Soulamarin isolated from Calophyllum brasiliense (Clusiaceae) induces plasma membrane permeabilization of Trypanosoma cruzi and mytochondrial dysfunction.

abstract：:The tick-borne flavivirus, Powassan virus (POWV) causes life-threatening encephalitis in humans in North America and Europe. POWV is transmitted by ixodid tick vectors that feed on small to medium-sized mammals, such as Peromyscus leucopus mice, which may serve as either reservoir, bridge or amplification hosts. Intra...

journal_title：PLoS neglected tropical diseases

authors： Mlera L,Meade-White K,Saturday G,Scott D,Bloom ME

更新日期：2017-01-31 00:00:00

abstract：:Zika virus (ZIKV) is a Flavivirus (Flaviviridae) transmitted to humans mainly by the bite of an infected Aedes mosquitoes. Aedes aegypti is the primary epidemic vector of ZIKV and Ae. albopictus, the secondary one. However, the epidemiological role of both Aedes species in Central Africa where Ae. albopictus was recen...

journal_title：PLoS neglected tropical diseases

authors： Kamgang B,Vazeille M,Tedjou A,Yougang AP,Wilson-Bahun TA,Mousson L,Wondji CS,Failloux AB

更新日期：2020-03-23 00:00:00

abstract：BACKGROUND:The liver fluke Opisthorchis viverrini is classified as a class I carcinogen due to the association between cholangiocarcinoma and chronic O. viverrini infection. During its feeding activity within the bile duct, the parasite secretes several cathepsin F cysteine proteases that may induce or contribute to th...

journal_title：PLoS neglected tropical diseases

authors： Pinlaor P,Kaewpitoon N,Laha T,Sripa B,Kaewkes S,Morales ME,Mann VH,Parriott SK,Suttiprapa S,Robinson MW,To J,Dalton JP,Loukas A,Brindley PJ

更新日期：2009-01-01 00:00:00

abstract：:Tanzania has recently experienced outbreaks of dengue in two coastal regions of Dar es Salaam and Tanga. Chikungunya and Rift Valley Fever outbreaks have also been recorded in the past decade. Little is known on the burden of the arboviral disease causing viruses (Dengue, Rift Valley and Chikungunya) endemically in th...

journal_title：PLoS neglected tropical diseases

authors： Budodo RM,Horumpende PG,Mkumbaye SI,Mmbaga BT,Mwakapuja RS,Chilongola JO

更新日期：2020-07-20 00:00:00

abstract：:Schistosomes are amongst the most important and neglected pathogens in the world, and schistosomiasis control relies almost exclusively on a single drug. The neuromuscular system of schistosomes is fertile ground for therapeutic intervention, yet the details of physiological events involved in neuromuscular function r...

journal_title：PLoS neglected tropical diseases

authors： Novozhilova E,Kimber MJ,Qian H,McVeigh P,Robertson AP,Zamanian M,Maule AG,Day TA

更新日期：2010-08-10 00:00:00

abstract：INTRODUCTION:In addition to the commonly accepted importance of the vampire bat in the maintenance and transmission of the rabies virus (RABV) in South America, RABV infection of other species is widely evidenced, challenging their role in the viral cycle. METHODOLOGY / PRINCIPLES FINDINGS:To identify the bioecologica...

journal_title：PLoS neglected tropical diseases

authors： de Thoisy B,Bourhy H,Delaval M,Pontier D,Dacheux L,Darcissac E,Donato D,Guidez A,Larrous F,Lavenir R,Salmier A,Lacoste V,Lavergne A

更新日期：2016-01-25 00:00:00

abstract：OBJECTIVE:Where human African trypanosomiasis (HAT) patients are seen, failure to microscopically diagnose infections by Trypanosoma brucei gambiense in blood smears and/or cerebrospinal fluid (CSF) in the critical early stages of the disease is the single most important factor in treatment failure, a result of delayed...

journal_title：PLoS neglected tropical diseases

authors： Grab DJ,Nikolskaia OV,Courtioux B,Thekisoe OMM,Magez S,Bogorad M,Dumler JS,Bisser S

更新日期：2019-08-19 00:00:00

abstract：:Clinical manifestations in onchocerciasis range from generalized onchocerciasis (GEO) to the rare but severe hyperreactive (HO)/sowda form. Since disease pathogenesis is associated with host inflammatory reactions, we investigated whether Th17 responses could be related to aggravated pathology in HO. Using flow cytome...

journal_title：PLoS neglected tropical diseases

authors： Katawa G,Layland LE,Debrah AY,von Horn C,Batsa L,Kwarteng A,Arriens S,W Taylor D,Specht S,Hoerauf A,Adjobimey T

更新日期：2015-01-08 00:00:00

abstract：:Schistosomiasis is an important neglected tropical disease caused by digenean helminth parasites of the genus Schistosoma. Schistosomes are unusual in that they are dioecious and the adult worms live in the blood system. MicroRNAs play crucial roles during gene regulation and are likely to be important in sex differen...

journal_title：PLoS neglected tropical diseases

authors： Marco A,Kozomara A,Hui JH,Emery AM,Rollinson D,Griffiths-Jones S,Ronshaugen M

更新日期：2013-09-12 00:00:00

abstract：BACKGROUND:Most available drugs against visceral leishmaniasis are toxic, and growing limitations in available chemotherapeutic strategies due to emerging resistant strains and lack of an effective vaccine against visceral leishmaniasis deepens the crisis. Antineoplastic drugs like miltefosine have in the past been eff...

journal_title：PLoS neglected tropical diseases

authors： Sharma M,Sehgal R,Kaur S

更新日期：2012-01-01 00:00:00

abstract：:In the current study, a comprehensive, data driven, mathematical model for cholera transmission in Haiti is presented. Along with the inclusion of short cycle human-to-human transmission and long cycle human-to-environment and environment-to-human transmission, this novel dynamic model incorporates both the reported c...

journal_title：PLoS neglected tropical diseases

authors： Kirpich A,Weppelmann TA,Yang Y,Ali A,Morris JG Jr,Longini IM

更新日期：2015-10-21 00:00:00

abstract：BACKGROUND:Between 20 and 30 bacteriologically confirmed cases of leprosy are diagnosed each year at the French National Reference Center for mycobacteria. Patients are mainly immigrants from various endemic countries or living in French overseas territories. We aimed at expanding data regarding the geographical distri...

journal_title：PLoS neglected tropical diseases

authors： Reibel F,Chauffour A,Brossier F,Jarlier V,Cambau E,Aubry A

更新日期：2015-10-06 00:00:00

abstract：BACKGROUND:Typhoid fever, caused by the Gram-negative bacterium Salmonella enterica serovar Typhi, is a major cause of community-acquired bacteremia and death worldwide. S100A8 (MRP8) and S100A9 (MRP14) form bioactive antimicrobial heterodimers (calprotectin) that can activate Toll-like receptor 4, promoting lethal, en...

journal_title：PLoS neglected tropical diseases

authors： De Jong HK,Achouiti A,Koh GC,Parry CM,Baker S,Faiz MA,van Dissel JT,Vollaard AM,van Leeuwen EM,Roelofs JJ,de Vos AF,Roth J,van der Poll T,Vogl T,Wiersinga WJ

更新日期：2015-04-10 00:00:00

abstract：:Dengue virus transmission is endemic in Makassar, Indonesia, with the majority of cases reported soon after the start of the annual rainy season. Before 2006, larval source reduction, larvaciding, and reactive routine, outdoor, insecticide fogging campaigns did not result in a reduction in seasonal dengue incidence. B...

journal_title：PLoS neglected tropical diseases

authors： Wahid I,Ishak H,Hafid A,Fajri M,Sidjal S,Nurdin A,Azikin NT,Sudirman R,Hasan H,Yusuf M,Bachtiar I,Hawley WA,Rosenberg R,Lobo NF

更新日期：2019-08-05 00:00:00

abstract：BACKGROUND:South Sudan is one of the most endemic countries for visceral leishmaniasis (VL), and is frequently affected by large epidemics. In resource-limited settings, clinicians require a simple clinical tool to identify VL patients who are at increased risk of dying, and who need specialised treatment with liposoma...

journal_title：PLoS neglected tropical diseases

authors： Kämink SS,Collin SM,Harrison T,Gatluak F,Mullahzada AW,Ritmeijer K

更新日期：2017-10-02 00:00:00

abstract：:In order to rapidly inform polices in the international response to the ongoing pandemic of coronavirus disease 19 (COVID-19), we summarize in this review current evidence on epidemiological and clinical features of the infection, transmission routes, problems of nucleic-acid testing, the epidemiological trend in Chin...

journal_title：PLoS neglected tropical diseases

authors： Liang H,Zheng L,Xia H,Tang J

更新日期：2020-08-06 00:00:00

abstract：BACKGROUND:Dengue virus infection (DVI) among children is a leading cause of hospitalization in endemic areas. Hospitalized patients are at risk of receiving unnecessary antibiotics. METHODS:A retrospective medical review analysis study was conducted to evaluate the prevalence, indication, and choice of antibiotics gi...

journal_title：PLoS neglected tropical diseases

authors： Adrizain R,Setiabudi D,Chairulfatah A

更新日期：2019-06-21 00:00:00

abstract：BACKGROUND:Arboviruses have overlapping geographical distributions and can cause symptoms that coincide with more common infections. Therefore, arbovirus infections are often neglected by travel diagnostics. Here, we assessed the potential of syndrome-based approaches for diagnosis and surveillance of neglected arbovir...

journal_title：PLoS neglected tropical diseases

authors： Cleton NB,Reusken CB,Wagenaar JF,van der Vaart EE,Reimerink J,van der Eijk AA,Koopmans MP

更新日期：2015-09-15 00:00:00

abstract：:A budget proposal to stop the U.S. Centers for Disease Control and Prevention (CDC) funding in surveillance and research for mosquito-borne diseases such as dengue and West Nile virus has the potential to leave the country ill-prepared to handle new emerging diseases and manage existing ones. In order to demonstrate t...

journal_title：PLoS neglected tropical diseases

authors： Vazquez-Prokopec GM,Chaves LF,Ritchie SA,Davis J,Kitron U

更新日期：2010-10-26 00:00:00

abstract：BACKGROUND:Rabies is a fatal encephalitis caused by viruses belonging to the genus Lyssavirus of the family Rhabdoviridae. It is a viral disease primarily affecting mammals, though all warm blooded animals are susceptible. Experimental rabies virus infection in birds has been reported, but naturally occurring infection...

journal_title：PLoS neglected tropical diseases

authors： Baby J,Mani RS,Abraham SS,Thankappan AT,Pillai PM,Anand AM,Madhusudana SN,Ramachandran J,Sreekumar S

更新日期：2015-07-22 00:00:00

abstract：BACKGROUND:Leptospirosis is an emerging zoonosis that is often under-recognized in children and commonly confused with dengue in tropical settings. An enhanced ability to distinguish leptospirosis from dengue in children would guide clinicians and public health personnel in the appropriate use of limited healthcare res...

journal_title：PLoS neglected tropical diseases

authors： Libraty DH,Myint KS,Murray CK,Gibbons RV,Mammen MP,Endy TP,Li W,Vaughn DW,Nisalak A,Kalayanarooj S,Hospenthal DR,Green S,Rothman AL,Ennis FA

更新日期：2007-12-26 00:00:00

abstract：BACKGROUND:African trypanosomosis, primarily transmitted by tsetse flies, remains a serious public health and economic challenge in sub-Saharan Africa. Interventions employing natural repellents from non-preferred hosts of tsetse flies represent a promising management approach. Although zebras have been identified as n...

journal_title：PLoS neglected tropical diseases

authors： Olaide OY,Tchouassi DP,Yusuf AA,Pirk CWW,Masiga DK,Saini RK,Torto B

更新日期：2019-06-10 00:00:00

abstract：:Rabies is a fatal neurologic disease caused by lyssavirus infection. Bats are important natural reservoir hosts of various lyssaviruses that can be transmitted to people. The epidemiology and pathogenesis of rabies in bats are poorly understood, making it difficult to prevent zoonotic transmission. To further our unde...

journal_title：PLoS neglected tropical diseases

authors： Begeman L,Suu-Ire R,Banyard AC,Drosten C,Eggerbauer E,Freuling CM,Gibson L,Goharriz H,Horton DL,Jennings D,Marston DA,Ntiamoa-Baidu Y,Riesle Sbarbaro S,Selden D,Wise EL,Kuiken T,Fooks AR,Müller T,Wood JLN,Cunningham

更新日期：2020-12-15 00:00:00

abstract：BACKGROUND:Schistosomiasis in one of the most prevalent parasitic diseases, affecting millions of people and animals in developing countries. Amongst the human-infective species S. haematobium is one of the most widespread causing urogenital schistosomiasis, a major human health problem across Africa, however in terms ...

journal_title：PLoS neglected tropical diseases

authors： Webster BL,Emery AM,Webster JP,Gouvras A,Garba A,Diaw O,Seye MM,Tchuente LA,Simoonga C,Mwanga J,Lange C,Kariuki C,Mohammed KA,Stothard JR,Rollinson D

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The mosquito Aedes aegypti is the primary global vector for dengue and yellow fever viruses. Sequencing of the Ae. aegypti genome has stimulated research in vector biology and insect genomics. However, the current genome assembly is highly fragmented with only ~31% of the genome being assigned to chromosomes...

journal_title：PLoS neglected tropical diseases

authors： Sharakhova MV,Timoshevskiy VA,Yang F,Demin SIu,Severson DW,Sharakhov IV

更新日期：2011-10-01 00:00:00

abstract：:Benzimidazole anthelmintics have long been employed for the control of soil-transmitted helminth infections. Flubendazole (FBZ) was approved in 1980 for the treatment of gastrointestinal nematode infections in both veterinary and human medicine. It has also long been known that parenteral administration of FBZ can lea...

journal_title：PLoS neglected tropical diseases

authors： Geary TG,Mackenzie CD,Silber SA

更新日期：2019-01-16 00:00:00

abstract：BACKGROUND:Leishmania uses the amino acid L-arginine as a substrate for arginase, enzyme that produces urea and ornithine, last precursor of polyamine pathway. This pathway is used by the parasite to replicate and it is essential to establish the infection in the mammalian host. L-arginine is not synthesized by the par...

journal_title：PLoS neglected tropical diseases

authors： Aoki JI,Muxel SM,Zampieri RA,Acuña SM,Fernandes JCR,Vanderlinde RH,Sales MCOP,Floeter-Winter LM

更新日期：2017-10-26 00:00:00

abstract：:Greece was declared malaria-free in 1974 after a long antimalarial fight. In 2011-2012, an outbreak of P. vivax malaria was reported in Evrotas, an agricultural area in Southern Greece, where a large number of immigrants from endemic countries live and work. A total of 46 locally acquired and 38 imported malaria cases...

journal_title：PLoS neglected tropical diseases

authors： Tseroni M,Baka A,Kapizioni C,Snounou G,Tsiodras S,Charvalakou M,Georgitsou M,Panoutsakou M,Psinaki I,Tsoromokou M,Karakitsos G,Pervanidou D,Vakali A,Mouchtouri V,Georgakopoulou T,Mamuris Z,Papadopoulos N,Koliopoulos G,

更新日期：2015-11-19 00:00:00

abstract：:The toxicity of available drugs for treatment of leishmaniasis, coupled with emerging drug resistance, make it urgent to find new therapies. Antimicrobial peptides (AMPs) have a strong broad-spectrum antimicrobial activity with distinctive modes of action and are considered as promising therapeutic agents. The defensi...

journal_title：PLoS neglected tropical diseases

authors： Dabirian S,Taslimi Y,Zahedifard F,Gholami E,Doustdari F,Motamedirad M,Khatami S,Azadmanesh K,Nylen S,Rafati S

更新日期：2013-10-17 00:00:00

abstract：BACKGROUND:For decades La Réunion has experienced a number of epidemics that have resulted in efforts to control the density of Aedes species on this Island. This study was conducted to assess household-level expenditure on protective measures against mosquito nuisance on the Island of La Réunion in 2012. METHODOLOGY/...

journal_title：PLoS neglected tropical diseases

authors： Thuilliez J,Bellia C,Dehecq JS,Reilhes O

更新日期：2014-01-02 00:00:00