Comparative assessment of ELISAs using recombinant saposin-like protein 2 and recombinant cathepsin L-1 from Fasciola hepatica for the serodiagnosis of human Fasciolosis.

abstract：BACKGROUND:The frequency of accidental spider bites in Brazil is growing, and poisoning due to bites from the spider genus Phoneutria nigriventer is the second most frequent source of such accidents. Intense local pain is the major symptom reported after bites of P. nigriventer, although the mechanisms involved are sti...

journal_title：PLoS neglected tropical diseases

authors： Gewehr C,Oliveira SM,Rossato MF,Trevisan G,Dalmolin GD,Rigo FK,de Castro Júnior CJ,Cordeiro MN,Ferreira J,Gomez MV

更新日期：2013-04-25 00:00:00

abstract：BACKGROUND:Leishmaniases are parasitic diseases present worldwide that are transmitted to the vertebrate host by the bite of an infected sand fly during a blood feeding. Phlebotomine sand flies inoculate into the mammalian host Leishmania parasites embedded in promastigote secretory gel (PSG) with saliva, which is comp...

journal_title：PLoS neglected tropical diseases

authors： Lestinova T,Rohousova I,Sima M,de Oliveira CI,Volf P

更新日期：2017-07-13 00:00:00

abstract：BACKGROUND:Leishmaniasis is a complex disease in which clinical outcome depends on factors such as parasite species, host genetics and immunity and vector species. In Brazil, Leishmania (Viannia) braziliensis is a major etiological agent of cutaneous (CL) and mucosal leishmaniasis (MCL), a disfiguring form of the disea...

journal_title：PLoS neglected tropical diseases

authors： Alves-Ferreira EV,Toledo JS,De Oliveira AH,Ferreira TR,Ruy PC,Pinzan CF,Santos RF,Boaventura V,Rojo D,López-Gonzálvez Á,Rosa JC,Barbas C,Barral-Netto M,Barral A,Cruz AK

更新日期：2015-09-14 00:00:00

abstract：BACKGROUND:The World Health Organization identified Uganda as one of the 10 highly endemic countries for schistosomiasis. Annual mass drug administration (MDA) with praziquantel has led to a decline in intensity of Schistosoma mansoni infections in several areas. However, as hotspots with high (re)infection rates remai...

journal_title：PLoS neglected tropical diseases

authors： Trienekens SCM,Faust CL,Meginnis K,Pickering L,Ericsson O,Nankasi A,Moses A,Tukahebwa EM,Lamberton PHL

更新日期：2020-05-13 00:00:00

abstract：:Pathogens originating from wildlife (zoonoses) pose a significant public health burden, comprising the majority of emerging infectious diseases. Efforts to control and prevent zoonotic disease have traditionally focused on animal-to-human transmission, or "spillover." However, in the modern era, increasing internation...

journal_title：PLoS neglected tropical diseases

authors： Guth S,Hanley KA,Althouse BM,Boots M

更新日期：2020-08-13 00:00:00

abstract：BACKGROUND:Amebic colitis, caused by intestinal infection with the parasite, Entamoeba histolytica, is a common cause of diarrhea worldwide. Fulminant amebic colitis is the most devastating complication of this infection, associated with both high mortality and morbidity. We conducted a review of the English literature...

journal_title：PLoS neglected tropical diseases

authors： Shirley DA,Moonah S

更新日期：2016-07-28 00:00:00

abstract：:Dengue continues to be the most important vector-borne viral disease globally and in Brazil, where more than 1.4 million cases and over 500 deaths were reported in 2016. Mosquito control programmes and other interventions have not stopped the alarming trend of increasingly large epidemics in the past few years. Here, ...

journal_title：PLoS neglected tropical diseases

authors： Churakov M,Villabona-Arenas CJ,Kraemer MUG,Salje H,Cauchemez S

更新日期：2019-04-22 00:00:00

abstract：OBJECTIVES:Burkholderia pseudomallei, the causative agent for melioidosis, has become a public health problem in India and across the world. Melioidosis can be difficult to diagnose because of the inconsistent clinical presentations of the disease. This study aims to determine the genetic diversity among the clinical i...

journal_title：PLoS neglected tropical diseases

authors： Balaji V,Perumalla S,Perumal R,Inbanathan FY,Rajamani Sekar SK,Paul MM,Sahni RD,Prakash JAJ,Iyadurai R

更新日期：2018-06-27 00:00:00

abstract：:Rift Valley fever (RVF), a re-emerging mosquito-borne disease of ruminants and man, was endemic in Africa but spread to Saudi Arabia and Yemen, meaning it could spread even further. Little is known about innate and cell-mediated immunity to RVF virus (RVFV) in ruminants, which is knowledge required for adequate vaccin...

journal_title：PLoS neglected tropical diseases

authors： Nfon CK,Marszal P,Zhang S,Weingartl HM

更新日期：2012-01-01 00:00:00

abstract：:During the recent Ebola outbreak in West Africa several international mobile laboratories were deployed to the mainly affected countries Guinea, Sierra Leone and Liberia to provide ebolavirus diagnostic capacity. Additionally, imported cases and small outbreaks in other countries required global preparedness for Ebola...

journal_title：PLoS neglected tropical diseases

authors： Ellerbrok H,Jacobsen S,Patel P,Rieger T,Eickmann M,Becker S,Günther S,Naidoo D,Schrick L,Keeren K,Targosz A,Teichmann A,Formenty P,Niedrig M

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Brucellosis and coxiellosis are known to be endemic in ruminant populations throughout Afghanistan, but information about their prevalence and factors that affect prevalence in householders and livestock under diverse husbandry systems and pastoral settings is sparse. METHODS/PRINCIPAL FINDINGS:We conducted...

journal_title：PLoS neglected tropical diseases

authors： Akbarian Z,Ziay G,Schauwers W,Noormal B,Saeed I,Qanee AH,Shahab Z,Dennison T,Dohoo I,Jackson R

更新日期：2015-10-20 00:00:00

abstract：:We recently developed a superhydrophobic cone-based method for the collection of mosquito excreta/feces (E/F) for the molecular xenomonitoring of vector-borne parasites showing higher throughput compared to the traditional approach. To test its field applicability, we used this platform to detect the presence of filar...

journal_title：PLoS neglected tropical diseases

authors： Minetti C,Pilotte N,Zulch M,Canelas T,Tettevi EJ,Veriegh FBD,Osei-Atweneboana MY,Williams SA,Reimer LJ

更新日期：2020-04-08 00:00:00

abstract：:Most studies evaluating epidemiologic relationships between helminths and HIV have been conducted in the pre-ART era, and evidence of the impact of helminth infections on HIV disease progression remains conflicting. Less is known about helminth infection and clinical outcomes in HIV-infected adults receiving antiretro...

journal_title：PLoS neglected tropical diseases

authors： Morawski BM,Yunus M,Kerukadho E,Turyasingura G,Barbra L,Ojok AM,DiNardo AR,Sowinski S,Boulware DR,Mejia R

更新日期：2017-05-25 00:00:00

abstract：BACKGROUND:Trachoma, caused by Chlamydia trachomatis (Ct), is the leading infectious cause of blindness. Sequence-based analysis of the multiple strains typically present in endemic communities may be informative for epidemiology, transmission, response to treatment, and understanding the host response. METHODS:Conjun...

journal_title：PLoS neglected tropical diseases

authors： Andreasen AA,Burton MJ,Holland MJ,Polley S,Faal N,Mabey DC,Bailey RL

更新日期：2008-09-24 00:00:00

abstract：BACKGROUND:The factors influencing variation in the clinical forms of Chagas disease have not been elucidated; however, it is likely that the genetics of both the host and the parasite are involved. Several studies have attempted to correlate the T. cruzi strains involved in infection with the clinical forms of the dis...

journal_title：PLoS neglected tropical diseases

authors： Mendes TA,Reis Cunha JL,de Almeida Lourdes R,Rodrigues Luiz GF,Lemos LD,dos Santos AR,da Câmara AC,Galvão LM,Bern C,Gilman RH,Fujiwara RT,Gazzinelli RT,Bartholomeu DC

更新日期：2013-10-31 00:00:00

abstract：:The increasing burden of dengue, and the relative failure of traditional vector control programs highlight the need to develop new control methods. SIT using self-limiting genetic technology is one such promising method. A self-limiting strain of Aedes aegypti, OX513A, has already reached the stage of field evaluation...

journal_title：PLoS neglected tropical diseases

authors： Carvalho DO,McKemey AR,Garziera L,Lacroix R,Donnelly CA,Alphey L,Malavasi A,Capurro ML

更新日期：2015-07-02 00:00:00

abstract：BACKGROUND:The parasitic protozoan Trypanosoma brucei utilizes glycolysis exclusively for ATP production during infection of the mammalian host. The first step in this metabolic pathway is mediated by hexokinase (TbHK), an enzyme essential to the parasite that transfers the gamma-phospho of ATP to a hexose. Here we des...

journal_title：PLoS neglected tropical diseases

authors： Sharlow ER,Lyda TA,Dodson HC,Mustata G,Morris MT,Leimgruber SS,Lee KH,Kashiwada Y,Close D,Lazo JS,Morris JC

更新日期：2010-04-13 00:00:00

abstract：BACKGROUND:The immune response in the skin of dogs infected with Leishmania infantum is poorly understood, and limited studies have described the immunopathological profile with regard to distinct levels of tissue parasitism and the clinical progression of canine visceral leishmaniasis (CVL). METHODOLOGY/PRINCIPAL FIN...

journal_title：PLoS neglected tropical diseases

authors： Menezes-Souza D,Guerra-Sá R,Carneiro CM,Vitoriano-Souza J,Giunchetti RC,Teixeira-Carvalho A,Silveira-Lemos D,Oliveira GC,Corrêa-Oliveira R,Reis AB

更新日期：2012-01-01 00:00:00

abstract：:Trachoma, caused by Chlamydia trachomatis (Ct), is the leading infectious blinding disease worldwide. Chronic conjunctival inflammation develops in childhood and leads to eyelid scarring and blindness in adulthood. The immune response to Ct provides only partial protection against re-infection, which can be frequent. ...

journal_title：PLoS neglected tropical diseases

authors： Hu VH,Holland MJ,Burton MJ

更新日期：2013-01-01 00:00:00

abstract：:Crimean-Congo Hemorrhagic Fever Virus (CCHFV) and Hazara virus (HAZV) belong to the same viral serotype and family. HAZV has lately been used as a model system and surrogate to CCHFV. However, virus-host cell interaction and level of pathogenicity for these viruses are not well investigated nor compared. In this study...

journal_title：PLoS neglected tropical diseases

authors： Monteil V,Salata C,Appelberg S,Mirazimi A

更新日期：2020-11-24 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) is hypoendemic in the Mediterranean region, where it is caused by the protozoan Leishmania infantum. An effective vaccine for humans is not yet available and the severe side-effects of the drugs in clinical use, linked to the parenteral administration route of most of them, are si...

journal_title：PLoS neglected tropical diseases

authors： Calvo-Álvarez E,Stamatakis K,Punzón C,Álvarez-Velilla R,Tejería A,Escudero-Martínez JM,Pérez-Pertejo Y,Fresno M,Balaña-Fouce R,Reguera RM

更新日期：2015-03-31 00:00:00

abstract：BACKGROUND:Syphilis is resurgent in many regions of the world. Molecular typing is a robust tool for investigating strain diversity and epidemiology. This study aimed to review original research on molecular typing of Treponema pallidum (T. pallidum) with three objectives: (1) to determine specimen types most suitable ...

journal_title：PLoS neglected tropical diseases

authors： Peng RR,Wang AL,Li J,Tucker JD,Yin YP,Chen XS

更新日期：2011-11-01 00:00:00

abstract：:The metacestode (larval) stage of the tapeworm Echinococcus multilocularis causes alveolar echinococcosis (AE), a very severe and in many cases incurable disease. To date, benzimidazoles such as albendazole and mebendazole are the only approved chemotherapeutical treatment options. Benzimidazoles inhibit metacestode p...

journal_title：PLoS neglected tropical diseases

authors： Stadelmann B,Rufener R,Aeschbacher D,Spiliotis M,Gottstein B,Hemphill A

更新日期：2016-03-11 00:00:00

abstract：BACKGROUND:The main objective of the study was to determine the degree of sensitization to Anisakis spp. antigens in healthy coastal population of Dalmatia given the high thermally unprocessed fish intake rate present in this area, suggested as a significant risk factor for anisakiasis. We performed a monocenter, cross...

journal_title：PLoS neglected tropical diseases

authors： Mladineo I,Poljak V,Martínez-Sernández V,Ubeira FM

更新日期：2014-02-06 00:00:00

abstract：BACKGROUND:Aedes control interventions are considered the cornerstone of dengue control programmes, but there is scarce evidence on their effect on disease. We set-up a cluster randomized controlled trial in Santiago de Cuba to evaluate the entomological and epidemiological effectiveness of periodical intra- and peri-d...

journal_title：PLoS neglected tropical diseases

authors： Toledo ME,Vanlerberghe V,Rosales JP,Mirabal M,Cabrera P,Fonseca V,Gómez Padrón T,Pérez Menzies M,Montada D,Van der Stuyft P

更新日期：2017-11-08 00:00:00

abstract：:Soil-transmitted helminths (STH) are endemic and widespread across Sub-Saharan Africa. A community wide soil-transmitted helminth (STH) prevalence survey was performed on the island of Bubaque in Guinea-Bissau using both Kato-katz microscopy and qPCR methodology. Predictors of infection and morbidity indicators were i...

journal_title：PLoS neglected tropical diseases

authors： Farrant O,Marlais T,Houghton J,Goncalves A,Teixeira da Silva Cassama E,Cabral MG,Nakutum J,Manjuba C,Rodrigues A,Mabey D,Bailey R,Last A

更新日期：2020-12-16 00:00:00

abstract：:The vast burden of cryptococcal meningitis occurs in immunosuppressed patients, driven by HIV, and is caused by Cryptococcus neoformans var. grubii. We previously reported cryptococcal meningitis in Vietnam arising atypically in HIV uninfected, apparently immunocompetent patients, caused by a single amplified fragment...

journal_title：PLoS neglected tropical diseases

authors： Day JN,Qihui S,Thanh LT,Trieu PH,Van AD,Thu NH,Chau TTH,Lan NPH,Chau NVV,Ashton PM,Thwaites GE,Boni MF,Wolbers M,Nagarajan N,Tan PBO,Baker S

更新日期：2017-06-14 00:00:00

abstract：BACKGROUND:Arboviruses have overlapping geographical distributions and can cause symptoms that coincide with more common infections. Therefore, arbovirus infections are often neglected by travel diagnostics. Here, we assessed the potential of syndrome-based approaches for diagnosis and surveillance of neglected arbovir...

journal_title：PLoS neglected tropical diseases

authors： Cleton NB,Reusken CB,Wagenaar JF,van der Vaart EE,Reimerink J,van der Eijk AA,Koopmans MP

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:Burkholderia cepacia complex (Bcc) is a group of serious pathogens in cystic fibrosis patients and causes life threatening infections in immunocompromised patients. Species within the Bcc are widely distributed within the environment, can survive in the presence of disinfectants and antiseptics, and are inhe...

journal_title：PLoS neglected tropical diseases

authors： Farzana R,Jones LS,Rahman MA,Sands K,Portal E,Boostrom I,Kalam MA,Hasan B,Khan A,Walsh TR

更新日期：2020-04-09 00:00:00

abstract：:Orientia tsutsugamushi (Ots) frequently causes severe scrub typhus infections in the Asia-Pacific region. Korean investigators have demonstrated that Ots encodes five different autotransporter domain (ATD) proteins (ScaA-ScaE). ScaA functions as an adhesin and confers protective immunity in a lethal mouse model of Ots...

journal_title：PLoS neglected tropical diseases

authors： Koralur MC,Ramaiah A,Dasch GA

更新日期：2018-09-20 00:00:00