Clinical features and genetic background of the sympatric species Paracoccidioides brasiliensis and Paracoccidioides americana.

abstract：:Aedes aegypti is the primary vector of several medically relevant arboviruses including dengue virus (DENV) types 1-4. Ae. aegypti transmits DENV by inoculating virus-infected saliva into host skin during probing and feeding. Ae. aegypti saliva contains over one hundred unique proteins and these proteins have diverse ...

journal_title：PLoS neglected tropical diseases

authors： Conway MJ,Londono-Renteria B,Troupin A,Watson AM,Klimstra WB,Fikrig E,Colpitts TM

更新日期：2016-09-15 00:00:00

abstract：:As the most widespread tick-borne arbovirus causing infections in numerous countries in Asia, Africa and Europe, Crimean-Congo Hemorrhagic Fever Virus (CCHFV, family Nairoviridae) was included in the WHO priority list of emerging pathogens needing urgent Research & Development attention. To ensure preparedness for pot...

journal_title：PLoS neglected tropical diseases

authors： Emmerich P,Mika A,von Possel R,Rackow A,Liu Y,Schmitz H,Günther S,Sherifi K,Halili B,Jakupi X,Berisha L,Ahmeti S,Deschermeier C

更新日期：2018-03-26 00:00:00

abstract：:Tsetse flies (Glossina spp.) transmit parasitic African trypanosomes (Trypanosoma spp.), including Trypanosoma congolense, which causes animal African trypanosomiasis (AAT). AAT detrimentally affects agricultural activities in sub-Saharan Africa and has negative impacts on the livelihood and nutrient availability for ...

journal_title：PLoS neglected tropical diseases

authors： Awuoche EO,Weiss BL,Vigneron A,Mireji PO,Aksoy E,Nyambega B,Attardo GM,Wu Y,O'Neill M,Murilla G,Aksoy S

更新日期：2017-11-20 00:00:00

abstract：:Leishmaniasis is a complex parasitic disease from a taxonomic, clinical and epidemiological point of view. The role of genetic exchanges has been questioned for over twenty years and their recent experimental demonstration along with the identification of interspecific hybrids in natura has revived this debate. After ...

journal_title：PLoS neglected tropical diseases

authors： El Baidouri F,Diancourt L,Berry V,Chevenet F,Pratlong F,Marty P,Ravel C

更新日期：2013-06-13 00:00:00

abstract：BACKGROUND:Access to health care is a major requirement in improving health and fostering socioeconomic development. In the People's Republic of China (P.R. China), considerable changes have occurred in the social, economic, and health systems with a shift from a centrally planned to a socialist market economy. This br...

journal_title：PLoS neglected tropical diseases

authors： Balen J,Liu ZC,McManus DP,Raso G,Utzinger J,Xiao SY,Yu DB,Zhao ZY,Li YS

更新日期：2013-08-01 00:00:00

abstract：INTRODUCTION:This paper discusses the presence of Aedes aegypti pupae in different types of containers considering: volume, pH of the container, among other variables. METHODS:A nonlinear method for selection was applied, based on Mutual Information, by placing in order of importance the most appropriate variables for...

journal_title：PLoS neglected tropical diseases

authors： Medronho RA,Câmara VM,Macrini L

更新日期：2018-07-23 00:00:00

abstract：:Leprosy is a persistent infectious disease caused by Mycobacterium leprae that still affects over 200,000 new patients annually. The host genetic background is an important risk factor for leprosy susceptibility and the PARK2 gene is a replicated leprosy susceptibility candidate gene. The protein product of PARK2, Par...

journal_title：PLoS neglected tropical diseases

authors： de Léséleuc L,Orlova M,Cobat A,Girard M,Huong NT,Ba NN,Thuc NV,Truman R,Spencer JS,Adams L,Thai VH,Alcais A,Schurr E

更新日期：2013-01-01 00:00:00

abstract：:This study focused on Oeosophagostomum sp., and more especially on O. bifurcum, as a parasite that can be lethal to humans and is widespread among humans and monkeys in endemic regions, but has not yet been documented in apes. Its epidemiology and the role played by non-human primates in its transmission are still poo...

journal_title：PLoS neglected tropical diseases

authors： Krief S,Vermeulen B,Lafosse S,Kasenene JM,Nieguitsila A,Berthelemy M,L'hostis M,Bain O,Guillot J

更新日期：2010-03-16 00:00:00

abstract：:Leprosy is an infectious disease caused by Mycobacterium leprae and frequently resulting in irreversible deformities and disabilities. Ticks play an important role in infectious disease transmission due to their low host specificity, worldwide distribution, and the biological ability to support transovarial transmissi...

journal_title：PLoS neglected tropical diseases

authors： Ferreira JDS,Souza Oliveira DA,Santos JP,Ribeiro CCDU,Baêta BA,Teixeira RC,Neumann ADS,Rosa PS,Pessolani MCV,Moraes MO,Bechara GH,de Oliveira PL,Sorgine MHF,Suffys PN,Fontes ANB,Bell-Sakyi L,Fonseca AH,Lara FA

更新日期：2018-12-19 00:00:00

abstract：BACKGROUND:Though Nepal declared leprosy elimination in 2010, its burden is constantly rising in Terai communities for the past 2 years with 3000 new leprosy cases being diagnosed annually. Community's perception is important for prevention and control of leprosy and enhancing quality of life of leprosy patients. Poor ...

journal_title：PLoS neglected tropical diseases

authors： Singh R,Singh B,Mahato S

更新日期：2019-01-11 00:00:00

abstract：BACKGROUND:Schistosoma mansoni and Schistosoma japonicum are the most frequent causative agents of human intestinal schistosomiasis. Approximately 200 million people in the world are infected with schistosomes. Diagnosis of schistosomiasis is often difficult. High percentages of low level infections are missed in routi...

journal_title：PLoS neglected tropical diseases

authors： Karl S,Gutiérrez L,Lucyk-Maurer R,Kerr R,Candido RR,Toh SQ,Saunders M,Shaw JA,Suvorova A,Hofmann A,House MJ,Woodward RC,Graeff-Teixera C,St Pierre TG,Jones MK

更新日期：2013-05-16 00:00:00

abstract：:Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that can cause fever and chronic arthritis in humans. CHIKV that is generated in mosquito or mammalian cells differs in glycosylation patterns of viral proteins, which may affect its replication and virulence. Herein, we compare replication, pathogenicity,...

journal_title：PLoS neglected tropical diseases

authors： Acharya D,Paul AM,Anderson JF,Huang F,Bai F

更新日期：2015-10-20 00:00:00

abstract：:The infectious form of many parasitic nematodes, which afflict over one billion people globally, is a developmentally arrested third-stage larva (L3i). The parasitic nematode Strongyloides stercoralis differs from other nematode species that infect humans, in that its life cycle includes both parasitic and free-living...

journal_title：PLoS neglected tropical diseases

authors： Stoltzfus JD,Minot S,Berriman M,Nolan TJ,Lok JB

更新日期：2012-01-01 00:00:00

abstract：:Control of arbovirus transmission remains focused on vector control through application of insecticides directly to the environment. However, these insecticide applications are often reactive interventions that can be poorly-targeted, inadequate for localized control during outbreaks, and opposed due to environmental ...

journal_title：PLoS neglected tropical diseases

authors： Nguyen C,Gray M,Burton TA,Foy SL,Foster JR,Gendernalik AL,Rückert C,Alout H,Young MC,Boze B,Ebel GD,Clapsaddle B,Foy BD

更新日期：2019-03-07 00:00:00

abstract：BACKGROUND:Diagnosis of human African trypanosomiasis (HAT) remains a challenge both for active screening, which is critical in control of the disease, and in the point-of-care scenario where early and accurate diagnosis is essential. Recently, the first field deployment of a lateral flow rapid diagnostic test (RDT) fo...

journal_title：PLoS neglected tropical diseases

authors： Sternberg JM,Gierliński M,Biéler S,Ferguson MA,Ndung'u JM

更新日期：2014-12-18 00:00:00

abstract：:The human gut has been continuously exposed to a broad spectrum of intestinal organisms, including viruses, bacteria, fungi, and parasites (protozoa and worms), over millions of years of coevolution, and plays a central role in human health. The modern lifestyles of Western countries, such as the adoption of highly hy...

journal_title：PLoS neglected tropical diseases

authors： Marzano V,Mancinelli L,Bracaglia G,Del Chierico F,Vernocchi P,Di Girolamo F,Garrone S,Tchidjou Kuekou H,D'Argenio P,Dallapiccola B,Urbani A,Putignani L

更新日期：2017-11-02 00:00:00

abstract：:Orientia tsutsugamushi (Ots) frequently causes severe scrub typhus infections in the Asia-Pacific region. Korean investigators have demonstrated that Ots encodes five different autotransporter domain (ATD) proteins (ScaA-ScaE). ScaA functions as an adhesin and confers protective immunity in a lethal mouse model of Ots...

journal_title：PLoS neglected tropical diseases

authors： Koralur MC,Ramaiah A,Dasch GA

更新日期：2018-09-20 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pntd.0008129.]. ...

journal_title：PLoS neglected tropical diseases

authors： Alzaylaee H,Collins RA,Rinaldi G,Shechonge A,Ngatunga B,Morgan ER,Genner MJ

更新日期：2020-09-01 00:00:00

abstract：:In the current study, a comprehensive, data driven, mathematical model for cholera transmission in Haiti is presented. Along with the inclusion of short cycle human-to-human transmission and long cycle human-to-environment and environment-to-human transmission, this novel dynamic model incorporates both the reported c...

journal_title：PLoS neglected tropical diseases

authors： Kirpich A,Weppelmann TA,Yang Y,Ali A,Morris JG Jr,Longini IM

更新日期：2015-10-21 00:00:00

abstract：BACKGROUND:Trachoma prevalence surveys provide the evidence base for district and community-wide implementation of the SAFE strategy, and are used to evaluate the impact of trachoma control interventions. An economic analysis was performed to estimate the cost of trachoma prevalence surveys conducted between 2006 and 2...

journal_title：PLoS neglected tropical diseases

authors： Chen C,Cromwell EA,King JD,Mosher A,Harding-Esch EM,Ngondi JM,Emerson PM

更新日期：2011-03-08 00:00:00

abstract：BACKGROUND:The long-term treatment outcome of visceral leishmaniasis (VL) patients with HIV co-infection is complicated by a high rate of relapse, especially when the CD4 count is low. Although use of secondary prophylaxis is recommended, it is not routinely practiced and data on its effectiveness and safety are limite...

journal_title：PLoS neglected tropical diseases

authors： Diro E,Edwards T,Ritmeijer K,Fikre H,Abongomera C,Kibret A,Bardonneau C,Soipei P,Mutinda B,Omollo R,van Griensven J,Zijlstra EE,Wasunna M,Alves F,Alvar J,Hailu A,Alexander N,Blesson S

更新日期：2019-02-21 00:00:00

abstract：BACKGROUND:Leptospirosis is a neglected zoonosis affecting animals and humans caused by infection with Leptospira. The bacteria can survive outside of hosts for long periods of time in soil and water. While identification of Leptospira species from human cases and animal reservoirs are increasingly reported, little is ...

journal_title：PLoS neglected tropical diseases

authors： Mason MR,Encina C,Sreevatsan S,Muñoz-Zanzi C

更新日期：2016-08-16 00:00:00

abstract：:The increasing use of immunosuppressants in areas where visceral leishmaniasis (VL) is endemic has increased the number of people susceptible to developing more severe forms of the disease. Few studies have examined the quality of the immune response in immunosuppressed patients or experimental animals with VL. The pr...

journal_title：PLoS neglected tropical diseases

authors： Bernardo L,Solana JC,Romero-Kauss A,Sánchez C,Carrillo E,Moreno J

更新日期：2021-02-01 00:00:00

abstract：:Immunosuppression contributes significantly to the caseload of visceral leishmaniasis (VL). HIV coinfection, solid organ transplantation, malnutrition, and helminth infections are the most important immunosuppression-related factors. This review briefly describes the challenges of these associations. East Africa and t...

journal_title：PLoS neglected tropical diseases

authors： Akuffo H,Costa C,van Griensven J,Burza S,Moreno J,Herrero M

更新日期：2018-05-10 00:00:00

abstract：BACKGROUND:The mosquito Aedes aegypti is the primary global vector for dengue and yellow fever viruses. Sequencing of the Ae. aegypti genome has stimulated research in vector biology and insect genomics. However, the current genome assembly is highly fragmented with only ~31% of the genome being assigned to chromosomes...

journal_title：PLoS neglected tropical diseases

authors： Sharakhova MV,Timoshevskiy VA,Yang F,Demin SIu,Severson DW,Sharakhov IV

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis has now emerged as an important opportunistic disease in patients coinfected with human immunodeficiency virus type-1 (HIV-1). Although the effectiveness of HIV-1 protease inhibitors, such as nelfinavir, in antiretroviral therapies is well documented, little is known of the impact of t...

journal_title：PLoS neglected tropical diseases

authors： Kumar P,Lodge R,Trudel N,Ouellet M,Ouellette M,Tremblay MJ

更新日期：2010-03-30 00:00:00

abstract：BACKGROUND:Hookworm disease is one of the most common infections and cause of a high disease burden in the tropics and subtropics. Remotely sensed ecological data and model-based geostatistics have been used recently to identify areas in need for hookworm control. METHODOLOGY:Cross-sectional interview data and stool s...

journal_title：PLoS neglected tropical diseases

authors： Riess H,Clowes P,Kroidl I,Kowuor DO,Nsojo A,Mangu C,Schüle SA,Mansmann U,Geldmacher C,Mhina S,Maboko L,Hoelscher M,Saathoff E

更新日期：2013-09-05 00:00:00

abstract：BACKGROUND:Extreme precipitation events are increasing as a result of ongoing global warming, but controversy surrounds the relationship between flooding and mosquito-borne diseases. A common view among the scientific community and public health officers is that heavy rainfalls have a flushing effect on breeding sites,...

journal_title：PLoS neglected tropical diseases

authors： Roiz D,Boussès P,Simard F,Paupy C,Fontenille D

更新日期：2015-06-16 00:00:00

abstract：BACKGROUND:Worldwide, an estimated 30 to 100 million people are infected with Strongyloides stercoralis, a soil-transmitted helminth. Information on the parasite is scarce in most settings. In semi-rural Cambodia, we determined infection rates and risk factors; compared two diagnostic methods (Koga agar plate [KAP] cul...

journal_title：PLoS neglected tropical diseases

authors： Khieu V,Schär F,Marti H,Sayasone S,Duong S,Muth S,Odermatt P

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Diagnosis of Trypanosoma cruzi infection by direct pathogen detection is complicated by the low parasite burden in subjects persistently infected with this agent of human Chagas disease. Determination of infection status by serological analysis has also been faulty, largely due to the lack of well-characteri...

journal_title：PLoS neglected tropical diseases

authors： Cooley G,Etheridge RD,Boehlke C,Bundy B,Weatherly DB,Minning T,Haney M,Postan M,Laucella S,Tarleton RL

更新日期：2008-10-08 00:00:00