Prevalence and risk factors associated with human Taenia solium infections in Mbozi District, Mbeya Region, Tanzania.

abstract：BACKGROUND:The Norway rat (Rattus norvegicus) is the principal reservoir for leptospirosis in many urban settings. Few studies have identified markers for rat infestation in slum environments while none have evaluated the association between household rat infestation and Leptospira infection in humans or the use of inf...

journal_title：PLoS neglected tropical diseases

authors： Costa F,Ribeiro GS,Felzemburgh RD,Santos N,Reis RB,Santos AC,Fraga DB,Araujo WN,Santana C,Childs JE,Reis MG,Ko AI

更新日期：2014-12-04 00:00:00

abstract：INTRODUCTION:Neglected tropical diseases produce an enormous burden on many of the poorest and most disenfranchised populations in sub-Saharan Africa. Similar to other developing areas throughout the world, this region's dearth of skilled health providers renders Western-style primary care efforts to address such disea...

journal_title：PLoS neglected tropical diseases

authors： Corley AG,Thornton CP,Glass NE

更新日期：2016-09-15 00:00:00

abstract：INTRODUCTION:Chikungunya is an emerging public health problem in tropical and subtropical regions, due to ongoing transmission and its incapacitating acute disease phase, and chronic sequelae. The disease is responsible for a major impact on Health Related Quality of Life (HRQoL), which may last several years. To our k...

journal_title：PLoS neglected tropical diseases

authors： Elsinga J,Grobusch MP,Tami A,Gerstenbluth I,Bailey A

更新日期：2017-10-09 00:00:00

abstract：BACKGROUND:Standard diagnosis of human soil-transmitted helminth (STH) infections is based on the microscopic detection of helminth eggs in stool and supports programmatic decision making in control programs. However, the current standard diagnostic techniques still show a number of limitations. Recently, the FECPAKG2 ...

journal_title：PLoS neglected tropical diseases

authors： Ayana M,Vlaminck J,Cools P,Ame S,Albonico M,Dana D,Keiser J,Manly H,Matoso LF,Mekonnen Z,Montresor A,Correa-Oliveira R,Rinaldi L,Sayasone S,Sowersby SJ,Tesfaye L,Vercruysse J,Mirams G,Levecke B

更新日期：2018-10-15 00:00:00

abstract：BACKGROUND:Zika virus (ZIKV) is a mosquito-borne flavivirus distributed throughout much of Africa and Asia. Infection with the virus may cause acute febrile illness that clinically resembles dengue fever. A recent study indicated the existence of three geographically distinct viral lineages; however this analysis utili...

journal_title：PLoS neglected tropical diseases

authors： Haddow AD,Schuh AJ,Yasuda CY,Kasper MR,Heang V,Huy R,Guzman H,Tesh RB,Weaver SC

更新日期：2012-01-01 00:00:00

abstract：:Zika virus (ZIKV) has emerged since 2013 as a significant global human health threat following outbreaks in the Pacific Islands and rapid spread throughout South and Central America. Severe congenital and neurological sequelae have been linked to ZIKV infections. Assessing the ability of common mosquito species to tra...

journal_title：PLoS neglected tropical diseases

authors： Main BJ,Nicholson J,Winokur OC,Steiner C,Riemersma KK,Stuart J,Takeshita R,Krasnec M,Barker CM,Coffey LL

更新日期：2018-06-21 00:00:00

abstract：BACKGROUND:Soil-transmitted helminth (STH) infections are among the most prevalent neglected tropical diseases (NTD) worldwide. Since the publication of the WHO road map to combat NTD in 2012, there has been a renewed commitment to control STH. In this study, we analysed the geographical distribution and effect of comm...

journal_title：PLoS neglected tropical diseases

authors： Silver ZA,Kaliappan SP,Samuel P,Venugopal S,Kang G,Sarkar R,Ajjampur SSR

更新日期：2018-01-18 00:00:00

abstract：:In French Guiana, cutaneous leishmaniasis is highly endemic, whereas no autochthonous case of visceral leishmaniasis have been reported so far. However, due to its proximity to Brazil which is highly endemic for visceral leishmaniasis, and the high transboundary population flow, an epidemiological challenge could aris...

journal_title：PLoS neglected tropical diseases

authors： Medkour H,Davoust B,Dulieu F,Maurizi L,Lamour T,Marié JL,Mediannikov O

更新日期：2019-06-19 00:00:00

abstract：BACKGROUND:Human cysticercosis is a zoonotic disease causing severe health disorders and even death. While prevalence data become available worldwide, incidence rate and cumulative incidence figures are lacking, which limits the understanding of the Taenia solium epidemiology. METHODOLOGY/PRINCIPAL FINDINGS:A seroepid...

journal_title：PLoS neglected tropical diseases

authors： Coral-Almeida M,Rodríguez-Hidalgo R,Celi-Erazo M,García HH,Rodríguez S,Devleesschauwer B,Benítez-Ortiz W,Dorny P,Praet N

更新日期：2014-05-22 00:00:00

abstract：:Trypanosomes rely on post-transcriptional mechanisms and mRNA-binding proteins for control of gene expression. Trypanosoma brucei ZC3H30 is an mRNA-binding protein that is expressed in both the bloodstream form (which grows in mammals) and the procyclic form (which grows in the tsetse fly midgut). Attachment of ZC3H30...

journal_title：PLoS neglected tropical diseases

authors： Chakraborty C,Clayton C

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Socioeconomically deprived children are at increased risk of ill-health associated with sedentary behavior, malnutrition, and helminth infection. The resulting reduced physical fitness, growth retardation, and impaired cognitive abilities may impede children's capacity to pay attention. The present study exa...

journal_title：PLoS neglected tropical diseases

authors： Gall S,Müller I,Walter C,Seelig H,Steenkamp L,Pühse U,du Randt R,Smith D,Adams L,Nqweniso S,Yap P,Ludyga S,Steinmann P,Utzinger J,Gerber M

更新日期：2017-05-08 00:00:00

abstract：BACKGROUND:Schistosomiasis japonica is a zoonotic parasitic disease and oral vaccine delivery system would be benefit for prevention of this disease. Although attenuated salmonella has been used as an antigen expression vector for oral vaccine development, the membrane-bound vacuoles in which bacteria reside hinders th...

journal_title：PLoS neglected tropical diseases

authors： Chen G,Dai Y,Chen J,Wang X,Tang B,Zhu Y,Hua Z

更新日期：2011-09-01 00:00:00

abstract：:Q fever is a widespread zoonosis that is caused by Coxiella burnetii (C. burnetii), and ruminants are identified as the main sources of human infections. Some human cases have been described, but very limited information was available about Q fever in ruminants on Reunion Island, a tropical island in the Indian Ocean....

journal_title：PLoS neglected tropical diseases

authors： Cardinale E,Esnault O,Beral M,Naze F,Michault A

更新日期：2014-08-07 00:00:00

abstract：BACKGROUND:The objectives of this study were to 1) evaluate the influence of treatment with praziquantel on the inflammatory milieu in maternal, placental, and cord blood, 2) assess the extent to which proinflammatory signatures in placental and cord blood impacts birth outcomes, and 3) evaluate the impact of other hel...

journal_title：PLoS neglected tropical diseases

authors： Abioye AI,McDonald EA,Park S,Joshi A,Kurtis JD,Wu H,Pond-Tor S,Sharma S,Ernerudh J,Baltazar P,Acosta LP,Olveda RM,Tallo V,Friedman JF

更新日期：2019-06-12 00:00:00

abstract：BACKGROUND:The global burden of cholera is largely unknown because the majority of cases are not reported. The low reporting can be attributed to limited capacity of epidemiological surveillance and laboratories, as well as social, political, and economic disincentives for reporting. We previously estimated 2.8 million...

journal_title：PLoS neglected tropical diseases

authors： Ali M,Nelson AR,Lopez AL,Sack DA

更新日期：2015-06-04 00:00:00

abstract：BACKGROUND:Mapping of lymphatic filariasis (LF) caused by Wuchereria bancrofti largely relies on the detection of circulating antigen using ICT cards. Several studies have recently shown that this test can be cross-reactive with sera of subjects heavily infected with Loa loa and thus mapping results in loiasis endemic ...

journal_title：PLoS neglected tropical diseases

authors： Wanji S,Esum ME,Njouendou AJ,Mbeng AA,Chounna Ndongmo PW,Abong RA,Fru J,Fombad FF,Nchanji GT,Ngongeh G,Ngandjui NV,Enyong PI,Storey H,Curtis KC,Fischer K,Fauver JR,Lew D,Goss CW,Fischer PU

更新日期：2019-03-08 00:00:00

abstract：OBJECTIVE:The aim of the study is to examine the spatiotemporal pattern of Japanese Encephalitis (JE) in mainland China during 2002-2010. Specific objectives of the study were to quantify the temporal variation in incidence of JE cases, to determine if clustering of JE cases exists, to detect high risk spatiotemporal c...

journal_title：PLoS neglected tropical diseases

authors： Wang LY,Zhang WY,Ding F,Hu WB,Soares Magalhaes RJ,Sun HL,Li YX,Zou W,Wang Y,Liu QY,Li SL,Yin WW,Huang LY,Clements AC,Bi P,Li CY

更新日期：2013-06-20 00:00:00

abstract：BACKGROUND:The rapid spread of Zika virus in the Americas and current outbreak of microcephaly in Brazil has raised attention to the possible deleterious effects that the virus may have on fetuses. METHODOLOGY/PRINCIPAL FINDINGS:We report a case of a 20-year-old pregnant woman who was referred to our service after a l...

journal_title：PLoS neglected tropical diseases

authors： Sarno M,Sacramento GA,Khouri R,do Rosário MS,Costa F,Archanjo G,Santos LA,Nery N Jr,Vasilakis N,Ko AI,de Almeida AR

更新日期：2016-02-25 00:00:00

abstract：:Dengue, a vector-borne disease spread by Aedes mosquitoes, is a global threat. In the absence of an efficacious dengue vaccine, vector control is the key intervention tool in Singapore. A good understanding of vector habitats is essential to formulate operational strategies. We examined the distribution, long-term tre...

journal_title：PLoS neglected tropical diseases

authors： Rajarethinam J,Ong J,Neo ZW,Ng LC,Aik J

更新日期：2020-04-20 00:00:00

abstract：BACKGROUND:There is a worldwide upscale in mass drug administration (MDA) programs to control the morbidity caused by soil-transmitted helminths (STHs): Ascaris lumbricoides, Trichuris trichiura and hookworm. Although anthelminthic drugs which are used for MDA are supplied by two pharmaceutical companies through donati...

journal_title：PLoS neglected tropical diseases

authors： Belew S,Getachew M,Suleman S,Mohammed T,Deti H,D'Hondt M,Wynendaele E,Mekonnen Z,Vercruysse J,Duchateau L,De Spiegeleer B,Levecke B

更新日期：2015-09-25 00:00:00

abstract：:Trypanosoma cruzi, the aetiological agent of Chagas disease possess extensive genetic diversity. This has led to the development of a plethora of molecular typing methods for the identification of both the known major genetic lineages and for more fine scale characterization of different multilocus genotypes within th...

journal_title：PLoS neglected tropical diseases

authors： Diosque P,Tomasini N,Lauthier JJ,Messenger LA,Monje Rumi MM,Ragone PG,Alberti-D'Amato AM,Pérez Brandán C,Barnabé C,Tibayrenc M,Lewis MD,Llewellyn MS,Miles MA,Yeo M

更新日期：2014-08-28 00:00:00

abstract：:Orientia tsutsugamushi (Ots) frequently causes severe scrub typhus infections in the Asia-Pacific region. Korean investigators have demonstrated that Ots encodes five different autotransporter domain (ATD) proteins (ScaA-ScaE). ScaA functions as an adhesin and confers protective immunity in a lethal mouse model of Ots...

journal_title：PLoS neglected tropical diseases

authors： Koralur MC,Ramaiah A,Dasch GA

更新日期：2018-09-20 00:00:00

abstract：BACKGROUND:Nifurtimox eflornithine combination therapy (NECT) to treat human African trypanosomiasis (HAT), commonly called sleeping sickness, was added to the World Health Organisation's (WHO) Essential Medicines List in 2009 and to the Paediatric List in 2012. NECT was further tested and documented in a phase IIIb cl...

journal_title：PLoS neglected tropical diseases

authors： Kuemmerle A,Schmid C,Kande V,Mutombo W,Ilunga M,Lumpungu I,Mutanda S,Nganzobo P,Ngolo D,Kisala M,Valverde Mordt O

更新日期：2020-01-27 00:00:00

abstract：:The leptospiral LigA protein consists of 13 bacterial immunoglobulin-like (Big) domains and is the only purified recombinant subunit vaccine that has been demonstrated to protect against lethal challenge by a clinical isolate of Leptospira interrogans in the hamster model of leptospirosis. We determined the minimum nu...

journal_title：PLoS neglected tropical diseases

authors： Coutinho ML,Choy HA,Kelley MM,Matsunaga J,Babbitt JT,Lewis MS,Aleixo JA,Haake DA

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Filarial nematodes currently infect up to 54 million people worldwide, with millions more at risk for infection, representing the leading cause of disability in the developing world. Brugia malayi is one of the causative agents of lymphatic filariasis and remains the only human filarial parasite that can be ...

journal_title：PLoS neglected tropical diseases

authors： Grote A,Voronin D,Ding T,Twaddle A,Unnasch TR,Lustigman S,Ghedin E

更新日期：2017-03-30 00:00:00

abstract：:Dengue continues to be the most important vector-borne viral disease globally and in Brazil, where more than 1.4 million cases and over 500 deaths were reported in 2016. Mosquito control programmes and other interventions have not stopped the alarming trend of increasingly large epidemics in the past few years. Here, ...

journal_title：PLoS neglected tropical diseases

authors： Churakov M,Villabona-Arenas CJ,Kraemer MUG,Salje H,Cauchemez S

更新日期：2019-04-22 00:00:00

abstract：BACKGROUND:Transmission of dengue virus (DENV) from humans to mosquitoes represents a critical component of dengue epidemiology. Examinations of this process have generally been hampered by a lack of methods that adequately represent natural acquisition of DENV by mosquitoes from humans. In this study, we assessed arti...

journal_title：PLoS neglected tropical diseases

authors： Long KC,Sulca J,Bazan I,Astete H,Jaba HL,Siles C,Kocher C,Vilcarromero S,Schwarz J,Escobedo-Vargas KS,Castro-Llanos F,Angulo L,Flores G,Ramal-Asayag C,Halsey ES,Hontz RD,Paz-Soldan VA,Scott TW,Lambrechts L,Morrison

更新日期：2019-02-12 00:00:00

abstract：BACKGROUND:Mosquito-borne viral diseases cause significant burden in much of the developing world. Although host-virus interactions have been studied extensively in the vertebrate host, little is known about mosquito responses to viral infection. In contrast to mosquitoes of the Aedes and Culex genera, Anopheles gambia...

journal_title：PLoS neglected tropical diseases

authors： Waldock J,Olson KE,Christophides GK

更新日期：2012-01-01 00:00:00

abstract：:Enzootic strains of Venezuelan equine encephalitis virus (VEEV) have been isolated from febrile patients in the Peruvian Amazon Basin at low but consistent levels since the early 1990s. Through a clinic-based febrile surveillance program, we detected an outbreak of VEEV infections in Iquitos, Peru, in the first half o...

journal_title：PLoS neglected tropical diseases

authors： Morrison AC,Forshey BM,Notyce D,Astete H,Lopez V,Rocha C,Carrion R,Carey C,Eza D,Montgomery JM,Kochel TJ

更新日期：2008-01-01 00:00:00

abstract：:Despite Nipah virus outbreaks having high mortality rates (>70% in Southeast Asia), there are no licensed drugs against it. In this study, we have considered all 9 Nipah proteins as potential therapeutic targets and computationally identified 4 putative peptide inhibitors (against G, F and M proteins) and 146 small mo...

journal_title：PLoS neglected tropical diseases

authors： Sen N,Kanitkar TR,Roy AA,Soni N,Amritkar K,Supekar S,Nair S,Singh G,Madhusudhan MS

更新日期：2019-12-12 00:00:00