Silent circulation of St. Louis encephalitis virus prior to an encephalitis outbreak in Cordoba, Argentina (2005).

abstract：:Schistosomiasis is endemic to many regions of the world and affects approximately 200 million people. Conventional adaptive T cell responses are considered to be the primary contributors to the pathogenesis of Schistosoma japonicum infection, leading to liver granuloma and fibrosis. However, the functional polarizatio...

journal_title：PLoS neglected tropical diseases

authors： Gong W,Huang F,Sun L,Yu A,Zhang X,Xu Y,Shen Y,Cao J

更新日期：2018-12-27 00:00:00

abstract：BACKGROUND:Epidemiological studies carried out using culture or microscopy in most of the amoebiasis endemic developing countries, yielded confusing results since none of these could differentiate the pathogenic Entamoeba histolytica from the non-pathogenic Entamoeba dispar and Entamoeba moshkovskii. The Northeastern p...

journal_title：PLoS neglected tropical diseases

authors： Nath J,Ghosh SK,Singha B,Paul J

更新日期：2015-12-03 00:00:00

abstract：BACKGROUND:Schistosomiasis japonica is a zoonotic parasitic disease. After nearly 70 years of control efforts in China, Schistosomiasis transmission has been reduced to a much lower level. The absence or near absence of infections in humans or livestock, based on traditional fecal and serological tests, has made the ta...

journal_title：PLoS neglected tropical diseases

authors： Qiu C,Zou HY,Deng Y,Liang YS,Lu DB

更新日期：2019-06-07 00:00:00

abstract：BACKGROUND:We identified the species of Leishmania isolated from traveling and migrant patients attended in a reference center from 2000 to 2015, we performed the georeferencing of these species in Rio de Janeiro (RJ) state and we had knowledge about the human flows between the likely location of infection (LLI) and pl...

journal_title：PLoS neglected tropical diseases

authors： Miranda LFC,Pacheco RDS,Pimentel MIF,Salgueiro MM,da Silva AF,de Mello CX,Barros JHDS,Valete-Rosalino CM,Madeira MF,Xavier SCDC,Schubach AO

更新日期：2019-11-15 00:00:00

abstract：:One of the most important clinical signs of dengue virus infection is the reduction of white blood cells and platelets in human peripheral blood (leukopenia and thrombocytopenia, respectively), which may significantly impair the clearance of dengue virus by the immune system. The cause of thrombocytopenia and leukopen...

journal_title：PLoS neglected tropical diseases

authors： Vogt MB,Lahon A,Arya RP,Spencer Clinton JL,Rico-Hesse R

更新日期：2019-11-25 00:00:00

abstract：BACKGROUND:Trachoma is a major cause of blindness in Southern Sudan. Its distribution has only been partially established and many communities in need of intervention have therefore not been identified or targeted. The present study aimed to develop a tool to improve targeting of survey and control activities. METHODS...

journal_title：PLoS neglected tropical diseases

authors： Clements AC,Kur LW,Gatpan G,Ngondi JM,Emerson PM,Lado M,Sabasio A,Kolaczinski JH

更新日期：2010-08-17 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) in human immunodeficiency virus (HIV) co-infected patients requires special case management. AmBisome monotherapy at 40 mg/kg is recommended by the World Health Organization. The objective of the study was to assess if a combination of a lower dose of AmBisome with miltefosine wou...

journal_title：PLoS neglected tropical diseases

authors： Diro E,Blesson S,Edwards T,Ritmeijer K,Fikre H,Admassu H,Kibret A,Ellis SJ,Bardonneau C,Zijlstra EE,Soipei P,Mutinda B,Omollo R,Kimutai R,Omwalo G,Wasunna M,Tadesse F,Alves F,Strub-Wourgaft N,Hailu A,Alexander N,

更新日期：2019-01-17 00:00:00

abstract：BACKGROUND:Schistosomiasis (or bilharzia), a major parasitic disease, affects more than 260 million people worldwide. In chronic cases of intestinal schistosomiasis caused by trematodes of the Schistosoma genus, hepatic fibrosis develops as a host immune response to the helminth eggs, followed by potentially lethal por...

journal_title：PLoS neglected tropical diseases

authors： Masi B,Perles-Barbacaru TA,Laprie C,Dessein H,Bernard M,Dessein A,Viola A

更新日期：2015-09-22 00:00:00

abstract：BACKGROUND:There is a pressing need for drug discovery against visceral leishmaniasis, a life-threatening protozoal infection, as the available chemotherapy is antiquated and not bereft of side effects. Plants as alternate drug resources has rewarded mankind in the past and aimed in this direction, we investigated the ...

journal_title：PLoS neglected tropical diseases

authors： Afrin F,Chouhan G,Islamuddin M,Want MY,Ozbak HA,Hemeg HA

更新日期：2019-05-09 00:00:00

abstract：:Dengue virus transmission is endemic in Makassar, Indonesia, with the majority of cases reported soon after the start of the annual rainy season. Before 2006, larval source reduction, larvaciding, and reactive routine, outdoor, insecticide fogging campaigns did not result in a reduction in seasonal dengue incidence. B...

journal_title：PLoS neglected tropical diseases

authors： Wahid I,Ishak H,Hafid A,Fajri M,Sidjal S,Nurdin A,Azikin NT,Sudirman R,Hasan H,Yusuf M,Bachtiar I,Hawley WA,Rosenberg R,Lobo NF

更新日期：2019-08-05 00:00:00

abstract：:Enterotoxigenic Escherichia coli (ETEC), defined by their elaboration of heat-labile (LT) and/or heat-stable (ST) enterotoxins, are a common cause of diarrheal illness in developing countries. Efficient delivery of these toxins requires ETEC to engage target host enterocytes. This engagement is accomplished using a va...

journal_title：PLoS neglected tropical diseases

authors： Sheikh A,Rashu R,Begum YA,Kuhlman FM,Ciorba MA,Hultgren SJ,Qadri F,Fleckenstein JM

更新日期：2017-05-22 00:00:00

abstract：BACKGROUND:In the roadmap on the neglected tropical diseases (NTD) the World Health Organization (WHO) aims at attaining at least 75% coverage of preventive chemotherapy in pre-school and school-age children by 2020. A randomized controlled trial was used to compare the effectiveness of praziquantel in treating Schisto...

journal_title：PLoS neglected tropical diseases

authors： Wang XY,He J,Juma S,Kabole F,Guo JG,Dai JR,Li W,Yang K

更新日期：2019-04-10 00:00:00

abstract：:Over two-thirds of the world's population lives in regions where rabies is endemic, resulting in over 15 million people receiving multi-dose post-exposure prophylaxis (PEP) and over 55,000 deaths per year globally. A major goal in rabies virus (RABV) research is to develop a single-dose PEP that would simplify vaccina...

journal_title：PLoS neglected tropical diseases

authors： Dorfmeier CL,Tzvetkov EP,Gatt A,McGettigan JP

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Control of onchocerciasis as a public health problem in Africa relies on annual mass ivermectin distribution. New tools are needed to achieve elimination of infection. This study determined in a small number of Onchocerca volvulus infected individuals whether moxidectin, a veterinary anthelminthic, is safe e...

journal_title：PLoS neglected tropical diseases

authors： Awadzi K,Opoku NO,Attah SK,Lazdins-Helds J,Kuesel AC

更新日期：2014-06-26 00:00:00

abstract：:As rabies in carnivores is increasingly controlled throughout much of the Americas, bats are emerging as a significant source of rabies virus infection of humans and domestic animals. Knowledge of the bat species that maintain rabies is a crucial first step in reducing this public health problem. In North America, sev...

journal_title：PLoS neglected tropical diseases

authors： Nadin-Davis S,Alnabelseya N,Knowles MK

更新日期：2017-05-19 00:00:00

abstract：:Filoviruses such as Ebola virus (EBOV) cause outbreaks of viral hemorrhagic fevers for which no FDA-approved vaccines or drugs are available. The 2014-2016 EBOV outbreak in West Africa infected approximately 30,000 people, killing more than 11,000 and affecting thousands more in areas still suffering from the effects ...

journal_title：PLoS neglected tropical diseases

authors： Haun BK,Kamara V,Dweh AS,Garalde-Machida K,Forkay SSE,Takaaze M,Namekar M,Wong TAS,Bell-Gam Woto AER,Humphreys P,Weeks OI,Fallah MP,Berestecky JM,Nerurkar VR,Lehrer AT

更新日期：2019-07-22 00:00:00

abstract：BACKGROUND:Vector control remains the primary method to prevent dengue infections. Environmental interventions represent sustainable and safe methods as there are limited risks of environmental contamination and toxicity. The objective of this study is to perform a systematic review and meta-analysis of the effectivene...

journal_title：PLoS neglected tropical diseases

authors： Buhler C,Winkler V,Runge-Ranzinger S,Boyce R,Horstick O

更新日期：2019-07-11 00:00:00

abstract：BACKGROUND:Current chemotherapy for Chagas disease is unsatisfactory due to its limited efficacy, particularly in the chronic phase, with frequent side effects that can lead to treatment discontinuation. Combined therapy is envisioned as an ideal approach since it may improve treatment efficacy whilst decreasing toxici...

journal_title：PLoS neglected tropical diseases

authors： Diniz Lde F,Urbina JA,de Andrade IM,Mazzeti AL,Martins TA,Caldas IS,Talvani A,Ribeiro I,Bahia MT

更新日期：2013-08-15 00:00:00

abstract：BACKGROUND:Diagnosis of Trypanosoma cruzi infection by direct pathogen detection is complicated by the low parasite burden in subjects persistently infected with this agent of human Chagas disease. Determination of infection status by serological analysis has also been faulty, largely due to the lack of well-characteri...

journal_title：PLoS neglected tropical diseases

authors： Cooley G,Etheridge RD,Boehlke C,Bundy B,Weatherly DB,Minning T,Haney M,Postan M,Laucella S,Tarleton RL

更新日期：2008-10-08 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis has now emerged as an important opportunistic disease in patients coinfected with human immunodeficiency virus type-1 (HIV-1). Although the effectiveness of HIV-1 protease inhibitors, such as nelfinavir, in antiretroviral therapies is well documented, little is known of the impact of t...

journal_title：PLoS neglected tropical diseases

authors： Kumar P,Lodge R,Trudel N,Ouellet M,Ouellette M,Tremblay MJ

更新日期：2010-03-30 00:00:00

abstract：BACKGROUND:Leishmaniasis is a complex disease in which clinical outcome depends on factors such as parasite species, host genetics and immunity and vector species. In Brazil, Leishmania (Viannia) braziliensis is a major etiological agent of cutaneous (CL) and mucosal leishmaniasis (MCL), a disfiguring form of the disea...

journal_title：PLoS neglected tropical diseases

authors： Alves-Ferreira EV,Toledo JS,De Oliveira AH,Ferreira TR,Ruy PC,Pinzan CF,Santos RF,Boaventura V,Rojo D,López-Gonzálvez Á,Rosa JC,Barbas C,Barral-Netto M,Barral A,Cruz AK

更新日期：2015-09-14 00:00:00

abstract：BACKGROUND:Since cholera appeared in Africa during the 1970s, cases have been reported on the continent every year. In Sub-Saharan Africa, cholera outbreaks primarily cluster at certain hotspots including the African Great Lakes Region and West Africa. METHODOLOGY/PRINCIPAL FINDINGS:In this study, we applied MLVA (Mul...

journal_title：PLoS neglected tropical diseases

authors： Moore S,Miwanda B,Sadji AY,Thefenne H,Jeddi F,Rebaudet S,de Boeck H,Bidjada B,Depina JJ,Bompangue D,Abedi AA,Koivogui L,Keita S,Garnotel E,Plisnier PD,Ruimy R,Thomson N,Muyembe JJ,Piarroux R

更新日期：2015-06-25 00:00:00

abstract：BACKGROUND:The options for treating the fatal disease human African trypanosomiasis are limited to a few drugs that are toxic or facing increasing resistance. New drugs that kill the causative agents, subspecies of Trypanosoma brucei, are therefore urgently needed. Little is known about the cellular mechanisms that lea...

journal_title：PLoS neglected tropical diseases

authors： Worthen C,Jensen BC,Parsons M

更新日期：2010-05-04 00:00:00

abstract：BACKGROUND:While considerable genomic and transcriptomic data are available for Schistosoma mansoni, many of its genes lack significant annotation. A transcriptomic study of individual tissues and organs of schistosomes could play an important role in functional annotation of the unknown genes, particularly by providin...

journal_title：PLoS neglected tropical diseases

authors： Nawaratna SS,McManus DP,Moertel L,Gobert GN,Jones MK

更新日期：2011-04-26 00:00:00

abstract：:Community drug distributors (CDDs) who are volunteers have the responsibility of awareness creation, household census, drug distribution and record-keeping and are thus key stakeholders in the campaign for Lymphatic Filariasis (LF) elimination. Taking into account their experiences and perceptions is important for a s...

journal_title：PLoS neglected tropical diseases

authors： Njomo DW,Kimani BW,Kibe LW,Okoyo C,Omondi WP,Sultani HM

更新日期：2020-12-28 00:00:00

abstract：BACKGROUND:Despite several leprosy control measures in Nigeria, child proportion and disability grade 2 cases remain high while new cases have not significantly reduced, suggesting continuous spread of the disease. Hence, there is the need to review detection methods to enhance identification of early cases for effecti...

journal_title：PLoS neglected tropical diseases

authors： Ezenduka C,Post E,John S,Suraj A,Namadi A,Onwujekwe O

更新日期：2012-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0004223.]. ...

journal_title：PLoS neglected tropical diseases

authors： Wardrop NA,Thomas LF,Atkinson PM,de Glanville WA,Cook EA,Wamae CN,Gabriël S,Dorny P,Harrison LJ,Fèvre EM

更新日期：2016-01-13 00:00:00

abstract：:Zika virus (ZIKV) emerged as a global public health threat throughout the Americas since 2014. Phylogenetically, the virus is composed of three main lineages, an African, Asian, and American lineage. The recent emergence and spread of ZIKV has raised questions regarding the breadth and potency of human primary ZIKV im...

journal_title：PLoS neglected tropical diseases

authors： Nix CD,Salberg J,Coulter FJ,Kareko BW,Lyski ZL,Booty BL,Messer WB

更新日期：2020-04-13 00:00:00

abstract：BACKGROUND:During blood feeding, sand flies inject Leishmania parasites in the presence of saliva. The types and functions of cells present at the first host-parasite contact are critical to the outcome on infection and sand fly saliva has been shown to play an important role in this setting. Herein, we investigated th...

journal_title：PLoS neglected tropical diseases

authors： de Moura TR,Oliveira F,Rodrigues GC,Carneiro MW,Fukutani KF,Novais FO,Miranda JC,Barral-Netto M,Brodskyn C,Barral A,de Oliveira CI

更新日期：2010-06-15 00:00:00

abstract：:In most low-resource settings, microscopy still is the standard method for diagnosis of cutaneous leishmaniasis, despite its limited sensitivity. In Ethiopia, the more sensitive molecular methods are not yet routinely used. This study compared five PCR methods with microscopy on two sample types collected from patient...

journal_title：PLoS neglected tropical diseases

authors： Merdekios B,Pareyn M,Tadesse D,Eligo N,Kassa M,Jacobs BKM,Leirs H,Van Geertruyden JP,van Griensven J,Caljon G,Cnops L

更新日期：2021-01-12 00:00:00