Abstract:
:Sand flies are the insects responsible for transmitting Leishmania parasites, the causative agents of leishmaniasis in humans. However, the effects of sand fly breeding sites on their biology and ecology remain poorly understood. Herein, we studied how larval nutrition associated with putative breeding sites of the sand fly Lutzomyia longipalpis affects their oviposition, development, microbiome, and susceptibility to Leishmania by rearing L. longipalpis on substrates collected from an endemic area for leishmaniasis in Brazil. The results showed that female L. longipalpis select the oviposition site based on its potential to promote larval maturation and while composting cashew leaf litter hindered the development, larvae reared on chicken feces developed rapidly. Typical gut microbial profiles were found in larvae reared upon cashew leaf litter. Adult females from larvae reared on substrate collected in chicken coops were infected with Leishmania infantum, indicating that they were highly susceptible to the parasite. In conclusion, the larval breeding sites can exert an important role in the epidemiology of leishmaniasis.
journal_name
PLoS Negl Trop Disjournal_title
PLoS neglected tropical diseasesauthors
Aguiar Martins K,Meirelles MHA,Mota TF,Abbasi I,de Queiroz ATL,Brodskyn CI,Veras PST,Mothé Fraga DB,Warburg Adoi
10.1371/journal.pntd.0009034subject
Has Abstractpub_date
2021-01-21 00:00:00pages
e0009034issue
1eissn
1935-2727issn
1935-2735pii
PNTD-D-20-01426journal_volume
15pub_type
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