimm C,Brehm K,Hrčková G,Lutz MB,Ferreira HB,Nono JK

更新日期：2016-10-13 00:00:00

abstract：BACKGROUND:Salmonella serovars Typhi (S. Typhi) and Paratyphi A (S. Paratyphi A), the causative agents of enteric fever, have been routinely isolated organisms from the blood of febrile patients in the Kathmandu Valley since the early 1990s. Susceptibility against commonly used antimicrobials for treating enteric fever...

journal_title：PLoS neglected tropical diseases

authors： Zellweger RM,Basnyat B,Shrestha P,Prajapati KG,Dongol S,Sharma PK,Koirala S,Darton TC,Dolecek C,Thompson CN,Thwaites GE,Baker SG,Karkey A

更新日期：2017-11-27 00:00:00

abstract：:An estimated 60,000 people die of rabies annually. The vast majority of cases of human rabies develop following a bite from an infected dog. Rabies can be controlled in both human and canine populations through widespread vaccination of dogs. Rabies is particularly problematic in Malawi, costing the country an estimat...

journal_title：PLoS neglected tropical diseases

authors： Gibson AD,Handel IG,Shervell K,Roux T,Mayer D,Muyila S,Maruwo GB,Nkhulungo EM,Foster RA,Chikungwa P,Chimera B,Bronsvoort BM,Mellanby RJ,Gamble L

更新日期：2016-07-14 00:00:00

abstract：:The bacterium Burkholderia ubonensis is commonly co-isolated from environmental specimens harbouring the melioidosis pathogen, Burkholderia pseudomallei. B. ubonensis has been reported in northern Australia and Thailand but not North America, suggesting similar geographic distribution to B. pseudomallei. Unlike most o...

journal_title：PLoS neglected tropical diseases

authors： Price EP,Sarovich DS,Webb JR,Hall CM,Jaramillo SA,Sahl JW,Kaestli M,Mayo M,Harrington G,Baker AL,Sidak-Loftis LC,Settles EW,Lummis M,Schupp JM,Gillece JD,Tuanyok A,Warner J,Busch JD,Keim P,Currie BJ,Wagner DM

更新日期：2017-09-14 00:00:00

abstract：BACKGROUND:A Global Programme to Eliminate Lymphatic Filariasis was launched in 2000, with mass drug administration (MDA) as the core strategy of the programme. After completing 13 years of operations through 2012 and with MDA in place in 55 of 73 endemic countries, the impact of the MDA programme on microfilaraemia, h...

journal_title：PLoS neglected tropical diseases

authors： Ramaiah KD,Ottesen EA

更新日期：2014-11-20 00:00:00

abstract：BACKGROUND:Previous studies investigating the role of cytokines in the pathogenesis of leprosy have either been on only small numbers of patients or have not combined clinical and histological data. The INFIR Cohort study is a prospective study of 303 new multibacillary leprosy patients to identify risk factors for rea...

journal_title：PLoS neglected tropical diseases

authors： Lockwood DN,Suneetha L,Sagili KD,Chaduvula MV,Mohammed I,van Brakel W,Smith WC,Nicholls P,Suneetha S

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Mass azithromycin distribution reduces under-5 child mortality. Trachoma control programs currently treat infants aged 6 months and older. Here, we report findings from an infant adverse event survey in 1-5 month olds who received azithromycin as part of a large community-randomized trial in Niger. METHODS ...

journal_title：PLoS neglected tropical diseases

authors： Oldenburg CE,Arzika AM,Maliki R,Kane MS,Lebas E,Ray KJ,Cook C,Cotter SY,Zhou Z,West SK,Bailey R,Porco TC,Keenan JD,Lietman TM,MORDOR Study Group.

更新日期：2018-11-12 00:00:00