Male mating competitiveness of a Wolbachia-introgressed Aedes polynesiensis strain under semi-field conditions.

Abstract:

BACKGROUND:Lymphatic filariasis (LF), a global public health problem affecting approximately 120 million people worldwide, is a leading cause of disability in the developing world including the South Pacific. Despite decades of ongoing mass drug administration (MDA) in the region, some island nations have not yet achieved the threshold levels of microfilaremia established by the World Health Organization for eliminating transmission. Previously, the generation of a novel Aedes polynesiensis strain (CP) infected with an exogenous type of Wolbachia has been described. The CP mosquito is cytoplasmically incompatible (i.e., effectively sterile) when mated with wildtype mosquitoes, and a strategy was proposed for the control of A. polynesiensis populations by repeated, inundative releases of CP males to disrupt fertility of wild females. Such a strategy could lead to suppression of the vector population and subsequently lead to a reduction in the transmission of filarial worms. METHODOLOGY/PRINCIPAL FINDINGS:CP males and F1 male offspring from wild-caught A. polynesiensis females exhibit near equal mating competitiveness with F1 females under semi-field conditions. CONCLUSIONS/SIGNIFICANCE:While laboratory experiments are important, prior projects have demonstrated the need for additional testing under semi-field conditions in order to recognize problems before field implementation. The results reported here from semi-field experiments encourage forward progression toward small-scale field releases.

journal_name

PLoS Negl Trop Dis

authors

Chambers EW,Hapairai L,Peel BA,Bossin H,Dobson SL

doi

10.1371/journal.pntd.0001271

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

e1271

issue

8

eissn

1935-2727

issn

1935-2735

pii

PNTD-D-11-00195

journal_volume

5

pub_type

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