Comprehensive Transcriptome Analysis of Sex-Biased Expressed Genes Reveals Discrete Biological and Physiological Features of Male and Female Schistosoma japonicum.

abstract：BACKGROUND:The options for treating the fatal disease human African trypanosomiasis are limited to a few drugs that are toxic or facing increasing resistance. New drugs that kill the causative agents, subspecies of Trypanosoma brucei, are therefore urgently needed. Little is known about the cellular mechanisms that lea...

journal_title：PLoS neglected tropical diseases

authors： Worthen C,Jensen BC,Parsons M

更新日期：2010-05-04 00:00:00

abstract：:The circulation of vector-borne zoonotic viruses is largely determined by the overlap in the geographical distributions of virus-competent vectors and reservoir hosts. What is less clear are the factors influencing the distribution of virus-specific lineages. Japanese encephalitis virus (JEV) is the most important eti...

journal_title：PLoS neglected tropical diseases

authors： Schuh AJ,Ward MJ,Brown AJ,Barrett AD

更新日期：2013-08-29 00:00:00

abstract：BACKGROUND:Talaromyces marneffei is an opportunistic dimorphic fungus prevalent in Southeast Asia. We previously demonstrated that Mp1p is an immunogenic surface and secretory mannoprotein of T. marneffei. Since Mp1p is a surface protein that can generate protective immunity, we hypothesized that Mp1p and/or its homolo...

journal_title：PLoS neglected tropical diseases

authors： Woo PC,Lau SK,Lau CC,Tung ET,Chong KT,Yang F,Zhang H,Lo RK,Cai JP,Au-Yeung RK,Ng WF,Tse H,Wong SS,Xu S,Lam WH,Tse MK,Sze KH,Kao RY,Reiner NE,Hao Q,Yuen KY

更新日期：2016-08-25 00:00:00

abstract：BACKGROUND:Noma is a gangrenous disease that leads to severe disfigurement of the face with high morbidity and mortality, but its etiology remains unknown. Young children in developing countries are almost exclusively affected. The purpose of the study was to record and compare bacterial diversity in oral samples from ...

journal_title：PLoS neglected tropical diseases

authors： Bolivar I,Whiteson K,Stadelmann B,Baratti-Mayer D,Gizard Y,Mombelli A,Pittet D,Schrenzel J,Geneva Study Group on Noma (GESNOMA).

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Human brucellosis (HB) is a bacterial zoonosis that is more frequent in low income and middle-income countries; it is sometimes associated with outbreaks. The aim of this study was to describe the largest outbreak of HB in Brazil. METHODS:A retrospective cohort study of patients suspected of having contract...

journal_title：PLoS neglected tropical diseases

authors： Lemos TS,Cequinel JC,Costa TP,Navarro AB,Sprada A,Shibata FK,Gondolfo R,Tuon FF

更新日期：2018-09-18 00:00:00

abstract：BACKGROUND:Trichinellosis is a serious zoonositc parasitosis worldwide. Because its clinical manifestations aren't specific, the diagnosis of trichinellosis is not easy to be made. Trichinella spiralis muscle larva (ML) excretory-secretory (ES) antigens are the most widely applied diagnostic antigens for human trichine...

journal_title：PLoS neglected tropical diseases

authors： Sun GG,Song YY,Jiang P,Ren HN,Yan SW,Han Y,Liu RD,Zhang X,Wang ZQ,Cui J

更新日期：2018-05-14 00:00:00

abstract：BACKGROUND:The parasite Onchocerca volvulus has, until recently, been regarded as the cause of a chronic yet non-fatal condition. Recent analyses, however, have indicated that in addition to blindness, the parasite can also be directly associated with human mortality. Such analyses also suggested that the relationship ...

journal_title：PLoS neglected tropical diseases

authors： Walker M,Little MP,Wagner KS,Soumbey-Alley EW,Boatin BA,Basáñez MG

更新日期：2012-01-01 00:00:00

abstract：:Epidemic growth rate, r, provides a more complete description of the potential for epidemics than the more commonly studied basic reproduction number, R0, yet the former has never been described as a function of temperature for dengue virus or other pathogens with temperature-sensitive transmission. The need to unders...

journal_title：PLoS neglected tropical diseases

authors： Siraj AS,Oidtman RJ,Huber JH,Kraemer MUG,Brady OJ,Johansson MA,Perkins TA

更新日期：2017-07-19 00:00:00

abstract：BACKGROUND:Filarial nematodes, including Brugia malayi, the causative agent of lymphatic filariasis, undergo molting in both arthropod and mammalian hosts to complete their life cycles. An understanding of how these parasites cross developmental checkpoints may reveal potential targets for intervention. Pharmacological...

journal_title：PLoS neglected tropical diseases

authors： Tzertzinis G,Egaña AL,Palli SR,Robinson-Rechavi M,Gissendanner CR,Liu C,Unnasch TR,Maina CV

更新日期：2010-03-09 00:00:00

abstract：:The present study aims to investigate how the social context contributes to the prognosis of Chagas disease (CD). This is a multilevel study that considered individual and contextual data. Individual data came from a Brazilian cohort study that followed 1,637 patients who lived in 21 municipalities to which CD is ende...

journal_title：PLoS neglected tropical diseases

authors： Ferreira AM,Sabino ÉC,Oliveira LC,Oliveira CDL,Cardoso CS,Ribeiro ALP,Damasceno RF,Nunes MDCP,Haikal DSA

更新日期：2020-06-29 00:00:00

abstract：:The Global Programme to Eliminate Lymphatic Filariasis has made significant progress toward interrupting transmission of lymphatic filariasis (LF) through mass drug administration (MDA). Operational challenges in defining endpoints of elimination programs include the need to determine appropriate post-MDA surveillance...

journal_title：PLoS neglected tropical diseases

authors： Lau CL,Won KY,Lammie PJ,Graves PM

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Chromoblastomycosis (CBM) is a difficult-to-treat chronic subcutaneous mycosis. In Brazil, the main agent of this disease is Fonsecaea pedrosoi, which is phenotypically very similar to other Fonsecaea species, differing only genetically. The correct species identification is relevant since different species ...

journal_title：PLoS neglected tropical diseases

authors： Coelho RA,Brito-Santos F,Figueiredo-Carvalho MHG,Silva JVDS,Gutierrez-Galhardo MC,do Valle ACF,Zancopé-Oliveira RM,Trilles L,Meyer W,Freitas DFS,Almeida-Paes R

更新日期：2018-07-26 00:00:00

abstract：BACKGROUND:Schistosomiasis japonica is a zoonotic parasitic disease and oral vaccine delivery system would be benefit for prevention of this disease. Although attenuated salmonella has been used as an antigen expression vector for oral vaccine development, the membrane-bound vacuoles in which bacteria reside hinders th...

journal_title：PLoS neglected tropical diseases

authors： Chen G,Dai Y,Chen J,Wang X,Tang B,Zhu Y,Hua Z

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:In India, dengue disease is emerging as the most important vector borne public health problem due to rapid and unplanned urbanization, high human density and week management of the disease. Clinical cases are grossly underreported and not much information is available on prevalence and incidence of the disea...

journal_title：PLoS neglected tropical diseases

authors： Mishra AC,Arankalle VA,Gadhave SA,Mahadik PH,Shrivastava S,Bhutkar M,Vaidya VM

更新日期：2018-08-06 00:00:00

abstract：:Mycetoma is considered a neglected tropical disease globally. However, data on its burden and the associated complications in Uganda are limited. Hence we aimed to estimate its burden in Uganda. Firstly, a systematic PubMed search for all studies of any design on mycetoma in Uganda without restriction to the year of p...

journal_title：PLoS neglected tropical diseases

authors： Kwizera R,Bongomin F,Meya DB,Denning DW,Fahal AH,Lukande R

更新日期：2020-04-29 00:00:00

abstract：BACKGROUND:Praziquantel remains the drug of choice for the worldwide treatment and control of schistosomiasis. The drug is synthesized and administered as a racemate. Use of the pure active enantiomer would be desirable since the inactive enantiomer is associated with side effects and is responsible for the extremely b...

journal_title：PLoS neglected tropical diseases

authors： Woelfle M,Seerden JP,de Gooijer J,Pouwer K,Olliaro P,Todd MH

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) or Kala-azar has been a major public health problem in Bihar, India, for several decades. A few VL infected districts including Vaishali have reported >600 cases annually. Hence, in 2015, the Government of India entrusted ICMR-Rajendra Memorial Research Institute of Medical Scienc...

journal_title：PLoS neglected tropical diseases

authors： Kumar V,Mandal R,Das S,Kesari S,Dinesh DS,Pandey K,Das VR,Topno RK,Sharma MP,Dasgupta RK,Das P

更新日期：2020-05-04 00:00:00

abstract：BACKGROUND:A cluster of eleven patients, including eight family members and three healthcare workers with fever and thrombocytopenia occurred in Yixing County, Jiangsu Province, China, from October to November 1996. However, the initial investigation failed to identify its etiology. Severe fever with thrombocytopenia s...

journal_title：PLoS neglected tropical diseases

authors： Hu J,Shi C,Li Z,Guo X,Qian Y,Tan W,Li X,Qi X,Su X,Zhou M,Wang H,Jiao Y,Bao C

更新日期：2018-06-25 00:00:00

abstract：BACKGROUND:Dengue diagnosis is complex and until recently only specialized laboratories were able to definitively confirm dengue infection. Rapid tests are now available commercially making biological diagnosis possible in the field. The aim of this study was to evaluate a combined dengue rapid test for the detection o...

journal_title：PLoS neglected tropical diseases

authors： Andries AC,Duong V,Ngan C,Ong S,Huy R,Sroin KK,Te V,Y B,Try PL,Buchy P

更新日期：2012-01-01 00:00:00

abstract：:Dengue, a vector-borne disease spread by Aedes mosquitoes, is a global threat. In the absence of an efficacious dengue vaccine, vector control is the key intervention tool in Singapore. A good understanding of vector habitats is essential to formulate operational strategies. We examined the distribution, long-term tre...

journal_title：PLoS neglected tropical diseases

authors： Rajarethinam J,Ong J,Neo ZW,Ng LC,Aik J

更新日期：2020-04-20 00:00:00

abstract：BACKGROUND:Travelers who acquire dengue infection are often routes for virus transmission to other regions. Nevertheless, the interplay between infected travelers, climate, vectors, and indigenous dengue incidence remains unclear. The role of foreign-origin cases on local dengue epidemics thus has been largely neglecte...

journal_title：PLoS neglected tropical diseases

authors： Shang CS,Fang CT,Liu CM,Wen TH,Tsai KH,King CC

更新日期：2010-08-03 00:00:00

abstract：BACKGROUND:Worldwide, an estimated 30 to 100 million people are infected with Strongyloides stercoralis, a soil-transmitted helminth. Information on the parasite is scarce in most settings. In semi-rural Cambodia, we determined infection rates and risk factors; compared two diagnostic methods (Koga agar plate [KAP] cul...

journal_title：PLoS neglected tropical diseases

authors： Khieu V,Schär F,Marti H,Sayasone S,Duong S,Muth S,Odermatt P

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The possible emergence of resistance to the only available drug for schistosomiasis spurs drug discovery that has been recently incentivized by the availability of improved transcriptome and genome sequence information. Transient RNAi has emerged as a straightforward and important technique to interrogate th...

journal_title：PLoS neglected tropical diseases

authors： Stefanić S,Dvořák J,Horn M,Braschi S,Sojka D,Ruelas DS,Suzuki B,Lim KC,Hopkins SD,McKerrow JH,Caffrey CR

更新日期：2010-10-19 00:00:00

abstract：BACKGROUND:Dengue is the most important mosquito-borne viral disease affecting humans. The only prevention measure currently available is the control of its vectors, primarily Aedes aegypti. Recent advances in genetic engineering have opened the possibility for a new range of control strategies based on genetically mod...

journal_title：PLoS neglected tropical diseases

authors： Magori K,Legros M,Puente ME,Focks DA,Scott TW,Lloyd AL,Gould F

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Arboviruses have overlapping geographical distributions and can cause symptoms that coincide with more common infections. Therefore, arbovirus infections are often neglected by travel diagnostics. Here, we assessed the potential of syndrome-based approaches for diagnosis and surveillance of neglected arbovir...

journal_title：PLoS neglected tropical diseases

authors： Cleton NB,Reusken CB,Wagenaar JF,van der Vaart EE,Reimerink J,van der Eijk AA,Koopmans MP

更新日期：2015-09-15 00:00:00

abstract：:Diagnosis of a first-time visceral leishmaniasis (VL) infection in Ethiopia is established by use of a rapid diagnostic test (RDT) detecting antibodies against rK39, direct agglutination test (DAT) and microscopy according to the national algorithm. The performance of individual tests and algorithm is variable and dep...

journal_title：PLoS neglected tropical diseases

authors： Kassa M,Abdellati S,Cnops L,Bremer Hinckel BC,Yeshanew A,Hailemichael W,Vogt F,Adriaensen W,Mertens P,Diro E,van Griensven J,Van den Bossche D

更新日期：2020-12-31 00:00:00

abstract：BACKGROUND:The neglected tropical disease Buruli ulcer (BU) caused by Mycobacterium ulcerans is an infection of the subcutaneous tissue leading to chronic ulcerative skin lesions. Histopathological features are progressive tissue necrosis, extracellular clusters of acid fast bacilli (AFB) and poor inflammatory response...

journal_title：PLoS neglected tropical diseases

authors： Ruf MT,Chauty A,Adeye A,Ardant MF,Koussemou H,Johnson RC,Pluschke G

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Melioidosis, a fatal infectious disease caused by Burkholderia pseudomallei, is increasingly diagnosed in tropical regions. However, data on risk factors and the geographic epidemiology of the disease are still limited. Previous studies have also largely been based on the analysis of case series data. Here, ...

journal_title：PLoS neglected tropical diseases

authors： Abu Hassan MR,Aziz N,Ismail N,Shafie Z,Mayala B,Donohue RE,Pani SP,Michael E

更新日期：2019-03-18 00:00:00

abstract：BACKGROUND:The Asian bush mosquito Aedes japonicus is invading Europe and was first discovered in Lelystad, the Netherlands in 2013, where it has established a permanent population. In this study, we investigated the vector competence of Ae. japonicus from the Netherlands for the emerging Zika virus (ZIKV) and zoonotic...

journal_title：PLoS neglected tropical diseases

authors： Abbo SR,Visser TM,Wang H,Göertz GP,Fros JJ,Abma-Henkens MHC,Geertsema C,Vogels CBF,Koopmans MPG,Reusken CBEM,Hall-Mendelin S,Hall RA,van Oers MM,Koenraadt CJM,Pijlman GP

更新日期：2020-04-13 00:00:00

abstract：:(•)NO is considered to be a key macrophage-derived cytotoxic effector during Trypanosoma cruzi infection. On the other hand, the microbicidal properties of reactive oxygen species (ROS) are well recognized, but little importance has been attributed to them during in vivo infection with T. cruzi. In order to investigat...

journal_title：PLoS neglected tropical diseases

authors： Santiago HC,Gonzalez Lombana CZ,Macedo JP,Utsch L,Tafuri WL,Campagnole-Santos MJ,Alves RO,Alves-Filho JC,Romanha AJ,Cunha FQ,Teixeira MM,Radi R,Vieira LQ

更新日期：2012-01-01 00:00:00