Family relationship, water contact and occurrence of Buruli ulcer in Benin.

abstract：:Despite Nipah virus outbreaks having high mortality rates (>70% in Southeast Asia), there are no licensed drugs against it. In this study, we have considered all 9 Nipah proteins as potential therapeutic targets and computationally identified 4 putative peptide inhibitors (against G, F and M proteins) and 146 small mo...

journal_title：PLoS neglected tropical diseases

authors： Sen N,Kanitkar TR,Roy AA,Soni N,Amritkar K,Supekar S,Nair S,Singh G,Madhusudhan MS

更新日期：2019-12-12 00:00:00

abstract：:Erythema nodosum leprosum (ENL), or type 2 lepra reaction, is a multi-system immune-mediated complication in patients with multibacillary leprosy, frequently associated with chronicity and recurrences. Management of ENL requires high doses of oral corticosteroids, which may not be universally effective and pose seriou...

journal_title：PLoS neglected tropical diseases

authors： Upputuri B,Pallapati MS,Tarwater P,Srikantam A

更新日期：2020-10-09 00:00:00

abstract：:Visceral leishmaniasis is hypoendemic in Mediterranean countries, where it is caused by the flagellate protozoan Leishmania infantum. VL cases in this area account for 5%-6% of the global burden. Cases of Leishmania/HIV coinfection have been reported in the Mediterranean region, mainly in France, Italy, Portugal, and ...

journal_title：PLoS neglected tropical diseases

authors： Monge-Maillo B,Norman FF,Cruz I,Alvar J,López-Vélez R

更新日期：2014-08-21 00:00:00

abstract：BACKGROUND:Melioidosis, caused by the Gram-negative bacterium Burkholderia pseudomallei, is an emerging cause of pneumonia-derived sepsis in the tropics. The gut microbiota supports local mucosal immunity and is increasingly recognized as a protective mediator in host defenses against systemic infection. Here, we aimed...

journal_title：PLoS neglected tropical diseases

authors： Lankelma JM,Birnie E,Weehuizen TAF,Scicluna BP,Belzer C,Houtkooper RH,Roelofs JJTH,de Vos AF,van der Poll T,Budding AE,Wiersinga WJ

更新日期：2017-04-19 00:00:00

abstract：BACKGROUND:Schistosomiasis japonica is a zoonotic parasitic disease and oral vaccine delivery system would be benefit for prevention of this disease. Although attenuated salmonella has been used as an antigen expression vector for oral vaccine development, the membrane-bound vacuoles in which bacteria reside hinders th...

journal_title：PLoS neglected tropical diseases

authors： Chen G,Dai Y,Chen J,Wang X,Tang B,Zhu Y,Hua Z

更新日期：2011-09-01 00:00:00

abstract：:Hansen's disease (HD) belongs to the group of neglected diseases and can cause physical deformities and disabilities, in addition to leading to social discrimination. Ocular involvement in HD is estimated at 70-75% worldwide. About 10-50% suffer from severe ocular symptoms and loss of vision occurs in approximately 5%...

journal_title：PLoS neglected tropical diseases

authors： Pavezzi PD,do Prado RB,Boin Filho PÂ,Gon ADS,Tuma B,Fornazieri MA,Scalone FM,Alves LRM,Montero RH,Casella AMB

更新日期：2020-09-21 00:00:00

abstract：:Aedes aegypti is the major vector of yellow and dengue fevers. After 10 generations of adult selection, an A. aegypti strain (SP) developed 1650-fold resistance to permethrin, which is one of the most widely used pyrethroid insecticides for mosquito control. SP larvae also developed 8790-fold resistance following sele...

journal_title：PLoS neglected tropical diseases

authors： Kasai S,Komagata O,Itokawa K,Shono T,Ng LC,Kobayashi M,Tomita T

更新日期：2014-06-19 00:00:00

abstract：BACKGROUND:Since cholera appeared in Africa during the 1970s, cases have been reported on the continent every year. In Sub-Saharan Africa, cholera outbreaks primarily cluster at certain hotspots including the African Great Lakes Region and West Africa. METHODOLOGY/PRINCIPAL FINDINGS:In this study, we applied MLVA (Mul...

journal_title：PLoS neglected tropical diseases

authors： Moore S,Miwanda B,Sadji AY,Thefenne H,Jeddi F,Rebaudet S,de Boeck H,Bidjada B,Depina JJ,Bompangue D,Abedi AA,Koivogui L,Keita S,Garnotel E,Plisnier PD,Ruimy R,Thomson N,Muyembe JJ,Piarroux R

更新日期：2015-06-25 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) is characterized by parasite-specific immunosuppression besides an intense pro-inflammatory response. Lipopolisaccharide (LPS) has been implicated in the immune activation of T-cell deficient diseases such as HIV/AIDS and idiopathic lymphocytopenia. The source of LPS is gram-negat...

journal_title：PLoS neglected tropical diseases

authors： Santos-Oliveira JR,Regis EG,Leal CR,Cunha RV,Bozza PT,Da-Cruz AM

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:The initial response to Leishmania parasites is essential in determining disease development or resistance. In vitro, a divergent response to Leishmania, characterized by high or low IFN-γ production has been described as a potential tool to predict both vaccine response and disease susceptibility in vivo. ...

journal_title：PLoS neglected tropical diseases

authors： Carneiro MW,Fukutani KF,Andrade BB,Curvelo RP,Cristal JR,Carvalho AM,Barral A,Van Weyenbergh J,Barral-Netto M,de Oliveira CI

更新日期：2016-11-21 00:00:00

abstract：BACKGROUND:Trypanosoma cruzi is a protozoan pathogen responsible for Chagas disease. Current therapies are inadequate because of their severe host toxicity and numerous side effects. The identification of new biotargets is essential for the development of more efficient therapeutic alternatives. Inhibition of sirtuins ...

journal_title：PLoS neglected tropical diseases

authors： Ritagliati C,Alonso VL,Manarin R,Cribb P,Serra EC

更新日期：2015-04-15 00:00:00

abstract：:Intracerebral microhemorrhages (CMHs) are small foci of hemorrhages in the cerebrum. Acute infections induced by some intracellular pathogens, including rickettsia, can result in CMHs. Annexin a2 (ANXA2) has been documented to play a functional role during intracellular bacterial adhesion. Here we report that ANXA2-kn...

journal_title：PLoS neglected tropical diseases

authors： Su Z,Chang Q,Drelich A,Shelite T,Judy B,Liu Y,Xiao J,Zhou C,He X,Jin Y,Saito T,Tang S,Soong L,Wakamiya M,Fang X,Bukreyev A,Ksiazek T,Russell WK,Gong B

更新日期：2020-07-20 00:00:00

abstract：:Recent years have seen the greatest ecological disturbances of our times, with global human expansion, species and habitat loss, climate change, and the emergence of new and previously-known infectious diseases. Biodiversity loss affects infectious disease risk by disrupting normal relationships between hosts and path...

journal_title：PLoS neglected tropical diseases

authors： Thongsripong P,Green A,Kittayapong P,Kapan D,Wilcox B,Bennett S

更新日期：2013-10-31 00:00:00

abstract：BACKGROUND:The sensitivity and specificity of two in-house MAC-ELISA assays were tested and compared with the performance of commercially-available CTK lateral flow rapid test and EUROIMMUN IFA assays for the detection of anti-Chikungunya virus (CHIKV) IgM. Each MAC-ELISA assay used a whole virus-based antigen derived ...

journal_title：PLoS neglected tropical diseases

authors： Yap G,Pok KY,Lai YL,Hapuarachchi HC,Chow A,Leo YS,Tan LK,Ng LC

更新日期：2010-07-20 00:00:00

abstract：:Due to the large geographical overlap of populations exposed to Zika virus (ZIKV) and human immunodeficiency virus (HIV), understanding the disease pathogenesis of co-infection is urgently needed. This warrants the development of an animal model for HIV-ZIKV co-infection. In this study, we used adult non-pregnant maca...

journal_title：PLoS neglected tropical diseases

authors： Bidokhti MRM,Dutta D,Madduri LSV,Woollard SM,Norgren R Jr,Giavedoni L,Byrareddy SN

更新日期：2018-10-25 00:00:00

abstract：BACKGROUND:Epidemiological studies carried out using culture or microscopy in most of the amoebiasis endemic developing countries, yielded confusing results since none of these could differentiate the pathogenic Entamoeba histolytica from the non-pathogenic Entamoeba dispar and Entamoeba moshkovskii. The Northeastern p...

journal_title：PLoS neglected tropical diseases

authors： Nath J,Ghosh SK,Singha B,Paul J

更新日期：2015-12-03 00:00:00

abstract：:The increasing burden of dengue, and the relative failure of traditional vector control programs highlight the need to develop new control methods. SIT using self-limiting genetic technology is one such promising method. A self-limiting strain of Aedes aegypti, OX513A, has already reached the stage of field evaluation...

journal_title：PLoS neglected tropical diseases

authors： Carvalho DO,McKemey AR,Garziera L,Lacroix R,Donnelly CA,Alphey L,Malavasi A,Capurro ML

更新日期：2015-07-02 00:00:00

abstract：BACKGROUND:On the Zanzibar islands, United Republic of Tanzania, elimination of urogenital schistosomiasis is strived for in the coming years. This qualitative study aimed to better understand community knowledge, perceptions, and practices associated with schistosomiasis among school-aged children on Unguja and Pemba ...

journal_title：PLoS neglected tropical diseases

authors： Person B,Ali SM,A'Kadir FM,Ali JN,Mohammed UA,Mohammed KA,Rollinson D,Knopp S

更新日期：2016-07-11 00:00:00

abstract：BACKGROUND:With few studies conducted to date, very little is known about the epidemiology of rickettsioses in Bhutan. Due to two previous outbreaks and increasing clinical cases, scrub typhus is better recognized than other rickettsial infections and Q fever. METHODOLOGY:A descriptive cross-sectional serosurvey was c...

journal_title：PLoS neglected tropical diseases

authors： Tshokey T,Stenos J,Durrheim DN,Eastwood K,Nguyen C,Graves SR

更新日期：2017-11-27 00:00:00

abstract：BACKGROUND:The relationships between heterogeneities in host infection and infectiousness (transmission to arthropod vectors) can provide important insights for disease management. Here, we quantify heterogeneities in Leishmania infantum parasite numbers in reservoir and non-reservoir host populations, and relate this ...

journal_title：PLoS neglected tropical diseases

authors： Courtenay O,Carson C,Calvo-Bado L,Garcez LM,Quinnell RJ

更新日期：2014-01-09 00:00:00

abstract：:Nipah virus (NiV) is a paramyxovirus (genus Henipavirus) that emerged in the late 1990s in Malaysia and has since been identified as the cause of sporadic outbreaks of severe febrile disease in Bangladesh and India. NiV infection is frequently associated with severe respiratory or neurological disease in infected huma...

journal_title：PLoS neglected tropical diseases

authors： Cong Y,Lentz MR,Lara A,Alexander I,Bartos C,Bohannon JK,Hammoud D,Huzella L,Jahrling PB,Janosko K,Jett C,Kollins E,Lackemeyer M,Mollura D,Ragland D,Rojas O,Solomon J,Xu Z,Munster V,Holbrook MR

更新日期：2017-04-07 00:00:00

abstract：INTRODUCTION:Plasmodium knowlesi is now recognised as a leading cause of malaria in Malaysia. As humans come into increasing contact with the reservoir host (long-tailed macaques) as a consequence of deforestation, assessing the potential for a shift from zoonotic to sustained P. knowlesi transmission between humans is...

journal_title：PLoS neglected tropical diseases

authors： Imai N,White MT,Ghani AC,Drakeley CJ

更新日期：2014-07-24 00:00:00

abstract：BACKGROUND:Paragonimiasis is a food-borne trematodiasis leading to lung disease. Worldwide, an estimated 21 million people are infected. Foci of ongoing transmission remain often unnoticed. We evaluated a simple questionnaire approach using lay-informants at the village level to identify paragonimiasis foci and suspect...

journal_title：PLoS neglected tropical diseases

authors： Odermatt P,Veasna D,Zhang W,Vannavong N,Phrommala S,Habe S,Barennes H,Strobel M

更新日期：2009-09-22 00:00:00

abstract：BACKGROUND:Enteric fever, a systemic infection caused by the bacteria Salmonella Typhi and Salmonella Paratyphi A, is endemic in Kathmandu, Nepal. Previous work identified proximity to poor quality water sources as a community-level risk for infection. Here, we sought to examine individual-level risk factors related to...

journal_title：PLoS neglected tropical diseases

authors： Karkey A,Thompson CN,Tran Vu Thieu N,Dongol S,Le Thi Phuong T,Voong Vinh P,Arjyal A,Martin LB,Rondini S,Farrar JJ,Dolecek C,Basnyat B,Baker S

更新日期：2013-08-22 00:00:00

abstract：:Chikungunya virus (CHIKV) infection is characterized by rash, acute high fever, chills, headache, nausea, photophobia, vomiting, and severe polyarthralgia. There is evidence that arthralgia can persist for years and result in long-term discomfort. Neurologic disease with fatal outcome has been documented, although at ...

journal_title：PLoS neglected tropical diseases

authors： van den Doel P,Volz A,Roose JM,Sewbalaksing VD,Pijlman GP,van Middelkoop I,Duiverman V,van de Wetering E,Sutter G,Osterhaus AD,Martina BE

更新日期：2014-09-04 00:00:00

abstract：BACKGROUND:The World Health Organization now recommends semiannual mass drug administration (MDA) of albendazole with integrated vector management as an option for eliminating lymphatic filariasis (LF) in areas of loiasis-endemic countries where it may not be safe to use diethylcarbamazine or ivermectin in MDA programs...

journal_title：PLoS neglected tropical diseases

authors： Pion SDS,Chesnais CB,Awaca-Uvon NP,Vlaminck J,Abdou A,Kunyu-Shako B,Kuyangisa Simuna G,Tambwe JP,Weil GJ,Boussinesq M

更新日期：2020-06-23 00:00:00

abstract：BACKGROUND:Cure after treatment for human African trypanosomiasis (HAT) is assessed by examination of the cerebrospinal fluid every 6 months, for a total period of 2 years. So far, no markers for cure or treatment failure have been identified in blood. Trypanosome-specific antibodies are detectable in blood by the Card...

journal_title：PLoS neglected tropical diseases

authors： Lejon V,Ngoyi DM,Boelaert M,Büscher P

更新日期：2010-01-26 00:00:00

abstract：BACKGROUND:In the Old World, sandfly species of the genus Phlebotomus are known vectors of Leishmania, Bartonella and several viruses. Recent sandfly catches and autochthonous cases of leishmaniasis hint on spreading tendencies of the vectors towards Central Europe. However, studies addressing potential future distribu...

journal_title：PLoS neglected tropical diseases

authors： Fischer D,Moeller P,Thomas SM,Naucke TJ,Beierkuhnlein C

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Leishmania uses the amino acid L-arginine as a substrate for arginase, enzyme that produces urea and ornithine, last precursor of polyamine pathway. This pathway is used by the parasite to replicate and it is essential to establish the infection in the mammalian host. L-arginine is not synthesized by the par...

journal_title：PLoS neglected tropical diseases

authors： Aoki JI,Muxel SM,Zampieri RA,Acuña SM,Fernandes JCR,Vanderlinde RH,Sales MCOP,Floeter-Winter LM

更新日期：2017-10-26 00:00:00

abstract：BACKGROUND:Despite the reported success in reducing morbidity, praziquantel alone is insufficient for the control and elimination of schistosomiasis, partly due to its poor efficacy against the juvenile worms. Artemisinin derivatives are effective against juvenile worms but are less effective against adult worms. We co...

journal_title：PLoS neglected tropical diseases

authors： Mnkugwe RH,Minzi O,Kinung'hi S,Kamuhabwa A,Aklillu E

更新日期：2020-09-23 00:00:00