Abstract：
:A budget proposal to stop the U.S. Centers for Disease Control and Prevention (CDC) funding in surveillance and research for mosquito-borne diseases such as dengue and West Nile virus has the potential to leave the country ill-prepared to handle new emerging diseases and manage existing ones. In order to demonstrate the consequences of such a measure, if implemented, we evaluated the impact of delayed control responses to dengue epidemics (a likely scenario emerging from the proposed CDC budget cut) in an economically developed urban environment. We used a mathematical model to generate hypothetical scenarios of delayed response to a dengue introduction (a consequence of halted mosquito surveillance) in the City of Cairns, Queensland, Australia. We then coupled the results of such a model with mosquito surveillance and case management costs to estimate the cumulative costs of each response scenario. Our study shows that halting mosquito surveillance can increase the management costs of epidemics by up to an order of magnitude in comparison to a strategy with sustained surveillance and early case detection. Our analysis shows that the total costs of preparedness through surveillance are far lower than the ones needed to respond to the introduction of vector-borne pathogens, even without consideration of the cost in human lives and well-being. More specifically, our findings provide a science-based justification for the re-assessment of the current proposal to slash the budget of the CDC vector-borne diseases program, and emphasize the need for improved and sustainable systems for vector-borne disease surveillance.
journal_name
PLoS Negl Trop Disjournal_title
PLoS neglected tropical diseasesauthors
Vazquez-Prokopec GM,Chaves LF,Ritchie SA,Davis J,Kitron Udoi
10.1371/journal.pntd.0000858subject
Has Abstractpub_date
2010-10-26 00:00:00pages
e858issue
10eissn
1935-2727issn
1935-2735journal_volume
4pub_type
杂志文章abstract：:The World Health Organization, the World Organization for Animal Health, and the Food and Agriculture Organization have resolved to eliminate human rabies deaths due to dog bites by 2030, and the Vaccine Alliance (Gavi) has added human rabies vaccines to their investments for 2021-2025. Implementing these goals cost-e...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0007630
更新日期：2019-09-26 00:00:00
abstract：:A comprehensive analysis was done to evaluate the potential use of anti-parasitic macrocyclic lactones (including avermectins and milbemycins) for Buruli ulcer (BU) therapy. A panel containing nearly all macrocyclic lactones used in human or in veterinary medicine was analyzed for activity in vitro against clinical is...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0003996
更新日期：2015-08-13 00:00:00
abstract：:P. vivax and P. falciparum parasites display different tropism for host cells and induce very different clinical symptoms and pathology, suggesting that the immune responses required for protection may differ between these two species. However, no study has qualitatively compared the immune responses to P. falciparum ...
journal_title：PLoS neglected tropical diseases
pub_type： 临床试验,杂志文章
doi：10.1371/journal.pntd.0005031
更新日期：2016-12-08 00:00:00
abstract：BACKGROUND:Cholera remains an important public health problem in major cities in Bangladesh, especially in slum areas. In response to growing interest among local policymakers to control this disease, this study estimated the impact and cost-effectiveness of preventive cholera vaccination over a ten-year period in a hi...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0006652
更新日期：2018-10-09 00:00:00
abstract：BACKGROUND:Taenia solium cysticercosis/taeniosis is emerging as a serious public health and economic problem in many developing countries. This study was conducted to determine prevalence and risk factors of human T. solium infections in Mbeya Region, Tanzania. METHODS AND FINDINGS:A cross-sectional survey was conduct...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0002102
更新日期：2013-01-01 00:00:00
abstract：:Schistosomiasis is endemic to many regions of the world and affects approximately 200 million people. Conventional adaptive T cell responses are considered to be the primary contributors to the pathogenesis of Schistosoma japonicum infection, leading to liver granuloma and fibrosis. However, the functional polarizatio...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0007000
更新日期：2018-12-27 00:00:00
abstract：BACKGROUND:Scabies is a disease of worldwide significance, causing considerable morbidity in both humans and other animals. The scabies mite Sarcoptes scabiei burrows into the skin of its host, obtaining nutrition from host skin and blood. Aspartic proteases mediate a range of diverse and essential physiological functi...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0002525
更新日期：2013-11-07 00:00:00
abstract：BACKGROUND:The main objective of the study was to determine the degree of sensitization to Anisakis spp. antigens in healthy coastal population of Dalmatia given the high thermally unprocessed fish intake rate present in this area, suggested as a significant risk factor for anisakiasis. We performed a monocenter, cross...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0002673
更新日期：2014-02-06 00:00:00
abstract：BACKGROUND:Access to health care is a major requirement in improving health and fostering socioeconomic development. In the People's Republic of China (P.R. China), considerable changes have occurred in the social, economic, and health systems with a shift from a centrally planned to a socialist market economy. This br...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0002350
更新日期：2013-08-01 00:00:00
abstract：:Strongyloidiasis is a much-neglected but sometimes fatal soil born helminthiasis. The causing agent, the small intestinal parasitic nematode Strongyloides stercoralis can reproduce sexually through the indirect/heterogonic life cycle, or asexually through the auto-infective or the direct/homogonic life cycles. Usually...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0007396
更新日期：2019-05-06 00:00:00
abstract：:Infection with the intracellular protozoan parasite Leishmania mexicana causes chronic disease in C57BL/6 mice, in which cutaneous lesions persist for many months with high parasite burdens (10(7)-10(8) parasites). This chronic disease process requires host IL-10 and FcγRIII. When Leishmania amastigotes are released f...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0002224
更新日期：2013-05-09 00:00:00
abstract：BACKGROUND:In view of the current widespread use of and reliance on a single schistosomicide, praziquantel, there is a pressing need to discover and develop alternative drugs for schistosomiasis. One approach to this is to develop High Throughput in vitro whole organism screens (HTS) to identify hits amongst large comp...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0000795
更新日期：2010-08-10 00:00:00
abstract：:Despite Nipah virus outbreaks having high mortality rates (>70% in Southeast Asia), there are no licensed drugs against it. In this study, we have considered all 9 Nipah proteins as potential therapeutic targets and computationally identified 4 putative peptide inhibitors (against G, F and M proteins) and 146 small mo...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0007419
更新日期：2019-12-12 00:00:00
abstract：:Leprosy is a chronic infectious disease that is caused by the obligate intracellular pathogen Mycobacterium leprae (M.leprae), which is the leading cause of all non-traumatic peripheral neuropathies worldwide. Although both myelinating and non-myelinating Schwann cells are infected by M.leprae in patients with leproma...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0005687
更新日期：2017-06-21 00:00:00
abstract：BACKGROUND:Control of onchocerciasis as a public health problem in Africa relies on annual mass ivermectin distribution. New tools are needed to achieve elimination of infection. This study determined in a small number of Onchocerca volvulus infected individuals whether moxidectin, a veterinary anthelminthic, is safe e...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章,随机对照试验
doi：10.1371/journal.pntd.0002953
更新日期：2014-06-26 00:00:00
abstract：:The burden of leptospirosis in humans and animals in Africa is higher than that reported from other parts of the world. However, the disease is not routinely diagnosed in the continent. One of major factors limiting diagnosis is the poor availability of live isolates of locally circulating Leptospira serovars for incl...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0004251
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:The simian parasite Plasmodium knowlesi is a common cause of human malaria in Malaysian Borneo and threatens the prospect of malaria elimination. However, little is known about the emergence of P. knowlesi, particularly in Sabah. We reviewed Sabah Department of Health records to investigate the trend of each...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0002026
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Efforts to control soil-transmitted helminth (STH) infections have intensified over the past decade. Field-survey data on STH prevalence, infection intensity and drug efficacy is necessary to guide the implementation of control programs and should be of the best possible quality. METHODOLOGY:During four cli...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0008625
更新日期：2020-09-21 00:00:00
abstract：BACKGROUND:Hydatidosis is a zoonotic disease of worldwide distribution caused by Echinococcus granulosus. Our study aimed to determine the prevalence of human and canine echinococcosis as well as the associated risk factors in a rural area of the Limarí province in northern Chile. METHODOLOGY/PRINCIPAL FINDINGS:A cros...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0003090
更新日期：2014-08-28 00:00:00
abstract：:Theileria parva is an economically important, intracellular, tick-transmitted parasite of cattle. A live vaccine against the parasite is effective against challenge from cattle-transmissible T. parva but not against genotypes originating from the African Cape buffalo, a major wildlife reservoir, prompting the need to ...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0008781
更新日期：2020-10-29 00:00:00
abstract：BACKGROUND:Dengue is the most prevalent arboviral disease transmitted by Aedes aegypti worldwide, whose chemical control is difficult, expensive, and of inconsistent efficacy. Releases of Metarhizium anisopliae--exposed Ae. aegypti males to disseminate conidia among female mosquitoes by mating represents a promising bi...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0004144
更新日期：2015-10-16 00:00:00
abstract：:Chromoblastomycosis (CBM) is a chronic, progressive, cutaneous and subcutaneous fungal infection following the traumatic implantation of certain dematiaceous fungi. The disease has worldwide prevalence with predominant cases reported from humid tropical and subtropical regions of America, Asia, and Africa. Diagnosis i...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章,评审
doi：10.1371/journal.pntd.0005534
更新日期：2017-08-03 00:00:00
abstract：BACKGROUND:Soil-transmitted helminth (STH) infection leads to malnutrition and anemia, and has been linked to impaired child development. Previous research on this topic is limited and mostly conducted in school-age children. The goal of this study was to determine the effect of the number of detected STH infections be...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0006688
更新日期：2018-07-27 00:00:00
abstract：BACKGROUND:In the roadmap on the neglected tropical diseases (NTD) the World Health Organization (WHO) aims at attaining at least 75% coverage of preventive chemotherapy in pre-school and school-age children by 2020. A randomized controlled trial was used to compare the effectiveness of praziquantel in treating Schisto...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章,随机对照试验
doi：10.1371/journal.pntd.0007238
更新日期：2019-04-10 00:00:00
abstract：BACKGROUND:Dengue is a mosquito-borne viral disease caused by the four dengue viruses (DENV-1 to 4) that can also be transmitted by blood transfusion and organ transplantation. The distribution of DENV in the components of blood from infected donors is poorly understood. METHODS:We used an in-house TaqMan qRT-PCR assa...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0004445
更新日期：2016-02-12 00:00:00
abstract：:Q fever is a widespread zoonosis that is caused by Coxiella burnetii (C. burnetii), and ruminants are identified as the main sources of human infections. Some human cases have been described, but very limited information was available about Q fever in ruminants on Reunion Island, a tropical island in the Indian Ocean....
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0003055
更新日期：2014-08-07 00:00:00
abstract：BACKGROUND:Leishmaniases are parasitic diseases present worldwide that are transmitted to the vertebrate host by the bite of an infected sand fly during a blood feeding. Phlebotomine sand flies inoculate into the mammalian host Leishmania parasites embedded in promastigote secretory gel (PSG) with saliva, which is comp...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章,评审
doi：10.1371/journal.pntd.0005600
更新日期：2017-07-13 00:00:00
abstract：BACKGROUND:Chagas disease is caused by the parasite Trypanosoma cruzi and is transmitted through triatomines (Hemiptera: Reduviidae). In the last year, many studies of triatomine gut microbiota have outlined its potential role in modulating vector competence. However, little is known about the microbiota present in the...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0006739
更新日期：2018-09-13 00:00:00
abstract：BACKGROUND:The neglected human diseases caused by trypanosomatids are currently treated with toxic therapy with limited efficacy. In search for novel anti-trypanosomatid agents, we showed previously that the Crotalus viridis viridis (Cvv) snake venom was active against infective forms of Trypanosoma cruzi. Here, we des...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0003252
更新日期：2014-10-16 00:00:00
abstract：BACKGROUND:Dengue viral infection is a global health threat without vaccine or specific treatment. The clinical outcome varies from asymptomatic, mild dengue fever (DF) to severe dengue hemorrhagic fever (DHF). While adaptive immune responses were found to be detrimental in the dengue pathogenesis, the roles of earlier...
journal_title：PLoS neglected tropical diseases
pub_type： 杂志文章
doi：10.1371/journal.pntd.0002955
更新日期：2014-06-19 00:00:00
