Interaction of ATP with a small heat shock protein from Mycobacterium leprae: effect on its structure and function.

abstract：BACKGROUND:The World Health Organization identified Uganda as one of the 10 highly endemic countries for schistosomiasis. Annual mass drug administration (MDA) with praziquantel has led to a decline in intensity of Schistosoma mansoni infections in several areas. However, as hotspots with high (re)infection rates remai...

journal_title：PLoS neglected tropical diseases

authors： Trienekens SCM,Faust CL,Meginnis K,Pickering L,Ericsson O,Nankasi A,Moses A,Tukahebwa EM,Lamberton PHL

更新日期：2020-05-13 00:00:00

abstract：:Sand flies are the insects responsible for transmitting Leishmania parasites, the causative agents of leishmaniasis in humans. However, the effects of sand fly breeding sites on their biology and ecology remain poorly understood. Herein, we studied how larval nutrition associated with putative breeding sites of the sa...

journal_title：PLoS neglected tropical diseases

authors： Aguiar Martins K,Meirelles MHA,Mota TF,Abbasi I,de Queiroz ATL,Brodskyn CI,Veras PST,Mothé Fraga DB,Warburg A

更新日期：2021-01-21 00:00:00

abstract：BACKGROUND:Standard diagnosis of human soil-transmitted helminth (STH) infections is based on the microscopic detection of helminth eggs in stool and supports programmatic decision making in control programs. However, the current standard diagnostic techniques still show a number of limitations. Recently, the FECPAKG2 ...

journal_title：PLoS neglected tropical diseases

authors： Ayana M,Vlaminck J,Cools P,Ame S,Albonico M,Dana D,Keiser J,Manly H,Matoso LF,Mekonnen Z,Montresor A,Correa-Oliveira R,Rinaldi L,Sayasone S,Sowersby SJ,Tesfaye L,Vercruysse J,Mirams G,Levecke B

更新日期：2018-10-15 00:00:00

abstract：:Epidemic growth rate, r, provides a more complete description of the potential for epidemics than the more commonly studied basic reproduction number, R0, yet the former has never been described as a function of temperature for dengue virus or other pathogens with temperature-sensitive transmission. The need to unders...

journal_title：PLoS neglected tropical diseases

authors： Siraj AS,Oidtman RJ,Huber JH,Kraemer MUG,Brady OJ,Johansson MA,Perkins TA

更新日期：2017-07-19 00:00:00

abstract：BACKGROUND:Viral hemorrhagic fevers (VHF) are acute diseases associated with bleeding, organ failure, and shock. VHF may hardly be distinguished clinically from other diseases in the African hospital, including viral hepatitis. This study was conducted to determine if VHF and viral hepatitis contribute to hospital morb...

journal_title：PLoS neglected tropical diseases

authors： Bonney JH,Osei-Kwasi M,Adiku TK,Barnor JS,Amesiya R,Kubio C,Ahadzie L,Olschläger S,Lelke M,Becker-Ziaja B,Pahlmann M,Günther S

更新日期：2013-09-19 00:00:00

abstract：:Schistosomes are parasitic platyhelminths that currently infect over 200 million people globally. The parasites can live for years in a putatively hostile environment - the blood of vertebrates. We have hypothesized that the unusual schistosome tegument (outer-covering) plays a role in protecting parasites in the bloo...

journal_title：PLoS neglected tropical diseases

authors： Bhardwaj R,Skelly PJ

更新日期：2011-04-05 00:00:00

abstract：BACKGROUND:Leptospirosis is a potentially fatal bacterial zoonosis that is endemic throughout the tropics and may be misdiagnosed as dengue. Delayed hospital admission of leptospirosis patients is associated with increased mortality. METHODOLOGY/PRINCIPAL FINDINGS:During a concurrent dengue/leptospirosis epidemic in P...

journal_title：PLoS neglected tropical diseases

authors： Sharp TM,Rivera García B,Pérez-Padilla J,Galloway RL,Guerra M,Ryff KR,Haberling D,Ramakrishnan S,Shadomy S,Blau D,Tomashek KM,Bower WA

更新日期：2016-02-25 00:00:00

abstract：BACKGROUND:Trachoma programs rely on guidelines made in large part using expert opinion of what will happen with and without intervention. Large community-randomized trials offer an opportunity to actually compare forecasting methods in a masked fashion. METHODS:The Program for the Rapid Elimination of Trachoma trials...

journal_title：PLoS neglected tropical diseases

authors： Liu F,Porco TC,Amza A,Kadri B,Nassirou B,West SK,Bailey RL,Keenan JD,Solomon AW,Emerson PM,Gambhir M,Lietman TM

更新日期：2015-08-24 00:00:00

abstract：BACKGROUND:Burkholderia pseudomallei is a soil saprophytic bacterium that causes melioidosis. The infection occurs through cutaneous inoculation, inhalation or ingestion. Bacteriophages (phages) in the same ecosystem may significantly impact the biology of this bacterium in the environment, and in their culturability i...

journal_title：PLoS neglected tropical diseases

authors： Withatanung P,Chantratita N,Muangsombut V,Saiprom N,Lertmemongkolchai G,Klumpp J,Clokie MR,Galyov EE,Korbsrisate S

更新日期：2016-09-26 00:00:00

abstract：:Chikungunya virus (CHIKV) is the only causative agent of CHIKV fever with persistent arthralgia, and in some cases may lead to neurological complications which can be highly fatal, therefore it poses severe health issues in many parts of the world. CHIKV transmission can be mediated via the Aedes albopictus mosquito; ...

journal_title：PLoS neglected tropical diseases

authors： Lee RC,Chu JJ

更新日期：2015-03-04 00:00:00

abstract：:Snakebite is a neglected tropical disease with significant morbidity and mortality. Thrombotic microangiopathy (TMA) is an important but poorly understood complication of snakebite associated with acute kidney injury (AKI). Numerous treatments have been attempted based on limited evidence. We conducted a systematic re...

journal_title：PLoS neglected tropical diseases

authors： Noutsos T,Currie BJ,Lek RA,Isbister GK

更新日期：2020-12-08 00:00:00

abstract：:The infectious form of many parasitic nematodes, which afflict over one billion people globally, is a developmentally arrested third-stage larva (L3i). The parasitic nematode Strongyloides stercoralis differs from other nematode species that infect humans, in that its life cycle includes both parasitic and free-living...

journal_title：PLoS neglected tropical diseases

authors： Stoltzfus JD,Minot S,Berriman M,Nolan TJ,Lok JB

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Imported strongyloidiasis is increasingly being diagnosed in non-endemic areas. The aim of this study was to describe the epidemiological, clinical and microbiological characteristics of patients with imported strongyloidiasis in Spain. METHODOLOGY:This is an observational retrospective study that included ...

journal_title：PLoS neglected tropical diseases

authors： Salvador F,Treviño B,Chamorro-Tojeiro S,Sánchez-Montalvá A,Herrero-Martínez JM,Rodríguez-Guardado A,Serre-Delcor N,Torrús D,Goikoetxea J,Zubero Z,Velasco M,Sulleiro E,Molina I,López-Vélez R,Pérez-Molina JA,on behalf the +RE

更新日期：2019-05-16 00:00:00

abstract：BACKGROUND:Schistosomiasis japonica is a zoonotic parasitic disease and oral vaccine delivery system would be benefit for prevention of this disease. Although attenuated salmonella has been used as an antigen expression vector for oral vaccine development, the membrane-bound vacuoles in which bacteria reside hinders th...

journal_title：PLoS neglected tropical diseases

authors： Chen G,Dai Y,Chen J,Wang X,Tang B,Zhu Y,Hua Z

更新日期：2011-09-01 00:00:00

abstract：:Post-kala-azar dermal leishmaniasis (PKDL) is clinical outcome of visceral leishmaniasis (VL) and is thought to be the potential reservoir of parasite. Miltefosine (MF) is the only oral drug existing for treatment of post-kala-azar dermal leishmaniasis (PKDL). Increased miltefosine tolerance in clinical isolates of Le...

journal_title：PLoS neglected tropical diseases

authors： Topno RK,Rabi Das VN,Kumar M,Madhukar M,Pandey K,Verma N,Agrawal K,Lal CS,Siddiqui NA,Bimal S,Das P

更新日期：2020-03-23 00:00:00

abstract：:Andes virus (ANDV) is the etiological agent of hantavirus cardiopulmonary syndrome in Chile. In this study, we evaluated the profile of the pro-inflammatory cytokines IL-1β, IL-12p70, IL-21, TNF-α, IFN-γ, IL-10 and IL-6 in serum samples of ANDV-infected patients at the time of hospitalization. The mean levels of circu...

journal_title：PLoS neglected tropical diseases

authors： Angulo J,Martínez-Valdebenito C,Marco C,Galeno H,Villagra E,Vera L,Lagos N,Becerra N,Mora J,Bermúdez A,Díaz J,Ferrés M,López-Lastra M

更新日期：2017-07-14 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) is highly prevalent in the Indian state of Bihar and, without proper diagnosis and treatment, is associated with high fatality. However, lack of efficient reporting mechanism had been an impediment in estimating the burden of mortality and its antecedents among symptomatic VL case...

journal_title：PLoS neglected tropical diseases

authors： Das A,Karthick M,Dwivedi S,Banerjee I,Mahapatra T,Srikantiah S,Chaudhuri I

更新日期：2016-11-21 00:00:00

abstract：BACKGROUND:Intestinal schistosomiasis and soil-transmitted helminth (STH) infections constitute major public health problems in many parts of sub-Saharan Africa. In this study we examined the functional significance of such polyparasite infections in anemia and undernutrition in Rwandan individuals. METHODS:Three poly...

journal_title：PLoS neglected tropical diseases

authors： Mupfasoni D,Karibushi B,Koukounari A,Ruberanziza E,Kaberuka T,Kramer MH,Mukabayire O,Kabera M,Nizeyimana V,Deville MA,Ruxin J,Webster JP,Fenwick A

更新日期：2009-09-15 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Hookworm infection is among the major causes of anaemia in poor communities, but its importance in causing maternal anaemia is poorly understood, and this has hampered effective lobbying for the inclusion of anthelmintic treatment in maternal health packages. We sought to review existing evide...

journal_title：PLoS neglected tropical diseases

authors： Brooker S,Hotez PJ,Bundy DA

更新日期：2008-09-17 00:00:00

abstract：:This paper reports the prevalence and intensity of soil-transmitted helminth (STH) infections measured in Zimbabwe before and after a control intervention based on annual deworming of school-age children (SAC) conducted from 2012 to 2018. In 2010, epidemiological data were collected from 13 195 SAC in 255 randomly sel...

journal_title：PLoS neglected tropical diseases

authors： Midzi N,Montresor A,Mutsaka-Makuvaza MJ,Fronterre C,Manangazira P,Phiri I,Johnson O,Mhlanga G,Diggle PJ

更新日期：2020-10-23 00:00:00

abstract：BACKGROUND:Praziquantel remains the drug of choice for the worldwide treatment and control of schistosomiasis. The drug is synthesized and administered as a racemate. Use of the pure active enantiomer would be desirable since the inactive enantiomer is associated with side effects and is responsible for the extremely b...

journal_title：PLoS neglected tropical diseases

authors： Woelfle M,Seerden JP,de Gooijer J,Pouwer K,Olliaro P,Todd MH

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:With few studies conducted to date, very little is known about the epidemiology of rickettsioses in Bhutan. Due to two previous outbreaks and increasing clinical cases, scrub typhus is better recognized than other rickettsial infections and Q fever. METHODOLOGY:A descriptive cross-sectional serosurvey was c...

journal_title：PLoS neglected tropical diseases

authors： Tshokey T,Stenos J,Durrheim DN,Eastwood K,Nguyen C,Graves SR

更新日期：2017-11-27 00:00:00

abstract：BACKGROUND:Visceral leishmaniasis (VL) is a life-threatening disease caused by protozoan parasites of the Leishmania donovani complex. Early case detection followed by adequate treatment is essential to the control of VL. However, the available diagnostic tests are either invasive and require considerable expertise (pa...

journal_title：PLoS neglected tropical diseases

authors： Gao CH,Yang YT,Shi F,Wang JY,Steverding D,Wang X

更新日期：2015-06-30 00:00:00

abstract：BACKGROUND:Sustainable control of soil-transmitted helminths requires a combination of chemotherapy treatment and environmental interventions, including access to safe drinking water, sufficient water for hygiene, use of clean sanitation facilities, and handwashing (WASH). We quantified associations between home-, scho...

journal_title：PLoS neglected tropical diseases

authors： Baker JM,Trinies V,Bronzan RN,Dorkenoo AM,Garn JV,Sognikin S,Freeman MC

更新日期：2018-03-28 00:00:00

abstract：BACKGROUND:A Global Programme to Eliminate Lymphatic Filariasis was launched in 2000, with mass drug administration (MDA) as the core strategy of the programme. After completing 13 years of operations through 2012 and with MDA in place in 55 of 73 endemic countries, the impact of the MDA programme on microfilaraemia, h...

journal_title：PLoS neglected tropical diseases

authors： Ramaiah KD,Ottesen EA

更新日期：2014-11-20 00:00:00

abstract：BACKGROUND:There is a pressing need for drug discovery against visceral leishmaniasis, a life-threatening protozoal infection, as the available chemotherapy is antiquated and not bereft of side effects. Plants as alternate drug resources has rewarded mankind in the past and aimed in this direction, we investigated the ...

journal_title：PLoS neglected tropical diseases

authors： Afrin F,Chouhan G,Islamuddin M,Want MY,Ozbak HA,Hemeg HA

更新日期：2019-05-09 00:00:00

abstract：:Eumycetoma (mycotic mycetoma) is the fungal form of mycetoma, a subcutaneous infection occurring in individuals living in endemic areas of the disease. The Sudan is hyperendemic for mycetoma, with the highest incidence being reported from Gezira State, Central Sudan. The present study was conducted at the Gezira Mycet...

journal_title：PLoS neglected tropical diseases

authors： Ahmed EA,Nour BYM,Abakar AD,Hamid S,Mohamadani AA,Daffalla M,Mahmoud M,Altayb HN,Desnos-Ollivier M,de Hoog S,Ahmed SA

更新日期：2020-07-30 00:00:00

abstract：BACKGROUND:Soil-transmitted helminth (STH) infections are among the most prevalent neglected tropical diseases (NTD) worldwide. Since the publication of the WHO road map to combat NTD in 2012, there has been a renewed commitment to control STH. In this study, we analysed the geographical distribution and effect of comm...

journal_title：PLoS neglected tropical diseases

authors： Silver ZA,Kaliappan SP,Samuel P,Venugopal S,Kang G,Sarkar R,Ajjampur SSR

更新日期：2018-01-18 00:00:00

abstract：BACKGROUND:Trypanosoma cruzi, the etiologic agent of Chagas Disease, is a major vector borne health problem in Latin America and an emerging infectious disease in the United States. METHODS:We tested the efficacy of a multi-component DNA-prime/DNA-boost vaccine (TcVac1) against experimental T. cruzi infection in a can...

journal_title：PLoS neglected tropical diseases

authors： Aparicio-Burgos JE,Ochoa-García L,Zepeda-Escobar JA,Gupta S,Dhiman M,Martínez JS,de Oca-Jiménez RM,Val Arreola M,Barbabosa-Pliego A,Vázquez-Chagoyán JC,Garg NJ

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The caterpillar of the moth Premolis semirufa (Lepidoptera: Arctiidae), commonly named Pararama, is endemic of the Amazon basin. Accidental contact with these caterpillar bristles causes local symptoms such as intense heat, pain, edema and itching which last for three to seven days; however, after multiples ...

journal_title：PLoS neglected tropical diseases

authors： Villas-Boas IM,Gonçalves-de-Andrade RM,Pidde-Queiroz G,Assaf SL,Portaro FC,Sant'Anna OA,van den Berg CW,Tambourgi DV

更新日期：2012-01-01 00:00:00