Cost-effectiveness analysis of three leprosy case detection methods in Northern Nigeria.

abstract：:Benzimidazole anthelmintics have long been employed for the control of soil-transmitted helminth infections. Flubendazole (FBZ) was approved in 1980 for the treatment of gastrointestinal nematode infections in both veterinary and human medicine. It has also long been known that parenteral administration of FBZ can lea...

journal_title：PLoS neglected tropical diseases

authors： Geary TG,Mackenzie CD,Silber SA

更新日期：2019-01-16 00:00:00

abstract：:Sporotrichosis is endemic in the Sub-Himalayan belt, which ranges from the northern to the north-eastern Indian subcontinent. Similar to many parts of the developing world, sporotrichosis is commonly recognized clinically in this region however consolidated epidemiological data is lacking. We report epidemiological, c...

journal_title：PLoS neglected tropical diseases

authors： Verma S,Verma GK,Singh G,Kanga A,Shanker V,Singh D,Gupta P,Mokta K,Sharma V

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Fascioliasis is an emerging zoonotic disease of considerable veterinary and public health importance. Triclabendazole is the only available drug for treatment. Laboratory studies have documented promising fasciocidal properties of the artemisinins (e.g., artemether). METHODOLOGY:We carried out two explorato...

journal_title：PLoS neglected tropical diseases

authors： Keiser J,Sayed H,el-Ghanam M,Sabry H,Anani S,el-Wakeel A,Hatz C,Utzinger J,el-Din SS,el-Maadawy W,Botros S

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Chagas disease is endemic to the southern Andean region of Ecuador, an area with one of the highest poverty rates in the country. However, few studies have looked into the epidemiology, vectors and transmission risks in this region. In this study we describe the triatomine household infestation in Loja provi...

journal_title：PLoS neglected tropical diseases

authors： Grijalva MJ,Villacis AG,Ocaña-Mayorga S,Yumiseva CA,Moncayo AL,Baus EG

更新日期：2015-10-06 00:00:00

abstract：BACKGROUND:Ecological determinants of most emerging vector-borne diseases are understudied, particularly for neglected tropical disease. Moreover, although socioeconomic impacts can have significant downstream effects on human risks to vector-borne diseases via a change in land cover, particularly facilitating the inva...

journal_title：PLoS neglected tropical diseases

authors： Wei CY,Wang JK,Shih HC,Wang HC,Kuo CC

更新日期：2020-01-21 00:00:00

abstract：:Leprosy is a chronic infectious disease that is caused by the obligate intracellular pathogen Mycobacterium leprae (M.leprae), which is the leading cause of all non-traumatic peripheral neuropathies worldwide. Although both myelinating and non-myelinating Schwann cells are infected by M.leprae in patients with leproma...

journal_title：PLoS neglected tropical diseases

authors： Jin SH,An SK,Lee SB

更新日期：2017-06-21 00:00:00

abstract：:The metacestode (larval) stage of the tapeworm Echinococcus multilocularis causes alveolar echinococcosis (AE), a very severe and in many cases incurable disease. To date, benzimidazoles such as albendazole and mebendazole are the only approved chemotherapeutical treatment options. Benzimidazoles inhibit metacestode p...

journal_title：PLoS neglected tropical diseases

authors： Stadelmann B,Rufener R,Aeschbacher D,Spiliotis M,Gottstein B,Hemphill A

更新日期：2016-03-11 00:00:00

abstract：:In Latin America and the Caribbean, around 195 million people live in poverty, a situation that increases the burden of some infectious diseases. Neglected diseases, in particular, are often restricted to poor, marginalized sections of the population. Tools exist to combat these diseases, making it imperative to work ...

journal_title：PLoS neglected tropical diseases

authors： Schneider MC,Aguilera XP,Barbosa da Silva Junior J,Ault SK,Najera P,Martinez J,Requejo R,Nicholls RS,Yadon Z,Silva JC,Leanes LF,Periago MR

更新日期：2011-02-15 00:00:00

abstract：BACKGROUND:Congenital toxoplasmosis is a serious but preventable and treatable disease. Gestational screening facilitates early detection and treatment of primary acquisition. Thus, fetal infection can be promptly diagnosed and treated and outcomes can be improved. METHODS:We tested 180 sera with the Toxoplasma ICT Ig...

journal_title：PLoS neglected tropical diseases

authors： Begeman IJ,Lykins J,Zhou Y,Lai BS,Levigne P,El Bissati K,Boyer K,Withers S,Clouser F,Noble AG,Rabiah P,Swisher CN,Heydemann PT,Contopoulos-Ioannidis DG,Montoya JG,Maldonado Y,Ramirez R,Press C,Stillwaggon E,Peyron F

更新日期：2017-06-26 00:00:00

abstract：:We evaluated the protection conferred by a first documented visit for clinical care of typhoid fever against recurrent typhoid fever prompting a visit. This study takes advantage of multi-year follow-up of a population with endemic typhoid participating in a cluster-randomized control trial of Vi capsular polysacchari...

journal_title：PLoS neglected tropical diseases

authors： Im J,Islam MT,Kim DR,Ahmmed F,Chon Y,Zaman K,Khan AI,Ali M,Sur D,Kanungo S,Dutta S,Bhattacharya SK,Dougan G,Holt KE,Marks F,Kim JH,Qadri F,Clemens JD

更新日期：2020-08-17 00:00:00

abstract：BACKGROUND:Even though human hookworm infection is highly endemic in many countries throughout the world, its global economic and health impact is not well known. Without a better understanding of hookworm's economic burden worldwide, it is difficult for decision makers such as funders, policy makers, disease control o...

journal_title：PLoS neglected tropical diseases

authors： Bartsch SM,Hotez PJ,Asti L,Zapf KM,Bottazzi ME,Diemert DJ,Lee BY

更新日期：2016-09-08 00:00:00

abstract：BACKGROUND:Human brucellosis (HB) is a bacterial zoonosis that is more frequent in low income and middle-income countries; it is sometimes associated with outbreaks. The aim of this study was to describe the largest outbreak of HB in Brazil. METHODS:A retrospective cohort study of patients suspected of having contract...

journal_title：PLoS neglected tropical diseases

authors： Lemos TS,Cequinel JC,Costa TP,Navarro AB,Sprada A,Shibata FK,Gondolfo R,Tuon FF

更新日期：2018-09-18 00:00:00

abstract：BACKGROUND:Extreme precipitation events are increasing as a result of ongoing global warming, but controversy surrounds the relationship between flooding and mosquito-borne diseases. A common view among the scientific community and public health officers is that heavy rainfalls have a flushing effect on breeding sites,...

journal_title：PLoS neglected tropical diseases

authors： Roiz D,Boussès P,Simard F,Paupy C,Fontenille D

更新日期：2015-06-16 00:00:00

abstract：:The vast burden of cryptococcal meningitis occurs in immunosuppressed patients, driven by HIV, and is caused by Cryptococcus neoformans var. grubii. We previously reported cryptococcal meningitis in Vietnam arising atypically in HIV uninfected, apparently immunocompetent patients, caused by a single amplified fragment...

journal_title：PLoS neglected tropical diseases

authors： Day JN,Qihui S,Thanh LT,Trieu PH,Van AD,Thu NH,Chau TTH,Lan NPH,Chau NVV,Ashton PM,Thwaites GE,Boni MF,Wolbers M,Nagarajan N,Tan PBO,Baker S

更新日期：2017-06-14 00:00:00

abstract：:The 2015-2017 epidemics of Zika virus (ZIKV) in the Americas caused widespread infection, followed by protective immunity. The timing and burden of the next Zika virus outbreak remains unclear. We used an agent-based model to simulate the dynamics of age-specific immunity to ZIKV, and predict the future age-specific r...

journal_title：PLoS neglected tropical diseases

authors： Counotte MJ,Althaus CL,Low N,Riou J

更新日期：2019-12-26 00:00:00

abstract：BACKGROUND:Oncomelania hupensis is the unique intermediate host of Schistosoma japonicum, which causes schistosomiasis endemic in the Far East, and especially in mainland China. O. hupensis largely determines the parasite's geographical range. How O. hupensis's genetic diversity is distributed geographically in mainlan...

journal_title：PLoS neglected tropical diseases

authors： Zhao QP,Jiang MS,Littlewood DT,Nie P

更新日期：2010-03-02 00:00:00

abstract：BACKGROUND:Malaysia experienced an unprecedented dengue outbreak from the year 2014 to 2016 that resulted in an enormous increase in the number of cases and mortality as compared to previous years. The causes that attribute to a dengue outbreak can be multifactorial. Viral factors, such as dengue serotype and genotype,...

journal_title：PLoS neglected tropical diseases

authors： Suppiah J,Ching SM,Amin-Nordin S,Mat-Nor LA,Ahmad-Najimudin NA,Low GK,Abdul-Wahid MZ,Thayan R,Chee HY

更新日期：2018-09-18 00:00:00

abstract：:Leishmaniasis is a serious global health problem affecting many people worldwide. While patients with leishmaniasis can be treated with several agents, drug toxicicty and the emergence of resistant strains render available treatments ineffective in the long run. Inhibitors of the mammalian target of rapamycin (mTOR) h...

journal_title：PLoS neglected tropical diseases

authors： Khadir F,Shaler CR,Oryan A,Rudak PT,Mazzuca DM,Taheri T,Dikeakos JD,Haeryfar SMM,Rafati S

更新日期：2018-08-22 00:00:00

abstract：:Trypanosoma cruzi, the aetiological agent of Chagas disease possess extensive genetic diversity. This has led to the development of a plethora of molecular typing methods for the identification of both the known major genetic lineages and for more fine scale characterization of different multilocus genotypes within th...

journal_title：PLoS neglected tropical diseases

authors： Diosque P,Tomasini N,Lauthier JJ,Messenger LA,Monje Rumi MM,Ragone PG,Alberti-D'Amato AM,Pérez Brandán C,Barnabé C,Tibayrenc M,Lewis MD,Llewellyn MS,Miles MA,Yeo M

更新日期：2014-08-28 00:00:00

abstract：BACKGROUND:Despite the reported success in reducing morbidity, praziquantel alone is insufficient for the control and elimination of schistosomiasis, partly due to its poor efficacy against the juvenile worms. Artemisinin derivatives are effective against juvenile worms but are less effective against adult worms. We co...

journal_title：PLoS neglected tropical diseases

authors： Mnkugwe RH,Minzi O,Kinung'hi S,Kamuhabwa A,Aklillu E

更新日期：2020-09-23 00:00:00

abstract：BACKGROUND:Previous studies investigating the role of cytokines in the pathogenesis of leprosy have either been on only small numbers of patients or have not combined clinical and histological data. The INFIR Cohort study is a prospective study of 303 new multibacillary leprosy patients to identify risk factors for rea...

journal_title：PLoS neglected tropical diseases

authors： Lockwood DN,Suneetha L,Sagili KD,Chaduvula MV,Mohammed I,van Brakel W,Smith WC,Nicholls P,Suneetha S

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:From the 17th to 19th January 2012, a group of 92 college students and teachers attended a retreat in a hotel located on Pangkor Island, off the west coast of Peninsular Malaysia. Following the onset of symptoms in many participants who presented to our institute, an investigation was undertaken which ultima...

journal_title：PLoS neglected tropical diseases

authors： Italiano CM,Wong KT,AbuBakar S,Lau YL,Ramli N,Syed Omar SF,Kahar Bador M,Tan CT

更新日期：2014-05-22 00:00:00

abstract：:Cysticercosis is caused by Taenia solium, a parasitic disease that affects humans and rurally bred pigs in developing countries. The cysticercus may localize in the central nervous system of the human, causing neurocysticercosis, the most severe and frequent form of the disease. There appears to be an association betw...

journal_title：PLoS neglected tropical diseases

authors： Morales J,Martínez JJ,Rosetti M,Fleury A,Maza V,Hernandez M,Villalobos N,Fragoso G,de Aluja AS,Larralde C,Sciutto E

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Chagas disease is caused by the parasite Trypanosoma cruzi and is transmitted through triatomines (Hemiptera: Reduviidae). In the last year, many studies of triatomine gut microbiota have outlined its potential role in modulating vector competence. However, little is known about the microbiota present in the...

journal_title：PLoS neglected tropical diseases

authors： Lima MS,Laport MS,Lorosa ES,Jurberg J,Dos Santos KRN,da Silva Neto MAC,Rachid CTCDC,Atella GC

更新日期：2018-09-13 00:00:00

abstract：BACKGROUND:Sensitive diagnostic tools are required for an accurate assessment of prevalence and intensity of helminth infections in areas undergoing regular deworming, and for monitoring anthelmintic drug efficacy. We compared the diagnostic accuracy of the Kato-Katz and FLOTAC techniques in the frame of a drug efficac...

journal_title：PLoS neglected tropical diseases

authors： Knopp S,Speich B,Hattendorf J,Rinaldi L,Mohammed KA,Khamis IS,Mohammed AS,Albonico M,Rollinson D,Marti H,Cringoli G,Utzinger J

更新日期：2011-04-12 00:00:00

abstract：BACKGROUND:Zika virus (ZIKV) is an emergent threat provoking a worldwide explosive outbreak. Since January 2015, 41 countries reported autochthonous cases. In Brazil, an increase in Guillain-Barré syndrome and microcephaly cases was linked to ZIKV infections. A recent report describing low experimental transmission eff...

journal_title：PLoS neglected tropical diseases

authors： Bonaldo MC,Ribeiro IP,Lima NS,Dos Santos AA,Menezes LS,da Cruz SO,de Mello IS,Furtado ND,de Moura EE,Damasceno L,da Silva KA,de Castro MG,Gerber AL,de Almeida LG,Lourenço-de-Oliveira R,Vasconcelos AT,Brasil P

更新日期：2016-06-24 00:00:00

abstract：:A comprehensive analysis was done to evaluate the potential use of anti-parasitic macrocyclic lactones (including avermectins and milbemycins) for Buruli ulcer (BU) therapy. A panel containing nearly all macrocyclic lactones used in human or in veterinary medicine was analyzed for activity in vitro against clinical is...

journal_title：PLoS neglected tropical diseases

authors： Scherr N,Pluschke G,Thompson CJ,Ramón-García S

更新日期：2015-08-13 00:00:00

abstract：BACKGROUND:With approximately 3 billion people at risk of acquiring the infection, dengue fever is now considered the most important mosquito-borne viral disease in the world, with 390 million dengue infections occurring every year, of which 96 million manifest symptoms with any level of disease severity. Treatment of ...

journal_title：PLoS neglected tropical diseases

authors： Aguiar M,Stollenwerk N,Halstead SB

更新日期：2016-12-21 00:00:00

abstract：OBJECTIVES:To assess if a probabilistic model could be used to estimate the combined prevalence of infection with any species of intestinal nematode worm when only the separate prevalence of each species is reported, and to estimate the extent to which simply taking the highest individual species prevalence underestima...

journal_title：PLoS neglected tropical diseases

authors： de Silva N,Hall A

更新日期：2010-04-13 00:00:00

abstract：BACKGROUND:Hospitalization of patients during outbreaks of chikungunya virus has been reported to be uncommon (0.5-8.7%), but more frequent among infants and the elderly. CHIKV was first detected in Puerto Rico in May 2014. We enrolled patients with acute febrile illness (AFI) presenting to two hospital emergency depar...

journal_title：PLoS neglected tropical diseases

authors： Hsu CH,Cruz-Lopez F,Vargas Torres D,Perez-Padilla J,Lorenzi OD,Rivera A,Staples JE,Lugo E,Munoz-Jordan J,Fischer M,Garcia Gubern C,Rivera Garcia B,Alvarado L,Sharp TM

更新日期：2019-01-14 00:00:00