Seroepidemiology of helminths and the association with severe malaria among infants and young children in Tanzania.

abstract：:Global efforts to control morbidity associated with soil-transmitted helminth infections (STH) have focused largely on the targeted treatment of high-risk groups, including children and pregnant women. However, it is not clear when such programs can be discontinued and there are concerns about the sustainability of cu...

journal_title：PLoS neglected tropical diseases

authors： DeWorm3 Trials Team.

更新日期：2020-11-02 00:00:00

abstract：:Rift Valley fever virus is an arbovirus that affects both livestock and humans throughout Africa and in the Middle East. Despite its endemicity throughout Africa, it is a rare event to identify an infected individual during the acute phase of the disease and an even rarer event to collect serial blood samples from the...

journal_title：PLoS neglected tropical diseases

authors： de St Maurice A,Harmon J,Nyakarahuka L,Balinandi S,Tumusiime A,Kyondo J,Mulei S,Namutebi A,Knust B,Shoemaker T,Nichol ST,McElroy AK,Spiropoulou CF

更新日期：2018-05-04 00:00:00

abstract：:Canine rabies was endemic pre-urbanisation, yet little is known about how it persists in small populations of dogs typically seen in rural and remote regions. By simulating rabies outbreaks in such populations (50-90 dogs) using a network-based model, our objective was to determine if rabies-induced behavioural change...

journal_title：PLoS neglected tropical diseases

authors： Brookes VJ,Dürr S,Ward MP

更新日期：2019-09-23 00:00:00

abstract：:The tick-borne flavivirus, Powassan virus (POWV) causes life-threatening encephalitis in humans in North America and Europe. POWV is transmitted by ixodid tick vectors that feed on small to medium-sized mammals, such as Peromyscus leucopus mice, which may serve as either reservoir, bridge or amplification hosts. Intra...

journal_title：PLoS neglected tropical diseases

authors： Mlera L,Meade-White K,Saturday G,Scott D,Bloom ME

更新日期：2017-01-31 00:00:00

abstract：BACKGROUND:Current WHO recommendations for lymphatic filariasis (LF) surveillance advise programs to implement activities to monitor for new foci of transmission after stopping mass drug administration (MDA). A current need in the global effort to eliminate LF is to standardize diagnostic tools and surveillance activit...

journal_title：PLoS neglected tropical diseases

authors： Won KY,Robinson K,Hamlin KL,Tufa J,Seespesara M,Wiegand RE,Gass K,Kubofcik J,Nutman TB,Lammie PJ,Fuimaono S

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:The diagnosis of Strongyloides stercoralis (S. stercoralis) infection is hampered by the suboptimal sensitivity of fecal-based tests. Serological methods are believed to be more sensitive, although assessing their accuracy is difficult because of the lack of sensitivity of a fecal-based reference ("gold") st...

journal_title：PLoS neglected tropical diseases

authors： Bisoffi Z,Buonfrate D,Sequi M,Mejia R,Cimino RO,Krolewiecki AJ,Albonico M,Gobbo M,Bonafini S,Angheben A,Requena-Mendez A,Muñoz J,Nutman TB

更新日期：2014-01-09 00:00:00

abstract：BACKGROUND:During the 2014-2016 West Africa Ebola Virus Disease (EVD) epidemic, the public health community had concerns that sexual transmission of the Ebola virus (EBOV) from EVD survivors was a risk, due to EBOV persistence in body fluids of EVD survivors, particularly semen. The Sierra Leone Ebola Virus Persistence...

journal_title：PLoS neglected tropical diseases

authors： Abad N,Malik T,Ariyarajah A,Ongpin P,Hogben M,McDonald SLR,Marrinan J,Massaquoi T,Thorson A,Ervin E,Bernstein K,Ross C,Liu WJ,Kroeger K,Durski KN,Broutet N,Knust B,Deen GF,Sierra Leone Ebola Virus Persistence Study Gr

更新日期：2017-09-11 00:00:00

abstract：BACKGROUND:Congenital toxoplasmosis is a serious but preventable and treatable disease. Gestational screening facilitates early detection and treatment of primary acquisition. Thus, fetal infection can be promptly diagnosed and treated and outcomes can be improved. METHODS:We tested 180 sera with the Toxoplasma ICT Ig...

journal_title：PLoS neglected tropical diseases

authors： Begeman IJ,Lykins J,Zhou Y,Lai BS,Levigne P,El Bissati K,Boyer K,Withers S,Clouser F,Noble AG,Rabiah P,Swisher CN,Heydemann PT,Contopoulos-Ioannidis DG,Montoya JG,Maldonado Y,Ramirez R,Press C,Stillwaggon E,Peyron F

更新日期：2017-06-26 00:00:00

abstract：:Glossina (G.) spp. (Diptera: Glossinidae), known as tsetse flies, are vectors of African trypanosomes that cause sleeping sickness in humans and nagana in domestic livestock. Knowledge on tsetse distribution and accurate species identification help identify potential vector intervention sites. Morphological species id...

journal_title：PLoS neglected tropical diseases

authors： Hoppenheit A,Murugaiyan J,Bauer B,Steuber S,Clausen PH,Roesler U

更新日期：2013-07-11 00:00:00

abstract：INTRODUCTION:The mosquito Aedes aegypti is the principal vector of dengue and yellow fever flaviviruses. Temephos is an organophosphate insecticide used globally to suppress Ae. aegypti larval populations but resistance has evolved in many locations. METHODOLOGY/PRINCIPAL FINDINGS:Quantitative Trait Loci (QTL) control...

journal_title：PLoS neglected tropical diseases

authors： Reyes-Solis Gdel C,Saavedra-Rodriguez K,Suarez AF,Black WC 4th

更新日期：2014-10-16 00:00:00

abstract：:The causative agent of cholera, Vibrio cholerae, regulates its diverse virulence factors to thrive in the human small intestine and environmental reservoirs. Among this pathogen's arsenal of virulence factors is the tightly regulated type VI secretion system (T6SS). This system acts as an inverted bacteriophage to inj...

journal_title：PLoS neglected tropical diseases

authors： Bachmann V,Kostiuk B,Unterweger D,Diaz-Satizabal L,Ogg S,Pukatzki S

更新日期：2015-08-28 00:00:00

abstract：BACKGROUND:A majority infections caused by dengue virus (DENV) are asymptomatic, but a higher incidence of severe illness, such as dengue hemorrhagic fever, is associated with secondary infections, suggesting that pre-existing immunity plays a central role in dengue pathogenesis. Primary infections are typically associ...

journal_title：PLoS neglected tropical diseases

authors： Chaudhury S,Gromowski GD,Ripoll DR,Khavrutskii IV,Desai V,Wallqvist A

更新日期：2017-02-21 00:00:00

abstract：BACKGROUND:Scabies is a disease of worldwide significance, causing considerable morbidity in both humans and other animals. The scabies mite Sarcoptes scabiei burrows into the skin of its host, obtaining nutrition from host skin and blood. Aspartic proteases mediate a range of diverse and essential physiological functi...

journal_title：PLoS neglected tropical diseases

authors： Mahmood W,Viberg LT,Fischer K,Walton SF,Holt DC

更新日期：2013-11-07 00:00:00

abstract：BACKGROUND:The role of the immune response in influencing leptospirosis clinical outcomes is not yet well understood. We hypothesized that acute-phase serum cytokine responses may play a role in disease progression, risk for death, and severe pulmonary hemorrhage syndrome (SPHS). METHODOLOGY/PRINCIPAL FINDINGS:We perf...

journal_title：PLoS neglected tropical diseases

authors： Reis EA,Hagan JE,Ribeiro GS,Teixeira-Carvalho A,Martins-Filho OA,Montgomery RR,Shaw AC,Ko AI,Reis MG

更新日期：2013-09-19 00:00:00

abstract：BACKGROUND:The Brugia malayi Bm-103 and Bm-RAL-2 proteins are orthologous to Onchocerca volvulus Ov-103 and Ov-RAL-2, and which were selected as the best candidates for the development of an O. volvulus vaccine. The B. malayi gerbil model was used to confirm the efficacy of these Ov vaccine candidates on adult worms an...

journal_title：PLoS neglected tropical diseases

authors： Arumugam S,Wei J,Liu Z,Abraham D,Bell A,Bottazzi ME,Hotez PJ,Zhan B,Lustigman S,Klei TR

更新日期：2016-04-05 00:00:00

abstract：BACKGROUND:Aedes aegypti, vector of dengue, chikungunya and Zika viruses, is found at high densities in tropical urban areas. The dissemination of this vector is partially the consequence of failures in current vector control methods, still mainly relying upon insecticides. In the State of São Paulo (SP), Brazil, publi...

journal_title：PLoS neglected tropical diseases

authors： Macoris ML,Martins AJ,Andrighetti MTM,Lima JBP,Valle D

更新日期：2018-03-30 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the relationship between prior Anisakis infections and upper gastrointestinal bleeding (UGIB), and its interaction with non-steroidal anti-inflammatory drug (NSAID) intake. METHODS/PRINCIPAL FINDINGS:We conducted a hospital-based case-control study covering 215 UGIB ...

journal_title：PLoS neglected tropical diseases

authors： Ubeira FM,Anadón AM,Salgado A,Carvajal A,Ortega S,Aguirre C,López-Goikoetxea MJ,Ibanez L,Figueiras A

更新日期：2011-06-01 00:00:00

abstract：:Diarrheal diseases are a major cause of morbidity and mortality worldwide. In many cases, antibiotic therapy is either ineffective or not recommended due to concerns about emergence of resistance. The pathogenesis of several of the most prevalent infections, including cholera and enteroxigenic Escherichia coli, is dom...

journal_title：PLoS neglected tropical diseases

authors： Das S,Angsantikul P,Le C,Bao D,Miyamoto Y,Gao W,Zhang L,Eckmann L

更新日期：2018-02-22 00:00:00

abstract：BACKGROUND:The frequency of accidental spider bites in Brazil is growing, and poisoning due to bites from the spider genus Phoneutria nigriventer is the second most frequent source of such accidents. Intense local pain is the major symptom reported after bites of P. nigriventer, although the mechanisms involved are sti...

journal_title：PLoS neglected tropical diseases

authors： Gewehr C,Oliveira SM,Rossato MF,Trevisan G,Dalmolin GD,Rigo FK,de Castro Júnior CJ,Cordeiro MN,Ferreira J,Gomez MV

更新日期：2013-04-25 00:00:00

abstract：BACKGROUND:We identified the species of Leishmania isolated from traveling and migrant patients attended in a reference center from 2000 to 2015, we performed the georeferencing of these species in Rio de Janeiro (RJ) state and we had knowledge about the human flows between the likely location of infection (LLI) and pl...

journal_title：PLoS neglected tropical diseases

authors： Miranda LFC,Pacheco RDS,Pimentel MIF,Salgueiro MM,da Silva AF,de Mello CX,Barros JHDS,Valete-Rosalino CM,Madeira MF,Xavier SCDC,Schubach AO

更新日期：2019-11-15 00:00:00

abstract：:Zika virus (ZIKV) is an arbovirus primarily transmitted by Aedes mosquitoes. Like most viral infections, ZIKV viremia varies over several orders of magnitude, with unknown consequences for transmission. To determine the effect of viral concentration on ZIKV transmission risk, we exposed field-derived Ae. aegypti mosqu...

journal_title：PLoS neglected tropical diseases

authors： Tesla B,Demakovsky LR,Packiam HS,Mordecai EA,Rodríguez AD,Bonds MH,Brindley MA,Murdock CC

更新日期：2018-08-22 00:00:00

abstract：BACKGROUND:Sri Lankan Russell's viper (Daboia russelii) envenoming is reported to cause myotoxicity and neurotoxicity, which are different to the effects of envenoming by most other populations of Russell's vipers. This study aimed to investigate evidence of myotoxicity in Russell's viper envenoming, response to antive...

journal_title：PLoS neglected tropical diseases

authors： Silva A,Johnston C,Kuruppu S,Kneisz D,Maduwage K,Kleifeld O,Smith AI,Siribaddana S,Buckley NA,Hodgson WC,Isbister GK

更新日期：2016-12-02 00:00:00

abstract：BACKGROUND:The diagnosis of Human African Trypanosomiasis relies mainly on the Card Agglutination Test for Trypanosomiasis (CATT). While this test is successful, it is acknowledged that there may be room for improvement. Our aim was to develop a prototype lateral flow test based on the detection of antibodies to trypan...

journal_title：PLoS neglected tropical diseases

authors： Sullivan L,Wall SJ,Carrington M,Ferguson MA

更新日期：2013-01-01 00:00:00

abstract：:Parasitic infections are a major source of human suffering, mortality, and economic loss, but drug development for these diseases has been stymied by the significant expense involved in bringing a drug though clinical trials and to market. Identification of single compounds active against multiple parasitic pathogens ...

journal_title：PLoS neglected tropical diseases

authors： Ehrenkaufer G,Li P,Stebbins EE,Kangussu-Marcolino MM,Debnath A,White CV,Moser MS,DeRisi J,Gisselberg J,Yeh E,Wang SC,Company AH,Monti L,Caffrey CR,Huston CD,Wang B,Singh U

更新日期：2020-03-20 00:00:00

abstract：BACKGROUND:There is a pressing need for drug discovery against visceral leishmaniasis, a life-threatening protozoal infection, as the available chemotherapy is antiquated and not bereft of side effects. Plants as alternate drug resources has rewarded mankind in the past and aimed in this direction, we investigated the ...

journal_title：PLoS neglected tropical diseases

authors： Afrin F,Chouhan G,Islamuddin M,Want MY,Ozbak HA,Hemeg HA

更新日期：2019-05-09 00:00:00

abstract：BACKGROUND:The two front-line drugs for chronic Trypanosoma cruzi infections are limited by adverse side-effects and declining efficacy. One potential new target for Chagas' disease chemotherapy is sterol 14alpha-demethylase (CYP51), a cytochrome P450 enzyme involved in biosynthesis of membrane sterols. METHODOLOGY/PR...

journal_title：PLoS neglected tropical diseases

authors： Chen CK,Doyle PS,Yermalitskaya LV,Mackey ZB,Ang KK,McKerrow JH,Podust LM

更新日期：2009-01-01 00:00:00

abstract：:The increasing use of immunosuppressants in areas where visceral leishmaniasis (VL) is endemic has increased the number of people susceptible to developing more severe forms of the disease. Few studies have examined the quality of the immune response in immunosuppressed patients or experimental animals with VL. The pr...

journal_title：PLoS neglected tropical diseases

authors： Bernardo L,Solana JC,Romero-Kauss A,Sánchez C,Carrillo E,Moreno J

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Chagas disease is endemic to the southern Andean region of Ecuador, an area with one of the highest poverty rates in the country. However, few studies have looked into the epidemiology, vectors and transmission risks in this region. In this study we describe the triatomine household infestation in Loja provi...

journal_title：PLoS neglected tropical diseases

authors： Grijalva MJ,Villacis AG,Ocaña-Mayorga S,Yumiseva CA,Moncayo AL,Baus EG

更新日期：2015-10-06 00:00:00

abstract：BACKGROUND:Chikungunya virus (CHIKV) is a re-emerging arbovirus associated with febrile illness often accompanied by rash and arthralgia that may persist for several years. Outbreaks are associated with high morbidity and create a public health challenge for countries affected. Recent outbreaks have occurred in both Eu...

journal_title：PLoS neglected tropical diseases

authors： Weger-Lucarelli J,Chu H,Aliota MT,Partidos CD,Osorio JE

更新日期：2014-07-24 00:00:00

abstract：BACKGROUND:Currently, molecular xenomonitoring efforts for lymphatic filariasis rely on PCR or real-time PCR-based detection of Brugia malayi, Brugia timori and Wuchereria bancrofti in mosquito vectors. Most commonly, extraction of DNA from mosquitoes is performed using silica column-based technologies. However, such e...

journal_title：PLoS neglected tropical diseases

authors： Zaky WI,Tomaino FR,Pilotte N,Laney SJ,Williams SA

更新日期：2018-11-21 00:00:00