Molecular investigations of a locally acquired case of melioidosis in Southern AZ, USA.

Abstract:

:Melioidosis is caused by Burkholderia pseudomallei, a Gram-negative bacillus, primarily found in soils in Southeast Asia and northern Australia. A recent case of melioidosis in non-endemic Arizona was determined to be the result of locally acquired infection, as the patient had no travel history to endemic regions and no previous history of disease. Diagnosis of the case was confirmed through multiple microbiologic and molecular techniques. To enhance the epidemiological analysis, we conducted several molecular genotyping procedures, including multi-locus sequence typing, SNP-profiling, and whole genome sequence typing. Each technique has different molecular epidemiologic advantages, all of which provided evidence that the infecting strain was most similar to those found in Southeast Asia, possibly originating in, or around, Malaysia. Advancements in new typing technologies provide genotyping resolution not previously available to public health investigators, allowing for more accurate source identification.

journal_name

PLoS Negl Trop Dis

authors

Engelthaler DM,Bowers J,Schupp JA,Pearson T,Ginther J,Hornstra HM,Dale J,Stewart T,Sunenshine R,Waddell V,Levy C,Gillece J,Price LB,Contente T,Beckstrom-Sternberg SM,Blaney DD,Wagner DM,Mayo M,Currie BJ,Keim P,Tua

doi

10.1371/journal.pntd.0001347

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

e1347

issue

10

eissn

1935-2727

issn

1935-2735

pii

PNTD-D-11-00313

journal_volume

5

pub_type

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