Venezuelan equine encephalitis virus in Iquitos, Peru: urban transmission of a sylvatic strain.

abstract：INTRODUCTION:Plasmodium spp. and helminths are co-endemic in many parts of the tropics; hence, co-infection is a common phenomenon. Interactions between Plasmodium and helminth infections may alter the host's immune response and susceptibility and thus impact on morbidity. There is little information on the direction a...

journal_title：PLoS neglected tropical diseases

authors： Hürlimann E,Houngbedji CA,Yapi RB,N'Dri PB,Silué KD,Ouattara M,Utzinger J,N'Goran EK,Raso G

更新日期：2019-01-10 00:00:00

abstract：:Rickettsia (R.) helvetica is the most prevalent rickettsia found in Ixodes ricinus ticks in Germany. Several studies reported antibodies against R. helvetica up to 12.5% in humans investigated, however, fulminant clinical cases are rare indicating a rather low pathogenicity compared to other rickettsiae. We investigat...

journal_title：PLoS neglected tropical diseases

authors： Speck S,Kern T,Aistleitner K,Dilcher M,Dobler G,Essbauer S

更新日期：2018-02-12 00:00:00

abstract：:Mycetoma is a unique neglected tropical disease which is endemic in what is known as the "mycetoma belt". The disease has many devastating impacts on patients and communities in endemic area and is characterised by massive deformity, destruction and disability. Mycetoma is commonly seen in the foot and hand and less f...

journal_title：PLoS neglected tropical diseases

authors： Fahal A,Mahgoub el S,El Hassan AM,Jacoub AO,Hassan D

更新日期：2015-03-13 00:00:00

abstract：BACKGROUND:The use of DNA microarray technology to study global Schistosoma gene expression has led to the rapid identification of novel biological processes, pathways or associations. Implementation of standardized DNA microarray protocols across laboratories would assist maximal interpretation of generated datasets a...

journal_title：PLoS neglected tropical diseases

authors： Fitzpatrick JM,Protasio AV,McArdle AJ,Williams GA,Johnston DA,Hoffmann KF

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The cestode Echinococcus granulosus--the agent of cystic echinococcosis, a zoonosis affecting humans and domestic animals worldwide--is an excellent model for the study of host-parasite cross-talk that interfaces with two mammalian hosts. To develop the molecular analysis of these interactions, we carried ou...

journal_title：PLoS neglected tropical diseases

authors： Parkinson J,Wasmuth JD,Salinas G,Bizarro CV,Sanford C,Berriman M,Ferreira HB,Zaha A,Blaxter ML,Maizels RM,Fernández C

更新日期：2012-01-01 00:00:00

abstract：:Entamoeba histolytica infection may have various clinical manifestations. Nine out of ten E. histolytica infections remain asymptomatic, while the remainder become invasive and cause disease. The most common form of invasive infection is amebic diarrhea and colitis, whereas the most common extra-intestinal disease is ...

journal_title：PLoS neglected tropical diseases

authors： Ali IK,Solaymani-Mohammadi S,Akhter J,Roy S,Gorrini C,Calderaro A,Parker SK,Haque R,Petri WA Jr,Clark CG

更新日期：2008-04-09 00:00:00

abstract：:We recently reported that larval stage Aedes aegypti and several other species of mosquitoes grow when living bacteria are present in the gut but do not grow when living bacteria are absent. We further reported that living bacteria induce a hypoxia signal in the gut, which activates hypoxia-induced transcription facto...

journal_title：PLoS neglected tropical diseases

authors： Valzania L,Martinson VG,Harrison RE,Boyd BM,Coon KL,Brown MR,Strand MR

更新日期：2018-07-06 00:00:00

abstract：:Sporotrichosis is endemic in the Sub-Himalayan belt, which ranges from the northern to the north-eastern Indian subcontinent. Similar to many parts of the developing world, sporotrichosis is commonly recognized clinically in this region however consolidated epidemiological data is lacking. We report epidemiological, c...

journal_title：PLoS neglected tropical diseases

authors： Verma S,Verma GK,Singh G,Kanga A,Shanker V,Singh D,Gupta P,Mokta K,Sharma V

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Aminoacyl tRNA synthetases are central enzymes required for protein synthesis. These enzymes are the known drug targets in bacteria and fungi. Here, we for the first time report the functional characterization of threonyl tRNA synthetase (LdThrRS) of Leishmania donovani, a protozoan parasite, the primary cau...

journal_title：PLoS neglected tropical diseases

authors： Chadha S,Vijayan R,Gupta S,Munde M,Gourinath S,Madhubala R

更新日期：2018-06-13 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) is characterized by parasite-specific immunosuppression besides an intense pro-inflammatory response. Lipopolisaccharide (LPS) has been implicated in the immune activation of T-cell deficient diseases such as HIV/AIDS and idiopathic lymphocytopenia. The source of LPS is gram-negat...

journal_title：PLoS neglected tropical diseases

authors： Santos-Oliveira JR,Regis EG,Leal CR,Cunha RV,Bozza PT,Da-Cruz AM

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Severe fever with thrombocytopenia syndrome virus (SFTSV), the causative agent for the fatal life-threatening infectious disease, severe fever with thrombocytopenia syndrome (SFTS), was first identified in the central and eastern regions of China. Although the viral RNA was detected in free-living and parasi...

journal_title：PLoS neglected tropical diseases

authors： Jiao Y,Qi X,Liu D,Zeng X,Han Y,Guo X,Shi Z,Wang H,Zhou M

更新日期：2015-10-20 00:00:00

abstract：:Chagas disease is caused by the parasitic protozoan Trypanosoma cruzi. It has high mortality as well as morbidity rates and usually affects the poorer sections of the population. The development of new, less harmful and more effective drugs is a promising research target, since current standard treatments are highly t...

journal_title：PLoS neglected tropical diseases

authors： Rea A,Tempone AG,Pinto EG,Mesquita JT,Rodrigues E,Silva LG,Sartorelli P,Lago JH

更新日期：2013-12-05 00:00:00

abstract：:The major arboviral diseases in mainland China include Japanese encephalitis, dengue fever, Crimean-Congo hemorrhagic fever (also known as Xinjiang hemorrhagic fever), and tick-borne encephalitis. These and other newly found arbovirus infections due to Banna virus and Tahyna virus contribute to a large and relatively ...

journal_title：PLoS neglected tropical diseases

authors： Gao X,Nasci R,Liang G

更新日期：2010-04-27 00:00:00

abstract：BACKGROUND:Entomological indicators are considered key metrics to document the interruption of transmission of Onchocerca volvulus, the etiological agent of human onchocerciasis. Human landing collection is the standard employed for collection of the vectors for this parasite. Recent studies reported the development of...

journal_title：PLoS neglected tropical diseases

authors： Young RM,Burkett-Cadena ND,McGaha TW Jr,Rodriguez-Perez MA,Toé LD,Adeleke MA,Sanfo M,Soungalo T,Katholi CR,Noblet R,Fadamiro H,Torres-Estrada JL,Salinas-Carmona MC,Baker B,Unnasch TR,Cupp EW

更新日期：2015-01-08 00:00:00

abstract：BACKGROUND:Blindness is caused by eye pathogens that include a free-living protist (Acanthamoeba castellanii, A. byersi, and/or other Acanthamoeba spp.), a fungus (Fusarium solani), and a bacterium (Chlamydia trachomatis). Hand-eye contact is likely a contributor to the spread of these pathogens, and so hand washing wi...

journal_title：PLoS neglected tropical diseases

authors： Aqeel Y,Rodriguez R,Chatterjee A,Ingalls RR,Samuelson J

更新日期：2017-02-09 00:00:00

abstract：:During the recent Ebola outbreak in West Africa several international mobile laboratories were deployed to the mainly affected countries Guinea, Sierra Leone and Liberia to provide ebolavirus diagnostic capacity. Additionally, imported cases and small outbreaks in other countries required global preparedness for Ebola...

journal_title：PLoS neglected tropical diseases

authors： Ellerbrok H,Jacobsen S,Patel P,Rieger T,Eickmann M,Becker S,Günther S,Naidoo D,Schrick L,Keeren K,Targosz A,Teichmann A,Formenty P,Niedrig M

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Cholera remains an important public health problem in major cities in Bangladesh, especially in slum areas. In response to growing interest among local policymakers to control this disease, this study estimated the impact and cost-effectiveness of preventive cholera vaccination over a ten-year period in a hi...

journal_title：PLoS neglected tropical diseases

authors： Khan AI,Levin A,Chao DL,DeRoeck D,Dimitrov DT,Khan JAM,Islam MS,Ali M,Islam MT,Sarker AR,Clemens JD,Qadri F

更新日期：2018-10-09 00:00:00

abstract：BACKGROUND:Viral hemorrhagic fevers (VHF) are acute diseases associated with bleeding, organ failure, and shock. VHF may hardly be distinguished clinically from other diseases in the African hospital, including viral hepatitis. This study was conducted to determine if VHF and viral hepatitis contribute to hospital morb...

journal_title：PLoS neglected tropical diseases

authors： Bonney JH,Osei-Kwasi M,Adiku TK,Barnor JS,Amesiya R,Kubio C,Ahadzie L,Olschläger S,Lelke M,Becker-Ziaja B,Pahlmann M,Günther S

更新日期：2013-09-19 00:00:00

abstract：BACKGROUND:Since cholera appeared in Africa during the 1970s, cases have been reported on the continent every year. In Sub-Saharan Africa, cholera outbreaks primarily cluster at certain hotspots including the African Great Lakes Region and West Africa. METHODOLOGY/PRINCIPAL FINDINGS:In this study, we applied MLVA (Mul...

journal_title：PLoS neglected tropical diseases

authors： Moore S,Miwanda B,Sadji AY,Thefenne H,Jeddi F,Rebaudet S,de Boeck H,Bidjada B,Depina JJ,Bompangue D,Abedi AA,Koivogui L,Keita S,Garnotel E,Plisnier PD,Ruimy R,Thomson N,Muyembe JJ,Piarroux R

更新日期：2015-06-25 00:00:00

abstract：BACKGROUND:In 2007, a novel bunyavirus was found in Henan Province, China and named fever, thrombocytopenia and leukocytopenia syndrome virus (FTLSV); since then, FTLSV has been found in ticks and animals in many Chinese provinces. Human-to-human transmission has been documented, indicating that FTLSV should be conside...

journal_title：PLoS neglected tropical diseases

authors： Huang X,Liu L,Du Y,Wu W,Wang H,Su J,Tang X,Liu Q,Yang Y,Jiang Y,Chen W,Xu B

更新日期：2014-10-16 00:00:00

abstract：BACKGROUND:Praziquantel remains the drug of choice for the worldwide treatment and control of schistosomiasis. The drug is synthesized and administered as a racemate. Use of the pure active enantiomer would be desirable since the inactive enantiomer is associated with side effects and is responsible for the extremely b...

journal_title：PLoS neglected tropical diseases

authors： Woelfle M,Seerden JP,de Gooijer J,Pouwer K,Olliaro P,Todd MH

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Congenital toxoplasmosis is a serious but preventable and treatable disease. Gestational screening facilitates early detection and treatment of primary acquisition. Thus, fetal infection can be promptly diagnosed and treated and outcomes can be improved. METHODS:We tested 180 sera with the Toxoplasma ICT Ig...

journal_title：PLoS neglected tropical diseases

authors： Begeman IJ,Lykins J,Zhou Y,Lai BS,Levigne P,El Bissati K,Boyer K,Withers S,Clouser F,Noble AG,Rabiah P,Swisher CN,Heydemann PT,Contopoulos-Ioannidis DG,Montoya JG,Maldonado Y,Ramirez R,Press C,Stillwaggon E,Peyron F

更新日期：2017-06-26 00:00:00

abstract：:Greece was declared malaria-free in 1974 after a long antimalarial fight. In 2011-2012, an outbreak of P. vivax malaria was reported in Evrotas, an agricultural area in Southern Greece, where a large number of immigrants from endemic countries live and work. A total of 46 locally acquired and 38 imported malaria cases...

journal_title：PLoS neglected tropical diseases

authors： Tseroni M,Baka A,Kapizioni C,Snounou G,Tsiodras S,Charvalakou M,Georgitsou M,Panoutsakou M,Psinaki I,Tsoromokou M,Karakitsos G,Pervanidou D,Vakali A,Mouchtouri V,Georgakopoulou T,Mamuris Z,Papadopoulos N,Koliopoulos G,

更新日期：2015-11-19 00:00:00

abstract：BACKGROUND:The protozoan parasite Giardia intestinalis and the pathogenic bacterium Helicobacter pylori are well known for their high prevalences in human hosts worldwide. The prevalence of both organisms is known to peak in densely populated, low resource settings and children are infected early in life. Different Gia...

journal_title：PLoS neglected tropical diseases

authors： Ankarklev J,Hestvik E,Lebbad M,Lindh J,Kaddu-Mulindwa DH,Andersson JO,Tylleskär T,Tumwine JK,Svärd SG

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The largest outbreak of sporotrichosis occurred between 1938 and 1947 in the gold mines of Witwatersrand in South Africa. Here, we describe an outbreak of lymphocutaneous sporotrichosis that was investigated in a South African gold mine in 2011. METHODOLOGY:Employees working at a reopened section of the min...

journal_title：PLoS neglected tropical diseases

authors： Govender NP,Maphanga TG,Zulu TG,Patel J,Walaza S,Jacobs C,Ebonwu JI,Ntuli S,Naicker SD,Thomas J

更新日期：2015-09-25 00:00:00

abstract：:Most statistical and mechanistic models used to predict mosquito-borne disease transmission incorporate climate drivers of disease transmission by utilizing environmental data collected at geographic scales that are potentially coarser than what mosquito populations may actually experience. Temperature and relative hu...

journal_title：PLoS neglected tropical diseases

authors： Murdock CC,Evans MV,McClanahan TD,Miazgowicz KL,Tesla B

更新日期：2017-05-30 00:00:00

abstract：:In the current study, a comprehensive, data driven, mathematical model for cholera transmission in Haiti is presented. Along with the inclusion of short cycle human-to-human transmission and long cycle human-to-environment and environment-to-human transmission, this novel dynamic model incorporates both the reported c...

journal_title：PLoS neglected tropical diseases

authors： Kirpich A,Weppelmann TA,Yang Y,Ali A,Morris JG Jr,Longini IM

更新日期：2015-10-21 00:00:00

abstract：BACKGROUND:Dengue is the most prevalent arboviral disease of humans. Virus neutralizing antibodies are likely to be critical for clinical immunity after vaccination or natural infection. A number of human monoclonal antibodies (mAbs) have previously been characterized as able to neutralize the infectivity of dengue vir...

journal_title：PLoS neglected tropical diseases

authors： Tuan Vu T,Clapham H,Huynh VTT,Vo Thi L,Le Thi D,Vu NT,Nguyen GT,Huynh TTX,Duong KTH,Tran VT,Huynh HLA,Le Huynh DT,Huynh TLP,Nguyen TTV,Nguyen NM,Luong TTH,Phong NT,Nguyen CVV,Gough G,Wills B,Carrington LB,Simmon

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Wolbachia inherited intracellular bacteria can manipulate the reproduction of their insect hosts through cytoplasmic incompatibility (CI), and certain strains have also been shown to inhibit the replication or dissemination of viruses. Wolbachia strains also vary in their relative fitness effects on their ho...

journal_title：PLoS neglected tropical diseases

authors： Blagrove MS,Arias-Goeta C,Di Genua C,Failloux AB,Sinkins SP

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Standard diagnosis of human soil-transmitted helminth (STH) infections is based on the microscopic detection of helminth eggs in stool and supports programmatic decision making in control programs. However, the current standard diagnostic techniques still show a number of limitations. Recently, the FECPAKG2 ...

journal_title：PLoS neglected tropical diseases

authors： Ayana M,Vlaminck J,Cools P,Ame S,Albonico M,Dana D,Keiser J,Manly H,Matoso LF,Mekonnen Z,Montresor A,Correa-Oliveira R,Rinaldi L,Sayasone S,Sowersby SJ,Tesfaye L,Vercruysse J,Mirams G,Levecke B

更新日期：2018-10-15 00:00:00