Outbreak of human brucellosis in Southern Brazil and historical review of data from 2009 to 2018.

abstract：BACKGROUND:Leptospirosis occurs worldwide, but the global incidence of human disease and its mortality are not well understood. Many patients are undiagnosed and untreated due to its non-specific symptoms and a lack of access to diagnostics. This study systematically reviews the literature to clarify the mortality from...

journal_title：PLoS neglected tropical diseases

authors： Taylor AJ,Paris DH,Newton PN

更新日期：2015-06-25 00:00:00

abstract：INTRODUCTION:The mosquito Aedes aegypti is the principal vector of dengue and yellow fever flaviviruses. Temephos is an organophosphate insecticide used globally to suppress Ae. aegypti larval populations but resistance has evolved in many locations. METHODOLOGY/PRINCIPAL FINDINGS:Quantitative Trait Loci (QTL) control...

journal_title：PLoS neglected tropical diseases

authors： Reyes-Solis Gdel C,Saavedra-Rodriguez K,Suarez AF,Black WC 4th

更新日期：2014-10-16 00:00:00

abstract：BACKGROUND:The use of DNA microarray technology to study global Schistosoma gene expression has led to the rapid identification of novel biological processes, pathways or associations. Implementation of standardized DNA microarray protocols across laboratories would assist maximal interpretation of generated datasets a...

journal_title：PLoS neglected tropical diseases

authors： Fitzpatrick JM,Protasio AV,McArdle AJ,Williams GA,Johnston DA,Hoffmann KF

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Most commonly used malaria diagnostic tests, including microscopy and antigen-detecting rapid tests, cannot reliably detect low-density infections which are frequent in low transmission settings. Molecular methods such as polymerase chain reaction (PCR) are highly sensitive but remain too laborious for field...

journal_title：PLoS neglected tropical diseases

authors： Vallejo AF,Martínez NL,González IJ,Arévalo-Herrera M,Herrera S

更新日期：2015-01-08 00:00:00

abstract：BACKGROUND:Since leprosy is both treated and controlled by multidrug therapy (MDT) it is important to monitor recurrent cases for drug resistance and to distinguish between relapse and reinfection as a means of assessing therapeutic efficacy. All three objectives can be reached with single nucleotide resolution using n...

journal_title：PLoS neglected tropical diseases

authors： Stefani MMA,Avanzi C,Bührer-Sékula S,Benjak A,Loiseau C,Singh P,Pontes MAA,Gonçalves HS,Hungria EM,Busso P,Piton J,Silveira MIS,Cruz R,Schetinni A,Costa MB,Virmond MCL,Diorio SM,Dias-Baptista IMF,Rosa PS,Matsuoka M

更新日期：2017-06-15 00:00:00

abstract：BACKGROUND:Sustainable control of soil-transmitted helminths requires a combination of chemotherapy treatment and environmental interventions, including access to safe drinking water, sufficient water for hygiene, use of clean sanitation facilities, and handwashing (WASH). We quantified associations between home-, scho...

journal_title：PLoS neglected tropical diseases

authors： Baker JM,Trinies V,Bronzan RN,Dorkenoo AM,Garn JV,Sognikin S,Freeman MC

更新日期：2018-03-28 00:00:00

abstract：BACKGROUND:Reduced susceptibility of mosquito vectors to currently used insecticides hampers control interventions. Recently pyriproxyfen, an insect growth regulator has been demonstrated to effectively reduce the reproductive potential in vector mosquitoes. METHODS:Pyriproxyfen (PPF), in different concentrations (0.7...

journal_title：PLoS neglected tropical diseases

authors： Yadav K,Dhiman S,Acharya BN,Ghorpade RR,Sukumaran D

更新日期：2019-11-18 00:00:00

abstract：BACKGROUND:Although antibody responses to dengue virus (DENV) in naturally infected individuals have been extensively studied, the functionality of DENV specific memory T cell responses in relation to clinical disease severity is incompletely understood. METHODOLOGY/PRINCIPAL FINDINGS:Using ex vivo IFNγ ELISpot assays...

journal_title：PLoS neglected tropical diseases

authors： Jeewandara C,Adikari TN,Gomes L,Fernando S,Fernando RH,Perera MK,Ariyaratne D,Kamaladasa A,Salimi M,Prathapan S,Ogg GS,Malavige GN

更新日期：2015-04-13 00:00:00

abstract：:Aedes aegypti is the major vector of yellow and dengue fevers. After 10 generations of adult selection, an A. aegypti strain (SP) developed 1650-fold resistance to permethrin, which is one of the most widely used pyrethroid insecticides for mosquito control. SP larvae also developed 8790-fold resistance following sele...

journal_title：PLoS neglected tropical diseases

authors： Kasai S,Komagata O,Itokawa K,Shono T,Ng LC,Kobayashi M,Tomita T

更新日期：2014-06-19 00:00:00

abstract：:Several studies have shown Dengue Virus (DENV) nucleic acids and/or antibodies present in Neotropical wildlife including bats, suggesting that some bat species may be susceptible to DENV infection. Here we aim to elucidate the role of house-roosting bats in the DENV transmission cycle. Bats were sampled in households ...

journal_title：PLoS neglected tropical diseases

authors： Vicente-Santos A,Moreira-Soto A,Soto-Garita C,Chaverri LG,Chaves A,Drexler JF,Morales JA,Alfaro-Alarcón A,Rodríguez-Herrera B,Corrales-Aguilar E

更新日期：2017-05-18 00:00:00

abstract：:Japanese encephalitis (JE) is the leading form of viral encephalitis in Asia. It is caused by the JE virus (JEV), which belongs to the family Flaviviridae. JEV is endemic to many parts of Asia, where periodic outbreaks take hundreds of lives. Despite the catastrophes it causes, JE has remained a tropical disease uncom...

journal_title：PLoS neglected tropical diseases

authors： Ghosh D,Basu A

更新日期：2009-09-29 00:00:00

abstract：BACKGROUND:Schistosomiasis in one of the most prevalent parasitic diseases, affecting millions of people and animals in developing countries. Amongst the human-infective species S. haematobium is one of the most widespread causing urogenital schistosomiasis, a major human health problem across Africa, however in terms ...

journal_title：PLoS neglected tropical diseases

authors： Webster BL,Emery AM,Webster JP,Gouvras A,Garba A,Diaw O,Seye MM,Tchuente LA,Simoonga C,Mwanga J,Lange C,Kariuki C,Mohammed KA,Stothard JR,Rollinson D

更新日期：2012-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0004618.]. ...

journal_title：PLoS neglected tropical diseases

authors： Kroidl I,Saathoff E,Maganga L,Clowes P,Maboko L,Hoerauf A,Makunde WH,Haule A,Mviombo P,Pitter B,Mgeni N,Mabuye J,Kowuor D,Mwingira U,Malecela MN,Löscher T,Hoelscher M

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:The possible emergence of resistance to the only available drug for schistosomiasis spurs drug discovery that has been recently incentivized by the availability of improved transcriptome and genome sequence information. Transient RNAi has emerged as a straightforward and important technique to interrogate th...

journal_title：PLoS neglected tropical diseases

authors： Stefanić S,Dvořák J,Horn M,Braschi S,Sojka D,Ruelas DS,Suzuki B,Lim KC,Hopkins SD,McKerrow JH,Caffrey CR

更新日期：2010-10-19 00:00:00

abstract：:Rift Valley fever virus is an arbovirus that affects both livestock and humans throughout Africa and in the Middle East. Despite its endemicity throughout Africa, it is a rare event to identify an infected individual during the acute phase of the disease and an even rarer event to collect serial blood samples from the...

journal_title：PLoS neglected tropical diseases

authors： de St Maurice A,Harmon J,Nyakarahuka L,Balinandi S,Tumusiime A,Kyondo J,Mulei S,Namutebi A,Knust B,Shoemaker T,Nichol ST,McElroy AK,Spiropoulou CF

更新日期：2018-05-04 00:00:00

abstract：:Mycobacterium africanum is a member of the Mycobacterium tuberculosis complex (MTBC) and an important cause of human tuberculosis in West Africa that is rarely observed elsewhere. Here we genotyped 613 MTBC clinical isolates from Ghana, and searched for associations between the different phylogenetic lineages of MTBC ...

journal_title：PLoS neglected tropical diseases

authors： Asante-Poku A,Yeboah-Manu D,Otchere ID,Aboagye SY,Stucki D,Hattendorf J,Borrell S,Feldmann J,Danso E,Gagneux S

更新日期：2015-01-08 00:00:00

abstract：BACKGROUND:Resistance emergence against antileishmanial drugs, particularly Sodium Antimony Gluconate (SAG) has severely hampered the therapeutic strategy against visceral leishmaniasis, the mechanism of resistance being indistinguishable. Cysteine leucine rich protein (CLrP), was recognized as one of the overexpressed...

journal_title：PLoS neglected tropical diseases

authors： Das S,Shah P,Tandon R,Yadav NK,Sahasrabuddhe AA,Sundar S,Siddiqi MI,Dube A

更新日期：2015-08-21 00:00:00

abstract：INTRODUCTION:Yaws is endemic in Ghana. The World Health Organization (WHO) has launched a new global eradication campaign based on total community mass treatment with azithromycin. Achieving high coverage of mass treatment will be fundamental to the success of this new strategy; coverage is dependent, in part, on appro...

journal_title：PLoS neglected tropical diseases

authors： Marks M,Kwakye-Maclean C,Doherty R,Adwere P,Aziz Abdulai A,Duah F,Ohene SA,Mitja O,Oguti B,Solomon AW,Mabey DCW,Adu-Sarkodie Y,Asiedu K,Ackumey MM

更新日期：2017-07-31 00:00:00

abstract：BACKGROUND:Dengue is a mosquito-borne viral disease caused by four closely related serotypes of Dengue viruses (DENVs). This disease whose symptoms range from mild fever to potentially fatal haemorrhagic fever and hypovolemic shock, threatens nearly half the global population. There is neither a preventive vaccine nor ...

journal_title：PLoS neglected tropical diseases

authors： Korrapati AB,Swaminathan G,Singh A,Khanna N,Swaminathan S

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Paragonimiasis is a food-borne trematodiasis leading to lung disease. Worldwide, an estimated 21 million people are infected. Foci of ongoing transmission remain often unnoticed. We evaluated a simple questionnaire approach using lay-informants at the village level to identify paragonimiasis foci and suspect...

journal_title：PLoS neglected tropical diseases

authors： Odermatt P,Veasna D,Zhang W,Vannavong N,Phrommala S,Habe S,Barennes H,Strobel M

更新日期：2009-09-22 00:00:00

abstract：:In mammals subverted as hosts by protozoan parasites, the latter and/or the agonists they release are detected and processed by sensors displayed by many distinct immune cell lineages, in a tissue(s)-dependent context. Focusing on the T lymphocyte lineage, we review our present understanding on its transient or durabl...

journal_title：PLoS neglected tropical diseases

authors： Rodrigues V,Cordeiro-da-Silva A,Laforge M,Ouaissi A,Akharid K,Silvestre R,Estaquier J

更新日期：2014-02-13 00:00:00

abstract：BACKGROUND:The parasite Onchocerca volvulus has, until recently, been regarded as the cause of a chronic yet non-fatal condition. Recent analyses, however, have indicated that in addition to blindness, the parasite can also be directly associated with human mortality. Such analyses also suggested that the relationship ...

journal_title：PLoS neglected tropical diseases

authors： Walker M,Little MP,Wagner KS,Soumbey-Alley EW,Boatin BA,Basáñez MG

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Access to health care is a major requirement in improving health and fostering socioeconomic development. In the People's Republic of China (P.R. China), considerable changes have occurred in the social, economic, and health systems with a shift from a centrally planned to a socialist market economy. This br...

journal_title：PLoS neglected tropical diseases

authors： Balen J,Liu ZC,McManus DP,Raso G,Utzinger J,Xiao SY,Yu DB,Zhao ZY,Li YS

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:In mass vaccination campaigns, large volumes of data must be managed efficiently and accurately. In a reactive oral cholera vaccination (OCV) campaign in rural Haiti during an ongoing epidemic, we used a mobile health (mHealth) system to manage data on 50,000 participants in two isolated communities. METHOD...

journal_title：PLoS neglected tropical diseases

authors： Teng JE,Thomson DR,Lascher JS,Raymond M,Ivers LC

更新日期：2014-07-31 00:00:00

abstract：BACKGROUND:Third-stage larvae (L3) of the canine hookworm, Ancylostoma caninum, undergo arrested development preceding transmission to a host. Many of the mRNAs up-regulated at this stage are likely to encode proteins that facilitate the transition from a free-living to a parasitic larva. The initial phase of mammalian...

journal_title：PLoS neglected tropical diseases

authors： Datu BJ,Gasser RB,Nagaraj SH,Ong EK,O'Donoghue P,McInnes R,Ranganathan S,Loukas A

更新日期：2008-01-09 00:00:00

abstract：BACKGROUND:Leprosy Type 1 (T1R) reactions are immune-mediated events leading to nerve damage and preventable disability affecting hands, feet and eyes. Type 1 Reactions are treated with oral corticosteroids. There is little evidence on alternative treatments for patients who do not respond to steroids or experience ste...

journal_title：PLoS neglected tropical diseases

authors： Lambert SM,Alembo DT,Nigusse SD,Yamuah LK,Walker SL,Lockwood DN

更新日期：2016-04-05 00:00:00

abstract：:Rift Valley fever (RVF) is endemic in most parts of Africa and has also been reported to occur in the Arabian Peninsula. It is responsible for significant morbidity and mortality, particularly in livestock, but also in humans. During the last two decades several outbreaks of RVF have been reported in countries in Sout...

journal_title：PLoS neglected tropical diseases

authors： Fafetine J,Neves L,Thompson PN,Paweska JT,Rutten VP,Coetzer JA

更新日期：2013-01-01 00:00:00

abstract：:Chromoblastomycosis (CBM) is a chronic, progressive, cutaneous and subcutaneous fungal infection following the traumatic implantation of certain dematiaceous fungi. The disease has worldwide prevalence with predominant cases reported from humid tropical and subtropical regions of America, Asia, and Africa. Diagnosis i...

journal_title：PLoS neglected tropical diseases

authors： Agarwal R,Singh G,Ghosh A,Verma KK,Pandey M,Xess I

更新日期：2017-08-03 00:00:00

abstract：BACKGROUND:Trichinellosis is a serious zoonositc parasitosis worldwide. Because its clinical manifestations aren't specific, the diagnosis of trichinellosis is not easy to be made. Trichinella spiralis muscle larva (ML) excretory-secretory (ES) antigens are the most widely applied diagnostic antigens for human trichine...

journal_title：PLoS neglected tropical diseases

authors： Sun GG,Song YY,Jiang P,Ren HN,Yan SW,Han Y,Liu RD,Zhang X,Wang ZQ,Cui J

更新日期：2018-05-14 00:00:00

abstract：:Rabies is an ancient viral disease that significantly impacts human and animal health throughout the world. In the developing parts of the world, dog bites represent the highest risk of rabies infection to people, livestock, and other animals. However, in North America, where several rabies virus variants currently ci...

journal_title：PLoS neglected tropical diseases

authors： Elmore SA,Chipman RB,Slate D,Huyvaert KP,VerCauteren KC,Gilbert AT

更新日期：2017-03-16 00:00:00