Impairment of T cell function in parasitic infections.

abstract：:The mosquito Aedes aegypti, the principal vector of dengue virus, has recently been infected experimentally with Wolbachia: intracellular bacteria that possess potential as dengue biological control agents. Wolbachia depend on their hosts for nutrients they are unable to synthesize themselves. Consequently, competitio...

journal_title：PLoS neglected tropical diseases

authors： Ross PA,Endersby NM,Hoffmann AA

更新日期：2016-01-08 00:00:00

abstract：BACKGROUND:Lymphatic filariasis (LF) is targeted for elimination by the year 2020. As of 2017, 67 of the 72 endemic countries have implemented annual Mass Drug Administration (MDA) for interrupting LF transmission. Transmission Assessment Survey (TAS) is the recommended protocol to evaluate the impact of MDA and to dec...

journal_title：PLoS neglected tropical diseases

authors： Subramanian S,Jambulingam P,Krishnamoorthy K,Sivagnaname N,Sadanandane C,Vasuki V,Palaniswamy C,Vijayakumar B,Srividya A,Raju HKK

更新日期：2020-01-24 00:00:00

abstract：BACKGROUND:Leprosy is a condition that has long been associated with stigma and discrimination, even when infected persons have been cured. This paper describes stigma and discrimination as viewed by caregivers who are associated with people affected by leprosy in Ghana. METHODS:A qualitative interview with semi-struc...

journal_title：PLoS neglected tropical diseases

authors： Asampong E,Dako-Gyeke M,Oduro R

更新日期：2018-01-29 00:00:00

abstract：:Intracerebral microhemorrhages (CMHs) are small foci of hemorrhages in the cerebrum. Acute infections induced by some intracellular pathogens, including rickettsia, can result in CMHs. Annexin a2 (ANXA2) has been documented to play a functional role during intracellular bacterial adhesion. Here we report that ANXA2-kn...

journal_title：PLoS neglected tropical diseases

authors： Su Z,Chang Q,Drelich A,Shelite T,Judy B,Liu Y,Xiao J,Zhou C,He X,Jin Y,Saito T,Tang S,Soong L,Wakamiya M,Fang X,Bukreyev A,Ksiazek T,Russell WK,Gong B

更新日期：2020-07-20 00:00:00

abstract：:The World Health Organization, the World Organization for Animal Health, and the Food and Agriculture Organization have resolved to eliminate human rabies deaths due to dog bites by 2030, and the Vaccine Alliance (Gavi) has added human rabies vaccines to their investments for 2021-2025. Implementing these goals cost-e...

journal_title：PLoS neglected tropical diseases

authors： Yoder J,Younce E,Lankester F,Palmer GH

更新日期：2019-09-26 00:00:00

abstract：BACKGROUND:MPT64 rapid speciation tests are increasingly being used in diagnosis of tuberculosis (TB). Mycobacterium africanum West Africa 2 (Maf 2) remains an important cause of TB in West Africa and causes one third of disease in The Gambia. Since the introduction of MPT64 antigen tests, a higher than expected rate o...

journal_title：PLoS neglected tropical diseases

authors： Ofori-Anyinam B,Kanuteh F,Agbla SC,Adetifa I,Okoi C,Dolganov G,Schoolnik G,Secka O,Antonio M,de Jong BC,Gehre F

更新日期：2016-07-07 00:00:00

abstract：:In the rabbit model of syphilis, infection phenotypes associated with the Nichols and Chicago strains of Treponema pallidum (T. pallidum), though similar, are not identical. Between these strains, significant differences are found in expression of, and antibody responses to some candidate virulence factors, suggesting...

journal_title：PLoS neglected tropical diseases

authors： Giacani L,Chattopadhyay S,Centurion-Lara A,Jeffrey BM,Le HT,Molini BJ,Lukehart SA,Sokurenko EV,Rockey DD

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) is highly prevalent in the Indian state of Bihar and, without proper diagnosis and treatment, is associated with high fatality. However, lack of efficient reporting mechanism had been an impediment in estimating the burden of mortality and its antecedents among symptomatic VL case...

journal_title：PLoS neglected tropical diseases

authors： Das A,Karthick M,Dwivedi S,Banerjee I,Mahapatra T,Srikantiah S,Chaudhuri I

更新日期：2016-11-21 00:00:00

abstract：BACKGROUND:Despite the known burden of neglected tropical diseases (NTDs) on child health, there is limited information on current efforts to increase pediatric therapeutic options. Our objective was to quantify and characterize research activity and treatment availability for NTDs in children in order to inform the pr...

journal_title：PLoS neglected tropical diseases

authors： Rees CA,Hotez PJ,Monuteaux MC,Niescierenko M,Bourgeois FT

更新日期：2019-01-29 00:00:00

abstract：:Phlebotomine sand flies are insects that are highly relevant in medicine, particularly as the sole proven vectors of leishmaniasis. Accurate identification of sand fly species is an essential prerequisite for eco-epidemiological studies aiming to better understand the disease. Traditional morphological identification ...

journal_title：PLoS neglected tropical diseases

authors： Chavy A,Nabet C,Normand AC,Kocher A,Ginouves M,Prévot G,Vasconcelos Dos Santos T,Demar M,Piarroux R,de Thoisy B

更新日期：2019-02-01 00:00:00

abstract：:Due to the large geographical overlap of populations exposed to Zika virus (ZIKV) and human immunodeficiency virus (HIV), understanding the disease pathogenesis of co-infection is urgently needed. This warrants the development of an animal model for HIV-ZIKV co-infection. In this study, we used adult non-pregnant maca...

journal_title：PLoS neglected tropical diseases

authors： Bidokhti MRM,Dutta D,Madduri LSV,Woollard SM,Norgren R Jr,Giavedoni L,Byrareddy SN

更新日期：2018-10-25 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) is characterized by parasite-specific immunosuppression besides an intense pro-inflammatory response. Lipopolisaccharide (LPS) has been implicated in the immune activation of T-cell deficient diseases such as HIV/AIDS and idiopathic lymphocytopenia. The source of LPS is gram-negat...

journal_title：PLoS neglected tropical diseases

authors： Santos-Oliveira JR,Regis EG,Leal CR,Cunha RV,Bozza PT,Da-Cruz AM

更新日期：2011-07-01 00:00:00

abstract：:St. Louis encephalitis virus is a complex zoonoses. In 2005, 47 laboratory-confirmed and probable clinical cases of SLEV infection were reported in Córdoba, Argentina. Although the causes of 2005 outbreak remain unknown, they might be related not only to virological factors, but also to ecological and environmental co...

journal_title：PLoS neglected tropical diseases

authors： Díaz LA,Albrieu Llinás G,Vázquez A,Tenorio A,Contigiani MS

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Dengue infection is endemic in many regions throughout the world. While insecticide fogging targeting the vector mosquito Aedes aegypti is a major control measure against dengue epidemics, the impact of this method remains controversial. A previous mathematical simulation study indicated that insecticide fog...

journal_title：PLoS neglected tropical diseases

authors： Oki M,Sunahara T,Hashizume M,Yamamoto T

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVES:Burkholderia pseudomallei, the causative agent for melioidosis, has become a public health problem in India and across the world. Melioidosis can be difficult to diagnose because of the inconsistent clinical presentations of the disease. This study aims to determine the genetic diversity among the clinical i...

journal_title：PLoS neglected tropical diseases

authors： Balaji V,Perumalla S,Perumal R,Inbanathan FY,Rajamani Sekar SK,Paul MM,Sahni RD,Prakash JAJ,Iyadurai R

更新日期：2018-06-27 00:00:00

abstract：BACKGROUND:Dengue has become a major concern for international public health. Frequent epidemic outbreaks are believed to be driven by a complex interplay of immunological interactions between its four co-circulating serotypes and large fluctuations in mosquito densities. Viral lineage replacement events, caused for ex...

journal_title：PLoS neglected tropical diseases

authors： Lourenço J,Recker M

更新日期：2010-11-23 00:00:00

abstract：BACKGROUND:Onchocerciasis in Yemen is one of the most neglected diseases, where baseline estimates of onchocerciasis and monitoring of the impact of ivermectin regularly administered to the affected individuals on its transmission are lacking. Therefore, this study aimed to determine the anti-Ov16 IgG4 seroprevalence a...

journal_title：PLoS neglected tropical diseases

authors： Mahdy MAK,Abdul-Ghani R,Abdulrahman TAA,Al-Eryani SMA,Al-Mekhlafi AM,Alhaidari SAA,Azazy AA

更新日期：2018-03-05 00:00:00

abstract：:Aedes aegypti is the major vector of yellow and dengue fevers. After 10 generations of adult selection, an A. aegypti strain (SP) developed 1650-fold resistance to permethrin, which is one of the most widely used pyrethroid insecticides for mosquito control. SP larvae also developed 8790-fold resistance following sele...

journal_title：PLoS neglected tropical diseases

authors： Kasai S,Komagata O,Itokawa K,Shono T,Ng LC,Kobayashi M,Tomita T

更新日期：2014-06-19 00:00:00

abstract：BACKGROUND:Echinococcosis is a life-threatening parasitic disease caused by Echinococcus spp. tapeworms with over one million people affected globally at any time. The Echinococcus spp. tapeworms in the human body release DNA to the circulatory system, which can be a biomarker for echinococcosis. Cell-free DNA (cfDNA) ...

journal_title：PLoS neglected tropical diseases

authors： Ji J,Li B,Li J,Danzeng W,Li J,Zhao Y,Qiangba G,Zhang Q,Renzhen N,Basang Z,Jia C,Gongsang Q,Ma J,Wang Y,Chen F,Zhou H,Huasang,Yin J,Xie J,Pei N,Cai H,Jiang H,Yang H,Wang J,Asan,Han X,Li J,Chen W,Yan

更新日期：2020-04-13 00:00:00

abstract：BACKGROUND:Ofloxacin is a fluoroquinolone (FQ) used for the treatment of leprosy. FQs are known to interact with both A and B subunits of DNA gyrase and inhibit supercoiling activity of this enzyme. Mutations conferring FQ resistance have been reported to be found only in the gene encoding A subunit of this enzyme (gyr...

journal_title：PLoS neglected tropical diseases

authors： Yokoyama K,Kim H,Mukai T,Matsuoka M,Nakajima C,Suzuki Y

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Chromoblastomycosis (CBM) is a difficult-to-treat chronic subcutaneous mycosis. In Brazil, the main agent of this disease is Fonsecaea pedrosoi, which is phenotypically very similar to other Fonsecaea species, differing only genetically. The correct species identification is relevant since different species ...

journal_title：PLoS neglected tropical diseases

authors： Coelho RA,Brito-Santos F,Figueiredo-Carvalho MHG,Silva JVDS,Gutierrez-Galhardo MC,do Valle ACF,Zancopé-Oliveira RM,Trilles L,Meyer W,Freitas DFS,Almeida-Paes R

更新日期：2018-07-26 00:00:00

abstract：:The leptospiral LigA protein consists of 13 bacterial immunoglobulin-like (Big) domains and is the only purified recombinant subunit vaccine that has been demonstrated to protect against lethal challenge by a clinical isolate of Leptospira interrogans in the hamster model of leptospirosis. We determined the minimum nu...

journal_title：PLoS neglected tropical diseases

authors： Coutinho ML,Choy HA,Kelley MM,Matsunaga J,Babbitt JT,Lewis MS,Aleixo JA,Haake DA

更新日期：2011-12-01 00:00:00

abstract：:Schistosomes are intravascular helminths that infect over 200 million people worldwide. Deposition of eggs by adult schistosomes stimulates Th2 responses to egg antigens and induces granulomatous pathology that is a hallmark of schistosome infection. Paradoxically, schistosomes require host immune function for their d...

journal_title：PLoS neglected tropical diseases

authors： Ferragine CE,Walls CD,Davies SJ

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:For decades La Réunion has experienced a number of epidemics that have resulted in efforts to control the density of Aedes species on this Island. This study was conducted to assess household-level expenditure on protective measures against mosquito nuisance on the Island of La Réunion in 2012. METHODOLOGY/...

journal_title：PLoS neglected tropical diseases

authors： Thuilliez J,Bellia C,Dehecq JS,Reilhes O

更新日期：2014-01-02 00:00:00

abstract：BACKGROUND:Cutaneous leishmaniasis is caused by several Leishmania species that are associated with variable outcomes before and after therapy. Optimal treatment decision is based on an accurate identification of the infecting species but current methods to type Leishmania isolates are relatively complex and/or slow. T...

journal_title：PLoS neglected tropical diseases

authors： Mouri O,Morizot G,Van der Auwera G,Ravel C,Passet M,Chartrel N,Joly I,Thellier M,Jauréguiberry S,Caumes E,Mazier D,Marinach-Patrice C,Buffet P

更新日期：2014-06-05 00:00:00

abstract：BACKGROUND:A relatively simple life history allows us to derive an expression for the extinction probability of populations of tsetse, vectors of African sleeping sickness. We present the uncertainty and sensitivity analysis of the extinction probability, to offer key insights into factors affecting the control or erad...

journal_title：PLoS neglected tropical diseases

authors： Are EB,Hargrove JW

更新日期：2020-05-11 00:00:00

abstract：BACKGROUND:Chagas disease is a neglected parasitic infection caused by the protozoan Trypanosoma cruzi (T. cruzi) that affects more than 6 million people, mainly in Latin America. Benznidazole is still the drug of choice in many countries to treat it in spite of its dosage regimen and adverse side effects such as such ...

journal_title：PLoS neglected tropical diseases

authors： Rial MS,Scalise ML,Arrúa EC,Esteva MI,Salomon CJ,Fichera LE

更新日期：2017-12-21 00:00:00

abstract：:The toxicity of available drugs for treatment of leishmaniasis, coupled with emerging drug resistance, make it urgent to find new therapies. Antimicrobial peptides (AMPs) have a strong broad-spectrum antimicrobial activity with distinctive modes of action and are considered as promising therapeutic agents. The defensi...

journal_title：PLoS neglected tropical diseases

authors： Dabirian S,Taslimi Y,Zahedifard F,Gholami E,Doustdari F,Motamedirad M,Khatami S,Azadmanesh K,Nylen S,Rafati S

更新日期：2013-10-17 00:00:00

abstract：BACKGROUND:The immune response in the skin of dogs infected with Leishmania infantum is poorly understood, and limited studies have described the immunopathological profile with regard to distinct levels of tissue parasitism and the clinical progression of canine visceral leishmaniasis (CVL). METHODOLOGY/PRINCIPAL FIN...

journal_title：PLoS neglected tropical diseases

authors： Menezes-Souza D,Guerra-Sá R,Carneiro CM,Vitoriano-Souza J,Giunchetti RC,Teixeira-Carvalho A,Silveira-Lemos D,Oliveira GC,Corrêa-Oliveira R,Reis AB

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The cestode Echinococcus granulosus--the agent of cystic echinococcosis, a zoonosis affecting humans and domestic animals worldwide--is an excellent model for the study of host-parasite cross-talk that interfaces with two mammalian hosts. To develop the molecular analysis of these interactions, we carried ou...

journal_title：PLoS neglected tropical diseases

authors： Parkinson J,Wasmuth JD,Salinas G,Bizarro CV,Sanford C,Berriman M,Ferreira HB,Zaha A,Blaxter ML,Maizels RM,Fernández C

更新日期：2012-01-01 00:00:00