Hospital-based surveillance for viral hemorrhagic fevers and hepatitides in Ghana.

abstract：BACKGROUND:Previous studies investigating the role of cytokines in the pathogenesis of leprosy have either been on only small numbers of patients or have not combined clinical and histological data. The INFIR Cohort study is a prospective study of 303 new multibacillary leprosy patients to identify risk factors for rea...

journal_title：PLoS neglected tropical diseases

authors： Lockwood DN,Suneetha L,Sagili KD,Chaduvula MV,Mohammed I,van Brakel W,Smith WC,Nicholls P,Suneetha S

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Carrion' disease, caused by Bartonella bacilliformis, remains truly neglected due to its focal geographical nature. A wide spectrum of clinical manifestations, including asymptomatic bacteremia, and lack of a sensitive diagnostic test can potentially lead to a spread of the disease into non-endemic regions w...

journal_title：PLoS neglected tropical diseases

authors： Angkasekwinai N,Atkins EH,Johnson RN,Grieco JP,Ching WM,Chao CC

更新日期：2014-12-18 00:00:00

abstract：BACKGROUND:From the 17th to 19th January 2012, a group of 92 college students and teachers attended a retreat in a hotel located on Pangkor Island, off the west coast of Peninsular Malaysia. Following the onset of symptoms in many participants who presented to our institute, an investigation was undertaken which ultima...

journal_title：PLoS neglected tropical diseases

authors： Italiano CM,Wong KT,AbuBakar S,Lau YL,Ramli N,Syed Omar SF,Kahar Bador M,Tan CT

更新日期：2014-05-22 00:00:00

abstract：BACKGROUND:Dengue fever is a major public health concern in many parts of the tropics and subtropics. The first dengue vaccine has already been licensed in six countries. Given the growing interests in the effective use of the vaccine, it is critical to understand the economic burden of dengue fever to guide decision-m...

journal_title：PLoS neglected tropical diseases

authors： Lee JS,Mogasale V,Lim JK,Carabali M,Lee KS,Sirivichayakul C,Dang DA,Palencia-Florez DC,Nguyen THA,Riewpaiboon A,Chanthavanich P,Villar L,Maskery BA,Farlow A

更新日期：2017-10-30 00:00:00

abstract：:In Latin America and the Caribbean, around 195 million people live in poverty, a situation that increases the burden of some infectious diseases. Neglected diseases, in particular, are often restricted to poor, marginalized sections of the population. Tools exist to combat these diseases, making it imperative to work ...

journal_title：PLoS neglected tropical diseases

authors： Schneider MC,Aguilera XP,Barbosa da Silva Junior J,Ault SK,Najera P,Martinez J,Requejo R,Nicholls RS,Yadon Z,Silva JC,Leanes LF,Periago MR

更新日期：2011-02-15 00:00:00

abstract：BACKGROUND:New strategies for collecting post-mortem tissue are necessary, particularly in areas with emerging infections. Minimally invasive autopsy (MIA) has been proposed as an alternative to conventional autopsy (CA), with promising results. Previous studies using MIA addressed the cause of death in adults and chil...

journal_title：PLoS neglected tropical diseases

authors： Duarte-Neto AN,Monteiro RAA,Johnsson J,Cunha MDP,Pour SZ,Saraiva AC,Ho YL,da Silva LFF,Mauad T,Zanotto PMA,Saldiva PHN,de Oliveira IRS,Dolhnikoff M

更新日期：2019-07-22 00:00:00

abstract：:P. vivax and P. falciparum parasites display different tropism for host cells and induce very different clinical symptoms and pathology, suggesting that the immune responses required for protection may differ between these two species. However, no study has qualitatively compared the immune responses to P. falciparum ...

journal_title：PLoS neglected tropical diseases

authors： Burel JG,Apte SH,McCarthy JS,Doolan DL

更新日期：2016-12-08 00:00:00

abstract：BACKGROUND:Lymphatic filariasis (LF) is targeted for global elimination through treatment of entire at-risk populations with repeated annual mass drug administration (MDA). Essential for program success is defining and confirming the appropriate endpoint for MDA when transmission is presumed to have reached a level low...

journal_title：PLoS neglected tropical diseases

authors： Chu BK,Deming M,Biritwum NK,Bougma WR,Dorkenoo AM,El-Setouhy M,Fischer PU,Gass K,Gonzalez de Peña M,Mercado-Hernandez L,Kyelem D,Lammie PJ,Flueckiger RM,Mwingira UJ,Noordin R,Offei Owusu I,Ottesen EA,Pavluck A,Pilotte

更新日期：2013-12-05 00:00:00

abstract：BACKGROUND:Schistosome eggs must traverse tissues of the intestine or bladder to escape the human host and further the life cycle. Escape from host tissues is facilitated by secretion of immuno-reactive molecules by eggs and the formation of an intense strong granulomatous response by the host which acts to exclude the...

journal_title：PLoS neglected tropical diseases

authors： Jones MK,Bong SH,Green KM,Holmes P,Duke M,Loukas A,McManus DP

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Intestinal schistosomiasis and soil-transmitted helminth (STH) infections constitute major public health problems in many parts of sub-Saharan Africa. In this study we examined the functional significance of such polyparasite infections in anemia and undernutrition in Rwandan individuals. METHODS:Three poly...

journal_title：PLoS neglected tropical diseases

authors： Mupfasoni D,Karibushi B,Koukounari A,Ruberanziza E,Kaberuka T,Kramer MH,Mukabayire O,Kabera M,Nizeyimana V,Deville MA,Ruxin J,Webster JP,Fenwick A

更新日期：2009-09-15 00:00:00

abstract：BACKGROUND:Rift Valley fever virus (RVFV) causes outbreaks of severe disease in livestock and humans throughout Africa and the Arabian Peninsula. In people, RVFV generally causes a self-limiting febrile illness but in a subset of individuals, it progresses to more serious disease. One manifestation is a delayed-onset e...

journal_title：PLoS neglected tropical diseases

authors： Dodd KA,McElroy AK,Jones TL,Zaki SR,Nichol ST,Spiropoulou CF

更新日期：2014-06-12 00:00:00

abstract：BACKGROUND:Socioeconomically deprived children are at increased risk of ill-health associated with sedentary behavior, malnutrition, and helminth infection. The resulting reduced physical fitness, growth retardation, and impaired cognitive abilities may impede children's capacity to pay attention. The present study exa...

journal_title：PLoS neglected tropical diseases

authors： Gall S,Müller I,Walter C,Seelig H,Steenkamp L,Pühse U,du Randt R,Smith D,Adams L,Nqweniso S,Yap P,Ludyga S,Steinmann P,Utzinger J,Gerber M

更新日期：2017-05-08 00:00:00

abstract：BACKGROUND:The activities of the Global Programme for the Elimination of Lymphatic Filariasis have been in operation since the year 2000, with Mass Drug Administration (MDA) undertaken yearly in disease endemic communities. Information collected during MDA-such as population demographics, age, sex, drugs used and remai...

journal_title：PLoS neglected tropical diseases

authors： de Souza DK,Yirenkyi E,Otchere J,Biritwum NK,Ameme DK,Sackey S,Ahorlu C,Wilson MD

更新日期：2016-03-30 00:00:00

abstract：BACKGROUND:The initial response to Leishmania parasites is essential in determining disease development or resistance. In vitro, a divergent response to Leishmania, characterized by high or low IFN-γ production has been described as a potential tool to predict both vaccine response and disease susceptibility in vivo. ...

journal_title：PLoS neglected tropical diseases

authors： Carneiro MW,Fukutani KF,Andrade BB,Curvelo RP,Cristal JR,Carvalho AM,Barral A,Van Weyenbergh J,Barral-Netto M,de Oliveira CI

更新日期：2016-11-21 00:00:00

abstract：BACKGROUND:Human cysticercosis is a zoonotic disease causing severe health disorders and even death. While prevalence data become available worldwide, incidence rate and cumulative incidence figures are lacking, which limits the understanding of the Taenia solium epidemiology. METHODOLOGY/PRINCIPAL FINDINGS:A seroepid...

journal_title：PLoS neglected tropical diseases

authors： Coral-Almeida M,Rodríguez-Hidalgo R,Celi-Erazo M,García HH,Rodríguez S,Devleesschauwer B,Benítez-Ortiz W,Dorny P,Praet N

更新日期：2014-05-22 00:00:00

abstract：BACKGROUND:Cure after treatment for human African trypanosomiasis (HAT) is assessed by examination of the cerebrospinal fluid every 6 months, for a total period of 2 years. So far, no markers for cure or treatment failure have been identified in blood. Trypanosome-specific antibodies are detectable in blood by the Card...

journal_title：PLoS neglected tropical diseases

authors： Lejon V,Ngoyi DM,Boelaert M,Büscher P

更新日期：2010-01-26 00:00:00

abstract：BACKGROUND:Dengue viral infection is a global health threat without vaccine or specific treatment. The clinical outcome varies from asymptomatic, mild dengue fever (DF) to severe dengue hemorrhagic fever (DHF). While adaptive immune responses were found to be detrimental in the dengue pathogenesis, the roles of earlier...

journal_title：PLoS neglected tropical diseases

authors： Matangkasombut P,Chan-In W,Opasawaschai A,Pongchaikul P,Tangthawornchaikul N,Vasanawathana S,Limpitikul W,Malasit P,Duangchinda T,Screaton G,Mongkolsapaya J

更新日期：2014-06-19 00:00:00

abstract：BACKGROUND:Marburg virus (MARV), a zoonotic pathogen causing severe hemorrhagic fever in man, has emerged in Angola resulting in the largest outbreak of Marburg hemorrhagic fever (MHF) with the highest case fatality rate to date. METHODOLOGY/PRINCIPAL FINDINGS:A mobile laboratory unit (MLU) was deployed as part of the...

journal_title：PLoS neglected tropical diseases

authors： Grolla A,Jones SM,Fernando L,Strong JE,Ströher U,Möller P,Paweska JT,Burt F,Pablo Palma P,Sprecher A,Formenty P,Roth C,Feldmann H

更新日期：2011-05-01 00:00:00

abstract：:The new world arenavirus Junín virus (JUNV) is the causative agent of Argentine hemorrhagic fever, a lethal human infectious disease. Adult laboratory mice are generally resistant to peripheral infection by JUNV. The mechanism underlying the mouse resistance to JUNV infection is largely unknown. We have reported that ...

journal_title：PLoS neglected tropical diseases

authors： Huang C,Walker AG,Grant AM,Kolokoltsova OA,Yun NE,Seregin AV,Paessler S

更新日期：2014-06-05 00:00:00

abstract：BACKGROUND:Oncomelania hupensis is the unique intermediate host of Schistosoma japonicum, which causes schistosomiasis endemic in the Far East, and especially in mainland China. O. hupensis largely determines the parasite's geographical range. How O. hupensis's genetic diversity is distributed geographically in mainlan...

journal_title：PLoS neglected tropical diseases

authors： Zhao QP,Jiang MS,Littlewood DT,Nie P

更新日期：2010-03-02 00:00:00

abstract：:The 2015-2017 epidemics of Zika virus (ZIKV) in the Americas caused widespread infection, followed by protective immunity. The timing and burden of the next Zika virus outbreak remains unclear. We used an agent-based model to simulate the dynamics of age-specific immunity to ZIKV, and predict the future age-specific r...

journal_title：PLoS neglected tropical diseases

authors： Counotte MJ,Althaus CL,Low N,Riou J

更新日期：2019-12-26 00:00:00

abstract：BACKGROUND:Treponema pallidum subsp. endemicum (TEN) is the causative agent of endemic syphilis (bejel). An unusual human TEN 11q/j isolate was obtained from a syphilis-like primary genital lesion from a patient that returned to France from Pakistan. METHODOLOGY/PRINCIPAL FINDINGS:The TEN 11q/j isolate was characteriz...

journal_title：PLoS neglected tropical diseases

authors： Mikalová L,Strouhal M,Oppelt J,Grange PA,Janier M,Benhaddou N,Dupin N,Šmajs D

更新日期：2017-03-06 00:00:00

abstract：BACKGROUND:Trachomatous trichiasis (TT), inturned eyelashes from repeated infection with Chlamydia trachomatis, is the leading infectious cause of blindness in the world. Though surgery will correct entropion caused by trachoma, uptake of TT surgery remains low. In this case-control study, we identify barriers that pre...

journal_title：PLoS neglected tropical diseases

authors： Bickley RJ,Mkocha H,Munoz B,West S

更新日期：2017-01-04 00:00:00

abstract：:Kinetoplastids are a group of parasites that includes several medically-important species. These human-infective species are transmitted by insect vectors in which the parasites undergo specific developmental transformations. For each species, this includes a stage in which parasites adhere to insect tissue via a hemi...

journal_title：PLoS neglected tropical diseases

authors： Filosa JN,Berry CT,Ruthel G,Beverley SM,Warren WC,Tomlinson C,Myler PJ,Dudkin EA,Povelones ML,Povelones M

更新日期：2019-07-29 00:00:00

abstract：:Post-kala-azar dermal leishmaniasis (PKDL) is clinical outcome of visceral leishmaniasis (VL) and is thought to be the potential reservoir of parasite. Miltefosine (MF) is the only oral drug existing for treatment of post-kala-azar dermal leishmaniasis (PKDL). Increased miltefosine tolerance in clinical isolates of Le...

journal_title：PLoS neglected tropical diseases

authors： Topno RK,Rabi Das VN,Kumar M,Madhukar M,Pandey K,Verma N,Agrawal K,Lal CS,Siddiqui NA,Bimal S,Das P

更新日期：2020-03-23 00:00:00

abstract：BACKGROUND:Crimean-Congo hemorrhagic fever (CCHF) is a serious disease with a high fatality rate reported in many countries. The first case of CCHF in Oman was detected in 1995 and serosurveys have suggested widespread infection of humans and livestock throughout the country. METHODOLOGY:Cases of CCHF reported to the ...

journal_title：PLoS neglected tropical diseases

authors： Al-Abri SS,Hewson R,Al-Kindi H,Al-Abaidani I,Al-Jardani A,Al-Maani A,Almahrouqi S,Atkinson B,Al-Wahaibi A,Al-Rawahi B,Bawikar S,Beeching NJ

更新日期：2019-04-25 00:00:00

abstract：:Several medically important mosquito-borne flaviviruses have been detected in Argentina in recent years: Dengue (DENV), St. Louis encephalitis (SLEV), West Nile (WNV) and Yellow Fever (YFV) viruses. Evidence of Bussuquara virus (BSQV) and Ilheus virus (ILHV) activity were found, but they have not been associated with ...

journal_title：PLoS neglected tropical diseases

authors： Morales MA,Fabbri CM,Zunino GE,Kowalewski MM,Luppo VC,Enría DA,Levis SC,Calderón GE

更新日期：2017-02-10 00:00:00

abstract：BACKGROUND:Arboviruses have overlapping geographical distributions and can cause symptoms that coincide with more common infections. Therefore, arbovirus infections are often neglected by travel diagnostics. Here, we assessed the potential of syndrome-based approaches for diagnosis and surveillance of neglected arbovir...

journal_title：PLoS neglected tropical diseases

authors： Cleton NB,Reusken CB,Wagenaar JF,van der Vaart EE,Reimerink J,van der Eijk AA,Koopmans MP

更新日期：2015-09-15 00:00:00

abstract：INTRODUCTION:This paper discusses the presence of Aedes aegypti pupae in different types of containers considering: volume, pH of the container, among other variables. METHODS:A nonlinear method for selection was applied, based on Mutual Information, by placing in order of importance the most appropriate variables for...

journal_title：PLoS neglected tropical diseases

authors： Medronho RA,Câmara VM,Macrini L

更新日期：2018-07-23 00:00:00

abstract：:Cystic echinococcosis (CE) is distributed worldwide, extending from China to the Middle East and from Mediterranean countries to the sub-Saharan Africa and South America. According to WHO, one million people around the world are suffering from CE with an estimated burden of 183,573 DALYs. The annual monetary burden of...

journal_title：PLoS neglected tropical diseases

authors： Borhani M,Fathi S,Lahmar S,Ahmed H,Abdulhameed MF,Fasihi Harandi M

更新日期：2020-05-07 00:00:00