Lymphatic Filariasis Elimination in American Samoa: Evaluation of Molecular Xenomonitoring as a Surveillance Tool in the Endgame.

abstract：:Vector control is still our primary intervention for both prevention and mitigation of epidemics of many vector-borne diseases. Efficiently targeting control measures is important since control can involve substantial economic costs. Targeting is not always straightforward, as transmission of vector-borne diseases is ...

journal_title：PLoS neglected tropical diseases

authors： Stone CM,Schwab SR,Fonseca DM,Fefferman NH

更新日期：2019-07-03 00:00:00

abstract：BACKGROUND:The rapid spread of Zika virus in the Americas and current outbreak of microcephaly in Brazil has raised attention to the possible deleterious effects that the virus may have on fetuses. METHODOLOGY/PRINCIPAL FINDINGS:We report a case of a 20-year-old pregnant woman who was referred to our service after a l...

journal_title：PLoS neglected tropical diseases

authors： Sarno M,Sacramento GA,Khouri R,do Rosário MS,Costa F,Archanjo G,Santos LA,Nery N Jr,Vasilakis N,Ko AI,de Almeida AR

更新日期：2016-02-25 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) is a life-threatening disease caused by protozoan parasites of the Leishmania donovani complex. Early case detection followed by adequate treatment is essential to the control of VL. However, the available diagnostic tests are either invasive and require considerable expertise (pa...

journal_title：PLoS neglected tropical diseases

authors： Gao CH,Yang YT,Shi F,Wang JY,Steverding D,Wang X

更新日期：2015-06-30 00:00:00

abstract：BACKGROUND:Mycobacterium ulcerans (MU) is responsible for disfiguring skin lesions and is endemic on the Bellarine peninsula of southeastern Australia. Antibiotics have been shown to be highly effective in sterilizing lesions and preventing disease recurrences when used alone or in combination with surgery. Our practic...

journal_title：PLoS neglected tropical diseases

authors： Friedman ND,Athan E,Hughes AJ,Khajehnoori M,McDonald A,Callan P,Rahdon R,O'Brien DP

更新日期：2013-07-18 00:00:00

abstract：BACKGROUND:Traditional faecal-based methods have poor sensitivity for the detection of S. stercoralis, therefore are inadequate for post-treatment evaluation of infected patients who should be carefully monitored to exclude the persistence of the infection. In a previous study, we demonstrated high accuracy of five ser...

journal_title：PLoS neglected tropical diseases

authors： Buonfrate D,Sequi M,Mejia R,Cimino RO,Krolewiecki AJ,Albonico M,Degani M,Tais S,Angheben A,Requena-Mendez A,Muñoz J,Nutman TB,Bisoffi Z

更新日期：2015-02-10 00:00:00

abstract：:In French Guiana, from 1984 to 2011, 14 animal rabies cases and 1 human rabies case (2008) were diagnosed. In January 2011, vampire-bat attacks occurred in 2 isolated villages. In mid-January, a medical team from the Cayenne Centre for Anti-Rabies Treatment visited the sites to manage individuals potentially exposed t...

journal_title：PLoS neglected tropical diseases

authors： Berger F,Desplanches N,Baillargeaux S,Joubert M,Miller M,Ribadeau-Dumas F,Spiegel A,Bourhy H

更新日期：2013-06-27 00:00:00

abstract：:Snakebites are a major Collective Health problem worldwide. In Brazil, Bothrops jararaca snake venom (BjV) evokes hemostatic disturbances, bleeding manifestations, and redox status imbalance. Specific antivenom therapy, although efficacious to revert most snakebite-induced manifestations, is incapable of treating seco...

journal_title：PLoS neglected tropical diseases

authors： Sachetto ATA,Rosa JG,Santoro ML

更新日期：2018-10-11 00:00:00

abstract：BACKGROUND:The long-term treatment outcome of visceral leishmaniasis (VL) patients with HIV co-infection is complicated by a high rate of relapse, especially when the CD4 count is low. Although use of secondary prophylaxis is recommended, it is not routinely practiced and data on its effectiveness and safety are limite...

journal_title：PLoS neglected tropical diseases

authors： Diro E,Edwards T,Ritmeijer K,Fikre H,Abongomera C,Kibret A,Bardonneau C,Soipei P,Mutinda B,Omollo R,van Griensven J,Zijlstra EE,Wasunna M,Alves F,Alvar J,Hailu A,Alexander N,Blesson S

更新日期：2019-02-21 00:00:00

abstract：BACKGROUND:Aedes aegypti, the "yellow fever mosquito", is the primary vector to humans of the four serotypes of dengue viruses (DENV1-4) and yellow fever virus (YFV) and is a known vector of Chikungunya virus. There are two recognized subspecies of Ae. aegypti sensu latu (s.l.): the presumed ancestral form, Ae. aegypti...

journal_title：PLoS neglected tropical diseases

authors： Sylla M,Bosio C,Urdaneta-Marquez L,Ndiaye M,Black WC 4th

更新日期：2009-01-01 00:00:00

abstract：:Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) that recently caused outbreaks in the Americas. Over the past 60 years, this virus has been observed circulating among African, Asian, and Pacific Island populations, but little attention has been paid by the scientific community until the discovery that large-...

journal_title：PLoS neglected tropical diseases

authors： Epelboin Y,Talaga S,Epelboin L,Dusfour I

更新日期：2017-11-16 00:00:00

abstract：BACKGROUND:BALB/c mice are highly susceptible while C57BL/6 are relatively resistant to experimental Trypanosoma congolense infection. Although regulatory T cells (Tregs) have been shown to regulate the pathogenesis of experimental T. congolense infection, their exact role remains controversial. We wished to determine ...

journal_title：PLoS neglected tropical diseases

authors： Okwor I,Onyilagha C,Kuriakose S,Mou Z,Jia P,Uzonna JE

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Skin sores caused by Group A streptococcus (GAS) infection are a major public health problem in remote Aboriginal communities. Skin sores are often associated with scabies, which is evident in scabies intervention programs where a significant reduction of skin sores is seen after focusing solely on scabies c...

journal_title：PLoS neglected tropical diseases

authors： Aung PTZ,Cuningham W,Hwang K,Andrews RM,Carapetis JR,Kearns T,Clucas D,McVernon J,Simpson JA,Tong SYC,Campbell PT

更新日期：2018-07-25 00:00:00

abstract：BACKGROUND:Leishmania development in the sand fly gut leads to highly infective forms called metacyclic promastigotes. This process can be routinely mimicked in culture. Gene expression-profiling studies by transcriptome analysis have been performed with the aim of studying promastigote forms in the sand fly gut, as we...

journal_title：PLoS neglected tropical diseases

authors： Alcolea PJ,Alonso A,Molina R,Jiménez M,Myler PJ,Larraga V

更新日期：2019-05-09 00:00:00

abstract：BACKGROUND:The aetiological diagnostic of fevers in Laos remains difficult due to limited laboratory diagnostic facilities. However, it has recently become apparent that both scrub and murine typhus are common causes of previous undiagnosed fever. Epidemiological data suggests that scrub typhus would be more common in ...

journal_title：PLoS neglected tropical diseases

authors： Vallée J,Thaojaikong T,Moore CE,Phetsouvanh R,Richards AL,Souris M,Fournet F,Salem G,Gonzalez JP,Newton PN

更新日期：2010-12-07 00:00:00

abstract：BACKGROUND:Visceral Leishmaniasis in humans presents with fever, anemia, and splenomegaly and can be lethal if not treated. Nevertheless, the majority of Leishmania infantum-infected individuals does not manifest symptoms and remain so provided they are not immunosuppressed. In this work, the performance of different t...

journal_title：PLoS neglected tropical diseases

authors： Porcino GN,Carvalho KSS,Braz DC,Costa Silva V,Costa CHN,de Miranda Santos IKF

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) is highly prevalent in the Indian state of Bihar and, without proper diagnosis and treatment, is associated with high fatality. However, lack of efficient reporting mechanism had been an impediment in estimating the burden of mortality and its antecedents among symptomatic VL case...

journal_title：PLoS neglected tropical diseases

authors： Das A,Karthick M,Dwivedi S,Banerjee I,Mahapatra T,Srikantiah S,Chaudhuri I

更新日期：2016-11-21 00:00:00

abstract：:Simian T-Leukemia Virus type 1 and Simian Foamy Virus infect non-human primates. While STLV-1, as HTLV-1, causes Adult T-cell Leukemia/lymphoma, SFV infection is asymptomatic. Both retroviruses can be transmitted from NHPs to humans through bites that allow contact between infected saliva and recipient blood. Because ...

journal_title：PLoS neglected tropical diseases

authors： Alais S,Pasquier A,Jegado B,Journo C,Rua R,Gessain A,Tobaly-Tapiero J,Lacoste R,Turpin J,Mahieux R

更新日期：2018-10-01 00:00:00

abstract：:Two recombinant Fasciola hepatica antigens, saposin-like protein-2 (recSAP2) and cathepsin L-1 (recCL1), were assessed individually and in combination in enzyme-linked immunosorbent assays (ELISA) for the specific serodiagnosis of human fasciolosis in areas of low endemicity as encountered in Central Europe. Antibody ...

journal_title：PLoS neglected tropical diseases

authors： Gottstein B,Schneeberger M,Boubaker G,Merkle B,Huber C,Spiliotis M,Müller N,Garate T,Doherr MG

更新日期：2014-06-12 00:00:00

abstract：BACKGROUND:The transitional period between the oncosphere and the cysticercus of Taenia solium is the postoncospheral (PO) form, which has not yet been completely characterized. The aim of this work was to standardize a method to obtain T. solium PO forms by in vitro cultivation. We studied the morphology of the PO for...

journal_title：PLoS neglected tropical diseases

authors： Chile N,Clark T,Arana Y,Ortega YR,Palma S,Mejia A,Angulo N,Kosek JC,Kosek M,Gomez-Puerta LA,Garcia HH,Gavidia CM,Gilman RH,Verastegui M,Cysticercosis Working Group in Peru.

更新日期：2016-02-10 00:00:00

abstract：BACKGROUND:The liver fluke Opisthorchis viverrini is classified as a class I carcinogen due to the association between cholangiocarcinoma and chronic O. viverrini infection. During its feeding activity within the bile duct, the parasite secretes several cathepsin F cysteine proteases that may induce or contribute to th...

journal_title：PLoS neglected tropical diseases

authors： Pinlaor P,Kaewpitoon N,Laha T,Sripa B,Kaewkes S,Morales ME,Mann VH,Parriott SK,Suttiprapa S,Robinson MW,To J,Dalton JP,Loukas A,Brindley PJ

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Schistosoma mansoni and Schistosoma japonicum are the most frequent causative agents of human intestinal schistosomiasis. Approximately 200 million people in the world are infected with schistosomes. Diagnosis of schistosomiasis is often difficult. High percentages of low level infections are missed in routi...

journal_title：PLoS neglected tropical diseases

authors： Karl S,Gutiérrez L,Lucyk-Maurer R,Kerr R,Candido RR,Toh SQ,Saunders M,Shaw JA,Suvorova A,Hofmann A,House MJ,Woodward RC,Graeff-Teixera C,St Pierre TG,Jones MK

更新日期：2013-05-16 00:00:00

abstract：:Infected Ixodes scapularis (black-legged tick) transmit a host of serious pathogens via their bites, including Borrelia burgdorferi, Babesia microti, and tick-borne flaviviruses (TBFVs), such as Powassan virus (POWV). Although the role of female I. scapularis ticks in disease transmission is well characterized, the ro...

journal_title：PLoS neglected tropical diseases

authors： Kendall BL,Grabowski JM,Rosenke R,Pulliam M,Long DR,Scott DP,Offerdahl DK,Bloom ME

更新日期：2020-10-05 00:00:00

abstract：:Schistosomiasis is endemic to many regions of the world and affects approximately 200 million people. Conventional adaptive T cell responses are considered to be the primary contributors to the pathogenesis of Schistosoma japonicum infection, leading to liver granuloma and fibrosis. However, the functional polarizatio...

journal_title：PLoS neglected tropical diseases

authors： Gong W,Huang F,Sun L,Yu A,Zhang X,Xu Y,Shen Y,Cao J

更新日期：2018-12-27 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0004470.]. ...

journal_title：PLoS neglected tropical diseases

authors： Decuypere S,Meehan CJ,Van Puyvelde S,De Block T,Maltha J,Palpouguini L,Tahita M,Tinto H,Jacobs J,Deborggraeve S

更新日期：2017-07-28 00:00:00

abstract：BACKGROUND:Ecological determinants of most emerging vector-borne diseases are understudied, particularly for neglected tropical disease. Moreover, although socioeconomic impacts can have significant downstream effects on human risks to vector-borne diseases via a change in land cover, particularly facilitating the inva...

journal_title：PLoS neglected tropical diseases

authors： Wei CY,Wang JK,Shih HC,Wang HC,Kuo CC

更新日期：2020-01-21 00:00:00

abstract：:The 2015-2017 epidemics of Zika virus (ZIKV) in the Americas caused widespread infection, followed by protective immunity. The timing and burden of the next Zika virus outbreak remains unclear. We used an agent-based model to simulate the dynamics of age-specific immunity to ZIKV, and predict the future age-specific r...

journal_title：PLoS neglected tropical diseases

authors： Counotte MJ,Althaus CL,Low N,Riou J

更新日期：2019-12-26 00:00:00

abstract：BACKGROUND:There is conflicting evidence on the immunologic benefit of treating helminth co-infections ("deworming") in HIV-infected individuals. Several studies have documented reduced viral load and increased CD4 count in antiretroviral therapy (ART) naïve individuals after deworming. However, there are a lack of dat...

journal_title：PLoS neglected tropical diseases

authors： Lankowski AJ,Tsai AC,Kanyesigye M,Bwana M,Haberer JE,Wenger M,Martin JN,Bangsberg DR,Hunt PW,Siedner MJ

更新日期：2014-08-07 00:00:00

abstract：BACKGROUND:Giardiasis is an intestinal infection correlated with poverty and poor drinking water quality, and treatment options are limited. According to the Center for Disease Control and Prevention, Giardia infections afflict nearly 33% of people in developing countries, and 2% of the adult population in the develope...

journal_title：PLoS neglected tropical diseases

authors： Kunz S,Balmer V,Sterk GJ,Pollastri MP,Leurs R,Müller N,Hemphill A,Spycher C

更新日期：2017-09-15 00:00:00

abstract：:Leishmaniasis is a complex parasitic disease from a taxonomic, clinical and epidemiological point of view. The role of genetic exchanges has been questioned for over twenty years and their recent experimental demonstration along with the identification of interspecific hybrids in natura has revived this debate. After ...

journal_title：PLoS neglected tropical diseases

authors： El Baidouri F,Diancourt L,Berry V,Chevenet F,Pratlong F,Marty P,Ravel C

更新日期：2013-06-13 00:00:00

abstract：BACKGROUND:In 2005, there were outbreaks of febrile polyarthritis due to Chikungunya virus (CHIKV) in the Comoros Islands. CHIKV then spread to other islands in the Indian Ocean: La Réunion, Mauritius, Seychelles and Madagascar. These outbreaks revealed the lack of surveillance and preparedness of Madagascar and other ...

journal_title：PLoS neglected tropical diseases

authors： Andriamandimby SF,Heraud JM,Randrianasolo L,Rafisandratantsoa JT,Andriamamonjy S,Richard V

更新日期：2013-07-25 00:00:00