Implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients.

abstract：BACKGROUND:Sri Lankan Russell's viper (Daboia russelii) envenoming is reported to cause myotoxicity and neurotoxicity, which are different to the effects of envenoming by most other populations of Russell's vipers. This study aimed to investigate evidence of myotoxicity in Russell's viper envenoming, response to antive...

journal_title：PLoS neglected tropical diseases

authors： Silva A,Johnston C,Kuruppu S,Kneisz D,Maduwage K,Kleifeld O,Smith AI,Siribaddana S,Buckley NA,Hodgson WC,Isbister GK

更新日期：2016-12-02 00:00:00

abstract：:Mycetoma is a chronic infectious disease of the subcutaneous tissue with a high morbidity. This disease has been reported from countries between 30°N and 15°S since 1840 but the exact burden of disease is not known. It is currently unknown what the incidence, prevalence and the number of reported cases per year per co...

journal_title：PLoS neglected tropical diseases

authors： van de Sande WW

更新日期：2013-11-07 00:00:00

abstract：:In this communication, a case of black grain eumycetoma produced by the fungus C. atrobrunneum is reported. The patient was initially misdiagnosed with M. mycetomatis eumycetoma based on the grains' morphological and cytological features. However, further aerobic culture of the black grains generated a melanised fungu...

journal_title：PLoS neglected tropical diseases

authors： Mhmoud NA,Santona A,Fiamma M,Siddig EE,Deligios M,Bakhiet SM,Rubino S,Fahal AH

更新日期：2019-05-30 00:00:00

abstract：BACKGROUND:Ofloxacin is a fluoroquinolone (FQ) used for the treatment of leprosy. FQs are known to interact with both A and B subunits of DNA gyrase and inhibit supercoiling activity of this enzyme. Mutations conferring FQ resistance have been reported to be found only in the gene encoding A subunit of this enzyme (gyr...

journal_title：PLoS neglected tropical diseases

authors： Yokoyama K,Kim H,Mukai T,Matsuoka M,Nakajima C,Suzuki Y

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Plasmodium vivax and Hepatitis B virus (HBV) are globally outspread in similar geographic regions. The concurrence of both infections and its association with some degree of protection against symptomatic and/or severe vivax malaria has been already described. Nevertheless, data on how host response to both ...

journal_title：PLoS neglected tropical diseases

authors： Cruz LAB,Moraes MOA,Queiroga-Barros MR,Fukutani KF,Barral-Netto M,Andrade BB

更新日期：2019-06-24 00:00:00

abstract：BACKGROUND:Trachoma, caused by Chlamydia trachomatis (Ct), is the leading infectious cause of blindness. Sequence-based analysis of the multiple strains typically present in endemic communities may be informative for epidemiology, transmission, response to treatment, and understanding the host response. METHODS:Conjun...

journal_title：PLoS neglected tropical diseases

authors： Andreasen AA,Burton MJ,Holland MJ,Polley S,Faal N,Mabey DC,Bailey RL

更新日期：2008-09-24 00:00:00

abstract：BACKGROUND:Epilepsy is one of the most common signs of Neurocysticercosis (NCC). In this study, spatial and temporal variations in the incidence of hospitalized cases (IHC) of epilepsy and NCC in Ecuadorian municipalities were analyzed. Additionally, potential socio-economic and landscape indicators were evaluated in o...

journal_title：PLoS neglected tropical diseases

authors： Ron-Garrido L,Coral-Almeida M,Gabriël S,Benitez-Ortiz W,Saegerman C,Dorny P,Berkvens D,Abatih EN

更新日期：2015-11-18 00:00:00

abstract：BACKGROUND:The high rate of leprosy cases among children under 15 years of age in Brazil indicates ongoing transmission within the community. The identification of the new leprosy cases among contacts can help identify the source of infection and interrupt the transmission chain. This study aims to determine the detect...

journal_title：PLoS neglected tropical diseases

authors： Pedrosa VL,Dias LC,Galban E,Leturiondo A,Palheta J Jr,Santos M,Moraes MO,Talhari C

更新日期：2018-02-26 00:00:00

abstract：INTRODUCTION:A high proportion of grade 2 disability (visible deformity) is indicative of delay in detection of leprosy and leprosy is one of the major causes of preventable disability. We conducted this study to determine the risk factors associated with disability (G2D and G1D) among adult new leprosy cases and to me...

journal_title：PLoS neglected tropical diseases

authors： Srinivas G,Muthuvel T,Lal V,Vaikundanathan K,Schwienhorst-Stich EM,Kasang C

更新日期：2019-06-27 00:00:00

abstract：BACKGROUND:Mycobacterium ulcerans (MU) is responsible for disfiguring skin lesions and is endemic on the Bellarine peninsula of southeastern Australia. Antibiotics have been shown to be highly effective in sterilizing lesions and preventing disease recurrences when used alone or in combination with surgery. Our practic...

journal_title：PLoS neglected tropical diseases

authors： Friedman ND,Athan E,Hughes AJ,Khajehnoori M,McDonald A,Callan P,Rahdon R,O'Brien DP

更新日期：2013-07-18 00:00:00

abstract：:Cystic echinococcosis (CE) is distributed worldwide, extending from China to the Middle East and from Mediterranean countries to the sub-Saharan Africa and South America. According to WHO, one million people around the world are suffering from CE with an estimated burden of 183,573 DALYs. The annual monetary burden of...

journal_title：PLoS neglected tropical diseases

authors： Borhani M,Fathi S,Lahmar S,Ahmed H,Abdulhameed MF,Fasihi Harandi M

更新日期：2020-05-07 00:00:00

abstract：BACKGROUND:Though Nepal declared leprosy elimination in 2010, its burden is constantly rising in Terai communities for the past 2 years with 3000 new leprosy cases being diagnosed annually. Community's perception is important for prevention and control of leprosy and enhancing quality of life of leprosy patients. Poor ...

journal_title：PLoS neglected tropical diseases

authors： Singh R,Singh B,Mahato S

更新日期：2019-01-11 00:00:00

abstract：BACKGROUND:Dengue is a growing problem both in its geographical spread and in its intensity, and yet current global distribution remains highly uncertain. Challenges in diagnosis and diagnostic methods as well as highly variable national health systems mean no single data source can reliably estimate the distribution o...

journal_title：PLoS neglected tropical diseases

authors： Brady OJ,Gething PW,Bhatt S,Messina JP,Brownstein JS,Hoen AG,Moyes CL,Farlow AW,Scott TW,Hay SI

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Trachoma prevalence surveys provide the evidence base for district and community-wide implementation of the SAFE strategy, and are used to evaluate the impact of trachoma control interventions. An economic analysis was performed to estimate the cost of trachoma prevalence surveys conducted between 2006 and 2...

journal_title：PLoS neglected tropical diseases

authors： Chen C,Cromwell EA,King JD,Mosher A,Harding-Esch EM,Ngondi JM,Emerson PM

更新日期：2011-03-08 00:00:00

abstract：INTRODUCTION:Schistosomiasis is a chronic parasitic trematode disease that affects over 240 million people worldwide. The Schistosoma lifecycle is complex, involving transmission via specific intermediate-host freshwater snails. Predictive mathematical models of Schistosoma transmission have often chosen to simplify or...

journal_title：PLoS neglected tropical diseases

authors： Gurarie D,Lo NC,Ndeffo-Mbah ML,Durham DP,King CH

更新日期：2018-05-21 00:00:00

abstract：BACKGROUND:A family of hydrophilic acylated surface (HASP) proteins, containing extensive and variant amino acid repeats, is expressed at the plasma membrane in infective extracellular (metacyclic) and intracellular (amastigote) stages of Old World Leishmania species. While HASPs are antigenic in the host and can induc...

journal_title：PLoS neglected tropical diseases

authors： Depledge DP,MacLean LM,Hodgkinson MR,Smith BA,Jackson AP,Ma S,Uliana SR,Smith DF

更新日期：2010-09-28 00:00:00

abstract：BACKGROUND:Lymphatic filariasis (LF) is targeted for global elimination through treatment of entire at-risk populations with repeated annual mass drug administration (MDA). Essential for program success is defining and confirming the appropriate endpoint for MDA when transmission is presumed to have reached a level low...

journal_title：PLoS neglected tropical diseases

authors： Chu BK,Deming M,Biritwum NK,Bougma WR,Dorkenoo AM,El-Setouhy M,Fischer PU,Gass K,Gonzalez de Peña M,Mercado-Hernandez L,Kyelem D,Lammie PJ,Flueckiger RM,Mwingira UJ,Noordin R,Offei Owusu I,Ottesen EA,Pavluck A,Pilotte

更新日期：2013-12-05 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0007140.]. ...

journal_title：PLoS neglected tropical diseases

authors： PLOS Neglected Tropical Diseases Staff.

更新日期：2019-06-28 00:00:00

abstract：:In mammals subverted as hosts by protozoan parasites, the latter and/or the agonists they release are detected and processed by sensors displayed by many distinct immune cell lineages, in a tissue(s)-dependent context. Focusing on the T lymphocyte lineage, we review our present understanding on its transient or durabl...

journal_title：PLoS neglected tropical diseases

authors： Rodrigues V,Cordeiro-da-Silva A,Laforge M,Ouaissi A,Akharid K,Silvestre R,Estaquier J

更新日期：2014-02-13 00:00:00

abstract：BACKGROUND:Optimal management of eumycetoma, a severely debilitating chronic progressive fungal infection of skin, disseminating to bone and viscera, remains challenging. Especially, optimal antifungal treatment and duration are ill defined. METHODOLOGY/PRINCIPAL FINDINGS:We conducted a monocentric retrospective study...

journal_title：PLoS neglected tropical diseases

authors： Crabol Y,Poiree S,Bougnoux ME,Maunoury C,Barete S,Zeller V,Arvieux C,Pineau S,Amazzough K,Lecuit M,Lanternier F,Lortholary O,French Mycosis Study Group.

更新日期：2014-10-09 00:00:00

abstract：:Cutaneous leishmaniasis caused by Leishmania major is an emergent, uncontrolled public health problem and there is no vaccine. A promising prophylactic approach has been immunotherapy with Toll-like receptor (TLR) agonists to enhance parasite-specific immune responses. We have previously reported that vaccination of C...

journal_title：PLoS neglected tropical diseases

authors： Huang L,Hinchman M,Mendez S

更新日期：2015-03-04 00:00:00

abstract：BACKGROUND:Melioidosis, a fatal infectious disease caused by Burkholderia pseudomallei, is increasingly diagnosed in tropical regions. However, data on risk factors and the geographic epidemiology of the disease are still limited. Previous studies have also largely been based on the analysis of case series data. Here, ...

journal_title：PLoS neglected tropical diseases

authors： Abu Hassan MR,Aziz N,Ismail N,Shafie Z,Mayala B,Donohue RE,Pani SP,Michael E

更新日期：2019-03-18 00:00:00

abstract：:The Qinghai-Tibet plateau is a natural plague focus and is the largest such focus in China. In this area, while Marmota himalayana is the primary host, a total of 18 human plague outbreaks associated with Tibetan sheep (78 cases with 47 deaths) have been reported on the Qinghai-Tibet plateau since 1956. All of the ind...

journal_title：PLoS neglected tropical diseases

authors： Dai R,Wei B,Xiong H,Yang X,Peng Y,He J,Jin J,Wang Y,Zha X,Zhang Z,Liang Y,Zhang Q,Xu J,Wang Z,Li W

更新日期：2018-08-16 00:00:00

abstract：BACKGROUND:Mycobacterium ulcerans disease (Buruli ulcer) is the most widespread mycobacterial disease in the world after leprosy and tuberculosis. How M. ulcerans is introduced into the skin of humans remains unclear, but it appears that individuals living in the same environment may have different susceptibilities. O...

journal_title：PLoS neglected tropical diseases

authors： Sopoh GE,Barogui YT,Johnson RC,Dossou AD,Makoutodé M,Anagonou SY,Kestens L,Portaels F

更新日期：2010-07-13 00:00:00

abstract：BACKGROUND:Vector control remains the primary method to prevent dengue infections. Environmental interventions represent sustainable and safe methods as there are limited risks of environmental contamination and toxicity. The objective of this study is to perform a systematic review and meta-analysis of the effectivene...

journal_title：PLoS neglected tropical diseases

authors： Buhler C,Winkler V,Runge-Ranzinger S,Boyce R,Horstick O

更新日期：2019-07-11 00:00:00

abstract：BACKGROUND:Wolbachia inherited intracellular bacteria can manipulate the reproduction of their insect hosts through cytoplasmic incompatibility (CI), and certain strains have also been shown to inhibit the replication or dissemination of viruses. Wolbachia strains also vary in their relative fitness effects on their ho...

journal_title：PLoS neglected tropical diseases

authors： Blagrove MS,Arias-Goeta C,Di Genua C,Failloux AB,Sinkins SP

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:During Dec-2013, a chikungunya virus (CHIKV) outbreak was first detected in the French-West Indies. Subsequently, the virus dispersed to other Caribbean islands, continental America and many islands in the Pacific Ocean. Previous estimates of the attack rate were based on declaration of clinically suspected ...

journal_title：PLoS neglected tropical diseases

authors： Gallian P,Leparc-Goffart I,Richard P,Maire F,Flusin O,Djoudi R,Chiaroni J,Charrel R,Tiberghien P,de Lamballerie X

更新日期：2017-01-12 00:00:00

abstract：BACKGROUND:The control of neglected tropical diseases (NTDs) has primarily focused on preventive chemotherapy and case management. Less attention has been placed on the role of ensuring access to adequate water, sanitation, and hygiene and personal preventive measures in reducing exposure to infection. Our aim was to a...

journal_title：PLoS neglected tropical diseases

authors： Tomczyk S,Deribe K,Brooker SJ,Clark H,Rafique K,Knopp S,Utzinger J,Davey G

更新日期：2014-11-13 00:00:00

abstract：:The bacterium Burkholderia ubonensis is commonly co-isolated from environmental specimens harbouring the melioidosis pathogen, Burkholderia pseudomallei. B. ubonensis has been reported in northern Australia and Thailand but not North America, suggesting similar geographic distribution to B. pseudomallei. Unlike most o...

journal_title：PLoS neglected tropical diseases

authors： Price EP,Sarovich DS,Webb JR,Hall CM,Jaramillo SA,Sahl JW,Kaestli M,Mayo M,Harrington G,Baker AL,Sidak-Loftis LC,Settles EW,Lummis M,Schupp JM,Gillece JD,Tuanyok A,Warner J,Busch JD,Keim P,Currie BJ,Wagner DM

更新日期：2017-09-14 00:00:00

abstract：:Endemic mycoses are systemic fungal infections. Histoplasmosis is endemic in all temperate areas of the world; coccidioidomycosis and paracoccidioidomycosis are only present in the American continent. These pathogens are not present in Spain, but in the last years there has been an increase of reported cases due to mi...

journal_title：PLoS neglected tropical diseases

authors： Molina-Morant D,Sánchez-Montalvá A,Salvador F,Sao-Avilés A,Molina I

更新日期：2018-02-15 00:00:00