Evaluation of Chikungunya diagnostic assays: differences in sensitivity of serology assays in two independent outbreaks.

abstract：:Morbidity burden of lymphatic filariasis (LF) relies on the information from the Mass Drug Administration (MDA) programme where Community Health Volunteers (CHVs) passively report cases identified. Consequently, the exact prevalence of morbidity cases is not always accurate. The use of mobile phone technology to repor...

journal_title：PLoS neglected tropical diseases

authors： Debrah LB,Mohammed A,Osei-Mensah J,Mubarik Y,Agbenyega O,Ayisi-Boateng NK,Pfarr K,Kuehlwein JM,Klarmann-Schulz U,Hoerauf A,Debrah AY

更新日期：2020-11-12 00:00:00

abstract：BACKGROUND:Dengue is endemic in the Western Pacific and Oceania and the region reports more than 200,000 cases annually. Outbreaks of dengue and severe dengue occur regularly and movement of virus throughout the region has been reported. Disease surveillance systems, however, in many areas are not fully established and...

journal_title：PLoS neglected tropical diseases

authors： Luang-Suarkia D,Mitja O,Ernst T,Bennett S,Tay A,Hays R,Smith DW,Imrie A

更新日期：2018-03-01 00:00:00

abstract：INTRODUCTION:Buruli Ulcer (BU) is caused by the environmental microbe Mycobacterium ulcerans. Despite unclear transmission, contact with a BU endemic region is the key known risk factor. In Victoria, Australia, where endemic areas have been carefully mapped, we aimed to estimate the Incubation Period (IP) of BU by inte...

journal_title：PLoS neglected tropical diseases

authors： Trubiano JA,Lavender CJ,Fyfe JA,Bittmann S,Johnson PD

更新日期：2013-10-03 00:00:00

abstract：:Global efforts to address schistosomiasis and soil-transmitted helminthiases (STH) include deworming programs for school-aged children that are made possible by large-scale drug donations. Decisions on these mass drug administration (MDA) programs currently rely on microscopic examination of clinical specimens to dete...

journal_title：PLoS neglected tropical diseases

authors： Hawkins KR,Cantera JL,Storey HL,Leader BT,de Los Santos T

更新日期：2016-12-22 00:00:00

abstract：BACKGROUND:Enteric fever, a systemic infection caused by the bacteria Salmonella Typhi and Salmonella Paratyphi A, is endemic in Kathmandu, Nepal. Previous work identified proximity to poor quality water sources as a community-level risk for infection. Here, we sought to examine individual-level risk factors related to...

journal_title：PLoS neglected tropical diseases

authors： Karkey A,Thompson CN,Tran Vu Thieu N,Dongol S,Le Thi Phuong T,Voong Vinh P,Arjyal A,Martin LB,Rondini S,Farrar JJ,Dolecek C,Basnyat B,Baker S

更新日期：2013-08-22 00:00:00

abstract：BACKGROUND:The parasitic protozoan Trypanosoma brucei utilizes glycolysis exclusively for ATP production during infection of the mammalian host. The first step in this metabolic pathway is mediated by hexokinase (TbHK), an enzyme essential to the parasite that transfers the gamma-phospho of ATP to a hexose. Here we des...

journal_title：PLoS neglected tropical diseases

authors： Sharlow ER,Lyda TA,Dodson HC,Mustata G,Morris MT,Leimgruber SS,Lee KH,Kashiwada Y,Close D,Lazo JS,Morris JC

更新日期：2010-04-13 00:00:00

abstract：BACKGROUND:Chromoblastomycosis (CBM) is a difficult-to-treat chronic subcutaneous mycosis. In Brazil, the main agent of this disease is Fonsecaea pedrosoi, which is phenotypically very similar to other Fonsecaea species, differing only genetically. The correct species identification is relevant since different species ...

journal_title：PLoS neglected tropical diseases

authors： Coelho RA,Brito-Santos F,Figueiredo-Carvalho MHG,Silva JVDS,Gutierrez-Galhardo MC,do Valle ACF,Zancopé-Oliveira RM,Trilles L,Meyer W,Freitas DFS,Almeida-Paes R

更新日期：2018-07-26 00:00:00

abstract：:Murray Valley encephalitis virus (MVEV) is the most serious of the endemic arboviruses in Australia. It was responsible for six known large outbreaks of encephalitis in south-eastern Australia in the 1900s, with the last comprising 58 cases in 1974. Since then MVEV clinical cases have been largely confined to the west...

journal_title：PLoS neglected tropical diseases

authors： Selvey LA,Dailey L,Lindsay M,Armstrong P,Tobin S,Koehler AP,Markey PG,Smith DW

更新日期：2014-01-23 00:00:00

abstract：BACKGROUND:Filarial nematodes currently infect up to 54 million people worldwide, with millions more at risk for infection, representing the leading cause of disability in the developing world. Brugia malayi is one of the causative agents of lymphatic filariasis and remains the only human filarial parasite that can be ...

journal_title：PLoS neglected tropical diseases

authors： Grote A,Voronin D,Ding T,Twaddle A,Unnasch TR,Lustigman S,Ghedin E

更新日期：2017-03-30 00:00:00

abstract：:Mycobacterium leprae (M. leprae) is a human pathogen and the causative agent for leprosy, a chronic disease characterized by lesions of the skin and peripheral nerve damage. Zoonotic transmission of M. leprae to humans by nine-banded armadillos (Dasypus novemcinctus) has been shown to occur in the southern United Stat...

journal_title：PLoS neglected tropical diseases

authors： da Silva MB,Portela JM,Li W,Jackson M,Gonzalez-Juarrero M,Hidalgo AS,Belisle JT,Bouth RC,Gobbo AR,Barreto JG,Minervino AHH,Cole ST,Avanzi C,Busso P,Frade MAC,Geluk A,Salgado CG,Spencer JS

更新日期：2018-06-28 00:00:00

abstract：INTRODUCTION:Yaws is endemic in Ghana. The World Health Organization (WHO) has launched a new global eradication campaign based on total community mass treatment with azithromycin. Achieving high coverage of mass treatment will be fundamental to the success of this new strategy; coverage is dependent, in part, on appro...

journal_title：PLoS neglected tropical diseases

authors： Marks M,Kwakye-Maclean C,Doherty R,Adwere P,Aziz Abdulai A,Duah F,Ohene SA,Mitja O,Oguti B,Solomon AW,Mabey DCW,Adu-Sarkodie Y,Asiedu K,Ackumey MM

更新日期：2017-07-31 00:00:00

abstract：BACKGROUND:Hospitalization of patients during outbreaks of chikungunya virus has been reported to be uncommon (0.5-8.7%), but more frequent among infants and the elderly. CHIKV was first detected in Puerto Rico in May 2014. We enrolled patients with acute febrile illness (AFI) presenting to two hospital emergency depar...

journal_title：PLoS neglected tropical diseases

authors： Hsu CH,Cruz-Lopez F,Vargas Torres D,Perez-Padilla J,Lorenzi OD,Rivera A,Staples JE,Lugo E,Munoz-Jordan J,Fischer M,Garcia Gubern C,Rivera Garcia B,Alvarado L,Sharp TM

更新日期：2019-01-14 00:00:00

abstract：BACKGROUND:Yersinia pestis, the agent of plague, is considered a potential bioweapon due to rapid lethality when delivered as an aerosol. Levofloxacin was tested for primary pneumonic plague treatment in a nonhuman primate model mimicking human disease. METHODS AND RESULTS:Twenty-four African Green monkeys (AGMs, Chlo...

journal_title：PLoS neglected tropical diseases

authors： Layton RC,Mega W,McDonald JD,Brasel TL,Barr EB,Gigliotti AP,Koster F

更新日期：2011-02-08 00:00:00

abstract：BACKGROUND:A relatively simple life history allows us to derive an expression for the extinction probability of populations of tsetse, vectors of African sleeping sickness. We present the uncertainty and sensitivity analysis of the extinction probability, to offer key insights into factors affecting the control or erad...

journal_title：PLoS neglected tropical diseases

authors： Are EB,Hargrove JW

更新日期：2020-05-11 00:00:00

abstract：BACKGROUND:This year, Brazil will host about 600,000 foreign visitors during the 2014 FIFA World Cup. The concern of possible dengue transmission during this event has been raised given the high transmission rates reported in the past by this country. METHODOLOGY/PRINCIPAL FINDINGS:We used dengue incidence rates repor...

journal_title：PLoS neglected tropical diseases

authors： van Panhuis WG,Hyun S,Blaney K,Marques ET Jr,Coelho GE,Siqueira JB Jr,Tibshirani R,da Silva JB Jr,Rosenfeld R

更新日期：2014-07-31 00:00:00

abstract：OBJECTIVES:To assess if a probabilistic model could be used to estimate the combined prevalence of infection with any species of intestinal nematode worm when only the separate prevalence of each species is reported, and to estimate the extent to which simply taking the highest individual species prevalence underestima...

journal_title：PLoS neglected tropical diseases

authors： de Silva N,Hall A

更新日期：2010-04-13 00:00:00

abstract：BACKGROUND:Zika virus (ZIKV) is a mosquito-borne flavivirus distributed throughout much of Africa and Asia. Infection with the virus may cause acute febrile illness that clinically resembles dengue fever. A recent study indicated the existence of three geographically distinct viral lineages; however this analysis utili...

journal_title：PLoS neglected tropical diseases

authors： Haddow AD,Schuh AJ,Yasuda CY,Kasper MR,Heang V,Huy R,Guzman H,Tesh RB,Weaver SC

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Intestinal schistosomiasis and soil-transmitted helminth (STH) infections constitute major public health problems in many parts of sub-Saharan Africa. In this study we examined the functional significance of such polyparasite infections in anemia and undernutrition in Rwandan individuals. METHODS:Three poly...

journal_title：PLoS neglected tropical diseases

authors： Mupfasoni D,Karibushi B,Koukounari A,Ruberanziza E,Kaberuka T,Kramer MH,Mukabayire O,Kabera M,Nizeyimana V,Deville MA,Ruxin J,Webster JP,Fenwick A

更新日期：2009-09-15 00:00:00

abstract：:The 2015-2017 epidemics of Zika virus (ZIKV) in the Americas caused widespread infection, followed by protective immunity. The timing and burden of the next Zika virus outbreak remains unclear. We used an agent-based model to simulate the dynamics of age-specific immunity to ZIKV, and predict the future age-specific r...

journal_title：PLoS neglected tropical diseases

authors： Counotte MJ,Althaus CL,Low N,Riou J

更新日期：2019-12-26 00:00:00

abstract：:Fasciolosis caused by Fasciola gigantica is a neglected tropical disease but a constraint on the growth and productivity of cattle, buffaloes and sheep in the tropical countries of Asia and Africa. Resistance to commonly used anthelmintics in Fasciola has increased the need to search for alternative therapeutic target...

journal_title：PLoS neglected tropical diseases

authors： Anandanarayanan A,Raina OK,Lalrinkima H,Rialch A,Sankar M,Varghese A

更新日期：2017-12-12 00:00:00

abstract：BACKGROUND:treatment of Mycobacterium ulcerans disease, or Buruli ulcer (BU), has shifted from surgery to treatment with streptomycin(STR)+rifampin(RIF) since 2004 based on studies in a mouse model and clinical trials. We tested two entirely oral regimens for BU treatment, rifampin(RIF)+clarithromycin(CLR) and rifapent...

journal_title：PLoS neglected tropical diseases

authors： Almeida D,Converse PJ,Ahmad Z,Dooley KE,Nuermberger EL,Grosset JH

更新日期：2011-01-04 00:00:00

abstract：:Orientia tsutsugamushi (Ots) frequently causes severe scrub typhus infections in the Asia-Pacific region. Korean investigators have demonstrated that Ots encodes five different autotransporter domain (ATD) proteins (ScaA-ScaE). ScaA functions as an adhesin and confers protective immunity in a lethal mouse model of Ots...

journal_title：PLoS neglected tropical diseases

authors： Koralur MC,Ramaiah A,Dasch GA

更新日期：2018-09-20 00:00:00

abstract：OBJECTIVE:We conducted a systematic literature review with indirect comparison of studies evaluating therapeutic efficacy and toxicity associated to visceral leishmaniasis (VL) therapy among HIV infected individuals. MAIN OUTCOME MEASUREMENTS:The outcomes of interest were clinical and parasitological cure, mortality, ...

journal_title：PLoS neglected tropical diseases

authors： Cota GF,de Sousa MR,Fereguetti TO,Rabello A

更新日期：2013-05-02 00:00:00

abstract：BACKGROUND:The dengue virus is endemic in many low- and middle-income countries. In Burkina Faso, the proportion of fevers that could be due to dengue is growing. In 2013, a dengue epidemic spread there, followed by other seasonal outbreaks. Dengue is often confused with malaria, and health workers are not trained to d...

journal_title：PLoS neglected tropical diseases

authors： Hébert C,Dagenais C,Mc Sween-Cadieux E,Ridde V

更新日期：2020-06-10 00:00:00

abstract：:One of the stated goals of the London Declaration on Neglected Tropical Diseases is the interruption of domiciliary transmissions of Chagas disease in the region of the Americas. We used a game-theoretic approach to assess the voluntary use of insecticide treated nets (ITNs) in the prevention of the spread of infectio...

journal_title：PLoS neglected tropical diseases

authors： Han CY,Issa H,Rychtář J,Taylor D,Umana N

更新日期：2020-11-03 00:00:00

abstract：:Trypanosomes rely on post-transcriptional mechanisms and mRNA-binding proteins for control of gene expression. Trypanosoma brucei ZC3H30 is an mRNA-binding protein that is expressed in both the bloodstream form (which grows in mammals) and the procyclic form (which grows in the tsetse fly midgut). Attachment of ZC3H30...

journal_title：PLoS neglected tropical diseases

authors： Chakraborty C,Clayton C

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Cutaneous leishmaniasis (CL) is an infectious disease caused by various species of Leishmania and transmitted by several species of sand flies. CL is among the most neglected tropical diseases, and it has represented a major health threat over the past 20 years in Morocco. The main objectives of this study w...

journal_title：PLoS neglected tropical diseases

authors： Mhaidi I,El Kacem S,Ait Kbaich M,El Hamouchi A,Sarih M,Akarid K,Lemrani M

更新日期：2018-03-02 00:00:00

abstract：:We evaluated the protection conferred by a first documented visit for clinical care of typhoid fever against recurrent typhoid fever prompting a visit. This study takes advantage of multi-year follow-up of a population with endemic typhoid participating in a cluster-randomized control trial of Vi capsular polysacchari...

journal_title：PLoS neglected tropical diseases

authors： Im J,Islam MT,Kim DR,Ahmmed F,Chon Y,Zaman K,Khan AI,Ali M,Sur D,Kanungo S,Dutta S,Bhattacharya SK,Dougan G,Holt KE,Marks F,Kim JH,Qadri F,Clemens JD

更新日期：2020-08-17 00:00:00

abstract：:Salmonella enterica serovar Typhi (S. Typhi) is the causative agent of typhoid fever, a systemic human infection with a burden exceeding 20 million cases each year that occurs disproportionately among children in low and middle income countries. Antimicrobial therapy is the mainstay for treatment, but resistance to mu...

journal_title：PLoS neglected tropical diseases

authors： Ingle DJ,Nair S,Hartman H,Ashton PM,Dyson ZA,Day M,Freedman J,Chattaway MA,Holt KE,Dallman TJ

更新日期：2019-09-12 00:00:00

abstract：:In this communication, a case of black grain eumycetoma produced by the fungus C. atrobrunneum is reported. The patient was initially misdiagnosed with M. mycetomatis eumycetoma based on the grains' morphological and cytological features. However, further aerobic culture of the black grains generated a melanised fungu...

journal_title：PLoS neglected tropical diseases

authors： Mhmoud NA,Santona A,Fiamma M,Siddig EE,Deligios M,Bakhiet SM,Rubino S,Fahal AH

更新日期：2019-05-30 00:00:00