Efficacy and safety of artemether in the treatment of chronic fascioliasis in Egypt: exploratory phase-2 trials.

abstract：:Schistosomiasis affects approximately 240 million people in the world. Schistosoma mansoni eggs in the liver induce periportal fibrosis and hepatic failure driven by monocyte recruitment and macrophage activation, resulting in robust Th2 response. Here, we suggested a possible involvement of Galectin-3 (Gal-3), histon...

journal_title：PLoS neglected tropical diseases

authors： de Oliveira FL,Carneiro K,Brito JM,Cabanel M,Pereira JX,Paiva LA,Syn W,Henderson NC,El-Cheikh MC

更新日期：2017-02-23 00:00:00

abstract：BACKGROUND:The largest outbreak of sporotrichosis occurred between 1938 and 1947 in the gold mines of Witwatersrand in South Africa. Here, we describe an outbreak of lymphocutaneous sporotrichosis that was investigated in a South African gold mine in 2011. METHODOLOGY:Employees working at a reopened section of the min...

journal_title：PLoS neglected tropical diseases

authors： Govender NP,Maphanga TG,Zulu TG,Patel J,Walaza S,Jacobs C,Ebonwu JI,Ntuli S,Naicker SD,Thomas J

更新日期：2015-09-25 00:00:00

abstract：BACKGROUND:Trypanosoma cruzi is a protozoan pathogen responsible for Chagas disease. Current therapies are inadequate because of their severe host toxicity and numerous side effects. The identification of new biotargets is essential for the development of more efficient therapeutic alternatives. Inhibition of sirtuins ...

journal_title：PLoS neglected tropical diseases

authors： Ritagliati C,Alonso VL,Manarin R,Cribb P,Serra EC

更新日期：2015-04-15 00:00:00

abstract：:Rift Valley fever (RVF), a re-emerging mosquito-borne disease of ruminants and man, was endemic in Africa but spread to Saudi Arabia and Yemen, meaning it could spread even further. Little is known about innate and cell-mediated immunity to RVF virus (RVFV) in ruminants, which is knowledge required for adequate vaccin...

journal_title：PLoS neglected tropical diseases

authors： Nfon CK,Marszal P,Zhang S,Weingartl HM

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL or kala azar) is the most serious form of human leishmaniasis, responsible for over 20,000 deaths annually, and post kala azar dermal leishmaniasis (PKDL) is a stigmatizing skin condition that often occurs in patients after successful treatment for VL. Lack of effective or appropri...

journal_title：PLoS neglected tropical diseases

authors： Osman M,Mistry A,Keding A,Gabe R,Cook E,Forrester S,Wiggins R,Di Marco S,Colloca S,Siani L,Cortese R,Smith DF,Aebischer T,Kaye PM,Lacey CJ

更新日期：2017-05-12 00:00:00

abstract：:Diarrheal diseases are a major cause of morbidity and mortality worldwide. In many cases, antibiotic therapy is either ineffective or not recommended due to concerns about emergence of resistance. The pathogenesis of several of the most prevalent infections, including cholera and enteroxigenic Escherichia coli, is dom...

journal_title：PLoS neglected tropical diseases

authors： Das S,Angsantikul P,Le C,Bao D,Miyamoto Y,Gao W,Zhang L,Eckmann L

更新日期：2018-02-22 00:00:00

abstract：BACKGROUND:After many years of neglect, schistosomiasis control is going to scale. The strategy of choice is preventive chemotherapy, that is the repeated large-scale administration of praziquantel (a safe and highly efficacious drug) to at-risk populations. The frequency of praziquantel administration is based on ende...

journal_title：PLoS neglected tropical diseases

authors： Schur N,Vounatsou P,Utzinger J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Optimal management of eumycetoma, a severely debilitating chronic progressive fungal infection of skin, disseminating to bone and viscera, remains challenging. Especially, optimal antifungal treatment and duration are ill defined. METHODOLOGY/PRINCIPAL FINDINGS:We conducted a monocentric retrospective study...

journal_title：PLoS neglected tropical diseases

authors： Crabol Y,Poiree S,Bougnoux ME,Maunoury C,Barete S,Zeller V,Arvieux C,Pineau S,Amazzough K,Lecuit M,Lanternier F,Lortholary O,French Mycosis Study Group.

更新日期：2014-10-09 00:00:00

abstract：:Benzimidazole anthelmintics have long been employed for the control of soil-transmitted helminth infections. Flubendazole (FBZ) was approved in 1980 for the treatment of gastrointestinal nematode infections in both veterinary and human medicine. It has also long been known that parenteral administration of FBZ can lea...

journal_title：PLoS neglected tropical diseases

authors： Geary TG,Mackenzie CD,Silber SA

更新日期：2019-01-16 00:00:00

abstract：:Trypanosoma cruzi has been subdivided into seven Discrete Typing Units (DTUs), TcI-TcVI and Tcbat. Two major evolutionary models have been proposed to explain the origin of hybrid lineages, but while it is widely accepted that TcV and TcVI are the result of genetic exchange between TcII and TcIII strains, the origin o...

journal_title：PLoS neglected tropical diseases

authors： Ramírez JC,Torres C,Curto MLA,Schijman AG

更新日期：2017-12-18 00:00:00

abstract：BACKGROUND:During Dec-2013, a chikungunya virus (CHIKV) outbreak was first detected in the French-West Indies. Subsequently, the virus dispersed to other Caribbean islands, continental America and many islands in the Pacific Ocean. Previous estimates of the attack rate were based on declaration of clinically suspected ...

journal_title：PLoS neglected tropical diseases

authors： Gallian P,Leparc-Goffart I,Richard P,Maire F,Flusin O,Djoudi R,Chiaroni J,Charrel R,Tiberghien P,de Lamballerie X

更新日期：2017-01-12 00:00:00

abstract：BACKGROUND:Dengue is the most prevalent arthropod-borne viral illness in humans with half of the world's population at risk. During early infancy, severe dengue can develop after a primary dengue virus infection. There has been a clinical observation that severe dengue during the first year of life is seen only in chub...

journal_title：PLoS neglected tropical diseases

authors： Libraty DH,Wang P,Guo Z,Bigcas V,Brion JD,Capeding RZ

更新日期：2015-12-04 00:00:00

abstract：BACKGROUND:Mycobacterium tuberculosis complex (MTBC), the causative agent of tuberculosis (TB), is composed of eight subspecies. TB in West Africa, in contrast to other geographical regions, is caused by Mycobacterium africanum (MAF) in addition to M. tuberculosis (MTB), with both infections presenting similar symptoms...

journal_title：PLoS neglected tropical diseases

authors： Namasivayam S,Diarra B,Diabate S,Sarro YDS,Kone A,Kone B,Tolofoudie M,Baya B,Diakite MT,Kodio O,Cohen K,Holl J,Achenbach CJ,Chatterjee S,Murphy RL,Bishai W,Diallo S,Sher A,Maiga M

更新日期：2020-05-13 00:00:00

abstract：BACKGROUND:Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) has recently emerged in the field of entomology as a promising method for the identification of arthropods and the detection of associated pathogens. METHODOLOGY/PRINCIPAL FINDINGS:An experimental model of Ctenocepha...

journal_title：PLoS neglected tropical diseases

authors： El Hamzaoui B,Laroche M,Almeras L,Bérenger JM,Raoult D,Parola P

更新日期：2018-02-16 00:00:00

abstract：BACKGROUND:We identified the species of Leishmania isolated from traveling and migrant patients attended in a reference center from 2000 to 2015, we performed the georeferencing of these species in Rio de Janeiro (RJ) state and we had knowledge about the human flows between the likely location of infection (LLI) and pl...

journal_title：PLoS neglected tropical diseases

authors： Miranda LFC,Pacheco RDS,Pimentel MIF,Salgueiro MM,da Silva AF,de Mello CX,Barros JHDS,Valete-Rosalino CM,Madeira MF,Xavier SCDC,Schubach AO

更新日期：2019-11-15 00:00:00

abstract：BACKGROUND:Lymphatic filariasis (LF) is targeted for elimination by the year 2020. As of 2017, 67 of the 72 endemic countries have implemented annual Mass Drug Administration (MDA) for interrupting LF transmission. Transmission Assessment Survey (TAS) is the recommended protocol to evaluate the impact of MDA and to dec...

journal_title：PLoS neglected tropical diseases

authors： Subramanian S,Jambulingam P,Krishnamoorthy K,Sivagnaname N,Sadanandane C,Vasuki V,Palaniswamy C,Vijayakumar B,Srividya A,Raju HKK

更新日期：2020-01-24 00:00:00

abstract：:Leishmaniasis is a complex parasitic disease from a taxonomic, clinical and epidemiological point of view. The role of genetic exchanges has been questioned for over twenty years and their recent experimental demonstration along with the identification of interspecific hybrids in natura has revived this debate. After ...

journal_title：PLoS neglected tropical diseases

authors： El Baidouri F,Diancourt L,Berry V,Chevenet F,Pratlong F,Marty P,Ravel C

更新日期：2013-06-13 00:00:00

abstract：BACKGROUND:Typhoid fever, caused by the Gram-negative bacterium Salmonella enterica serovar Typhi, is a major cause of community-acquired bacteremia and death worldwide. S100A8 (MRP8) and S100A9 (MRP14) form bioactive antimicrobial heterodimers (calprotectin) that can activate Toll-like receptor 4, promoting lethal, en...

journal_title：PLoS neglected tropical diseases

authors： De Jong HK,Achouiti A,Koh GC,Parry CM,Baker S,Faiz MA,van Dissel JT,Vollaard AM,van Leeuwen EM,Roelofs JJ,de Vos AF,Roth J,van der Poll T,Vogl T,Wiersinga WJ

更新日期：2015-04-10 00:00:00

abstract：:The burden of leptospirosis in humans and animals in Africa is higher than that reported from other parts of the world. However, the disease is not routinely diagnosed in the continent. One of major factors limiting diagnosis is the poor availability of live isolates of locally circulating Leptospira serovars for incl...

journal_title：PLoS neglected tropical diseases

authors： Mgode GF,Machang'u RS,Mhamphi GG,Katakweba A,Mulungu LS,Durnez L,Leirs H,Hartskeerl RA,Belmain SR

更新日期：2015-12-01 00:00:00

abstract：:Snakebite is a neglected tropical disease with significant morbidity and mortality. Thrombotic microangiopathy (TMA) is an important but poorly understood complication of snakebite associated with acute kidney injury (AKI). Numerous treatments have been attempted based on limited evidence. We conducted a systematic re...

journal_title：PLoS neglected tropical diseases

authors： Noutsos T,Currie BJ,Lek RA,Isbister GK

更新日期：2020-12-08 00:00:00

abstract：:In the rabbit model of syphilis, infection phenotypes associated with the Nichols and Chicago strains of Treponema pallidum (T. pallidum), though similar, are not identical. Between these strains, significant differences are found in expression of, and antibody responses to some candidate virulence factors, suggesting...

journal_title：PLoS neglected tropical diseases

authors： Giacani L,Chattopadhyay S,Centurion-Lara A,Jeffrey BM,Le HT,Molini BJ,Lukehart SA,Sokurenko EV,Rockey DD

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:In Latin America, there are 13 geographically isolated endemic foci distributed among Mexico, Guatemala, Colombia, Venezuela, Brazil and Ecuador. The communities of the three endemic foci found within Mexico have been receiving ivermectin treatment since 1989. In this study, we predicted the trend of occurre...

journal_title：PLoS neglected tropical diseases

authors： Lara-Ramírez EE,Rodríguez-Pérez MA,Pérez-Rodríguez MA,Adeleke MA,Orozco-Algarra ME,Arrendondo-Jiménez JI,Guo X

更新日期：2013-01-01 00:00:00

abstract：:As rabies in carnivores is increasingly controlled throughout much of the Americas, bats are emerging as a significant source of rabies virus infection of humans and domestic animals. Knowledge of the bat species that maintain rabies is a crucial first step in reducing this public health problem. In North America, sev...

journal_title：PLoS neglected tropical diseases

authors： Nadin-Davis S,Alnabelseya N,Knowles MK

更新日期：2017-05-19 00:00:00

abstract：BACKGROUND:Urogenital schistosomiasis due to Schistosoma haematobium is a serious underestimated public health problem affecting 112 million people - particularly in sub-Saharan Africa. Microscopic examination of urine samples to detect parasite eggs still remains as definitive diagnosis. This work was focussed on deve...

journal_title：PLoS neglected tropical diseases

authors： Gandasegui J,Fernández-Soto P,Carranza-Rodríguez C,Pérez-Arellano JL,Vicente B,López-Abán J,Muro A

更新日期：2015-07-31 00:00:00

abstract：:Simian T-Leukemia Virus type 1 and Simian Foamy Virus infect non-human primates. While STLV-1, as HTLV-1, causes Adult T-cell Leukemia/lymphoma, SFV infection is asymptomatic. Both retroviruses can be transmitted from NHPs to humans through bites that allow contact between infected saliva and recipient blood. Because ...

journal_title：PLoS neglected tropical diseases

authors： Alais S,Pasquier A,Jegado B,Journo C,Rua R,Gessain A,Tobaly-Tapiero J,Lacoste R,Turpin J,Mahieux R

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Although leprosy is portrayed as a disappearing disease, leprosy affected persons in India are still suffering massively. Even further, nearly 60% of the world's newly detected cases are appearing from India alone. The problem has exacerbated due to the drastic decrease of global funding after India's offici...

journal_title：PLoS neglected tropical diseases

authors： Jung SH,Han HW,Koh H,Yu SY,Nawa N,Morita A,Ong KIC,Jimba M,Oh J

更新日期：2020-01-13 00:00:00

abstract：:Drug combinations for the treatment of leishmaniasis represent a promising and challenging chemotherapeutic strategy that has recently been implemented in different endemic areas. However, the vast majority of studies undertaken to date have ignored the potential risk that Leishmania parasites could develop resistance...

journal_title：PLoS neglected tropical diseases

authors： García-Hernández R,Manzano JI,Castanys S,Gamarro F

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Leishmania development in the sand fly gut leads to highly infective forms called metacyclic promastigotes. This process can be routinely mimicked in culture. Gene expression-profiling studies by transcriptome analysis have been performed with the aim of studying promastigote forms in the sand fly gut, as we...

journal_title：PLoS neglected tropical diseases

authors： Alcolea PJ,Alonso A,Molina R,Jiménez M,Myler PJ,Larraga V

更新日期：2019-05-09 00:00:00

abstract：BACKGROUND:Schistosomiasis (or bilharzia), a major parasitic disease, affects more than 260 million people worldwide. In chronic cases of intestinal schistosomiasis caused by trematodes of the Schistosoma genus, hepatic fibrosis develops as a host immune response to the helminth eggs, followed by potentially lethal por...

journal_title：PLoS neglected tropical diseases

authors： Masi B,Perles-Barbacaru TA,Laprie C,Dessein H,Bernard M,Dessein A,Viola A

更新日期：2015-09-22 00:00:00

abstract：BACKGROUND:Deposition of complement factors on Mycobacterium leprae may enhance phagocytosis. Such deposition may occur through the lectin pathway of complement. Three proteins of the lectin pathway are produced from the gene MASP1: Mannan-binding lectin-associated serine protease 1 (MASP-1) and MASP-3 and mannan-bindi...

journal_title：PLoS neglected tropical diseases

authors： Weinschutz Mendes H,Boldt ABW,von Rosen Seeling Stahlke E,Jensenius JC,Thiel S,Messias-Reason IJT

更新日期：2020-04-02 00:00:00