Impact of a Reference Center on Leprosy Control under a Decentralized Public Health Care Policy in Brazil.

abstract：:Chagas disease is caused by the parasitic protozoan Trypanosoma cruzi. It has high mortality as well as morbidity rates and usually affects the poorer sections of the population. The development of new, less harmful and more effective drugs is a promising research target, since current standard treatments are highly t...

journal_title：PLoS neglected tropical diseases

authors： Rea A,Tempone AG,Pinto EG,Mesquita JT,Rodrigues E,Silva LG,Sartorelli P,Lago JH

更新日期：2013-12-05 00:00:00

abstract：BACKGROUND:Diagnosis of human African trypanosomiasis (HAT) remains a challenge both for active screening, which is critical in control of the disease, and in the point-of-care scenario where early and accurate diagnosis is essential. Recently, the first field deployment of a lateral flow rapid diagnostic test (RDT) fo...

journal_title：PLoS neglected tropical diseases

authors： Sternberg JM,Gierliński M,Biéler S,Ferguson MA,Ndung'u JM

更新日期：2014-12-18 00:00:00

abstract：:Zika virus (ZIKV) has emerged since 2013 as a significant global human health threat following outbreaks in the Pacific Islands and rapid spread throughout South and Central America. Severe congenital and neurological sequelae have been linked to ZIKV infections. Assessing the ability of common mosquito species to tra...

journal_title：PLoS neglected tropical diseases

authors： Main BJ,Nicholson J,Winokur OC,Steiner C,Riemersma KK,Stuart J,Takeshita R,Krasnec M,Barker CM,Coffey LL

更新日期：2018-06-21 00:00:00

abstract：BACKGROUND:The two front-line drugs for chronic Trypanosoma cruzi infections are limited by adverse side-effects and declining efficacy. One potential new target for Chagas' disease chemotherapy is sterol 14alpha-demethylase (CYP51), a cytochrome P450 enzyme involved in biosynthesis of membrane sterols. METHODOLOGY/PR...

journal_title：PLoS neglected tropical diseases

authors： Chen CK,Doyle PS,Yermalitskaya LV,Mackey ZB,Ang KK,McKerrow JH,Podust LM

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Aedes aegypti, the yellow fever mosquito, is an efficient vector of arboviruses and a convenient model system for laboratory research. Extensive linkage mapping of morphological and molecular markers localized a number of quantitative trait loci (QTLs) related to the mosquito's ability to transmit various pa...

journal_title：PLoS neglected tropical diseases

authors： Timoshevskiy VA,Severson DW,Debruyn BS,Black WC,Sharakhov IV,Sharakhova MV

更新日期：2013-01-01 00:00:00

abstract：:Crimean-Congo Hemorrhagic Fever Virus (CCHFV) and Hazara virus (HAZV) belong to the same viral serotype and family. HAZV has lately been used as a model system and surrogate to CCHFV. However, virus-host cell interaction and level of pathogenicity for these viruses are not well investigated nor compared. In this study...

journal_title：PLoS neglected tropical diseases

authors： Monteil V,Salata C,Appelberg S,Mirazimi A

更新日期：2020-11-24 00:00:00

abstract：BACKGROUND:Global deworming programs aim to reach 75% of at-risk preschool-age children (pre-SAC) by 2020. The 2013 global pre-SAC deworming coverage initially published by the World Health Organization (WHO) was 23.9%, but this estimate inadequately captured deworming delivered through Child Health Day (CHD) platforms...

journal_title：PLoS neglected tropical diseases

authors： Kumapley RS,Kupka R,Dalmiya N

更新日期：2015-11-06 00:00:00

abstract：:Mycetoma is considered a neglected tropical disease globally. However, data on its burden and the associated complications in Uganda are limited. Hence we aimed to estimate its burden in Uganda. Firstly, a systematic PubMed search for all studies of any design on mycetoma in Uganda without restriction to the year of p...

journal_title：PLoS neglected tropical diseases

authors： Kwizera R,Bongomin F,Meya DB,Denning DW,Fahal AH,Lukande R

更新日期：2020-04-29 00:00:00

abstract：:Visceral leishmaniasis (VL) is caused by parasitic protozoa of the genus Leishmania and is characterized by clinical manifestations such as fever, hepatosplenomegaly and anemia. Hemophagocytosis, the phenomenon of phagocytosis of blood cells by macrophages, is found in VL patients. In a previous study we established a...

journal_title：PLoS neglected tropical diseases

authors： Morimoto A,Uchida K,Chambers JK,Sato K,Hong J,Sanjoba C,Matsumoto Y,Yamagishi J,Goto Y

更新日期：2019-11-18 00:00:00

abstract：BACKGROUND:Treatment needs for Schistosoma haematobium are commonly evaluated using urine filtration with detection of parasite eggs under a microscope. A common symptom of S. haematobium is hematuria, the passing of blood in urine. Hence, the use of hematuria-based diagnostic techniques as a proxy for the assessment o...

journal_title：PLoS neglected tropical diseases

authors： Midzi N,Bärenbold O,Manangazira P,Phiri I,Mutsaka-Makuvaza MJ,Mhlanga G,Utzinger J,Vounatsou P

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:A family of hydrophilic acylated surface (HASP) proteins, containing extensive and variant amino acid repeats, is expressed at the plasma membrane in infective extracellular (metacyclic) and intracellular (amastigote) stages of Old World Leishmania species. While HASPs are antigenic in the host and can induc...

journal_title：PLoS neglected tropical diseases

authors： Depledge DP,MacLean LM,Hodgkinson MR,Smith BA,Jackson AP,Ma S,Uliana SR,Smith DF

更新日期：2010-09-28 00:00:00

abstract：BACKGROUND:Previous studies investigating the role of cytokines in the pathogenesis of leprosy have either been on only small numbers of patients or have not combined clinical and histological data. The INFIR Cohort study is a prospective study of 303 new multibacillary leprosy patients to identify risk factors for rea...

journal_title：PLoS neglected tropical diseases

authors： Lockwood DN,Suneetha L,Sagili KD,Chaduvula MV,Mohammed I,van Brakel W,Smith WC,Nicholls P,Suneetha S

更新日期：2011-12-01 00:00:00

abstract：:Mycobacterium ulcerans, the causative agent of Buruli ulcer (BU) disease, is unique amongst human pathogens in its capacity to produce a lipid toxin called mycolactone. While previous studies have demonstrated that bacterially-released mycolactone diffuses beyond infection foci, the spatiotemporal distribution of myco...

journal_title：PLoS neglected tropical diseases

authors： Colucci-Guyon E,Rifflet A,Saint-Auret S,da Costa A,Boucontet L,Laval T,Prehaud C,Blanchard N,Levraud JP,Boneca IG,Demangel C,Guenin-Macé L

更新日期：2020-12-02 00:00:00

abstract：:The Global Programme to Eliminate Lymphatic Filariasis has made significant progress toward interrupting transmission of lymphatic filariasis (LF) through mass drug administration (MDA). Operational challenges in defining endpoints of elimination programs include the need to determine appropriate post-MDA surveillance...

journal_title：PLoS neglected tropical diseases

authors： Lau CL,Won KY,Lammie PJ,Graves PM

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Paragonimiasis is a food-borne trematodiasis leading to lung disease. Worldwide, an estimated 21 million people are infected. Foci of ongoing transmission remain often unnoticed. We evaluated a simple questionnaire approach using lay-informants at the village level to identify paragonimiasis foci and suspect...

journal_title：PLoS neglected tropical diseases

authors： Odermatt P,Veasna D,Zhang W,Vannavong N,Phrommala S,Habe S,Barennes H,Strobel M

更新日期：2009-09-22 00:00:00

abstract：:The toxicity of available drugs for treatment of leishmaniasis, coupled with emerging drug resistance, make it urgent to find new therapies. Antimicrobial peptides (AMPs) have a strong broad-spectrum antimicrobial activity with distinctive modes of action and are considered as promising therapeutic agents. The defensi...

journal_title：PLoS neglected tropical diseases

authors： Dabirian S,Taslimi Y,Zahedifard F,Gholami E,Doustdari F,Motamedirad M,Khatami S,Azadmanesh K,Nylen S,Rafati S

更新日期：2013-10-17 00:00:00

abstract：BACKGROUND:The IAEA colony is the only one available for mass rearing of Glossina pallidipes, a vector of human and animal African trypanosomiasis in eastern Africa. This colony is the source for Sterile Insect Technique (SIT) programs in East Africa. The source population of this colony is unclear and its genetic dive...

journal_title：PLoS neglected tropical diseases

authors： Ciosi M,Masiga DK,Turner CM

更新日期：2014-02-13 00:00:00

abstract：BACKGROUND:Rift Valley fever virus (RVFV) causes outbreaks of severe disease in livestock and humans throughout Africa and the Arabian Peninsula. In people, RVFV generally causes a self-limiting febrile illness but in a subset of individuals, it progresses to more serious disease. One manifestation is a delayed-onset e...

journal_title：PLoS neglected tropical diseases

authors： Dodd KA,McElroy AK,Jones TL,Zaki SR,Nichol ST,Spiropoulou CF

更新日期：2014-06-12 00:00:00

abstract：:Leishmaniasis is a neglected disease produced by the intracellular protozoan parasite Leishmania. In the present study, we show that LABCG2, a new ATP-binding cassette half-transporter (ABCG subfamily) from Leishmania, is involved in parasite virulence. Down-regulation of LABCG2 function upon expression of an inactive...

journal_title：PLoS neglected tropical diseases

authors： Campos-Salinas J,León-Guerrero D,González-Rey E,Delgado M,Castanys S,Pérez-Victoria JM,Gamarro F

更新日期：2013-04-25 00:00:00

abstract：:Drug combinations for the treatment of leishmaniasis represent a promising and challenging chemotherapeutic strategy that has recently been implemented in different endemic areas. However, the vast majority of studies undertaken to date have ignored the potential risk that Leishmania parasites could develop resistance...

journal_title：PLoS neglected tropical diseases

authors： García-Hernández R,Manzano JI,Castanys S,Gamarro F

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Primary infection of Toxoplasma gondii during pregnancy can be transmitted to the unborn child and may have serious consequences, including retinochoroiditis, hydrocephaly, cerebral calcifications, encephalitis, splenomegaly, hearing loss, blindness, and death. Austria, a country with moderate seroprevalence...

journal_title：PLoS neglected tropical diseases

authors： Prusa AR,Kasper DC,Sawers L,Walter E,Hayde M,Stillwaggon E

更新日期：2017-07-10 00:00:00

abstract：BACKGROUND:In 2010 and 2011, Haiti was heavily affected by a large cholera outbreak that spread throughout the country. Although national health structure-based cholera surveillance was rapidly initiated, a substantial number of community cases might have been missed, particularly in remote areas. We conducted a commun...

journal_title：PLoS neglected tropical diseases

authors： Page AL,Ciglenecki I,Jasmin ER,Desvignes L,Grandesso F,Polonsky J,Nicholas S,Alberti KP,Porten K,Luquero FJ

更新日期：2015-03-26 00:00:00

abstract：BACKGROUND:Amebic colitis, caused by intestinal infection with the parasite, Entamoeba histolytica, is a common cause of diarrhea worldwide. Fulminant amebic colitis is the most devastating complication of this infection, associated with both high mortality and morbidity. We conducted a review of the English literature...

journal_title：PLoS neglected tropical diseases

authors： Shirley DA,Moonah S

更新日期：2016-07-28 00:00:00

abstract：BACKGROUND:Trypanosoma cruzi, the etiologic agent of Chagas Disease, is a major vector borne health problem in Latin America and an emerging infectious disease in the United States. METHODS:We tested the efficacy of a multi-component DNA-prime/DNA-boost vaccine (TcVac1) against experimental T. cruzi infection in a can...

journal_title：PLoS neglected tropical diseases

authors： Aparicio-Burgos JE,Ochoa-García L,Zepeda-Escobar JA,Gupta S,Dhiman M,Martínez JS,de Oca-Jiménez RM,Val Arreola M,Barbabosa-Pliego A,Vázquez-Chagoyán JC,Garg NJ

更新日期：2011-01-01 00:00:00

abstract：:Burkholderia pseudomallei, the bacterial agent of melioidosis, causes disease through inhalation of infectious particles, and is classified as a Tier 1 Select Agent. Optical diagnostic imaging has demonstrated that murine respiratory disease models are subject to significant upper respiratory tract (URT) colonization....

journal_title：PLoS neglected tropical diseases

authors： Gutierrez MG,Pfeffer TL,Warawa JM

更新日期：2015-01-08 00:00:00

abstract：:Pathogens originating from wildlife (zoonoses) pose a significant public health burden, comprising the majority of emerging infectious diseases. Efforts to control and prevent zoonotic disease have traditionally focused on animal-to-human transmission, or "spillover." However, in the modern era, increasing internation...

journal_title：PLoS neglected tropical diseases

authors： Guth S,Hanley KA,Althouse BM,Boots M

更新日期：2020-08-13 00:00:00

abstract：:The spread of Aedes aegypti in California and other regions of the U.S. has increased the need to understand the potential for local chains of Ae. aegypti-borne virus transmission, particularly in arid regions where the ecology of these mosquitoes is less understood. For public health and vector control programs, it i...

journal_title：PLoS neglected tropical diseases

authors： Donnelly MAP,Kluh S,Snyder RE,Barker CM

更新日期：2020-07-21 00:00:00

abstract：:Humans who experience a primary dengue virus (DENV) infection develop antibodies that preferentially neutralize the homologous serotype responsible for infection. Affected individuals also generate cross-reactive antibodies against heterologous DENV serotypes, which are non-neutralizing. Dengue cross-reactive, non-neu...

journal_title：PLoS neglected tropical diseases

authors： de Alwis R,Beltramello M,Messer WB,Sukupolvi-Petty S,Wahala WM,Kraus A,Olivarez NP,Pham Q,Brien JD,Tsai WY,Wang WK,Halstead S,Kliks S,Diamond MS,Baric R,Lanzavecchia A,Sallusto F,de Silva AM

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Between 20 and 30 bacteriologically confirmed cases of leprosy are diagnosed each year at the French National Reference Center for mycobacteria. Patients are mainly immigrants from various endemic countries or living in French overseas territories. We aimed at expanding data regarding the geographical distri...

journal_title：PLoS neglected tropical diseases

authors： Reibel F,Chauffour A,Brossier F,Jarlier V,Cambau E,Aubry A

更新日期：2015-10-06 00:00:00

abstract：:The chemotherapy of lymphatic filariasis relies upon drugs such as diethylcarbamazine and ivermectin that largely target the microfilarial stages of the parasite, necessitating continued treatment over the long reproductive life span of the adult worm. The identification of compounds that target adult worms has been a...

journal_title：PLoS neglected tropical diseases

authors： Taldone T,Gillan V,Sun W,Rodina A,Patel P,Maitland K,O'Neill K,Chiosis G,Devaney E

更新日期：2010-06-15 00:00:00