Onchocerca volvulus infection in Tihama region - west of Yemen: Continuing transmission in ivermectin-targeted endemic foci and unveiled endemicity in districts with previously unknown status.

abstract：BACKGROUND:Talaromyces marneffei is an opportunistic dimorphic fungus prevalent in Southeast Asia. We previously demonstrated that Mp1p is an immunogenic surface and secretory mannoprotein of T. marneffei. Since Mp1p is a surface protein that can generate protective immunity, we hypothesized that Mp1p and/or its homolo...

journal_title：PLoS neglected tropical diseases

authors： Woo PC,Lau SK,Lau CC,Tung ET,Chong KT,Yang F,Zhang H,Lo RK,Cai JP,Au-Yeung RK,Ng WF,Tse H,Wong SS,Xu S,Lam WH,Tse MK,Sze KH,Kao RY,Reiner NE,Hao Q,Yuen KY

更新日期：2016-08-25 00:00:00

abstract：BACKGROUND:The liver fluke Opisthorchis viverrini is classified as a class I carcinogen due to the association between cholangiocarcinoma and chronic O. viverrini infection. During its feeding activity within the bile duct, the parasite secretes several cathepsin F cysteine proteases that may induce or contribute to th...

journal_title：PLoS neglected tropical diseases

authors： Pinlaor P,Kaewpitoon N,Laha T,Sripa B,Kaewkes S,Morales ME,Mann VH,Parriott SK,Suttiprapa S,Robinson MW,To J,Dalton JP,Loukas A,Brindley PJ

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Burkholderia pseudomallei is a soil saprophytic bacterium that causes melioidosis. The infection occurs through cutaneous inoculation, inhalation or ingestion. Bacteriophages (phages) in the same ecosystem may significantly impact the biology of this bacterium in the environment, and in their culturability i...

journal_title：PLoS neglected tropical diseases

authors： Withatanung P,Chantratita N,Muangsombut V,Saiprom N,Lertmemongkolchai G,Klumpp J,Clokie MR,Galyov EE,Korbsrisate S

更新日期：2016-09-26 00:00:00

abstract：:A budget proposal to stop the U.S. Centers for Disease Control and Prevention (CDC) funding in surveillance and research for mosquito-borne diseases such as dengue and West Nile virus has the potential to leave the country ill-prepared to handle new emerging diseases and manage existing ones. In order to demonstrate t...

journal_title：PLoS neglected tropical diseases

authors： Vazquez-Prokopec GM,Chaves LF,Ritchie SA,Davis J,Kitron U

更新日期：2010-10-26 00:00:00

abstract：BACKGROUND:A better understanding of reproductive processes in parasitic nematodes may lead to development of new anthelmintics and control strategies for combating disabling and disfiguring neglected tropical diseases such as lymphatic filariasis and onchocerciasis. Transcriptomatic analysis has provided important new...

journal_title：PLoS neglected tropical diseases

authors： Li BW,Rush AC,Jiang DJ,Mitreva M,Abubucker S,Weil GJ

更新日期：2011-01-25 00:00:00

abstract：:As the most widespread tick-borne arbovirus causing infections in numerous countries in Asia, Africa and Europe, Crimean-Congo Hemorrhagic Fever Virus (CCHFV, family Nairoviridae) was included in the WHO priority list of emerging pathogens needing urgent Research & Development attention. To ensure preparedness for pot...

journal_title：PLoS neglected tropical diseases

authors： Emmerich P,Mika A,von Possel R,Rackow A,Liu Y,Schmitz H,Günther S,Sherifi K,Halili B,Jakupi X,Berisha L,Ahmeti S,Deschermeier C

更新日期：2018-03-26 00:00:00

abstract：BACKGROUND:Blindness is caused by eye pathogens that include a free-living protist (Acanthamoeba castellanii, A. byersi, and/or other Acanthamoeba spp.), a fungus (Fusarium solani), and a bacterium (Chlamydia trachomatis). Hand-eye contact is likely a contributor to the spread of these pathogens, and so hand washing wi...

journal_title：PLoS neglected tropical diseases

authors： Aqeel Y,Rodriguez R,Chatterjee A,Ingalls RR,Samuelson J

更新日期：2017-02-09 00:00:00

abstract：BACKGROUND:Dengue virus (DENV) is the most important arbovirus worldwide, causing infections in endemic countries and returning travellers from these areas. Rapid diagnostic tests are needed to improve patient management and monitor local transmission. The detection of DENV non-structural protein 1 (NS1) is a useful to...

journal_title：PLoS neglected tropical diseases

authors： Alejo-Cancho I,Navero-Castillejos J,Peiró-Mestres A,Albarracín R,Barrachina J,Navarro A,Gonzalo V,Pastor V,Muñoz J,Martínez MJ

更新日期：2020-02-18 00:00:00

abstract：:Schistosomiasis affects approximately 240 million people in the world. Schistosoma mansoni eggs in the liver induce periportal fibrosis and hepatic failure driven by monocyte recruitment and macrophage activation, resulting in robust Th2 response. Here, we suggested a possible involvement of Galectin-3 (Gal-3), histon...

journal_title：PLoS neglected tropical diseases

authors： de Oliveira FL,Carneiro K,Brito JM,Cabanel M,Pereira JX,Paiva LA,Syn W,Henderson NC,El-Cheikh MC

更新日期：2017-02-23 00:00:00

abstract：BACKGROUND:In 2005, there were outbreaks of febrile polyarthritis due to Chikungunya virus (CHIKV) in the Comoros Islands. CHIKV then spread to other islands in the Indian Ocean: La Réunion, Mauritius, Seychelles and Madagascar. These outbreaks revealed the lack of surveillance and preparedness of Madagascar and other ...

journal_title：PLoS neglected tropical diseases

authors： Andriamandimby SF,Heraud JM,Randrianasolo L,Rafisandratantsoa JT,Andriamamonjy S,Richard V

更新日期：2013-07-25 00:00:00

abstract：BACKGROUND:The sensitivity and specificity of two in-house MAC-ELISA assays were tested and compared with the performance of commercially-available CTK lateral flow rapid test and EUROIMMUN IFA assays for the detection of anti-Chikungunya virus (CHIKV) IgM. Each MAC-ELISA assay used a whole virus-based antigen derived ...

journal_title：PLoS neglected tropical diseases

authors： Yap G,Pok KY,Lai YL,Hapuarachchi HC,Chow A,Leo YS,Tan LK,Ng LC

更新日期：2010-07-20 00:00:00

abstract：BACKGROUND:Chlamydia trachomatis is the etiological agent of trachoma the world's leading cause of infectious blindness. Here, we investigate whether protracted clearance of a primary infection in nonhuman primates is attributable to antigenic variation or related to the maturation of the anti-chlamydial humoral immune...

journal_title：PLoS neglected tropical diseases

authors： Kari L,Bakios LE,Goheen MM,Bess LN,Watkins HS,Southern TR,Song L,Whitmire WM,Olivares-Zavaleta N,Caldwell HD

更新日期：2013-05-30 00:00:00

abstract：BACKGROUND:The mainstay of toxoplasmosis treatment targets the folate biosynthetic pathways and has not changed for the last 50 years. The activity of these chemotherapeutic agents is restricted to one lifecycle stage of Toxoplasma gondii, they have significant toxicity, and the impending threat of emerging resistance ...

journal_title：PLoS neglected tropical diseases

authors： Andrade RM,Chaparro JD,Capparelli E,Reed SL

更新日期：2014-07-31 00:00:00

abstract：BACKGROUND:Leptospirosis, a spirochaetal zoonotic disease, is the cause of epidemics associated with high mortality in urban slum communities. Infection with pathogenic Leptospira occurs during environmental exposures and is traditionally associated with occupational risk activities. However, slum inhabitants reside in...

journal_title：PLoS neglected tropical diseases

authors： Maciel EA,de Carvalho AL,Nascimento SF,de Matos RB,Gouveia EL,Reis MG,Ko AI

更新日期：2008-01-30 00:00:00

abstract：:The World Health Organization (WHO) defines an effective round of mass drug administration (MDA) for lymphatic filariasis (LF) as one that reaches at least 65% of the target population. In its first round of MDA in 2011-2012, the National Program to Eliminate LF in Haiti achieved a 79% epidemiological coverage in urba...

journal_title：PLoS neglected tropical diseases

authors： Wodnik BK,Louis DH,Joseph M,Wilkers LT,Landskroener SD,Desir L,Lemoine JF,Lavery JV

更新日期：2020-05-29 00:00:00

abstract：BACKGROUND:Entomological indicators are considered key metrics to document the interruption of transmission of Onchocerca volvulus, the etiological agent of human onchocerciasis. Human landing collection is the standard employed for collection of the vectors for this parasite. Recent studies reported the development of...

journal_title：PLoS neglected tropical diseases

authors： Young RM,Burkett-Cadena ND,McGaha TW Jr,Rodriguez-Perez MA,Toé LD,Adeleke MA,Sanfo M,Soungalo T,Katholi CR,Noblet R,Fadamiro H,Torres-Estrada JL,Salinas-Carmona MC,Baker B,Unnasch TR,Cupp EW

更新日期：2015-01-08 00:00:00

abstract：:Erythema nodosum leprosum (ENL), or type 2 lepra reaction, is a multi-system immune-mediated complication in patients with multibacillary leprosy, frequently associated with chronicity and recurrences. Management of ENL requires high doses of oral corticosteroids, which may not be universally effective and pose seriou...

journal_title：PLoS neglected tropical diseases

authors： Upputuri B,Pallapati MS,Tarwater P,Srikantam A

更新日期：2020-10-09 00:00:00

abstract：:One of the stated goals of the London Declaration on Neglected Tropical Diseases is the interruption of domiciliary transmissions of Chagas disease in the region of the Americas. We used a game-theoretic approach to assess the voluntary use of insecticide treated nets (ITNs) in the prevention of the spread of infectio...

journal_title：PLoS neglected tropical diseases

authors： Han CY,Issa H,Rychtář J,Taylor D,Umana N

更新日期：2020-11-03 00:00:00

abstract：BACKGROUND:The high rate of leprosy cases among children under 15 years of age in Brazil indicates ongoing transmission within the community. The identification of the new leprosy cases among contacts can help identify the source of infection and interrupt the transmission chain. This study aims to determine the detect...

journal_title：PLoS neglected tropical diseases

authors： Pedrosa VL,Dias LC,Galban E,Leturiondo A,Palheta J Jr,Santos M,Moraes MO,Talhari C

更新日期：2018-02-26 00:00:00

abstract：BACKGROUND:Although leprosy is portrayed as a disappearing disease, leprosy affected persons in India are still suffering massively. Even further, nearly 60% of the world's newly detected cases are appearing from India alone. The problem has exacerbated due to the drastic decrease of global funding after India's offici...

journal_title：PLoS neglected tropical diseases

authors： Jung SH,Han HW,Koh H,Yu SY,Nawa N,Morita A,Ong KIC,Jimba M,Oh J

更新日期：2020-01-13 00:00:00

abstract：BACKGROUND:The two front-line drugs for chronic Trypanosoma cruzi infections are limited by adverse side-effects and declining efficacy. One potential new target for Chagas' disease chemotherapy is sterol 14alpha-demethylase (CYP51), a cytochrome P450 enzyme involved in biosynthesis of membrane sterols. METHODOLOGY/PR...

journal_title：PLoS neglected tropical diseases

authors： Chen CK,Doyle PS,Yermalitskaya LV,Mackey ZB,Ang KK,McKerrow JH,Podust LM

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Sri Lankan Russell's viper (Daboia russelii) envenoming is reported to cause myotoxicity and neurotoxicity, which are different to the effects of envenoming by most other populations of Russell's vipers. This study aimed to investigate evidence of myotoxicity in Russell's viper envenoming, response to antive...

journal_title：PLoS neglected tropical diseases

authors： Silva A,Johnston C,Kuruppu S,Kneisz D,Maduwage K,Kleifeld O,Smith AI,Siribaddana S,Buckley NA,Hodgson WC,Isbister GK

更新日期：2016-12-02 00:00:00

abstract：:Enzootic strains of Venezuelan equine encephalitis virus (VEEV) have been isolated from febrile patients in the Peruvian Amazon Basin at low but consistent levels since the early 1990s. Through a clinic-based febrile surveillance program, we detected an outbreak of VEEV infections in Iquitos, Peru, in the first half o...

journal_title：PLoS neglected tropical diseases

authors： Morrison AC,Forshey BM,Notyce D,Astete H,Lopez V,Rocha C,Carrion R,Carey C,Eza D,Montgomery JM,Kochel TJ

更新日期：2008-01-01 00:00:00

abstract：:Revealing the patterns and determinants of the spread of dengue virus (DENV) at local scales is central to understanding the epidemiology and evolution of this major human pathogen. We performed a phylogenetic analysis of the envelope (E) genes of DENV-1, -2, -3, and -4 isolates (involving 97, 23, 5, and 74 newly coll...

journal_title：PLoS neglected tropical diseases

authors： Rabaa MA,Klungthong C,Yoon IK,Holmes EC,Chinnawirotpisan P,Thaisomboonsuk B,Srikiatkhachorn A,Rothman AL,Tannitisupawong D,Aldstadt J,Nisalak A,Mammen MP,Gibbons RV,Endy TP,Fansiri T,Scott TW,Jarman RG

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Yaws is an infectious, debilitating and disfiguring disease of poverty that mainly affects children in rural communities in tropical areas. In Cameroon, mass-treatment campaigns carried out in the 1950s reduced yaws to such low levels that it was presumed the disease was eradicated. In 2010, an epidemiologic...

journal_title：PLoS neglected tropical diseases

authors： Boock AU,Awah PK,Mou F,Nichter M

更新日期：2017-05-08 00:00:00

abstract：BACKGROUND:Fascioliasis is an emerging zoonotic disease of considerable veterinary and public health importance. Triclabendazole is the only available drug for treatment. Laboratory studies have documented promising fasciocidal properties of the artemisinins (e.g., artemether). METHODOLOGY:We carried out two explorato...

journal_title：PLoS neglected tropical diseases

authors： Keiser J,Sayed H,el-Ghanam M,Sabry H,Anani S,el-Wakeel A,Hatz C,Utzinger J,el-Din SS,el-Maadawy W,Botros S

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Mosquitoes feed on plant-derived fluids such as nectar and sap and are exposed to bioactive molecules found in this dietary source. However, the role of such molecules on mosquito vectorial capacity is unknown. Weather has been recognized as a major determinant of the spread of dengue, and plants under abiot...

journal_title：PLoS neglected tropical diseases

authors： Nunes RD,Ventura-Martins G,Moretti DM,Medeiros-Castro P,Rocha-Santos C,Daumas-Filho CR,Bittencourt-Cunha PR,Martins-Cardoso K,Cudischevitch CO,Menna-Barreto RF,Oliveira JH,Gusmão DS,Alves Lemos FJ,Alviano DS,Oliveira PL,Low

更新日期：2016-10-12 00:00:00

abstract：:During Schistosoma infection, lack of B cells results in more severe granulomas, inflammation, and fibrosis in the liver, but the mechanisms underlying this pathology remain unclear. This study was to clarify the mechanisms underpinning the immunomodulation of B cells in mice infected with Schistosoma japonicum (S. ja...

journal_title：PLoS neglected tropical diseases

authors： Yong L,Tang Y,Ren C,Liu M,Shen J,Hou X

更新日期：2019-06-13 00:00:00

abstract：BACKGROUND:Between 20 and 30 bacteriologically confirmed cases of leprosy are diagnosed each year at the French National Reference Center for mycobacteria. Patients are mainly immigrants from various endemic countries or living in French overseas territories. We aimed at expanding data regarding the geographical distri...

journal_title：PLoS neglected tropical diseases

authors： Reibel F,Chauffour A,Brossier F,Jarlier V,Cambau E,Aubry A

更新日期：2015-10-06 00:00:00

abstract：:Hansen's disease (HD) belongs to the group of neglected diseases and can cause physical deformities and disabilities, in addition to leading to social discrimination. Ocular involvement in HD is estimated at 70-75% worldwide. About 10-50% suffer from severe ocular symptoms and loss of vision occurs in approximately 5%...

journal_title：PLoS neglected tropical diseases

authors： Pavezzi PD,do Prado RB,Boin Filho PÂ,Gon ADS,Tuma B,Fornazieri MA,Scalone FM,Alves LRM,Montero RH,Casella AMB

更新日期：2020-09-21 00:00:00