Chaetomium atrobrunneum causing human eumycetoma: The first report.

abstract：BACKGROUND:Although increased capillary permeability is the major clinical feature associated with severe dengue infections the mechanisms underlying this phenomenon remain unclear. Dextran clearance methodology has been used to investigate the molecular sieving properties of the microvasculature in clinical situations...

journal_title：PLoS neglected tropical diseases

authors： Nguyen-Pouplin J,Pouplin T,Van TP,The TD,Thi DN,Farrar J,Tinh HT,Wills B

更新日期：2011-08-01 00:00:00

abstract：:Infection with filarial parasites is associated with T cell hyporesponsiveness, which is thought to be partly mediated by their ability to induce regulatory T cells (Tregs) during human infections. This study investigates the functional capacity of Tregs from different groups of filarial patients to suppress filaria-s...

journal_title：PLoS neglected tropical diseases

authors： Wammes LJ,Hamid F,Wiria AE,Wibowo H,Sartono E,Maizels RM,Smits HH,Supali T,Yazdanbakhsh M

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:There is conflicting evidence on the immunologic benefit of treating helminth co-infections ("deworming") in HIV-infected individuals. Several studies have documented reduced viral load and increased CD4 count in antiretroviral therapy (ART) naïve individuals after deworming. However, there are a lack of dat...

journal_title：PLoS neglected tropical diseases

authors： Lankowski AJ,Tsai AC,Kanyesigye M,Bwana M,Haberer JE,Wenger M,Martin JN,Bangsberg DR,Hunt PW,Siedner MJ

更新日期：2014-08-07 00:00:00

abstract：:Yellow fever virus (YFV) is a mosquito-borne flavivirus that is a major public health problem in tropical areas of Africa and South America. There have been detailed studies on YFV ecology in West Africa and South America, but current understanding of YFV circulation on the African continent is incomplete. This inadeq...

journal_title：PLoS neglected tropical diseases

authors： Beck A,Guzman H,Li L,Ellis B,Tesh RB,Barrett AD

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Antibody-detecting rapid diagnostic tests (RDTs) against rK39 are available to aid in the diagnosis of visceral leishmaniasis (VL). Although these rK39 RDTs have been developed, validated and approved for use with serum, they are universally performed using whole blood. It was therefore necessary to determin...

journal_title：PLoS neglected tropical diseases

authors： Matlashewski G,Das VN,Pandey K,Singh D,Das S,Ghosh AK,Pandey RN,Das P

更新日期：2013-05-23 00:00:00

abstract：BACKGROUND:Leishmaniases are parasitic diseases present worldwide that are transmitted to the vertebrate host by the bite of an infected sand fly during a blood feeding. Phlebotomine sand flies inoculate into the mammalian host Leishmania parasites embedded in promastigote secretory gel (PSG) with saliva, which is comp...

journal_title：PLoS neglected tropical diseases

authors： Lestinova T,Rohousova I,Sima M,de Oliveira CI,Volf P

更新日期：2017-07-13 00:00:00

abstract：:Adenosine-5'-triphosphate (ATP) is an important phosphate metabolite abundantly found in Mycobacterium leprae bacilli. This pathogen does not derive ATP from its host but has its own mechanism for the generation of ATP. Interestingly, this molecule as well as several antigenic proteins act as bio-markers for the detec...

journal_title：PLoS neglected tropical diseases

authors： Nandi SK,Chakraborty A,Panda AK,Ray SS,Kar RK,Bhunia A,Biswas A

更新日期：2015-03-26 00:00:00

abstract：BACKGROUND:Loiasis, a filarial infection caused by Loa loa usually thought to cause relatively minor morbidity, can cause serious and often fatal reactions in patients carrying very high levels of circulating Loa loa microfilariae (mf) following administration of microfilaricidal drugs. An experimental model of this co...

journal_title：PLoS neglected tropical diseases

authors： Wanji S,Eyong EE,Tendongfor N,Ngwa C,Esuka E,Kengne-Ouafo A,Datchoua-Poutcheu F,Enyong P,Hopkins A,Mackenzie CD

更新日期：2015-11-10 00:00:00

abstract：BACKGROUND:In the past decade, research on neglected tropical diseases (NTDs) has intensified in response to the need to enhance community participation in health delivery, establish monitoring and surveillance systems, and integrate existing disease-specific treatment programs to control overlapping NTD burdens and de...

journal_title：PLoS neglected tropical diseases

authors： Armah FA,Quansah R,Luginaah I,Chuenpagdee R,Hambati H,Campbell G

更新日期：2015-08-04 00:00:00

abstract：:Vector control is still our primary intervention for both prevention and mitigation of epidemics of many vector-borne diseases. Efficiently targeting control measures is important since control can involve substantial economic costs. Targeting is not always straightforward, as transmission of vector-borne diseases is ...

journal_title：PLoS neglected tropical diseases

authors： Stone CM,Schwab SR,Fonseca DM,Fefferman NH

更新日期：2019-07-03 00:00:00

abstract：BACKGROUND:Leprosy, caused by Mycobacterium leprae, affects over 200,000 people annually worldwide and remains endemic in the ethnically diverse, mountainous and underdeveloped southwestern provinces of China. Delayed diagnosis of leprosy persists in China, thus, additional knowledge to support early diagnosis, especia...

journal_title：PLoS neglected tropical diseases

authors： Chen X,You YG,Yuan YH,Yuan LC,Wen Y

更新日期：2019-04-24 00:00:00

abstract：BACKGROUND:Emerging information technologies present new opportunities to reduce the burden of malaria, dengue and other infectious diseases. For example, use of a data management system software package can help disease control programs to better manage and analyze their data, and thus enhances their ability to carry ...

journal_title：PLoS neglected tropical diseases

authors： Eisen L,Coleman M,Lozano-Fuentes S,McEachen N,Orlans M,Coleman M

更新日期：2011-03-29 00:00:00

abstract：BACKGROUND:Traditional faecal-based methods have poor sensitivity for the detection of S. stercoralis, therefore are inadequate for post-treatment evaluation of infected patients who should be carefully monitored to exclude the persistence of the infection. In a previous study, we demonstrated high accuracy of five ser...

journal_title：PLoS neglected tropical diseases

authors： Buonfrate D,Sequi M,Mejia R,Cimino RO,Krolewiecki AJ,Albonico M,Degani M,Tais S,Angheben A,Requena-Mendez A,Muñoz J,Nutman TB,Bisoffi Z

更新日期：2015-02-10 00:00:00

abstract：BACKGROUND:Chagas disease is caused by the parasite Trypanosoma cruzi and is transmitted through triatomines (Hemiptera: Reduviidae). In the last year, many studies of triatomine gut microbiota have outlined its potential role in modulating vector competence. However, little is known about the microbiota present in the...

journal_title：PLoS neglected tropical diseases

authors： Lima MS,Laport MS,Lorosa ES,Jurberg J,Dos Santos KRN,da Silva Neto MAC,Rachid CTCDC,Atella GC

更新日期：2018-09-13 00:00:00

abstract：BACKGROUND:Trachoma is a major cause of blindness in Southern Sudan. Its distribution has only been partially established and many communities in need of intervention have therefore not been identified or targeted. The present study aimed to develop a tool to improve targeting of survey and control activities. METHODS...

journal_title：PLoS neglected tropical diseases

authors： Clements AC,Kur LW,Gatpan G,Ngondi JM,Emerson PM,Lado M,Sabasio A,Kolaczinski JH

更新日期：2010-08-17 00:00:00

abstract：:Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that can cause fever and chronic arthritis in humans. CHIKV that is generated in mosquito or mammalian cells differs in glycosylation patterns of viral proteins, which may affect its replication and virulence. Herein, we compare replication, pathogenicity,...

journal_title：PLoS neglected tropical diseases

authors： Acharya D,Paul AM,Anderson JF,Huang F,Bai F

更新日期：2015-10-20 00:00:00

abstract：BACKGROUND:Cutaneous leishmaniasis (CL) is a major public health concern in Turkey and Sanliurfa represents the most endemic city in Turkey. Although children are most commonly affected by CL, detailed studies of pediatric CL in Turkey are lacking. METHODOLOGY/PRINCIPAL FINDINGS:In this report we retrospectively evalu...

journal_title：PLoS neglected tropical diseases

authors： Aksoy M,Doni N,Ozkul HU,Yesilova Y,Ardic N,Yesilova A,Ahn-Jarvis J,Oghumu S,Terrazas C,Satoskar AR

更新日期：2016-07-14 00:00:00

abstract：BACKGROUND:The Norway rat (Rattus norvegicus) is the principal reservoir for leptospirosis in many urban settings. Few studies have identified markers for rat infestation in slum environments while none have evaluated the association between household rat infestation and Leptospira infection in humans or the use of inf...

journal_title：PLoS neglected tropical diseases

authors： Costa F,Ribeiro GS,Felzemburgh RD,Santos N,Reis RB,Santos AC,Fraga DB,Araujo WN,Santana C,Childs JE,Reis MG,Ko AI

更新日期：2014-12-04 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0007025.]. ...

journal_title：PLoS neglected tropical diseases

authors： Hotez PJ,Harrison W,Fenwick A,Bustinduy AL,Ducker C,Mbabazi PS,Engels D,Kjetland EF

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Dengue is the most prevalent arthropod-borne viral illness in humans with half of the world's population at risk. During early infancy, severe dengue can develop after a primary dengue virus infection. There has been a clinical observation that severe dengue during the first year of life is seen only in chub...

journal_title：PLoS neglected tropical diseases

authors： Libraty DH,Wang P,Guo Z,Bigcas V,Brion JD,Capeding RZ

更新日期：2015-12-04 00:00:00

abstract：BACKGROUND:Cutaneous dirofilariosis is a canine mosquito-borne zoonosis that can cause larva migrans disease in humans. Dirofilaria repens is considered an emerging pathogen occurring with high prevalence in Mediterranean areas and many parts of tropical Asia. In Hong Kong, a second species, Candidatus Dirofilaria hong...

journal_title：PLoS neglected tropical diseases

authors： Yilmaz E,Fritzenwanker M,Pantchev N,Lendner M,Wongkamchai S,Otranto D,Kroidl I,Dennebaum M,Le TH,Anh Le T,Ramünke S,Schaper R,von Samson-Himmelstjerna G,Poppert S,Krücken J

更新日期：2016-10-11 00:00:00

abstract：BACKGROUND:Vector-borne transmission of Trypanosoma cruzi is seen exclusively in the Americas where an estimated 8 million people are infected with the parasite. Significant research in southern Peru has been conducted to understand T. cruzi infection and vector control, however, much less is known about the burden of ...

journal_title：PLoS neglected tropical diseases

authors： Alroy KA,Huang C,Gilman RH,Quispe-Machaca VR,Marks MA,Ancca-Juarez J,Hillyard M,Verastegui M,Sanchez G,Cabrera L,Vidal E,Billig EM,Cama VA,Náquira C,Bern C,Levy MZ,Working Group on Chagas Disease in Peru.

更新日期：2015-05-22 00:00:00

abstract：BACKGROUND:Mosquito-borne viral diseases cause significant burden in much of the developing world. Although host-virus interactions have been studied extensively in the vertebrate host, little is known about mosquito responses to viral infection. In contrast to mosquitoes of the Aedes and Culex genera, Anopheles gambia...

journal_title：PLoS neglected tropical diseases

authors： Waldock J,Olson KE,Christophides GK

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Leptospirosis is a neglected zoonosis affecting animals and humans caused by infection with Leptospira. The bacteria can survive outside of hosts for long periods of time in soil and water. While identification of Leptospira species from human cases and animal reservoirs are increasingly reported, little is ...

journal_title：PLoS neglected tropical diseases

authors： Mason MR,Encina C,Sreevatsan S,Muñoz-Zanzi C

更新日期：2016-08-16 00:00:00

abstract：INTRODUCTION:While we lack a complete understanding of the molecular mechanisms by which parasites establish and achieve protection from host immune responses, it is accepted that many of these processes are mediated by products, primarily proteins, released from the parasite. Parasitic nematodes occur in different lif...

journal_title：PLoS neglected tropical diseases

authors： Moreno Y,Geary TG

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Plasmodium spp. and helminths are co-endemic in many parts of the tropics; hence, co-infection is a common phenomenon. Interactions between Plasmodium and helminth infections may alter the host's immune response and susceptibility and thus impact on morbidity. There is little information on the direction a...

journal_title：PLoS neglected tropical diseases

authors： Hürlimann E,Houngbedji CA,Yapi RB,N'Dri PB,Silué KD,Ouattara M,Utzinger J,N'Goran EK,Raso G

更新日期：2019-01-10 00:00:00

abstract：BACKGROUND:Although antibody responses to dengue virus (DENV) in naturally infected individuals have been extensively studied, the functionality of DENV specific memory T cell responses in relation to clinical disease severity is incompletely understood. METHODOLOGY/PRINCIPAL FINDINGS:Using ex vivo IFNγ ELISpot assays...

journal_title：PLoS neglected tropical diseases

authors： Jeewandara C,Adikari TN,Gomes L,Fernando S,Fernando RH,Perera MK,Ariyaratne D,Kamaladasa A,Salimi M,Prathapan S,Ogg GS,Malavige GN

更新日期：2015-04-13 00:00:00

abstract：:The vast burden of cryptococcal meningitis occurs in immunosuppressed patients, driven by HIV, and is caused by Cryptococcus neoformans var. grubii. We previously reported cryptococcal meningitis in Vietnam arising atypically in HIV uninfected, apparently immunocompetent patients, caused by a single amplified fragment...

journal_title：PLoS neglected tropical diseases

authors： Day JN,Qihui S,Thanh LT,Trieu PH,Van AD,Thu NH,Chau TTH,Lan NPH,Chau NVV,Ashton PM,Thwaites GE,Boni MF,Wolbers M,Nagarajan N,Tan PBO,Baker S

更新日期：2017-06-14 00:00:00

abstract：BACKGROUND:Care to patients with Chagas disease (CD) is still a challenge for health systems in endemic and non-endemic countries. In the Brazilian public health system, the expansion of Primary Health Care (PHC) services to remote and disadvantaged areas has facilitated the access of patients with CD to medical care, ...

journal_title：PLoS neglected tropical diseases

authors： Damasceno RF,Sabino EC,Ferreira AM,Ribeiro ALP,Moreira HF,Prates TEC,Sampaio CA,Haikal DSA

更新日期：2020-11-09 00:00:00

abstract：:Over the last years, there has been a remarkable increase in the number of unresponsive patients with anthroponotic cutaneous leishmaniasis (ACL) reported worldwide. The primary objective of this study was to explore the role of demographic, clinical and environmental risk related-factors in the development of treatme...

journal_title：PLoS neglected tropical diseases

authors： Bamorovat M,Sharifi I,Dabiri S,Shamsi Meymandi S,Karamoozian A,Amiri R,Heshmatkhah A,Borhani Zarandi M,Aflatoonian MR,Sharifi F,Kheirandish R,Hassanzadeh S

更新日期：2021-01-28 00:00:00