Correction: Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model.

abstract：BACKGROUND:Chlamydia trachomatis is the etiological agent of trachoma the world's leading cause of infectious blindness. Here, we investigate whether protracted clearance of a primary infection in nonhuman primates is attributable to antigenic variation or related to the maturation of the anti-chlamydial humoral immune...

journal_title：PLoS neglected tropical diseases

authors： Kari L,Bakios LE,Goheen MM,Bess LN,Watkins HS,Southern TR,Song L,Whitmire WM,Olivares-Zavaleta N,Caldwell HD

更新日期：2013-05-30 00:00:00

abstract：BACKGROUND:Diagnosis of Trypanosoma cruzi infection by direct pathogen detection is complicated by the low parasite burden in subjects persistently infected with this agent of human Chagas disease. Determination of infection status by serological analysis has also been faulty, largely due to the lack of well-characteri...

journal_title：PLoS neglected tropical diseases

authors： Cooley G,Etheridge RD,Boehlke C,Bundy B,Weatherly DB,Minning T,Haney M,Postan M,Laucella S,Tarleton RL

更新日期：2008-10-08 00:00:00

abstract：:Insecticide resistance poses a significant threat to the control of arthropods that transmit disease agents. Nanoparticle carriers offer exciting opportunities to expand the armamentarium of insecticides available for public health and other pests. Most chemical insecticides are delivered by contact or feeding, and fr...

journal_title：PLoS neglected tropical diseases

authors： Norris EJ,Mullis AS,Phanse Y,Narasimhan B,Coats JR,Bartholomay LC

更新日期：2020-09-08 00:00:00

abstract：BACKGROUND:Taenia solium cysticercosis/taeniosis is emerging as a serious public health and economic problem in many developing countries. This study was conducted to determine prevalence and risk factors of human T. solium infections in Mbeya Region, Tanzania. METHODS AND FINDINGS:A cross-sectional survey was conduct...

journal_title：PLoS neglected tropical diseases

authors： Mwanjali G,Kihamia C,Kakoko DV,Lekule F,Ngowi H,Johansen MV,Thamsborg SM,Willingham AL 3rd

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Rodents are major reservoirs of pathogens responsible for numerous zoonotic diseases in humans and livestock. Assessing their microbial diversity at both the individual and population level is crucial for monitoring endemic infections and revealing microbial association patterns within reservoirs. Recently, ...

journal_title：PLoS neglected tropical diseases

authors： Razzauti M,Galan M,Bernard M,Maman S,Klopp C,Charbonnel N,Vayssier-Taussat M,Eloit M,Cosson JF

更新日期：2015-08-18 00:00:00

abstract：:Schistosomiasis is a parasitic disease and its distribution, in space and time, can be influenced by environmental factors such as rivers, elevation, slope, land surface temperature, land use/cover and rainfall. The aim of this study is to identify the areas with suitable conditions for schistosomiasis transmission on...

journal_title：PLoS neglected tropical diseases

authors： Ajakaye OG,Adedeji OI,Ajayi PO

更新日期：2017-07-12 00:00:00

abstract：BACKGROUND:The treatment of Leishmaniasis caused by Leishmania (Viannia) guyanensis is based on a weak strength of evidence from very few clinical trials and some case series reports. Current treatment guidelines recommend pentamidine isethionate or meglumine antimoniate (Glucantime) as the first-line choices. Both are...

journal_title：PLoS neglected tropical diseases

authors： Francesconi VA,Francesconi F,Ramasawmy R,Romero GAS,Alecrim MDGC

更新日期：2018-02-26 00:00:00

abstract：:We recently reported the medicinal chemistry re-optimization of a series of compounds derived from the human tyrosine kinase inhibitor, lapatinib, for activity against Plasmodium falciparum. From this same library of compounds, we now report potent compounds against Trypanosoma brucei brucei (which causes human Africa...

journal_title：PLoS neglected tropical diseases

authors： Ferrins L,Sharma A,Thomas SM,Mehta N,Erath J,Tanghe S,Leed SE,Rodriguez A,Mensa-Wilmot K,Sciotti RJ,Gillingwater K,Pollastri MP

更新日期：2018-11-26 00:00:00

abstract：BACKGROUND:Even though human hookworm infection is highly endemic in many countries throughout the world, its global economic and health impact is not well known. Without a better understanding of hookworm's economic burden worldwide, it is difficult for decision makers such as funders, policy makers, disease control o...

journal_title：PLoS neglected tropical diseases

authors： Bartsch SM,Hotez PJ,Asti L,Zapf KM,Bottazzi ME,Diemert DJ,Lee BY

更新日期：2016-09-08 00:00:00

abstract：:The application of the organophosphate larvicide temephos to water storage containers is one of the most commonly employed dengue vector control methods. This systematic literature review is to the knowledge of the authors the first that aims to assess the community-effectiveness of temephos in controlling both vector...

journal_title：PLoS neglected tropical diseases

authors： George L,Lenhart A,Toledo J,Lazaro A,Han WW,Velayudhan R,Runge Ranzinger S,Horstick O

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:Rift Valley fever virus (RVFV) causes outbreaks of severe disease in livestock and humans throughout Africa and the Arabian Peninsula. In people, RVFV generally causes a self-limiting febrile illness but in a subset of individuals, it progresses to more serious disease. One manifestation is a delayed-onset e...

journal_title：PLoS neglected tropical diseases

authors： Dodd KA,McElroy AK,Jones TL,Zaki SR,Nichol ST,Spiropoulou CF

更新日期：2014-06-12 00:00:00

abstract：:Diarrheal diseases are a major cause of morbidity and mortality worldwide. In many cases, antibiotic therapy is either ineffective or not recommended due to concerns about emergence of resistance. The pathogenesis of several of the most prevalent infections, including cholera and enteroxigenic Escherichia coli, is dom...

journal_title：PLoS neglected tropical diseases

authors： Das S,Angsantikul P,Le C,Bao D,Miyamoto Y,Gao W,Zhang L,Eckmann L

更新日期：2018-02-22 00:00:00

abstract：BACKGROUND:Central nervous system (CNS) infections are important diseases in both children and adults worldwide. The spectrum of infections is broad, encompassing bacterial/aseptic meningitis and encephalitis. Viruses are regarded as the most common causes of encephalitis and aseptic meningitis. Better understanding of...

journal_title：PLoS neglected tropical diseases

authors： Tan le V,Thai le H,Phu NH,Nghia HD,Chuong LV,Sinh DX,Phong ND,Mai NT,Man DN,Hien VM,Vinh NT,Day J,Chau NV,Hien TT,Farrar J,de Jong MD,Thwaites G,van Doorn HR,Chau TT

更新日期：2014-08-28 00:00:00

abstract：BACKGROUND:Acute encephalitis is an important and severe disease in children in Vietnam. However, little is known about the etiology while such knowledge is essential for optimal prevention and treatment. To identify viral causes of encephalitis, in 2004 we conducted a one-year descriptive study at Children's Hospital ...

journal_title：PLoS neglected tropical diseases

authors： Le VT,Phan TQ,Do QH,Nguyen BH,Lam QB,Bach V,Truong H,Tran TH,Nguyen V,Tran T,Vo M,Tran VT,Schultsz C,Farrar J,van Doorn HR,de Jong MD

更新日期：2010-10-26 00:00:00

abstract：:Dengue appears to be endemic in Africa with a number of reported outbreaks. In February 2013, several individuals with dengue-like illnesses and negative malaria blood smears were identified in Mombasa, Kenya. Dengue was laboratory confirmed and an investigation was conducted to estimate the magnitude of local transmi...

journal_title：PLoS neglected tropical diseases

authors： Ellis EM,Neatherlin JC,Delorey M,Ochieng M,Mohamed AH,Mogeni DO,Hunsperger E,Patta S,Gikunju S,Waiboic L,Fields B,Ofula V,Konongoi SL,Torres-Velasquez B,Marano N,Sang R,Margolis HS,Montgomery JM,Tomashek KM

更新日期：2015-04-29 00:00:00

abstract：BACKGROUND:In endemic areas, leptospirosis is more common and more severe in adults compared with children. Reasons to explain this discrepancy remain unclear and limited data focusing on adolescents are available. The objective of the study was to describe disease spectrum and outcome differences in children and adole...

journal_title：PLoS neglected tropical diseases

authors： Guerrier G,Hie P,Gourinat AC,Huguon E,Polfrit Y,Goarant C,D'Ortenzio E,Missotte I

更新日期：2013-09-26 00:00:00

abstract：BACKGROUND:Dengue infection is endemic in many regions throughout the world. While insecticide fogging targeting the vector mosquito Aedes aegypti is a major control measure against dengue epidemics, the impact of this method remains controversial. A previous mathematical simulation study indicated that insecticide fog...

journal_title：PLoS neglected tropical diseases

authors： Oki M,Sunahara T,Hashizume M,Yamamoto T

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Transmission of Yersinia pestis by flea bite can occur by two mechanisms. After taking a blood meal from a bacteremic mammal, fleas have the potential to transmit the very next time they feed. This early-phase transmission resembles mechanical transmission in some respects, but the mechanism is unknown. Ther...

journal_title：PLoS neglected tropical diseases

authors： Hinnebusch BJ,Bland DM,Bosio CF,Jarrett CO

更新日期：2017-01-12 00:00:00

abstract：:For scientists working on gonochoric organisms, determining sex can be crucial for many biological questions and experimental studies, such as crossbreeding, but it can also be a challenging task, particularly when no sexual dimorphism is visible or cannot be directly observed. In metazoan parasites of the genus Schis...

journal_title：PLoS neglected tropical diseases

authors： Kincaid-Smith J,Boissier J,Allienne JF,Oleaga A,Djuikwo-Teukeng F,Toulza E

更新日期：2016-11-18 00:00:00

abstract：:Soil-transmitted helminths (STH) are endemic and widespread across Sub-Saharan Africa. A community wide soil-transmitted helminth (STH) prevalence survey was performed on the island of Bubaque in Guinea-Bissau using both Kato-katz microscopy and qPCR methodology. Predictors of infection and morbidity indicators were i...

journal_title：PLoS neglected tropical diseases

authors： Farrant O,Marlais T,Houghton J,Goncalves A,Teixeira da Silva Cassama E,Cabral MG,Nakutum J,Manjuba C,Rodrigues A,Mabey D,Bailey R,Last A

更新日期：2020-12-16 00:00:00

abstract：BACKGROUND:To be transmitted to vertebrate hosts via the saliva of their vectors, arthropod-borne viruses have to cross several barriers in the mosquito body, including the midgut infection and escape barriers. Yellow fever virus (YFV) belongs to the genus Flavivirus, which includes human viruses transmitted by Aedes m...

journal_title：PLoS neglected tropical diseases

authors： Danet L,Beauclair G,Berthet M,Moratorio G,Gracias S,Tangy F,Choumet V,Jouvenet N

更新日期：2019-08-14 00:00:00

abstract：BACKGROUND:A better understanding of reproductive processes in parasitic nematodes may lead to development of new anthelmintics and control strategies for combating disabling and disfiguring neglected tropical diseases such as lymphatic filariasis and onchocerciasis. Transcriptomatic analysis has provided important new...

journal_title：PLoS neglected tropical diseases

authors： Li BW,Rush AC,Jiang DJ,Mitreva M,Abubucker S,Weil GJ

更新日期：2011-01-25 00:00:00

abstract：BACKGROUND:Dog rabies annually causes 24,000-70,000 deaths globally. We built a spreadsheet tool, RabiesEcon, to aid public health officials to estimate the cost-effectiveness of dog rabies vaccination programs in East Africa. METHODS:RabiesEcon uses a mathematical model of dog-dog and dog-human rabies transmission to...

journal_title：PLoS neglected tropical diseases

authors： Borse RH,Atkins CY,Gambhir M,Undurraga EA,Blanton JD,Kahn EB,Dyer JL,Rupprecht CE,Meltzer MI

更新日期：2018-05-23 00:00:00

abstract：BACKGROUND:Standard diagnosis of human soil-transmitted helminth (STH) infections is based on the microscopic detection of helminth eggs in stool and supports programmatic decision making in control programs. However, the current standard diagnostic techniques still show a number of limitations. Recently, the FECPAKG2 ...

journal_title：PLoS neglected tropical diseases

authors： Ayana M,Vlaminck J,Cools P,Ame S,Albonico M,Dana D,Keiser J,Manly H,Matoso LF,Mekonnen Z,Montresor A,Correa-Oliveira R,Rinaldi L,Sayasone S,Sowersby SJ,Tesfaye L,Vercruysse J,Mirams G,Levecke B

更新日期：2018-10-15 00:00:00

abstract：BACKGROUND:Praziquantel remains the drug of choice for the worldwide treatment and control of schistosomiasis. The drug is synthesized and administered as a racemate. Use of the pure active enantiomer would be desirable since the inactive enantiomer is associated with side effects and is responsible for the extremely b...

journal_title：PLoS neglected tropical diseases

authors： Woelfle M,Seerden JP,de Gooijer J,Pouwer K,Olliaro P,Todd MH

更新日期：2011-09-01 00:00:00

abstract：:Schistosomiasis is an important neglected tropical disease caused by digenean helminth parasites of the genus Schistosoma. Schistosomes are unusual in that they are dioecious and the adult worms live in the blood system. MicroRNAs play crucial roles during gene regulation and are likely to be important in sex differen...

journal_title：PLoS neglected tropical diseases

authors： Marco A,Kozomara A,Hui JH,Emery AM,Rollinson D,Griffiths-Jones S,Ronshaugen M

更新日期：2013-09-12 00:00:00

abstract：BACKGROUND:Trypanosomiasis induces a remarkable myenteric neuronal degeneration leading to megacolon. Very little is known about the risk for colon cancer in chagasic megacolon patients. To clarify whether chagasic megacolon impacts on colon carcinogenesis, we investigated the risk for colon cancer in Trypanosoma cruzi...

journal_title：PLoS neglected tropical diseases

authors： Kannen V,de Oliveira EC,Motta BZ,Chaguri AJ,Brunaldi MO,Garcia SB

更新日期：2015-04-17 00:00:00

abstract：BACKGROUND:Aedes control interventions are considered the cornerstone of dengue control programmes, but there is scarce evidence on their effect on disease. We set-up a cluster randomized controlled trial in Santiago de Cuba to evaluate the entomological and epidemiological effectiveness of periodical intra- and peri-d...

journal_title：PLoS neglected tropical diseases

authors： Toledo ME,Vanlerberghe V,Rosales JP,Mirabal M,Cabrera P,Fonseca V,Gómez Padrón T,Pérez Menzies M,Montada D,Van der Stuyft P

更新日期：2017-11-08 00:00:00

abstract：BACKGROUND:Leishmaniasis is a serious multifactorial parasitic disease with limited treatment options. Current chemotherapy is mainly consisted of drugs with serious drawbacks such as toxicity, variable efficacy and resistance. Alternative bioactive phytocompounds may provide a promising source for discovering new anti...

journal_title：PLoS neglected tropical diseases

authors： Karampetsou K,Koutsoni OS,Gogou G,Angelis A,Skaltsounis LA,Dotsika E

更新日期：2021-01-11 00:00:00

abstract：:Mosquito-borne diseases continue to remain major threats to human and animal health and impediments to socioeconomic development. Increasing mosquito resistance to chemical insecticides is a great public health concern, and new strategies/technologies are necessary to develop the next-generation of vector control tool...

journal_title：PLoS neglected tropical diseases

authors： Phanse Y,Dunphy BM,Perry JL,Airs PM,Paquette CC,Carlson JO,Xu J,Luft JC,DeSimone JM,Beaty BJ,Bartholomay LC

更新日期：2015-05-21 00:00:00