Flubendazole as a macrofilaricide: History and background.

abstract：:Glossina (G.) spp. (Diptera: Glossinidae), known as tsetse flies, are vectors of African trypanosomes that cause sleeping sickness in humans and nagana in domestic livestock. Knowledge on tsetse distribution and accurate species identification help identify potential vector intervention sites. Morphological species id...

journal_title：PLoS neglected tropical diseases

authors： Hoppenheit A,Murugaiyan J,Bauer B,Steuber S,Clausen PH,Roesler U

更新日期：2013-07-11 00:00:00

abstract：:Coral snakes of the genus Micrurus have a high diversity and wide distribution in the Americas. Despite envenomings by these animals being uncommon, accidents are often severe and may result in death. Producing an antivenom to treat these envenomings has been challenging since coral snakes are difficult to catch, prod...

journal_title：PLoS neglected tropical diseases

authors： Castillo-Beltrán MC,Hurtado-Gómez JP,Corredor-Espinel V,Ruiz-Gómez FJ

更新日期：2019-03-11 00:00:00

abstract：BACKGROUND:During blood feeding, sand flies inject Leishmania parasites in the presence of saliva. The types and functions of cells present at the first host-parasite contact are critical to the outcome on infection and sand fly saliva has been shown to play an important role in this setting. Herein, we investigated th...

journal_title：PLoS neglected tropical diseases

authors： de Moura TR,Oliveira F,Rodrigues GC,Carneiro MW,Fukutani KF,Novais FO,Miranda JC,Barral-Netto M,Brodskyn C,Barral A,de Oliveira CI

更新日期：2010-06-15 00:00:00

abstract：OBJECTIVE:Where human African trypanosomiasis (HAT) patients are seen, failure to microscopically diagnose infections by Trypanosoma brucei gambiense in blood smears and/or cerebrospinal fluid (CSF) in the critical early stages of the disease is the single most important factor in treatment failure, a result of delayed...

journal_title：PLoS neglected tropical diseases

authors： Grab DJ,Nikolskaia OV,Courtioux B,Thekisoe OMM,Magez S,Bogorad M,Dumler JS,Bisser S

更新日期：2019-08-19 00:00:00

abstract：BACKGROUND:Patients with New World cutaneous leishmaniasis (NWCL) caused by Leishmania Viannia are treated with parenteral sodium stibogluconate (SbV) to reduce the risk of development of mucocutanous leishmaniasis. Our centre manages patients with NWCL on an outpatient-basis. This study was conducted to assess the saf...

journal_title：PLoS neglected tropical diseases

authors： Wise ES,Armstrong MS,Watson J,Lockwood DN

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Chlamydia trachomatis is the etiological agent of trachoma the world's leading cause of infectious blindness. Here, we investigate whether protracted clearance of a primary infection in nonhuman primates is attributable to antigenic variation or related to the maturation of the anti-chlamydial humoral immune...

journal_title：PLoS neglected tropical diseases

authors： Kari L,Bakios LE,Goheen MM,Bess LN,Watkins HS,Southern TR,Song L,Whitmire WM,Olivares-Zavaleta N,Caldwell HD

更新日期：2013-05-30 00:00:00

abstract：BACKGROUND:Singapore experiences endemic dengue, with 2013 being the largest outbreak year known to date, culminating in 22,170 cases. Given the limited resources available, and that vector control is the key approach for prevention in Singapore, it is important that public health professionals know where resources sho...

journal_title：PLoS neglected tropical diseases

authors： Ong J,Liu X,Rajarethinam J,Kok SY,Liang S,Tang CS,Cook AR,Ng LC,Yap G

更新日期：2018-06-18 00:00:00

abstract：BACKGROUND:The largest outbreak of sporotrichosis occurred between 1938 and 1947 in the gold mines of Witwatersrand in South Africa. Here, we describe an outbreak of lymphocutaneous sporotrichosis that was investigated in a South African gold mine in 2011. METHODOLOGY:Employees working at a reopened section of the min...

journal_title：PLoS neglected tropical diseases

authors： Govender NP,Maphanga TG,Zulu TG,Patel J,Walaza S,Jacobs C,Ebonwu JI,Ntuli S,Naicker SD,Thomas J

更新日期：2015-09-25 00:00:00

abstract：BACKGROUND:Leishmaniasis is a serious multifactorial parasitic disease with limited treatment options. Current chemotherapy is mainly consisted of drugs with serious drawbacks such as toxicity, variable efficacy and resistance. Alternative bioactive phytocompounds may provide a promising source for discovering new anti...

journal_title：PLoS neglected tropical diseases

authors： Karampetsou K,Koutsoni OS,Gogou G,Angelis A,Skaltsounis LA,Dotsika E

更新日期：2021-01-11 00:00:00

abstract：BACKGROUND:The initial response to Leishmania parasites is essential in determining disease development or resistance. In vitro, a divergent response to Leishmania, characterized by high or low IFN-γ production has been described as a potential tool to predict both vaccine response and disease susceptibility in vivo. ...

journal_title：PLoS neglected tropical diseases

authors： Carneiro MW,Fukutani KF,Andrade BB,Curvelo RP,Cristal JR,Carvalho AM,Barral A,Van Weyenbergh J,Barral-Netto M,de Oliveira CI

更新日期：2016-11-21 00:00:00

abstract：BACKGROUND:Melioidosis is gaining recognition as an emerging infectious disease with diverse clinical manifestations and high-case fatality rates worldwide. However, the molecular epidemiology of the disease outside the endemic regions such as northeast part of Thailand and northern Australia remains unclear. METHODOL...

journal_title：PLoS neglected tropical diseases

authors： Shaw T,Tellapragada C,Kamath A,Kalwaje Eshwara V,Mukhopadhyay C

更新日期：2019-05-15 00:00:00

abstract：BACKGROUND:Aedes aegypti, the "yellow fever mosquito", is the primary vector to humans of the four serotypes of dengue viruses (DENV1-4) and yellow fever virus (YFV) and is a known vector of Chikungunya virus. There are two recognized subspecies of Ae. aegypti sensu latu (s.l.): the presumed ancestral form, Ae. aegypti...

journal_title：PLoS neglected tropical diseases

authors： Sylla M,Bosio C,Urdaneta-Marquez L,Ndiaye M,Black WC 4th

更新日期：2009-01-01 00:00:00

abstract：:Rift Valley fever (RVF), a mosquito-borne zoonosis, is a major public health and veterinary problem in sub-Saharan Africa. Surveillance to monitor mosquito populations during the inter-epidemic period (IEP) and viral activity in these vectors is critical to informing public health decisions for early warning and contr...

journal_title：PLoS neglected tropical diseases

authors： Tchouassi DP,Sang R,Sole CL,Bastos AD,Teal PE,Borgemeister C,Torto B

更新日期：2013-01-01 00:00:00

abstract：:In this communication, a case of black grain eumycetoma produced by the fungus C. atrobrunneum is reported. The patient was initially misdiagnosed with M. mycetomatis eumycetoma based on the grains' morphological and cytological features. However, further aerobic culture of the black grains generated a melanised fungu...

journal_title：PLoS neglected tropical diseases

authors： Mhmoud NA,Santona A,Fiamma M,Siddig EE,Deligios M,Bakhiet SM,Rubino S,Fahal AH

更新日期：2019-05-30 00:00:00

abstract：INTRODUCTION:Most of the studies related to rickettsial infection in Colombia are cross-sectional because of the challenge in conducting prospective studies on infectious disease that may have a difficult diagnosis. Although cross-sectional studies are essential to detect people exposed to rickettsiae, they are not sui...

journal_title：PLoS neglected tropical diseases

authors： Quintero Vélez JC,Aguirre-Acevedo DC,Rodas JD,Arboleda M,Troyo A,Vega Aguilar F,Osorio Quintero L,Rojas Arbeláez C

更新日期：2018-10-31 00:00:00

abstract：:Soil-transmitted helminths (STH) are endemic and widespread across Sub-Saharan Africa. A community wide soil-transmitted helminth (STH) prevalence survey was performed on the island of Bubaque in Guinea-Bissau using both Kato-katz microscopy and qPCR methodology. Predictors of infection and morbidity indicators were i...

journal_title：PLoS neglected tropical diseases

authors： Farrant O,Marlais T,Houghton J,Goncalves A,Teixeira da Silva Cassama E,Cabral MG,Nakutum J,Manjuba C,Rodrigues A,Mabey D,Bailey R,Last A

更新日期：2020-12-16 00:00:00

abstract：:In order to rapidly inform polices in the international response to the ongoing pandemic of coronavirus disease 19 (COVID-19), we summarize in this review current evidence on epidemiological and clinical features of the infection, transmission routes, problems of nucleic-acid testing, the epidemiological trend in Chin...

journal_title：PLoS neglected tropical diseases

authors： Liang H,Zheng L,Xia H,Tang J

更新日期：2020-08-06 00:00:00

abstract：:Leptospirosis is a globally distributed bacterial infectious disease caused by pathogenic members of the genus Leptospira. Infection can lead to illness ranging from mild and non-specific to severe, with jaundice, kidney and liver dysfunction, and widespread endothelial damage. The adhesion of pathogenic Leptospira sp...

journal_title：PLoS neglected tropical diseases

authors： Evangelista KV,Hahn B,Wunder EA Jr,Ko AI,Haake DA,Coburn J

更新日期：2014-10-02 00:00:00

abstract：BACKGROUND:Chagas disease is one of the most important neglected tropical diseases in the Americas. Vectorborne transmission of Chagas disease has been historically rare in urban settings. However, in marginal communities near the city of Arequipa, Peru, urban transmission cycles have become established. We examined th...

journal_title：PLoS neglected tropical diseases

authors： Bayer AM,Hunter GC,Gilman RH,Cornejo Del Carpio JG,Naquira C,Bern C,Levy MZ

更新日期：2009-12-15 00:00:00

abstract：BACKGROUND:Animal tungiasis is believed to increase the prevalence and parasite burden in humans. Animal reservoirs of Tunga penetrans differ among endemic areas and their role in the epidemiology of tungiasis had never been investigated in Uganda. METHODS AND FINDINGS:To identify the major animal reservoirs of Tunga ...

journal_title：PLoS neglected tropical diseases

authors： Mutebi F,Krücken J,Feldmeier H,Waiswa C,Mencke N,Sentongo E,von Samson-Himmelstjerna G

更新日期：2015-10-16 00:00:00

abstract：:Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) that recently caused outbreaks in the Americas. Over the past 60 years, this virus has been observed circulating among African, Asian, and Pacific Island populations, but little attention has been paid by the scientific community until the discovery that large-...

journal_title：PLoS neglected tropical diseases

authors： Epelboin Y,Talaga S,Epelboin L,Dusfour I

更新日期：2017-11-16 00:00:00

abstract：:Leishmaniasis is a major health problem in some endemic areas and yet, no vaccine is available against any form of the disease. Historically, leishmanization (LZ) which is an inoculation of individual with live Leishmania, is the most effective control measure at least against cutaneous leishmaniasis (CL). Due to vari...

journal_title：PLoS neglected tropical diseases

authors： Davoudi N,Khamesipour A,Mahboudi F,McMaster WR

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:Though Nepal declared leprosy elimination in 2010, its burden is constantly rising in Terai communities for the past 2 years with 3000 new leprosy cases being diagnosed annually. Community's perception is important for prevention and control of leprosy and enhancing quality of life of leprosy patients. Poor ...

journal_title：PLoS neglected tropical diseases

authors： Singh R,Singh B,Mahato S

更新日期：2019-01-11 00:00:00

abstract：:Quantifying human mobility has significant consequences for studying physical activity, exposure to pathogens, and generating more realistic infectious disease models. Location-aware technologies such as Global Positioning System (GPS)-enabled devices are used increasingly as a gold standard for mobility research. The...

journal_title：PLoS neglected tropical diseases

authors： Paz-Soldan VA,Reiner RC Jr,Morrison AC,Stoddard ST,Kitron U,Scott TW,Elder JP,Halsey ES,Kochel TJ,Astete H,Vazquez-Prokopec GM

更新日期：2014-06-12 00:00:00

abstract：BACKGROUND:In 2005, there were outbreaks of febrile polyarthritis due to Chikungunya virus (CHIKV) in the Comoros Islands. CHIKV then spread to other islands in the Indian Ocean: La Réunion, Mauritius, Seychelles and Madagascar. These outbreaks revealed the lack of surveillance and preparedness of Madagascar and other ...

journal_title：PLoS neglected tropical diseases

authors： Andriamandimby SF,Heraud JM,Randrianasolo L,Rafisandratantsoa JT,Andriamamonjy S,Richard V

更新日期：2013-07-25 00:00:00

abstract：:Leishmaniasis is a neglected disease produced by the intracellular protozoan parasite Leishmania. In the present study, we show that LABCG2, a new ATP-binding cassette half-transporter (ABCG subfamily) from Leishmania, is involved in parasite virulence. Down-regulation of LABCG2 function upon expression of an inactive...

journal_title：PLoS neglected tropical diseases

authors： Campos-Salinas J,León-Guerrero D,González-Rey E,Delgado M,Castanys S,Pérez-Victoria JM,Gamarro F

更新日期：2013-04-25 00:00:00

abstract：BACKGROUND:There are health risks associated with wastewater and fecal sludge management and use, but little is known about the magnitude, particularly in rapidly growing urban settings of low- and middle-income countries. We assessed the point-prevalence and risk factors of intestinal parasite infections in people wit...

journal_title：PLoS neglected tropical diseases

authors： Fuhrimann S,Winkler MS,Kabatereine NB,Tukahebwa EM,Halage AA,Rutebemberwa E,Medlicott K,Schindler C,Utzinger J,Cissé G

更新日期：2016-03-03 00:00:00

abstract：BACKGROUND:Leptospirosis is a potentially fatal bacterial zoonosis that is endemic throughout the tropics and may be misdiagnosed as dengue. Delayed hospital admission of leptospirosis patients is associated with increased mortality. METHODOLOGY/PRINCIPAL FINDINGS:During a concurrent dengue/leptospirosis epidemic in P...

journal_title：PLoS neglected tropical diseases

authors： Sharp TM,Rivera García B,Pérez-Padilla J,Galloway RL,Guerra M,Ryff KR,Haberling D,Ramakrishnan S,Shadomy S,Blau D,Tomashek KM,Bower WA

更新日期：2016-02-25 00:00:00

abstract：BACKGROUND:Plasmodium vivax and Hepatitis B virus (HBV) are globally outspread in similar geographic regions. The concurrence of both infections and its association with some degree of protection against symptomatic and/or severe vivax malaria has been already described. Nevertheless, data on how host response to both ...

journal_title：PLoS neglected tropical diseases

authors： Cruz LAB,Moraes MOA,Queiroga-Barros MR,Fukutani KF,Barral-Netto M,Andrade BB

更新日期：2019-06-24 00:00:00

abstract：:Trypanosoma cruzi, the aetiological agent of Chagas disease possess extensive genetic diversity. This has led to the development of a plethora of molecular typing methods for the identification of both the known major genetic lineages and for more fine scale characterization of different multilocus genotypes within th...

journal_title：PLoS neglected tropical diseases

authors： Diosque P,Tomasini N,Lauthier JJ,Messenger LA,Monje Rumi MM,Ragone PG,Alberti-D'Amato AM,Pérez Brandán C,Barnabé C,Tibayrenc M,Lewis MD,Llewellyn MS,Miles MA,Yeo M

更新日期：2014-08-28 00:00:00