当前位置： SCI文献检索 > PLoS Neglected Tropical Diseases期刊下所有文献 > First human rabies case in French Guiana, 2008: epidemiological investigation and control.

First human rabies case in French Guiana, 2008: epidemiological investigation and control.

Abstract：

BACKGROUND:Until 2008, human rabies had never been reported in French Guiana. On 28 May 2008, the French National Reference Center for Rabies (Institut Pasteur, Paris) confirmed the rabies diagnosis, based on hemi-nested polymerase chain reaction on skin biopsy and saliva specimens from a Guianan, who had never travelled overseas and died in Cayenne after presenting clinically typical meningoencephalitis. METHODOLOGY/PRINCIPAL FINDINGS:Molecular typing of the virus identified a Lyssavirus (Rabies virus species), closely related to those circulating in hematophagous bats (mainly Desmodus rotundus) in Latin America. A multidisciplinary Crisis Unit was activated. Its objectives were to implement an epidemiological investigation and a veterinary survey, to provide control measures and establish a communications program. The origin of the contamination was not formally established, but was probably linked to a bat bite based on the virus type isolated. After confirming exposure of 90 persons, they were vaccinated against rabies: 42 from the case's entourage and 48 healthcare workers. To handle that emergence and the local population's increased demand to be vaccinated, a specific communications program was established using several media: television, newspaper, radio. CONCLUSION/SIGNIFICANCE:This episode, occurring in the context of a Department far from continental France, strongly affected the local population, healthcare workers and authorities, and the management team faced intense pressure. This observation confirms that the risk of contracting rabies in French Guiana is real, with consequences for population educational program, control measures, medical diagnosis and post-exposure prophylaxis.

journal_name

PLoS Negl Trop Dis

journal_title

PLoS neglected tropical diseases

authors

Meynard JB,Flamand C,Dupuy C,Mahamat A,Eltges F,Queuche F,Renner J,Fontanella JM,Hommel D,Dussart P,Grangier C,Djossou F,Dacheux L,Goudal M,Berger F,Ardillon V,Krieger N,Bourhy H,Spiegel A

doi

10.1371/journal.pntd.0001537

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

e1537

issue

eissn

1935-2727

issn

1935-2735

pii

PNTD-D-11-00735

journal_volume

pub_type

杂志文章

在线工具

First human rabies case in French Guiana, 2008: epidemiological investigation and control.