Uncertainty and sensitivity analyses of extinction probabilities suggest that adult female mortality is the weakest link for populations of tsetse (Glossina spp).

abstract：BACKGROUND:Schistosomiasis (or bilharzia), a major parasitic disease, affects more than 260 million people worldwide. In chronic cases of intestinal schistosomiasis caused by trematodes of the Schistosoma genus, hepatic fibrosis develops as a host immune response to the helminth eggs, followed by potentially lethal por...

journal_title：PLoS neglected tropical diseases

authors： Masi B,Perles-Barbacaru TA,Laprie C,Dessein H,Bernard M,Dessein A,Viola A

更新日期：2015-09-22 00:00:00

abstract：:Cutaneous leishmaniasis caused by Leishmania major is an emergent, uncontrolled public health problem and there is no vaccine. A promising prophylactic approach has been immunotherapy with Toll-like receptor (TLR) agonists to enhance parasite-specific immune responses. We have previously reported that vaccination of C...

journal_title：PLoS neglected tropical diseases

authors： Huang L,Hinchman M,Mendez S

更新日期：2015-03-04 00:00:00

abstract：:Konzo is a distinct neurological entity with selective upper motor neuron damage, characterized by an abrupt onset of an irreversible, non-progressive, and symmetrical spastic para/tetraparesis. Despite its severity, konzo remains a neglected disease. The disease is associated with high dietary cyanogen consumption fr...

journal_title：PLoS neglected tropical diseases

authors： Nzwalo H,Cliff J

更新日期：2011-06-01 00:00:00

abstract：INTRODUCTION:Plasmodium spp. and helminths are co-endemic in many parts of the tropics; hence, co-infection is a common phenomenon. Interactions between Plasmodium and helminth infections may alter the host's immune response and susceptibility and thus impact on morbidity. There is little information on the direction a...

journal_title：PLoS neglected tropical diseases

authors： Hürlimann E,Houngbedji CA,Yapi RB,N'Dri PB,Silué KD,Ouattara M,Utzinger J,N'Goran EK,Raso G

更新日期：2019-01-10 00:00:00

abstract：:Diarrheagenic Escherichia coli (DEC) cause acute and persistent diarrhoea worldwide, but little is known about their epidemiology in Mexico. We determined the prevalence of bacterial enteropathogens in 831 children with acute diarrhoea over a four-year period in Yucatan, Mexico. Six DEC supplementary virulence genes (...

journal_title：PLoS neglected tropical diseases

authors： Patzi-Vargas S,Zaidi MB,Perez-Martinez I,León-Cen M,Michel-Ayala A,Chaussabel D,Estrada-Garcia T

更新日期：2015-03-04 00:00:00

abstract：:Mycetoma is a unique neglected tropical disease which is endemic in what is known as the "mycetoma belt". The disease has many devastating impacts on patients and communities in endemic area and is characterised by massive deformity, destruction and disability. Mycetoma is commonly seen in the foot and hand and less f...

journal_title：PLoS neglected tropical diseases

authors： Fahal A,Mahgoub el S,El Hassan AM,Jacoub AO,Hassan D

更新日期：2015-03-13 00:00:00

abstract：BACKGROUND:Chagas disease is a neglected parasitic infection caused by the protozoan Trypanosoma cruzi (T. cruzi) that affects more than 6 million people, mainly in Latin America. Benznidazole is still the drug of choice in many countries to treat it in spite of its dosage regimen and adverse side effects such as such ...

journal_title：PLoS neglected tropical diseases

authors： Rial MS,Scalise ML,Arrúa EC,Esteva MI,Salomon CJ,Fichera LE

更新日期：2017-12-21 00:00:00

abstract：OBJECTIVES:Burkholderia pseudomallei, the causative agent for melioidosis, has become a public health problem in India and across the world. Melioidosis can be difficult to diagnose because of the inconsistent clinical presentations of the disease. This study aims to determine the genetic diversity among the clinical i...

journal_title：PLoS neglected tropical diseases

authors： Balaji V,Perumalla S,Perumal R,Inbanathan FY,Rajamani Sekar SK,Paul MM,Sahni RD,Prakash JAJ,Iyadurai R

更新日期：2018-06-27 00:00:00

abstract：BACKGROUND:French Guiana is a territory that has a decades-long history of dengue outbreaks and more recently, in 2014, a chikungunya outbreak. Zika virus (ZIKV) emerged in late 2015 and subsequently led to an important outbreak. METHODOLOGY/PRINCIPAL FINDINGS:A cross-sectional phone survey was conducted among the gen...

journal_title：PLoS neglected tropical diseases

authors： Fritzell C,Raude J,Kazanji M,Flamand C

更新日期：2018-01-25 00:00:00

abstract：BACKGROUND:Careful monitoring for recrudescence of Wuchereria bancrofti infection is necessary in communities where mass drug administration (MDA) for the elimination of lymphatic filariasis (LF) as a public health problem has been stopped. During the post-MDA period, transmission assessment surveys (TAS) are recommend...

journal_title：PLoS neglected tropical diseases

authors： Irish SR,Al-Amin HM,Paulin HN,Mahmood ASMS,Khan RK,Muraduzzaman AKM,Worrell CM,Flora MS,Karim MJ,Shirin T,Shamsuzzaman AKM,Tahmina S,Lenhart A,Dubray C

更新日期：2018-07-26 00:00:00

abstract：BACKGROUND:Leishmaniasis is a complex disease in which clinical outcome depends on factors such as parasite species, host genetics and immunity and vector species. In Brazil, Leishmania (Viannia) braziliensis is a major etiological agent of cutaneous (CL) and mucosal leishmaniasis (MCL), a disfiguring form of the disea...

journal_title：PLoS neglected tropical diseases

authors： Alves-Ferreira EV,Toledo JS,De Oliveira AH,Ferreira TR,Ruy PC,Pinzan CF,Santos RF,Boaventura V,Rojo D,López-Gonzálvez Á,Rosa JC,Barbas C,Barral-Netto M,Barral A,Cruz AK

更新日期：2015-09-14 00:00:00

abstract：BACKGROUND:In South Asia, hundreds of millions of people are infected with soil-transmitted helminths (Ascaris lumbricoides, hookworm, and Trichuris trichiura). However, high-resolution risk profiles and the estimated number of people infected have yet to be determined. In turn, such information will assist control pro...

journal_title：PLoS neglected tropical diseases

authors： Lai YS,Biedermann P,Shrestha A,Chammartin F,À Porta N,Montresor A,Mistry NF,Utzinger J,Vounatsou P

更新日期：2019-08-09 00:00:00

abstract：:Isothermal microcalorimetry is an established tool to measure heat flow of physical, chemical or biological processes. The metabolism of viable cells produces heat, and if sufficient cells are present, their heat production can be assessed by this method. In this study, we investigated the heat flow of two medically i...

journal_title：PLoS neglected tropical diseases

authors： Wenzler T,Steinhuber A,Wittlin S,Scheurer C,Brun R,Trampuz A

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The options for treating the fatal disease human African trypanosomiasis are limited to a few drugs that are toxic or facing increasing resistance. New drugs that kill the causative agents, subspecies of Trypanosoma brucei, are therefore urgently needed. Little is known about the cellular mechanisms that lea...

journal_title：PLoS neglected tropical diseases

authors： Worthen C,Jensen BC,Parsons M

更新日期：2010-05-04 00:00:00

abstract：:The genus Onchocerca encompasses parasitic nematodes including Onchocerca volvulus, causative agent of river blindness in humans, and the zoonotic Onchocerca lupi infecting dogs and cats. In dogs, O. lupi adult worms cause ocular lesions of various degrees while humans may bear the brunt of zoonotic onchocercosis with...

journal_title：PLoS neglected tropical diseases

authors： Colella V,Maia C,Pereira A,Gonçalves N,Caruso M,Martin C,Cardoso L,Campino L,Scandale I,Otranto D

更新日期：2018-01-29 00:00:00

abstract：:Rabies is a zoonotic infectious disease of the central nervous system (CNS). In unvaccinated or untreated subjects, rabies virus infection causes severe neurological symptoms and is invariably fatal. Despite the long-standing existence of effective vaccines, vaccine availability remains insufficient, with high numbers...

journal_title：PLoS neglected tropical diseases

authors： Schnee M,Vogel AB,Voss D,Petsch B,Baumhof P,Kramps T,Stitz L

更新日期：2016-06-23 00:00:00

abstract：:Melioidosis is caused by Burkholderia pseudomallei, a Gram-negative bacillus, primarily found in soils in Southeast Asia and northern Australia. A recent case of melioidosis in non-endemic Arizona was determined to be the result of locally acquired infection, as the patient had no travel history to endemic regions and...

journal_title：PLoS neglected tropical diseases

authors： Engelthaler DM,Bowers J,Schupp JA,Pearson T,Ginther J,Hornstra HM,Dale J,Stewart T,Sunenshine R,Waddell V,Levy C,Gillece J,Price LB,Contente T,Beckstrom-Sternberg SM,Blaney DD,Wagner DM,Mayo M,Currie BJ,Keim P,Tua

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Diagnosis of Trypanosoma cruzi infection by direct pathogen detection is complicated by the low parasite burden in subjects persistently infected with this agent of human Chagas disease. Determination of infection status by serological analysis has also been faulty, largely due to the lack of well-characteri...

journal_title：PLoS neglected tropical diseases

authors： Cooley G,Etheridge RD,Boehlke C,Bundy B,Weatherly DB,Minning T,Haney M,Postan M,Laucella S,Tarleton RL

更新日期：2008-10-08 00:00:00

abstract：:The increasing use of immunosuppressants in areas where visceral leishmaniasis (VL) is endemic has increased the number of people susceptible to developing more severe forms of the disease. Few studies have examined the quality of the immune response in immunosuppressed patients or experimental animals with VL. The pr...

journal_title：PLoS neglected tropical diseases

authors： Bernardo L,Solana JC,Romero-Kauss A,Sánchez C,Carrillo E,Moreno J

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:In some Pacific Island countries, such as Solomon Islands and Fiji, active trachoma is common, but ocular Chlamydia trachomatis (Ct) infection and trachomatous trichiasis (TT) are rare. On Tarawa, the most populous Kiribati island, both the active trachoma sign "trachomatous inflammation-follicular" (TF) and ...

journal_title：PLoS neglected tropical diseases

authors： Cama A,Müller A,Taoaba R,Butcher RMR,Itibita I,Migchelsen SJ,Kiauea T,Pickering H,Willis R,Roberts CH,Bakhtiari A,Le Mesurier RT,Alexander NDE,Martin DL,Tekeraoi R,Solomon AW,Global Trachoma Mapping Project.

更新日期：2017-09-12 00:00:00

abstract：:We briefly review cysteine proteases (orthologs of mammalian cathepsins B, L, F, and C) that are expressed in flatworm and nematode parasites. Emphasis is placed on enzyme activities that have been functionally characterized, are associated with the parasite gut, and putatively contribute to degrading host proteins to...

journal_title：PLoS neglected tropical diseases

authors： Caffrey CR,Goupil L,Rebello KM,Dalton JP,Smith D

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:Infants born to dengue immune mothers acquire maternal antibodies to dengue. These antibodies, though initially protective, decline during the first year of life to levels thought to be disease enhancing, before reaching undetectable levels. Infants have long been studied to understand the interaction betwee...

journal_title：PLoS neglected tropical diseases

authors： Clapham H,Cummings DA,Nisalak A,Kalayanarooj S,Thaisomboonsuk B,Klungthong C,Fernandez S,Srikiatkhachorn A,Macareo LR,Lessler J,Reiser J,Yoon IK

更新日期：2015-12-11 00:00:00

abstract：:Chromoblastomycosis (CBM) is a chronic, progressive, cutaneous and subcutaneous fungal infection following the traumatic implantation of certain dematiaceous fungi. The disease has worldwide prevalence with predominant cases reported from humid tropical and subtropical regions of America, Asia, and Africa. Diagnosis i...

journal_title：PLoS neglected tropical diseases

authors： Agarwal R,Singh G,Ghosh A,Verma KK,Pandey M,Xess I

更新日期：2017-08-03 00:00:00

abstract：BACKGROUND:Human echinococcosis is a neglected zoonosis caused by parasites of the genus Echinococcus. The most frequent clinical forms of echinococcosis, cystic echinococcosis (CE) and alveolar echinococcosis (AE), are responsible for a substantial health and economic burden, particularly to low-income societies. Quan...

journal_title：PLoS neglected tropical diseases

authors： Otero-Abad B,Torgerson PR

更新日期：2013-06-06 00:00:00

abstract：BACKGROUND:Culex tritaeniorhynchus is the primary vector of Japanese encephalitis virus (JEV), a leading cause of encephalitis in Asia. JEV is transmitted in an enzootic cycle involving large wading birds as the reservoirs and swine as amplifying hosts. The development of a JEV vaccine reduced the number of JE cases in...

journal_title：PLoS neglected tropical diseases

authors： Miller RH,Masuoka P,Klein TA,Kim HC,Somer T,Grieco J

更新日期：2012-01-01 00:00:00

abstract：:Successful and sustainable intervention against human helminthiases depends on optimal utilisation of available control measures and development of new tools and strategies, as well as an understanding of the evolutionary implications of prolonged intervention on parasite populations and those of their hosts and vecto...

journal_title：PLoS neglected tropical diseases

authors： Lustigman S,Geldhof P,Grant WN,Osei-Atweneboana MY,Sripa B,Basáñez MG

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Melioidosis, caused by the Gram-negative bacterium Burkholderia pseudomallei, is an emerging cause of pneumonia-derived sepsis in the tropics. The gut microbiota supports local mucosal immunity and is increasingly recognized as a protective mediator in host defenses against systemic infection. Here, we aimed...

journal_title：PLoS neglected tropical diseases

authors： Lankelma JM,Birnie E,Weehuizen TAF,Scicluna BP,Belzer C,Houtkooper RH,Roelofs JJTH,de Vos AF,van der Poll T,Budding AE,Wiersinga WJ

更新日期：2017-04-19 00:00:00

abstract：:Buruli ulcer (BU), caused by Mycobacterium ulcerans, is currently treated with a daily combination of rifampin and either injectable streptomycin or oral clarithromycin. An intermittent oral regimen would facilitate treatment supervision. We first evaluated the bactericidal activity of newer antimicrobials against M. ...

journal_title：PLoS neglected tropical diseases

authors： Chauffour A,Robert J,Veziris N,Aubry A,Pethe K,Jarlier V

更新日期：2020-08-31 00:00:00

abstract：BACKGROUND:Although infection with Trypanosoma cruzi is thought to be lifelong, less than half of those infected develop cardiomyopathy, suggesting greater parasite control or even clearance. Antibody levels appear to correlate with T. cruzi (antigen) load. We test the association between a downwards antibody trajector...

journal_title：PLoS neglected tropical diseases

authors： Buss LF,Campos de Oliveira-da Silva L,Moreira CHV,Manuli ER,Sales FC,Morales I,Di Germanio C,de Almeida-Neto C,Bakkour S,Constable P,Pinto-Filho MM,Ribeiro AL,Busch M,Sabino EC

更新日期：2020-10-27 00:00:00

abstract：:Australia is currently canine rabies free. However, communities located on the northern coastline-such as the Northern Peninsula Area (NPA), Queensland-are at risk of an incursion due to their large populations of susceptible free-roaming dogs and proximity to rabies-infected Indonesian islands. A rabies-spread model ...

journal_title：PLoS neglected tropical diseases

authors： Hudson EG,Brookes VJ,Dürr S,Ward MP

更新日期：2019-07-08 00:00:00