Molecular Epidemiology of Agents of Human Chromoblastomycosis in Brazil with the Description of Two Novel Species.

abstract：:Hand, foot and mouth disease (HFMD) continues to challenge Asia with pandemic potential. In Vietnam, there have been two major outbreaks occurring during 2011-2012 (>200,000 hospitalizations and >200 deaths) and more recently in 2018 (>130,000 hospitalizations and 17 deaths). Given the high burden and the complex epid...

journal_title：PLoS neglected tropical diseases

authors： Nhan LNT,Khanh TH,Hong NTT,Van HMT,Nhu LNT,Ny NTH,Nguyet LA,Thanh TT,Anh NT,Hang VTT,Qui PT,Viet HL,Tung TH,Ha DQ,Tuan HM,Thwaites G,Chau NVV,Thwaites L,Hung NT,van Doorn HR,Tan LV

更新日期：2020-08-17 00:00:00

abstract：:Erythema nodosum leprosum (ENL), or type 2 lepra reaction, is a multi-system immune-mediated complication in patients with multibacillary leprosy, frequently associated with chronicity and recurrences. Management of ENL requires high doses of oral corticosteroids, which may not be universally effective and pose seriou...

journal_title：PLoS neglected tropical diseases

authors： Upputuri B,Pallapati MS,Tarwater P,Srikantam A

更新日期：2020-10-09 00:00:00

abstract：BACKGROUND:Usutu virus (USUV) is a member of the Japanese encephalitis virus (JEV) serocomplex in the Flaviviridae family. Emergence of USUV in Europe has led to disease burdens in birds and created increasing concern for the potential zoonotic transmission to humans. Whilst USUV has not been detected in the New World,...

journal_title：PLoS neglected tropical diseases

authors： Cook CL,Huang YS,Lyons AC,Alto BW,Unlu I,Higgs S,Vanlandingham DL

更新日期：2018-08-17 00:00:00

abstract：BACKGROUND:During the 2014-2016 West Africa Ebola Virus Disease (EVD) epidemic, the public health community had concerns that sexual transmission of the Ebola virus (EBOV) from EVD survivors was a risk, due to EBOV persistence in body fluids of EVD survivors, particularly semen. The Sierra Leone Ebola Virus Persistence...

journal_title：PLoS neglected tropical diseases

authors： Abad N,Malik T,Ariyarajah A,Ongpin P,Hogben M,McDonald SLR,Marrinan J,Massaquoi T,Thorson A,Ervin E,Bernstein K,Ross C,Liu WJ,Kroeger K,Durski KN,Broutet N,Knust B,Deen GF,Sierra Leone Ebola Virus Persistence Study Gr

更新日期：2017-09-11 00:00:00

abstract：:Rabies virus kills tens of thousands of people globally each year, especially in resource-limited countries. Yet, there are genetically- and antigenically-related lyssaviruses, all capable of causing the disease rabies, circulating globally among bats without causing conspicuous disease outbreaks. The species richness...

journal_title：PLoS neglected tropical diseases

authors： Hayman DT,Fooks AR,Marston DA,Garcia-R JC

更新日期：2016-12-30 00:00:00

abstract：:Cystic echinococcosis is still a major concern in South America. While some regions show advances in the control of the disease, others have among the highest incidence in the world. To reverse this situation the Pan American Health Organization (PAHO) has launched a regional project on cystic echinococcosis control a...

journal_title：PLoS neglected tropical diseases

authors： Morel N,Lassabe G,Elola S,Bondad M,Herrera S,Marí C,Last JA,Jensen O,Gonzalez-Sapienza G

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Most available drugs against visceral leishmaniasis are toxic, and growing limitations in available chemotherapeutic strategies due to emerging resistant strains and lack of an effective vaccine against visceral leishmaniasis deepens the crisis. Antineoplastic drugs like miltefosine have in the past been eff...

journal_title：PLoS neglected tropical diseases

authors： Sharma M,Sehgal R,Kaur S

更新日期：2012-01-01 00:00:00

abstract：:Trypanosoma cruzi, the etiological agent of Chagas disease, consumes glucose and amino acids depending on the environmental availability of each nutrient during its complex life cycle. For example, amino acids are the major energy and carbon sources in the intracellular stages of the T. cruzi parasite, but their consu...

journal_title：PLoS neglected tropical diseases

authors： Crispim M,Damasceno FS,Hernández A,Barisón MJ,Pretto Sauter I,Souza Pavani R,Santos Moura A,Pral EMF,Cortez M,Elias MC,Silber AM

更新日期：2018-01-10 00:00:00

abstract：:The potential use of clinically approved beta-lactams for Buruli ulcer (BU) treatment was investigated with representative classes analyzed in vitro for activity against Mycobacterium ulcerans. Beta-lactams tested were effective alone and displayed a strong synergistic profile in combination with antibiotics currently...

journal_title：PLoS neglected tropical diseases

authors： Arenaz-Callao MP,González Del Río R,Lucía Quintana A,Thompson CJ,Mendoza-Losana A,Ramón-García S

更新日期：2019-01-28 00:00:00

abstract：:Infected Ixodes scapularis (black-legged tick) transmit a host of serious pathogens via their bites, including Borrelia burgdorferi, Babesia microti, and tick-borne flaviviruses (TBFVs), such as Powassan virus (POWV). Although the role of female I. scapularis ticks in disease transmission is well characterized, the ro...

journal_title：PLoS neglected tropical diseases

authors： Kendall BL,Grabowski JM,Rosenke R,Pulliam M,Long DR,Scott DP,Offerdahl DK,Bloom ME

更新日期：2020-10-05 00:00:00

abstract：BACKGROUND:Dengue fever is a major public health concern in many parts of the tropics and subtropics. The first dengue vaccine has already been licensed in six countries. Given the growing interests in the effective use of the vaccine, it is critical to understand the economic burden of dengue fever to guide decision-m...

journal_title：PLoS neglected tropical diseases

authors： Lee JS,Mogasale V,Lim JK,Carabali M,Lee KS,Sirivichayakul C,Dang DA,Palencia-Florez DC,Nguyen THA,Riewpaiboon A,Chanthavanich P,Villar L,Maskery BA,Farlow A

更新日期：2017-10-30 00:00:00

abstract：BACKGROUND:Soil-transmitted helminths (STH) have acute and chronic manifestations, and can result in lifetime morbidity. Disease burden is difficult to quantify, yet quantitative evidence is required to justify large-scale deworming programmes. A recent Cochrane systematic review, which influences Global Burden of Dise...

journal_title：PLoS neglected tropical diseases

authors： Campbell SJ,Nery SV,Doi SA,Gray DJ,Soares Magalhães RJ,McCarthy JS,Traub RJ,Andrews RM,Clements AC

更新日期：2016-05-19 00:00:00

abstract：:The Leishmania genus comprises up to 35 species, some with status still under discussion. The multilocus sequence typing (MLST)--extensively used for bacteria--has been proposed for pathogenic trypanosomatids. For Leishmania, however, a detailed analysis and revision on the taxonomy is still required. We have partiall...

journal_title：PLoS neglected tropical diseases

authors： Boité MC,Mauricio IL,Miles MA,Cupolillo E

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Although increased capillary permeability is the major clinical feature associated with severe dengue infections the mechanisms underlying this phenomenon remain unclear. Dextran clearance methodology has been used to investigate the molecular sieving properties of the microvasculature in clinical situations...

journal_title：PLoS neglected tropical diseases

authors： Nguyen-Pouplin J,Pouplin T,Van TP,The TD,Thi DN,Farrar J,Tinh HT,Wills B

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Anti-leishmanial drug regimens that include a single dose AmBisome could be suitable for eastern African patients with symptomatic visceral leishmaniasis (VL) but the appropriate single dose is unknown. METHODOLOGY:A multi-centre, open-label, non-inferiority, randomized controlled trial with an adaptive des...

journal_title：PLoS neglected tropical diseases

authors： Khalil EA,Weldegebreal T,Younis BM,Omollo R,Musa AM,Hailu W,Abuzaid AA,Dorlo TP,Hurissa Z,Yifru S,Haleke W,Smith PG,Ellis S,Balasegaram M,EL-Hassan AM,Schoone GJ,Wasunna M,Kimutai R,Edwards T,Hailu A

更新日期：2014-01-16 00:00:00

abstract：BACKGROUND:Chagas disease is a vector-borne disease of major importance in the Americas. Disease prevention is mostly limited to vector control. Integrated interventions targeting ecological, biological and social determinants of vector-borne diseases are increasingly used for improved control. METHODOLOGY/PRINCIPAL F...

journal_title：PLoS neglected tropical diseases

authors： Dumonteil E,Nouvellet P,Rosecrans K,Ramirez-Sierra MJ,Gamboa-León R,Cruz-Chan V,Rosado-Vallado M,Gourbière S

更新日期：2013-09-26 00:00:00

abstract：:Australia is currently canine rabies free. However, communities located on the northern coastline-such as the Northern Peninsula Area (NPA), Queensland-are at risk of an incursion due to their large populations of susceptible free-roaming dogs and proximity to rabies-infected Indonesian islands. A rabies-spread model ...

journal_title：PLoS neglected tropical diseases

authors： Hudson EG,Brookes VJ,Dürr S,Ward MP

更新日期：2019-07-08 00:00:00

abstract：INTRODUCTION:Between 1998 and 2010, S. Typhi was an uncommon cause of bloodstream infection (BSI) in Blantyre, Malawi and it was usually susceptible to first-line antimicrobial therapy. In 2011 an increase in a multidrug resistant (MDR) strain was detected through routine bacteriological surveillance conducted at Queen...

journal_title：PLoS neglected tropical diseases

authors： Feasey NA,Gaskell K,Wong V,Msefula C,Selemani G,Kumwenda S,Allain TJ,Mallewa J,Kennedy N,Bennett A,Nyirongo JO,Nyondo PA,Zulu MD,Parkhill J,Dougan G,Gordon MA,Heyderman RS

更新日期：2015-04-24 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0006212.]. ...

journal_title：PLoS neglected tropical diseases

authors： PLOS Neglected Tropical Diseases Staff.

更新日期：2019-01-31 00:00:00

abstract：BACKGROUND:Hantavirus pulmonary syndrome (HPS) is a life threatening disease transmitted by the rodent Oligoryzomys longicaudatus in Chile. Hantavirus outbreaks are typically small and geographically confined. Several studies have estimated risk based on spatial and temporal distribution of cases in relation to climate...

journal_title：PLoS neglected tropical diseases

authors： Nsoesie EO,Mekaru SR,Ramakrishnan N,Marathe MV,Brownstein JS

更新日期：2014-04-24 00:00:00

abstract：BACKGROUND:Intestinal schistosomiasis and soil-transmitted helminth (STH) infections constitute major public health problems in many parts of sub-Saharan Africa. In this study we examined the functional significance of such polyparasite infections in anemia and undernutrition in Rwandan individuals. METHODS:Three poly...

journal_title：PLoS neglected tropical diseases

authors： Mupfasoni D,Karibushi B,Koukounari A,Ruberanziza E,Kaberuka T,Kramer MH,Mukabayire O,Kabera M,Nizeyimana V,Deville MA,Ruxin J,Webster JP,Fenwick A

更新日期：2009-09-15 00:00:00

abstract：:Salmonella enterica serovar Typhi (S. Typhi) is the causative agent of typhoid fever, a systemic human infection with a burden exceeding 20 million cases each year that occurs disproportionately among children in low and middle income countries. Antimicrobial therapy is the mainstay for treatment, but resistance to mu...

journal_title：PLoS neglected tropical diseases

authors： Ingle DJ,Nair S,Hartman H,Ashton PM,Dyson ZA,Day M,Freedman J,Chattaway MA,Holt KE,Dallman TJ

更新日期：2019-09-12 00:00:00

abstract：:Dengue and chikungunya are viral diseases transmitted to humans by infected Aedes spp. mosquitoes. With an estimated 390 million infected people per year dengue virus (DENV) currently causes the most prevalent arboviral disease. During the last decade chikungunya virus (CHIKV) has caused large outbreaks and has expand...

journal_title：PLoS neglected tropical diseases

authors： Ruiz Silva M,Aguilar Briseño JA,Upasani V,van der Ende-Metselaar H,Smit JM,Rodenhuis-Zybert IA

更新日期：2017-06-23 00:00:00

abstract：BACKGROUND:In the Brazilian Amazon, clinical and epidemiological frameworks of Chagas disease are very dissimilar in relation to the endemic classical areas of transmission, possibly due to genetic and biological characteristics of the circulating Trypanosoma cruzi stocks. Twenty six T. cruzi stocks from Western Amazon...

journal_title：PLoS neglected tropical diseases

authors： Monteiro WM,Margioto Teston AP,Gruendling AP,dos Reis D,Gomes ML,de Araújo SM,Bahia MT,Magalhães LK,de Oliveira Guerra JA,Silveira H,Toledo MJ,Vale Barbosa Md

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:This paper discusses the presence of Aedes aegypti pupae in different types of containers considering: volume, pH of the container, among other variables. METHODS:A nonlinear method for selection was applied, based on Mutual Information, by placing in order of importance the most appropriate variables for...

journal_title：PLoS neglected tropical diseases

authors： Medronho RA,Câmara VM,Macrini L

更新日期：2018-07-23 00:00:00

abstract：:Kinetoplastids are a group of parasites that includes several medically-important species. These human-infective species are transmitted by insect vectors in which the parasites undergo specific developmental transformations. For each species, this includes a stage in which parasites adhere to insect tissue via a hemi...

journal_title：PLoS neglected tropical diseases

authors： Filosa JN,Berry CT,Ruthel G,Beverley SM,Warren WC,Tomlinson C,Myler PJ,Dudkin EA,Povelones ML,Povelones M

更新日期：2019-07-29 00:00:00

abstract：BACKGROUND:Singapore experiences endemic dengue, with 2013 being the largest outbreak year known to date, culminating in 22,170 cases. Given the limited resources available, and that vector control is the key approach for prevention in Singapore, it is important that public health professionals know where resources sho...

journal_title：PLoS neglected tropical diseases

authors： Ong J,Liu X,Rajarethinam J,Kok SY,Liang S,Tang CS,Cook AR,Ng LC,Yap G

更新日期：2018-06-18 00:00:00

abstract：BACKGROUND:Miltefosine (MF) is the only oral drug available for treatment of visceral leishmaniasis (VL) and post-kala-azar dermal leishmaniasis (PKDL). Although the drug is effective and well tolerated in treatment of VL, the efficacy and safety of MF for longer treatment durations (>28 days) in PKDL remains unclear. ...

journal_title：PLoS neglected tropical diseases

authors： Pijpers J,den Boer ML,Essink DR,Ritmeijer K

更新日期：2019-02-11 00:00:00

abstract：BACKGROUND:Human cysticercosis is a zoonotic disease causing severe health disorders and even death. While prevalence data become available worldwide, incidence rate and cumulative incidence figures are lacking, which limits the understanding of the Taenia solium epidemiology. METHODOLOGY/PRINCIPAL FINDINGS:A seroepid...

journal_title：PLoS neglected tropical diseases

authors： Coral-Almeida M,Rodríguez-Hidalgo R,Celi-Erazo M,García HH,Rodríguez S,Devleesschauwer B,Benítez-Ortiz W,Dorny P,Praet N

更新日期：2014-05-22 00:00:00

abstract：BACKGROUND:Dengue virus infection (DVI) among children is a leading cause of hospitalization in endemic areas. Hospitalized patients are at risk of receiving unnecessary antibiotics. METHODS:A retrospective medical review analysis study was conducted to evaluate the prevalence, indication, and choice of antibiotics gi...

journal_title：PLoS neglected tropical diseases

authors： Adrizain R,Setiabudi D,Chairulfatah A

更新日期：2019-06-21 00:00:00