Achievements and challenges of lymphatic filariasis elimination in Sierra Leone.

abstract：BACKGROUND:Efforts to control soil-transmitted helminth (STH) infections have intensified over the past decade. Field-survey data on STH prevalence, infection intensity and drug efficacy is necessary to guide the implementation of control programs and should be of the best possible quality. METHODOLOGY:During four cli...

journal_title：PLoS neglected tropical diseases

authors： Vlaminck J,Cools P,Albonico M,Ame S,Ayana M,Dana D,Keiser J,Matoso LF,Montresor A,Mekonnen Z,Corrêa-Oliveira R,Pinto SA,Sayasone S,Vercruysse J,Levecke B

更新日期：2020-09-21 00:00:00

abstract：BACKGROUND:Skin sores caused by Group A streptococcus (GAS) infection are a major public health problem in remote Aboriginal communities. Skin sores are often associated with scabies, which is evident in scabies intervention programs where a significant reduction of skin sores is seen after focusing solely on scabies c...

journal_title：PLoS neglected tropical diseases

authors： Aung PTZ,Cuningham W,Hwang K,Andrews RM,Carapetis JR,Kearns T,Clucas D,McVernon J,Simpson JA,Tong SYC,Campbell PT

更新日期：2018-07-25 00:00:00

abstract：:Orientia tsutsugamushi (Ots) frequently causes severe scrub typhus infections in the Asia-Pacific region. Korean investigators have demonstrated that Ots encodes five different autotransporter domain (ATD) proteins (ScaA-ScaE). ScaA functions as an adhesin and confers protective immunity in a lethal mouse model of Ots...

journal_title：PLoS neglected tropical diseases

authors： Koralur MC,Ramaiah A,Dasch GA

更新日期：2018-09-20 00:00:00

abstract：:The disease burden of Wuchereria bancrofti and Plasmodium falciparum malaria is high, particularly in Africa, and co-infection is common. However, the effects of filarial infection on the risk of severe malaria are unknown. We used the remaining serum samples from a large cohort study in Muheza, Tanzania to describe v...

journal_title：PLoS neglected tropical diseases

authors： Kwan JL,Seitz AE,Fried M,Lee KL,Metenou S,Morrison R,Kabyemela E,Nutman TB,Prevots DR,Duffy PE

更新日期：2018-03-26 00:00:00

abstract：BACKGROUND:Trachoma is a major cause of blindness in Southern Sudan. Its distribution has only been partially established and many communities in need of intervention have therefore not been identified or targeted. The present study aimed to develop a tool to improve targeting of survey and control activities. METHODS...

journal_title：PLoS neglected tropical diseases

authors： Clements AC,Kur LW,Gatpan G,Ngondi JM,Emerson PM,Lado M,Sabasio A,Kolaczinski JH

更新日期：2010-08-17 00:00:00

abstract：BACKGROUND:Canine rabies causes many thousands of human deaths every year in Africa, and continues to increase throughout much of the continent. METHODOLOGY/PRINCIPAL FINDINGS:This paper identifies four common reasons given for the lack of effective canine rabies control in Africa: (a) a low priority given for disease...

journal_title：PLoS neglected tropical diseases

authors： Lembo T,Hampson K,Kaare MT,Ernest E,Knobel D,Kazwala RR,Haydon DT,Cleaveland S

更新日期：2010-02-23 00:00:00

abstract：BACKGROUND:In 2005, there were outbreaks of febrile polyarthritis due to Chikungunya virus (CHIKV) in the Comoros Islands. CHIKV then spread to other islands in the Indian Ocean: La Réunion, Mauritius, Seychelles and Madagascar. These outbreaks revealed the lack of surveillance and preparedness of Madagascar and other ...

journal_title：PLoS neglected tropical diseases

authors： Andriamandimby SF,Heraud JM,Randrianasolo L,Rafisandratantsoa JT,Andriamamonjy S,Richard V

更新日期：2013-07-25 00:00:00

abstract：:Chagas disease is a significant health problem in Latin America and the available treatments have significant issues in terms of toxicity and efficacy. There is thus an urgent need to develop new treatments either via a repurposing strategy or through the development of new chemical entities. A key first step is the i...

journal_title：PLoS neglected tropical diseases

authors： De Rycker M,Thomas J,Riley J,Brough SJ,Miles TJ,Gray DW

更新日期：2016-04-15 00:00:00

abstract：BACKGROUND:Malaysia experienced an unprecedented dengue outbreak from the year 2014 to 2016 that resulted in an enormous increase in the number of cases and mortality as compared to previous years. The causes that attribute to a dengue outbreak can be multifactorial. Viral factors, such as dengue serotype and genotype,...

journal_title：PLoS neglected tropical diseases

authors： Suppiah J,Ching SM,Amin-Nordin S,Mat-Nor LA,Ahmad-Najimudin NA,Low GK,Abdul-Wahid MZ,Thayan R,Chee HY

更新日期：2018-09-18 00:00:00

abstract：:In mammals subverted as hosts by protozoan parasites, the latter and/or the agonists they release are detected and processed by sensors displayed by many distinct immune cell lineages, in a tissue(s)-dependent context. Focusing on the T lymphocyte lineage, we review our present understanding on its transient or durabl...

journal_title：PLoS neglected tropical diseases

authors： Rodrigues V,Cordeiro-da-Silva A,Laforge M,Ouaissi A,Akharid K,Silvestre R,Estaquier J

更新日期：2014-02-13 00:00:00

abstract：BACKGROUND:Mass drug administration (MDA) using praziquantel is the WHO-recommended approach for control of schistosomiasis. However, few studies have compared the impact of different schedules of MDA on the resultant infection levels. We wished to evaluate whether annual MDA was more effective than less frequent treat...

journal_title：PLoS neglected tropical diseases

authors： Karanja DMS,Awino EK,Wiegand RE,Okoth E,Abudho BO,Mwinzi PNM,Montgomery SP,Secor WE

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:Cholera remains an important public health problem in major cities in Bangladesh, especially in slum areas. In response to growing interest among local policymakers to control this disease, this study estimated the impact and cost-effectiveness of preventive cholera vaccination over a ten-year period in a hi...

journal_title：PLoS neglected tropical diseases

authors： Khan AI,Levin A,Chao DL,DeRoeck D,Dimitrov DT,Khan JAM,Islam MS,Ali M,Islam MT,Sarker AR,Clemens JD,Qadri F

更新日期：2018-10-09 00:00:00

abstract：BACKGROUND:The neglected tropical disease Buruli ulcer (BU) caused by Mycobacterium ulcerans is an infection of the subcutaneous tissue leading to chronic ulcerative skin lesions. Histopathological features are progressive tissue necrosis, extracellular clusters of acid fast bacilli (AFB) and poor inflammatory response...

journal_title：PLoS neglected tropical diseases

authors： Ruf MT,Chauty A,Adeye A,Ardant MF,Koussemou H,Johnson RC,Pluschke G

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) has recently emerged in the field of entomology as a promising method for the identification of arthropods and the detection of associated pathogens. METHODOLOGY/PRINCIPAL FINDINGS:An experimental model of Ctenocepha...

journal_title：PLoS neglected tropical diseases

authors： El Hamzaoui B,Laroche M,Almeras L,Bérenger JM,Raoult D,Parola P

更新日期：2018-02-16 00:00:00

abstract：BACKGROUND:Epidemiological studies carried out using culture or microscopy in most of the amoebiasis endemic developing countries, yielded confusing results since none of these could differentiate the pathogenic Entamoeba histolytica from the non-pathogenic Entamoeba dispar and Entamoeba moshkovskii. The Northeastern p...

journal_title：PLoS neglected tropical diseases

authors： Nath J,Ghosh SK,Singha B,Paul J

更新日期：2015-12-03 00:00:00

abstract：:The increasing burden of dengue, and the relative failure of traditional vector control programs highlight the need to develop new control methods. SIT using self-limiting genetic technology is one such promising method. A self-limiting strain of Aedes aegypti, OX513A, has already reached the stage of field evaluation...

journal_title：PLoS neglected tropical diseases

authors： Carvalho DO,McKemey AR,Garziera L,Lacroix R,Donnelly CA,Alphey L,Malavasi A,Capurro ML

更新日期：2015-07-02 00:00:00

abstract：BACKGROUND:Buruli ulcer (BU) is a subcutaneous skin disease listed among the neglected tropical diseases by the World Health Organization (WHO). Early case detection and management is very important to reduce morbidity and the accompanied characteristic disfiguring nature of BU. Since diagnosis based on clinical eviden...

journal_title：PLoS neglected tropical diseases

authors： Sakyi SA,Aboagye SY,Otchere ID,Liao AM,Caltagirone TG,Yeboah-Manu D

更新日期：2016-10-24 00:00:00

abstract：:The main consequence of oxidative stress is the formation of DNA lesions, which can result in genomic instability and lead to cell death. Guanine is the base that is most susceptible to oxidation, due to its low redox potential, and 8-oxoguanine (8-oxoG) is the most common lesion. These characteristics make 8-oxoG a g...

journal_title：PLoS neglected tropical diseases

authors： Aguiar PH,Furtado C,Repolês BM,Ribeiro GA,Mendes IC,Peloso EF,Gadelha FR,Macedo AM,Franco GR,Pena SD,Teixeira SM,Vieira LQ,Guarneri AA,Andrade LO,Machado CR

更新日期：2013-06-13 00:00:00

abstract：BACKGROUND:Anti-leishmanial drug regimens that include a single dose AmBisome could be suitable for eastern African patients with symptomatic visceral leishmaniasis (VL) but the appropriate single dose is unknown. METHODOLOGY:A multi-centre, open-label, non-inferiority, randomized controlled trial with an adaptive des...

journal_title：PLoS neglected tropical diseases

authors： Khalil EA,Weldegebreal T,Younis BM,Omollo R,Musa AM,Hailu W,Abuzaid AA,Dorlo TP,Hurissa Z,Yifru S,Haleke W,Smith PG,Ellis S,Balasegaram M,EL-Hassan AM,Schoone GJ,Wasunna M,Kimutai R,Edwards T,Hailu A

更新日期：2014-01-16 00:00:00

abstract：BACKGROUND:The search for novel chemical entities targeting essential and parasite-specific pathways is considered a priority for neglected diseases such as trypanosomiasis and leishmaniasis. The thiol-dependent redox metabolism of trypanosomatids relies on bis-glutathionylspermidine [trypanothione, T(SH)2], a low mole...

journal_title：PLoS neglected tropical diseases

authors： Benítez D,Medeiros A,Fiestas L,Panozzo-Zenere EA,Maiwald F,Prousis KC,Roussaki M,Calogeropoulou T,Detsi A,Jaeger T,Šarlauskas J,Peterlin Mašič L,Kunick C,Labadie GR,Flohé L,Comini MA

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:The long-term treatment outcome of visceral leishmaniasis (VL) patients with HIV co-infection is complicated by a high rate of relapse, especially when the CD4 count is low. Although use of secondary prophylaxis is recommended, it is not routinely practiced and data on its effectiveness and safety are limite...

journal_title：PLoS neglected tropical diseases

authors： Diro E,Edwards T,Ritmeijer K,Fikre H,Abongomera C,Kibret A,Bardonneau C,Soipei P,Mutinda B,Omollo R,van Griensven J,Zijlstra EE,Wasunna M,Alves F,Alvar J,Hailu A,Alexander N,Blesson S

更新日期：2019-02-21 00:00:00

abstract：BACKGROUND:Lymphatic filariasis (LF) is targeted for elimination by the year 2020. As of 2017, 67 of the 72 endemic countries have implemented annual Mass Drug Administration (MDA) for interrupting LF transmission. Transmission Assessment Survey (TAS) is the recommended protocol to evaluate the impact of MDA and to dec...

journal_title：PLoS neglected tropical diseases

authors： Subramanian S,Jambulingam P,Krishnamoorthy K,Sivagnaname N,Sadanandane C,Vasuki V,Palaniswamy C,Vijayakumar B,Srividya A,Raju HKK

更新日期：2020-01-24 00:00:00

abstract：:Approximately 300,000 persons in the United States (US) are infected with Trypanosoma cruzi, the protozoan that causes Chagas disease, but less than 1% are estimated to have received antiparasitic treatment. Benznidazole was approved by the US Food and Drug Administration (FDA) for treatment of T. cruzi infection in 2...

journal_title：PLoS neglected tropical diseases

authors： Yoshioka K,Manne-Goehler J,Maguire JH,Reich MR

更新日期：2020-06-22 00:00:00

abstract：BACKGROUND:Socioeconomically deprived children are at increased risk of ill-health associated with sedentary behavior, malnutrition, and helminth infection. The resulting reduced physical fitness, growth retardation, and impaired cognitive abilities may impede children's capacity to pay attention. The present study exa...

journal_title：PLoS neglected tropical diseases

authors： Gall S,Müller I,Walter C,Seelig H,Steenkamp L,Pühse U,du Randt R,Smith D,Adams L,Nqweniso S,Yap P,Ludyga S,Steinmann P,Utzinger J,Gerber M

更新日期：2017-05-08 00:00:00

abstract：BACKGROUND:Talaromyces marneffei is an opportunistic dimorphic fungus prevalent in Southeast Asia. We previously demonstrated that Mp1p is an immunogenic surface and secretory mannoprotein of T. marneffei. Since Mp1p is a surface protein that can generate protective immunity, we hypothesized that Mp1p and/or its homolo...

journal_title：PLoS neglected tropical diseases

authors： Woo PC,Lau SK,Lau CC,Tung ET,Chong KT,Yang F,Zhang H,Lo RK,Cai JP,Au-Yeung RK,Ng WF,Tse H,Wong SS,Xu S,Lam WH,Tse MK,Sze KH,Kao RY,Reiner NE,Hao Q,Yuen KY

更新日期：2016-08-25 00:00:00

abstract：:Buruli ulcer (BU) is a subcutaneous necrotic infection of the skin caused by Mycobacterium ulcerans. It is the third most common human mycobacterial disease after tuberculosis (TB) and leprosy. The available methods for detection of the bacilli in lesions are microscopic detection, isolation and cultivation of the bac...

journal_title：PLoS neglected tropical diseases

authors： Avumegah MS,Waidyatillake NT,Michalski WP,O'Brien DP,Nelson TM,Athan E

更新日期：2020-04-06 00:00:00

abstract：:Rhinoscleroma is a chronic granulomatous infection of the upper airways caused by the bacterium Klebsiella pneumoniae subsp. rhinoscleromatis. The disease is endemic in tropical and subtropical areas, but its diagnosis remains difficult. As a consequence, and despite available antibiotherapy, some patients evolve adva...

journal_title：PLoS neglected tropical diseases

authors： Fevre C,Passet V,Deletoile A,Barbe V,Frangeul L,Almeida AS,Sansonetti P,Tournebize R,Brisse S

更新日期：2011-05-01 00:00:00

abstract：:Human head lice are blood-sucking insects causing an infestation in humans called pediculosis capitis. The infestation is more prevalent in the school-aged population. Scalp itching, a common presenting symptom, results in scratching and sleep disturbance. The condition can lead to social stigmatization which can lead...

journal_title：PLoS neglected tropical diseases

authors： Brownell N,Sunantaraporn S,Phadungsaksawasdi K,Seatamanoch N,Kongdachalert S,Phumee A,Siriyasatien P

更新日期：2020-12-16 00:00:00

abstract：BACKGROUND:Until 2008, human rabies had never been reported in French Guiana. On 28 May 2008, the French National Reference Center for Rabies (Institut Pasteur, Paris) confirmed the rabies diagnosis, based on hemi-nested polymerase chain reaction on skin biopsy and saliva specimens from a Guianan, who had never travell...

journal_title：PLoS neglected tropical diseases

authors： Meynard JB,Flamand C,Dupuy C,Mahamat A,Eltges F,Queuche F,Renner J,Fontanella JM,Hommel D,Dussart P,Grangier C,Djossou F,Dacheux L,Goudal M,Berger F,Ardillon V,Krieger N,Bourhy H,Spiegel A

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Trachoma, caused by Chlamydia trachomatis (Ct), is the leading infectious cause of blindness. Sequence-based analysis of the multiple strains typically present in endemic communities may be informative for epidemiology, transmission, response to treatment, and understanding the host response. METHODS:Conjun...

journal_title：PLoS neglected tropical diseases

authors： Andreasen AA,Burton MJ,Holland MJ,Polley S,Faal N,Mabey DC,Bailey RL

更新日期：2008-09-24 00:00:00