Evaluation of oxfendazole in the treatment of zoonotic Onchocerca lupi infection in dogs.

abstract：BACKGROUND:Cure after treatment for human African trypanosomiasis (HAT) is assessed by examination of the cerebrospinal fluid every 6 months, for a total period of 2 years. So far, no markers for cure or treatment failure have been identified in blood. Trypanosome-specific antibodies are detectable in blood by the Card...

journal_title：PLoS neglected tropical diseases

authors： Lejon V,Ngoyi DM,Boelaert M,Büscher P

更新日期：2010-01-26 00:00:00

abstract：BACKGROUND:The transitional period between the oncosphere and the cysticercus of Taenia solium is the postoncospheral (PO) form, which has not yet been completely characterized. The aim of this work was to standardize a method to obtain T. solium PO forms by in vitro cultivation. We studied the morphology of the PO for...

journal_title：PLoS neglected tropical diseases

authors： Chile N,Clark T,Arana Y,Ortega YR,Palma S,Mejia A,Angulo N,Kosek JC,Kosek M,Gomez-Puerta LA,Garcia HH,Gavidia CM,Gilman RH,Verastegui M,Cysticercosis Working Group in Peru.

更新日期：2016-02-10 00:00:00

abstract：:The immunomodulatory properties of lipophosphoglycans (LPG) from New World species of Leishmania have been assessed in Leishmania infantum and Leishmania braziliensis, the causative agents of visceral and cutaneous leishmaniasis, respectively. This glycoconjugate is highly polymorphic among species with variation in s...

journal_title：PLoS neglected tropical diseases

authors： Nogueira PM,Assis RR,Torrecilhas AC,Saraiva EM,Pessoa NL,Campos MA,Marialva EF,Ríos-Velasquez CM,Pessoa FA,Secundino NF,Rugani JN,Nieves E,Turco SJ,Melo MN,Soares RP

更新日期：2016-08-10 00:00:00

abstract：BACKGROUND:Socioeconomically deprived children are at increased risk of ill-health associated with sedentary behavior, malnutrition, and helminth infection. The resulting reduced physical fitness, growth retardation, and impaired cognitive abilities may impede children's capacity to pay attention. The present study exa...

journal_title：PLoS neglected tropical diseases

authors： Gall S,Müller I,Walter C,Seelig H,Steenkamp L,Pühse U,du Randt R,Smith D,Adams L,Nqweniso S,Yap P,Ludyga S,Steinmann P,Utzinger J,Gerber M

更新日期：2017-05-08 00:00:00

abstract：BACKGROUND:Hydatidosis is a zoonotic disease of worldwide distribution caused by Echinococcus granulosus. Our study aimed to determine the prevalence of human and canine echinococcosis as well as the associated risk factors in a rural area of the Limarí province in northern Chile. METHODOLOGY/PRINCIPAL FINDINGS:A cros...

journal_title：PLoS neglected tropical diseases

authors： Acosta-Jamett G,Weitzel T,Boufana B,Adones C,Bahamonde A,Abarca K,Craig PS,Reiter-Owona I

更新日期：2014-08-28 00:00:00

abstract：BACKGROUND:Syphilis is resurgent in many regions of the world. Molecular typing is a robust tool for investigating strain diversity and epidemiology. This study aimed to review original research on molecular typing of Treponema pallidum (T. pallidum) with three objectives: (1) to determine specimen types most suitable ...

journal_title：PLoS neglected tropical diseases

authors： Peng RR,Wang AL,Li J,Tucker JD,Yin YP,Chen XS

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Cutaneous leishmaniasis is caused by several Leishmania species that are associated with variable outcomes before and after therapy. Optimal treatment decision is based on an accurate identification of the infecting species but current methods to type Leishmania isolates are relatively complex and/or slow. T...

journal_title：PLoS neglected tropical diseases

authors： Mouri O,Morizot G,Van der Auwera G,Ravel C,Passet M,Chartrel N,Joly I,Thellier M,Jauréguiberry S,Caumes E,Mazier D,Marinach-Patrice C,Buffet P

更新日期：2014-06-05 00:00:00

abstract：BACKGROUND:Canine rabies causes many thousands of human deaths every year in Africa, and continues to increase throughout much of the continent. METHODOLOGY/PRINCIPAL FINDINGS:This paper identifies four common reasons given for the lack of effective canine rabies control in Africa: (a) a low priority given for disease...

journal_title：PLoS neglected tropical diseases

authors： Lembo T,Hampson K,Kaare MT,Ernest E,Knobel D,Kazwala RR,Haydon DT,Cleaveland S

更新日期：2010-02-23 00:00:00

abstract：OBJECTIVE:The aim of the study is to examine the spatiotemporal pattern of Japanese Encephalitis (JE) in mainland China during 2002-2010. Specific objectives of the study were to quantify the temporal variation in incidence of JE cases, to determine if clustering of JE cases exists, to detect high risk spatiotemporal c...

journal_title：PLoS neglected tropical diseases

authors： Wang LY,Zhang WY,Ding F,Hu WB,Soares Magalhaes RJ,Sun HL,Li YX,Zou W,Wang Y,Liu QY,Li SL,Yin WW,Huang LY,Clements AC,Bi P,Li CY

更新日期：2013-06-20 00:00:00

abstract：:Chagas disease is caused by the parasitic protozoan Trypanosoma cruzi. It has high mortality as well as morbidity rates and usually affects the poorer sections of the population. The development of new, less harmful and more effective drugs is a promising research target, since current standard treatments are highly t...

journal_title：PLoS neglected tropical diseases

authors： Rea A,Tempone AG,Pinto EG,Mesquita JT,Rodrigues E,Silva LG,Sartorelli P,Lago JH

更新日期：2013-12-05 00:00:00

abstract：BACKGROUND:From the 17th to 19th January 2012, a group of 92 college students and teachers attended a retreat in a hotel located on Pangkor Island, off the west coast of Peninsular Malaysia. Following the onset of symptoms in many participants who presented to our institute, an investigation was undertaken which ultima...

journal_title：PLoS neglected tropical diseases

authors： Italiano CM,Wong KT,AbuBakar S,Lau YL,Ramli N,Syed Omar SF,Kahar Bador M,Tan CT

更新日期：2014-05-22 00:00:00

abstract：:Tsetse flies (Glossina spp.) transmit parasitic African trypanosomes (Trypanosoma spp.), including Trypanosoma congolense, which causes animal African trypanosomiasis (AAT). AAT detrimentally affects agricultural activities in sub-Saharan Africa and has negative impacts on the livelihood and nutrient availability for ...

journal_title：PLoS neglected tropical diseases

authors： Awuoche EO,Weiss BL,Vigneron A,Mireji PO,Aksoy E,Nyambega B,Attardo GM,Wu Y,O'Neill M,Murilla G,Aksoy S

更新日期：2017-11-20 00:00:00

abstract：BACKGROUND:This paper presents the development of an agent-based model (ABM) to incorporate climatic drivers which affect tsetse fly (G. m. morsitans) population dynamics, and ultimately disease transmission. The model was used to gain a greater understanding of how tsetse populations fluctuate seasonally, and investig...

journal_title：PLoS neglected tropical diseases

authors： Alderton S,Macleod ET,Anderson NE,Palmer G,Machila N,Simuunza M,Welburn SC,Atkinson PM

更新日期：2018-02-09 00:00:00

abstract：BACKGROUND:Pathogenesis of severe fever with thrombocytopenia syndrome (SFTS) has not been well described yet. Recent studies indicate that SFTSV could replicate in endothelial cells. Here we performed a case-control study to determine whether endothelial activation/dysfunction occurred in SFTSV infection and to identi...

journal_title：PLoS neglected tropical diseases

authors： Li XK,Yang ZD,Du J,Xing B,Cui N,Zhang PH,Li H,Zhang XA,Lu QB,Liu W

更新日期：2017-08-14 00:00:00

abstract：BACKGROUND:The cestode Echinococcus granulosus--the agent of cystic echinococcosis, a zoonosis affecting humans and domestic animals worldwide--is an excellent model for the study of host-parasite cross-talk that interfaces with two mammalian hosts. To develop the molecular analysis of these interactions, we carried ou...

journal_title：PLoS neglected tropical diseases

authors： Parkinson J,Wasmuth JD,Salinas G,Bizarro CV,Sanford C,Berriman M,Ferreira HB,Zaha A,Blaxter ML,Maizels RM,Fernández C

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Current WHO recommendations for lymphatic filariasis (LF) surveillance advise programs to implement activities to monitor for new foci of transmission after stopping mass drug administration (MDA). A current need in the global effort to eliminate LF is to standardize diagnostic tools and surveillance activit...

journal_title：PLoS neglected tropical diseases

authors： Won KY,Robinson K,Hamlin KL,Tufa J,Seespesara M,Wiegand RE,Gass K,Kubofcik J,Nutman TB,Lammie PJ,Fuimaono S

更新日期：2018-03-09 00:00:00

abstract：:Pathogens originating from wildlife (zoonoses) pose a significant public health burden, comprising the majority of emerging infectious diseases. Efforts to control and prevent zoonotic disease have traditionally focused on animal-to-human transmission, or "spillover." However, in the modern era, increasing internation...

journal_title：PLoS neglected tropical diseases

authors： Guth S,Hanley KA,Althouse BM,Boots M

更新日期：2020-08-13 00:00:00

abstract：BACKGROUND:Amebic colitis, caused by intestinal infection with the parasite, Entamoeba histolytica, is a common cause of diarrhea worldwide. Fulminant amebic colitis is the most devastating complication of this infection, associated with both high mortality and morbidity. We conducted a review of the English literature...

journal_title：PLoS neglected tropical diseases

authors： Shirley DA,Moonah S

更新日期：2016-07-28 00:00:00

abstract：BACKGROUND:Oncomelania hupensis is the unique intermediate host of Schistosoma japonicum, which causes schistosomiasis endemic in the Far East, and especially in mainland China. O. hupensis largely determines the parasite's geographical range. How O. hupensis's genetic diversity is distributed geographically in mainlan...

journal_title：PLoS neglected tropical diseases

authors： Zhao QP,Jiang MS,Littlewood DT,Nie P

更新日期：2010-03-02 00:00:00

abstract：:Filoviruses such as Ebola virus (EBOV) cause outbreaks of viral hemorrhagic fevers for which no FDA-approved vaccines or drugs are available. The 2014-2016 EBOV outbreak in West Africa infected approximately 30,000 people, killing more than 11,000 and affecting thousands more in areas still suffering from the effects ...

journal_title：PLoS neglected tropical diseases

authors： Haun BK,Kamara V,Dweh AS,Garalde-Machida K,Forkay SSE,Takaaze M,Namekar M,Wong TAS,Bell-Gam Woto AER,Humphreys P,Weeks OI,Fallah MP,Berestecky JM,Nerurkar VR,Lehrer AT

更新日期：2019-07-22 00:00:00

abstract：:We recently reported that larval stage Aedes aegypti and several other species of mosquitoes grow when living bacteria are present in the gut but do not grow when living bacteria are absent. We further reported that living bacteria induce a hypoxia signal in the gut, which activates hypoxia-induced transcription facto...

journal_title：PLoS neglected tropical diseases

authors： Valzania L,Martinson VG,Harrison RE,Boyd BM,Coon KL,Brown MR,Strand MR

更新日期：2018-07-06 00:00:00

abstract：:Medical staff treating Coronavirus Disease 2019 (COVID-19) patients are at high risk for exposure to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), and many have been infected, which may cause panic among medical workers, their relatives, health professionals, and government leaders. We report the epide...

journal_title：PLoS neglected tropical diseases

authors： Li J,Long X,Zhang Q,Fang X,Li N,Lin Z,Li J,Xiong N

更新日期：2020-12-22 00:00:00

abstract：BACKGROUND:Sporadic Japanese encephalitis (JE) cases still have been reported in Zhejiang Province in recent years, and concerns about vaccine cross-protection and population-level immunity have been raised off and on within the public health sphere. Genotype I (GI) has replaced GIII as the dominant genotype in Asian c...

journal_title：PLoS neglected tropical diseases

authors： Pan JR,Yan JY,Zhou JY,Tang XW,He HQ,Xie RH,Mao HY,Zhang YJ,Xie SY

更新日期：2016-08-25 00:00:00

abstract：:Trypanosoma cruzi, the etiological agent of Chagas disease, consumes glucose and amino acids depending on the environmental availability of each nutrient during its complex life cycle. For example, amino acids are the major energy and carbon sources in the intracellular stages of the T. cruzi parasite, but their consu...

journal_title：PLoS neglected tropical diseases

authors： Crispim M,Damasceno FS,Hernández A,Barisón MJ,Pretto Sauter I,Souza Pavani R,Santos Moura A,Pral EMF,Cortez M,Elias MC,Silber AM

更新日期：2018-01-10 00:00:00

abstract：BACKGROUND:Rift Valley fever (RVF) is a zoonotic arbovirosis for which the primary hosts are domestic livestock (cattle, sheep and goats). RVF was first described in South Africa in 1950-1951. Mechanisms for short and long distance transmission have been hypothesised, but there is little supporting evidence. Here we de...

journal_title：PLoS neglected tropical diseases

authors： Métras R,Porphyre T,Pfeiffer DU,Kemp A,Thompson PN,Collins LM,White RG

更新日期：2012-01-01 00:00:00

abstract：:Nucleoside hydrolases (NHs) show homology among parasite protozoa, fungi and bacteria. They are vital protagonists in the establishment of early infection and, therefore, are excellent candidates for the pathogen recognition by adaptive immune responses. Immune protection against NHs would prevent disease at the early...

journal_title：PLoS neglected tropical diseases

authors： Nico D,Claser C,Borja-Cabrera GP,Travassos LR,Palatnik M,Soares IS,Rodrigues MM,Palatnik-de-Sousa CB

更新日期：2010-11-09 00:00:00

abstract：BACKGROUND:Bartonella bacilliformis is the etiological agent of Carrion's disease, a neglected tropical poverty-linked illness. This infection is endemic of Andean regions and it is estimated that approximately 1.7 million of South Americans are at risk. This bacterium is a fastidious slow growing microorganism, which ...

journal_title：PLoS neglected tropical diseases

authors： Pons MJ,Silva-Caso W,Del Valle-Mendoza J,Ruiz J

更新日期：2016-01-29 00:00:00

abstract：BACKGROUND:Leishmania development in the sand fly gut leads to highly infective forms called metacyclic promastigotes. This process can be routinely mimicked in culture. Gene expression-profiling studies by transcriptome analysis have been performed with the aim of studying promastigote forms in the sand fly gut, as we...

journal_title：PLoS neglected tropical diseases

authors： Alcolea PJ,Alonso A,Molina R,Jiménez M,Myler PJ,Larraga V

更新日期：2019-05-09 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) or Kala-azar has been a major public health problem in Bihar, India, for several decades. A few VL infected districts including Vaishali have reported >600 cases annually. Hence, in 2015, the Government of India entrusted ICMR-Rajendra Memorial Research Institute of Medical Scienc...

journal_title：PLoS neglected tropical diseases

authors： Kumar V,Mandal R,Das S,Kesari S,Dinesh DS,Pandey K,Das VR,Topno RK,Sharma MP,Dasgupta RK,Das P

更新日期：2020-05-04 00:00:00

abstract：BACKGROUND:Trichinellosis is a serious zoonositc parasitosis worldwide. Because its clinical manifestations aren't specific, the diagnosis of trichinellosis is not easy to be made. Trichinella spiralis muscle larva (ML) excretory-secretory (ES) antigens are the most widely applied diagnostic antigens for human trichine...

journal_title：PLoS neglected tropical diseases

authors： Sun GG,Song YY,Jiang P,Ren HN,Yan SW,Han Y,Liu RD,Zhang X,Wang ZQ,Cui J

更新日期：2018-05-14 00:00:00