Advanced case of PKDL due to delayed treatment: A rare case report.

abstract：BACKGROUND:Anti-leishmanial drug regimens that include a single dose AmBisome could be suitable for eastern African patients with symptomatic visceral leishmaniasis (VL) but the appropriate single dose is unknown. METHODOLOGY:A multi-centre, open-label, non-inferiority, randomized controlled trial with an adaptive des...

journal_title：PLoS neglected tropical diseases

authors： Khalil EA,Weldegebreal T,Younis BM,Omollo R,Musa AM,Hailu W,Abuzaid AA,Dorlo TP,Hurissa Z,Yifru S,Haleke W,Smith PG,Ellis S,Balasegaram M,EL-Hassan AM,Schoone GJ,Wasunna M,Kimutai R,Edwards T,Hailu A

更新日期：2014-01-16 00:00:00

abstract：BACKGROUND:Lymphatic filariasis (LF), a global public health problem affecting approximately 120 million people worldwide, is a leading cause of disability in the developing world including the South Pacific. Despite decades of ongoing mass drug administration (MDA) in the region, some island nations have not yet achie...

journal_title：PLoS neglected tropical diseases

authors： Chambers EW,Hapairai L,Peel BA,Bossin H,Dobson SL

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Dengue is an important arboviral disease with about 100 million dengue cases per year, of which, ~5% result in severe disease. Clinical differentiation of dengue from other acute febrile illnesses (AFI) is difficult, and diagnostic blood tests are costly. We evaluated the utility of anti-DENV IgM in urine to...

journal_title：PLoS neglected tropical diseases

authors： Caraballo E,Poole-Smith BK,Tomashek KM,Torres-Velasquez B,Alvarado LI,Lorenzi OD,Ramos C,Carrión J,Hunsperger E

更新日期：2020-01-29 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0006212.]. ...

journal_title：PLoS neglected tropical diseases

authors： PLOS Neglected Tropical Diseases Staff.

更新日期：2019-01-31 00:00:00

abstract：BACKGROUND:Leptospirosis is a potentially fatal bacterial zoonosis that is endemic throughout the tropics and may be misdiagnosed as dengue. Delayed hospital admission of leptospirosis patients is associated with increased mortality. METHODOLOGY/PRINCIPAL FINDINGS:During a concurrent dengue/leptospirosis epidemic in P...

journal_title：PLoS neglected tropical diseases

authors： Sharp TM,Rivera García B,Pérez-Padilla J,Galloway RL,Guerra M,Ryff KR,Haberling D,Ramakrishnan S,Shadomy S,Blau D,Tomashek KM,Bower WA

更新日期：2016-02-25 00:00:00

abstract：BACKGROUND:We identified the species of Leishmania isolated from traveling and migrant patients attended in a reference center from 2000 to 2015, we performed the georeferencing of these species in Rio de Janeiro (RJ) state and we had knowledge about the human flows between the likely location of infection (LLI) and pl...

journal_title：PLoS neglected tropical diseases

authors： Miranda LFC,Pacheco RDS,Pimentel MIF,Salgueiro MM,da Silva AF,de Mello CX,Barros JHDS,Valete-Rosalino CM,Madeira MF,Xavier SCDC,Schubach AO

更新日期：2019-11-15 00:00:00

abstract：BACKGROUND:Many small studies have been done in Honduras estimating soil-transmitted helminthiasis (STH) prevalence but a country-wide study was last done in 2005. The country has the highest burden of malaria among all Central American countries. The present study was done to estimate country-wide STH prevalence and i...

journal_title：PLoS neglected tropical diseases

authors： Mejia Torres RE,Franco Garcia DN,Fontecha Sandoval GA,Hernandez Santana A,Singh P,Mancero Bucheli ST,Saboya M,Paz MY

更新日期：2014-10-16 00:00:00

abstract：:The East/Central/South African genotype of Chikungunya virus with the E1-A226V mutation emerged in 2011 in Cambodia and spread in 2012. An outbreak of 190 cases was documented in Trapeang Roka, a rural village. We surveyed 425 village residents within 3-4 weeks after the outbreak, and determined the sensitivity and sp...

journal_title：PLoS neglected tropical diseases

authors： Galatas B,Ly S,Duong V,Baisley K,Nguon K,Chan S,Huy R,Ly S,Sorn S,Som L,Buchy P,Tarantola A

更新日期：2016-01-11 00:00:00

abstract：INTRODUCTION:Individuals exposed to malaria infections for a long time develop immune responses capable of blocking Plasmodium transmission to mosquito vectors, potentially limiting parasite spreading in nature. Development of a malaria TB vaccine requires a better understanding of the mechanisms and main effectors res...

journal_title：PLoS neglected tropical diseases

authors： Vallejo AF,Rubiano K,Amado A,Krystosik AR,Herrera S,Arévalo-Herrera M

更新日期：2016-06-29 00:00:00

abstract：OBJECTIVE:Cotrimoxazole prevents opportunistic infections including falciparum malaria in HIV-infected individuals but there are concerns of cross-resistance to other antifolate drugs such as sulphadoxine-pyrimethamine (SP). In this study, we investigated the prevalence of antifolate-resistance mutations in Plasmodium ...

journal_title：PLoS neglected tropical diseases

authors： Juma DW,Muiruri P,Yuhas K,John-Stewart G,Ottichilo R,Waitumbi J,Singa B,Polyak C,Kamau E

更新日期：2019-03-21 00:00:00

abstract：BACKGROUND:The main objective of the study was to determine the degree of sensitization to Anisakis spp. antigens in healthy coastal population of Dalmatia given the high thermally unprocessed fish intake rate present in this area, suggested as a significant risk factor for anisakiasis. We performed a monocenter, cross...

journal_title：PLoS neglected tropical diseases

authors： Mladineo I,Poljak V,Martínez-Sernández V,Ubeira FM

更新日期：2014-02-06 00:00:00

abstract：BACKGROUND:The diagnosis of Human African Trypanosomiasis relies mainly on the Card Agglutination Test for Trypanosomiasis (CATT). While this test is successful, it is acknowledged that there may be room for improvement. Our aim was to develop a prototype lateral flow test based on the detection of antibodies to trypan...

journal_title：PLoS neglected tropical diseases

authors： Sullivan L,Wall SJ,Carrington M,Ferguson MA

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Rodents are major reservoirs of pathogens responsible for numerous zoonotic diseases in humans and livestock. Assessing their microbial diversity at both the individual and population level is crucial for monitoring endemic infections and revealing microbial association patterns within reservoirs. Recently, ...

journal_title：PLoS neglected tropical diseases

authors： Razzauti M,Galan M,Bernard M,Maman S,Klopp C,Charbonnel N,Vayssier-Taussat M,Eloit M,Cosson JF

更新日期：2015-08-18 00:00:00

abstract：BACKGROUND:Taenia solium cysticercosis affects millions of impoverished people worldwide and can cause neurocysticercosis, an infection of the central nervous system which is potentially fatal. Children may represent an especially vulnerable population to neurocysticercosis, due to the risk of cognitive impairment duri...

journal_title：PLoS neglected tropical diseases

authors： Openshaw JJ,Medina A,Felt SA,Li T,Huan Z,Rozelle S,Luby SP

更新日期：2018-05-08 00:00:00

abstract：:Plague, a zoonosis caused by Yersinia pestis, is still found in Africa, Asia, and the Americas. Madagascar reports almost one third of the cases worldwide. Y. pestis can be encountered in three very different types of foci: urban, rural, and sylvatic. Flea vector and wild rodent host population dynamics are tightly co...

journal_title：PLoS neglected tropical diseases

authors： Andrianaivoarimanana V,Kreppel K,Elissa N,Duplantier JM,Carniel E,Rajerison M,Jambou R

更新日期：2013-11-07 00:00:00

abstract：:Over two-thirds of the world's population lives in regions where rabies is endemic, resulting in over 15 million people receiving multi-dose post-exposure prophylaxis (PEP) and over 55,000 deaths per year globally. A major goal in rabies virus (RABV) research is to develop a single-dose PEP that would simplify vaccina...

journal_title：PLoS neglected tropical diseases

authors： Dorfmeier CL,Tzvetkov EP,Gatt A,McGettigan JP

更新日期：2013-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0004470.]. ...

journal_title：PLoS neglected tropical diseases

authors： Decuypere S,Meehan CJ,Van Puyvelde S,De Block T,Maltha J,Palpouguini L,Tahita M,Tinto H,Jacobs J,Deborggraeve S

更新日期：2017-07-28 00:00:00

abstract：BACKGROUND:Diagnosis of Trypanosoma cruzi infection by direct pathogen detection is complicated by the low parasite burden in subjects persistently infected with this agent of human Chagas disease. Determination of infection status by serological analysis has also been faulty, largely due to the lack of well-characteri...

journal_title：PLoS neglected tropical diseases

authors： Cooley G,Etheridge RD,Boehlke C,Bundy B,Weatherly DB,Minning T,Haney M,Postan M,Laucella S,Tarleton RL

更新日期：2008-10-08 00:00:00

abstract：BACKGROUND:Pathogenesis of severe fever with thrombocytopenia syndrome (SFTS) has not been well described yet. Recent studies indicate that SFTSV could replicate in endothelial cells. Here we performed a case-control study to determine whether endothelial activation/dysfunction occurred in SFTSV infection and to identi...

journal_title：PLoS neglected tropical diseases

authors： Li XK,Yang ZD,Du J,Xing B,Cui N,Zhang PH,Li H,Zhang XA,Lu QB,Liu W

更新日期：2017-08-14 00:00:00

abstract：:Global efforts to address schistosomiasis and soil-transmitted helminthiases (STH) include deworming programs for school-aged children that are made possible by large-scale drug donations. Decisions on these mass drug administration (MDA) programs currently rely on microscopic examination of clinical specimens to dete...

journal_title：PLoS neglected tropical diseases

authors： Hawkins KR,Cantera JL,Storey HL,Leader BT,de Los Santos T

更新日期：2016-12-22 00:00:00

abstract：BACKGROUND:Arboviruses have overlapping geographical distributions and can cause symptoms that coincide with more common infections. Therefore, arbovirus infections are often neglected by travel diagnostics. Here, we assessed the potential of syndrome-based approaches for diagnosis and surveillance of neglected arbovir...

journal_title：PLoS neglected tropical diseases

authors： Cleton NB,Reusken CB,Wagenaar JF,van der Vaart EE,Reimerink J,van der Eijk AA,Koopmans MP

更新日期：2015-09-15 00:00:00

abstract：:Konzo is a distinct neurological entity with selective upper motor neuron damage, characterized by an abrupt onset of an irreversible, non-progressive, and symmetrical spastic para/tetraparesis. Despite its severity, konzo remains a neglected disease. The disease is associated with high dietary cyanogen consumption fr...

journal_title：PLoS neglected tropical diseases

authors： Nzwalo H,Cliff J

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Paragonimiasis is a food-borne trematodiasis leading to lung disease. Worldwide, an estimated 21 million people are infected. Foci of ongoing transmission remain often unnoticed. We evaluated a simple questionnaire approach using lay-informants at the village level to identify paragonimiasis foci and suspect...

journal_title：PLoS neglected tropical diseases

authors： Odermatt P,Veasna D,Zhang W,Vannavong N,Phrommala S,Habe S,Barennes H,Strobel M

更新日期：2009-09-22 00:00:00

abstract：:Leprosy is an infectious disease caused by Mycobacterium leprae and frequently resulting in irreversible deformities and disabilities. Ticks play an important role in infectious disease transmission due to their low host specificity, worldwide distribution, and the biological ability to support transovarial transmissi...

journal_title：PLoS neglected tropical diseases

authors： Ferreira JDS,Souza Oliveira DA,Santos JP,Ribeiro CCDU,Baêta BA,Teixeira RC,Neumann ADS,Rosa PS,Pessolani MCV,Moraes MO,Bechara GH,de Oliveira PL,Sorgine MHF,Suffys PN,Fontes ANB,Bell-Sakyi L,Fonseca AH,Lara FA

更新日期：2018-12-19 00:00:00

abstract：:Clonorchiasis is one of the most important food-borne trematodiases affecting millions of people. Strategies were recommended by different organizations and control programmes were implemented but mostly in short-time periods. It's important to assess the long-term benefits and sustainability of possible control strat...

journal_title：PLoS neglected tropical diseases

authors： Huang XH,Qian MB,Zhu GH,Fang YY,Hao YT,Lai YS

更新日期：2020-03-27 00:00:00

abstract：BACKGROUND:Epilepsy is one of the most common signs of Neurocysticercosis (NCC). In this study, spatial and temporal variations in the incidence of hospitalized cases (IHC) of epilepsy and NCC in Ecuadorian municipalities were analyzed. Additionally, potential socio-economic and landscape indicators were evaluated in o...

journal_title：PLoS neglected tropical diseases

authors： Ron-Garrido L,Coral-Almeida M,Gabriël S,Benitez-Ortiz W,Saegerman C,Dorny P,Berkvens D,Abatih EN

更新日期：2015-11-18 00:00:00

abstract：BACKGROUND:The transitional period between the oncosphere and the cysticercus of Taenia solium is the postoncospheral (PO) form, which has not yet been completely characterized. The aim of this work was to standardize a method to obtain T. solium PO forms by in vitro cultivation. We studied the morphology of the PO for...

journal_title：PLoS neglected tropical diseases

authors： Chile N,Clark T,Arana Y,Ortega YR,Palma S,Mejia A,Angulo N,Kosek JC,Kosek M,Gomez-Puerta LA,Garcia HH,Gavidia CM,Gilman RH,Verastegui M,Cysticercosis Working Group in Peru.

更新日期：2016-02-10 00:00:00

abstract：:Non-typhoidal Salmonella (NTS) is a major global health concern that often causes bloodstream infections in areas of the world affected by malnutrition and comorbidities such as HIV and malaria. Developing a strategy to control the emergence and spread of highly invasive and antimicrobial resistant NTS isolates requir...

journal_title：PLoS neglected tropical diseases

authors： Kubicek-Sutherland JZ,Xie G,Shakya M,Dighe PK,Jacobs LL,Daligault H,Davenport K,Stromberg LR,Stromberg ZR,Cheng Q,Kempaiah P,Ong'echa JM,Otieno V,Raballah E,Anyona S,Ouma C,Chain PSG,Perkins DJ,Mukundan H,McMahon BH

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Among the different faces of immune reconstitution inflammatory syndrome (IRIS) developing in HIV-patients, no clinical definition has been reported for Schistosomiasis-IRIS (Schisto-IRIS). Although Schisto-IRIS remains largely uninvestigated, matrix metalloproteinases (MMP) and tissue inhibitors of metallop...

journal_title：PLoS neglected tropical diseases

authors： Goovaerts O,Mwinzi PNM,Muok EMO,Ceulemans A,Colebunders R,Kestens L

更新日期：2018-08-08 00:00:00

abstract：BACKGROUND:Incidence of Entamoeba histolytica infection and clinical manifestations and treatment response of invasive amebiasis (IA) in HIV-infected patients have rarely been investigated before. METHODOLOGY/PRINCIPAL FINDINGS:At the National Taiwan University Hospital, medical records of HIV-infected patients who re...

journal_title：PLoS neglected tropical diseases

authors： Hung CC,Ji DD,Sun HY,Lee YT,Hsu SY,Chang SY,Wu CH,Chan YH,Hsiao CF,Liu WC,Colebunders R

更新日期：2008-02-27 00:00:00