Identification of microRNA genes in three opisthorchiids.

abstract：:Epidemic growth rate, r, provides a more complete description of the potential for epidemics than the more commonly studied basic reproduction number, R0, yet the former has never been described as a function of temperature for dengue virus or other pathogens with temperature-sensitive transmission. The need to unders...

journal_title：PLoS neglected tropical diseases

authors： Siraj AS,Oidtman RJ,Huber JH,Kraemer MUG,Brady OJ,Johansson MA,Perkins TA

更新日期：2017-07-19 00:00:00

abstract：BACKGROUND:Lymphatic filariasis (LF) is a so-called neglected tropical disease, currently overshadowed by higher-profile efforts to address malaria, tuberculosis, and HIV/AIDS. Despite recent successes in arresting transmission, some 40 million people who already have the disease have been largely neglected. This study...

journal_title：PLoS neglected tropical diseases

authors： Perera M,Whitehead M,Molyneux D,Weerasooriya M,Gunatilleke G

更新日期：2007-11-21 00:00:00

abstract：:The metacestode (larval) stage of the tapeworm Echinococcus multilocularis causes alveolar echinococcosis (AE), a very severe and in many cases incurable disease. To date, benzimidazoles such as albendazole and mebendazole are the only approved chemotherapeutical treatment options. Benzimidazoles inhibit metacestode p...

journal_title：PLoS neglected tropical diseases

authors： Stadelmann B,Rufener R,Aeschbacher D,Spiliotis M,Gottstein B,Hemphill A

更新日期：2016-03-11 00:00:00

abstract：:The progression and variation of pathology during infections can be due to components from both host or pathogen, and/or the interaction between them. The influence of host genetic variation on disease pathology during infections with trypanosomes has been well studied in recent years, but the role of parasite genetic...

journal_title：PLoS neglected tropical diseases

authors： Morrison LJ,Tait A,McLellan S,Sweeney L,Turner CM,MacLeod A

更新日期：2009-12-01 00:00:00

abstract：INTRODUCTION:Yaws is endemic in Ghana. The World Health Organization (WHO) has launched a new global eradication campaign based on total community mass treatment with azithromycin. Achieving high coverage of mass treatment will be fundamental to the success of this new strategy; coverage is dependent, in part, on appro...

journal_title：PLoS neglected tropical diseases

authors： Marks M,Kwakye-Maclean C,Doherty R,Adwere P,Aziz Abdulai A,Duah F,Ohene SA,Mitja O,Oguti B,Solomon AW,Mabey DCW,Adu-Sarkodie Y,Asiedu K,Ackumey MM

更新日期：2017-07-31 00:00:00

abstract：:A comprehensive analysis was done to evaluate the potential use of anti-parasitic macrocyclic lactones (including avermectins and milbemycins) for Buruli ulcer (BU) therapy. A panel containing nearly all macrocyclic lactones used in human or in veterinary medicine was analyzed for activity in vitro against clinical is...

journal_title：PLoS neglected tropical diseases

authors： Scherr N,Pluschke G,Thompson CJ,Ramón-García S

更新日期：2015-08-13 00:00:00

abstract：BACKGROUND:With few studies conducted to date, very little is known about the epidemiology of rickettsioses in Bhutan. Due to two previous outbreaks and increasing clinical cases, scrub typhus is better recognized than other rickettsial infections and Q fever. METHODOLOGY:A descriptive cross-sectional serosurvey was c...

journal_title：PLoS neglected tropical diseases

authors： Tshokey T,Stenos J,Durrheim DN,Eastwood K,Nguyen C,Graves SR

更新日期：2017-11-27 00:00:00

abstract：:Canine rabies was endemic pre-urbanisation, yet little is known about how it persists in small populations of dogs typically seen in rural and remote regions. By simulating rabies outbreaks in such populations (50-90 dogs) using a network-based model, our objective was to determine if rabies-induced behavioural change...

journal_title：PLoS neglected tropical diseases

authors： Brookes VJ,Dürr S,Ward MP

更新日期：2019-09-23 00:00:00

abstract：BACKGROUND:A relatively simple life history allows us to derive an expression for the extinction probability of populations of tsetse, vectors of African sleeping sickness. We present the uncertainty and sensitivity analysis of the extinction probability, to offer key insights into factors affecting the control or erad...

journal_title：PLoS neglected tropical diseases

authors： Are EB,Hargrove JW

更新日期：2020-05-11 00:00:00

abstract：BACKGROUND:The parasitic protozoan Trypanosoma brucei utilizes glycolysis exclusively for ATP production during infection of the mammalian host. The first step in this metabolic pathway is mediated by hexokinase (TbHK), an enzyme essential to the parasite that transfers the gamma-phospho of ATP to a hexose. Here we des...

journal_title：PLoS neglected tropical diseases

authors： Sharlow ER,Lyda TA,Dodson HC,Mustata G,Morris MT,Leimgruber SS,Lee KH,Kashiwada Y,Close D,Lazo JS,Morris JC

更新日期：2010-04-13 00:00:00

abstract：BACKGROUND:Leptospirosis is an emerging zoonosis that is often under-recognized in children and commonly confused with dengue in tropical settings. An enhanced ability to distinguish leptospirosis from dengue in children would guide clinicians and public health personnel in the appropriate use of limited healthcare res...

journal_title：PLoS neglected tropical diseases

authors： Libraty DH,Myint KS,Murray CK,Gibbons RV,Mammen MP,Endy TP,Li W,Vaughn DW,Nisalak A,Kalayanarooj S,Hospenthal DR,Green S,Rothman AL,Ennis FA

更新日期：2007-12-26 00:00:00

abstract：BACKGROUND:The frequency of accidental spider bites in Brazil is growing, and poisoning due to bites from the spider genus Phoneutria nigriventer is the second most frequent source of such accidents. Intense local pain is the major symptom reported after bites of P. nigriventer, although the mechanisms involved are sti...

journal_title：PLoS neglected tropical diseases

authors： Gewehr C,Oliveira SM,Rossato MF,Trevisan G,Dalmolin GD,Rigo FK,de Castro Júnior CJ,Cordeiro MN,Ferreira J,Gomez MV

更新日期：2013-04-25 00:00:00

abstract：BACKGROUND:Leptospirosis, a spirochaetal zoonotic disease, is the cause of epidemics associated with high mortality in urban slum communities. Infection with pathogenic Leptospira occurs during environmental exposures and is traditionally associated with occupational risk activities. However, slum inhabitants reside in...

journal_title：PLoS neglected tropical diseases

authors： Maciel EA,de Carvalho AL,Nascimento SF,de Matos RB,Gouveia EL,Reis MG,Ko AI

更新日期：2008-01-30 00:00:00

abstract：:The major arboviral diseases in mainland China include Japanese encephalitis, dengue fever, Crimean-Congo hemorrhagic fever (also known as Xinjiang hemorrhagic fever), and tick-borne encephalitis. These and other newly found arbovirus infections due to Banna virus and Tahyna virus contribute to a large and relatively ...

journal_title：PLoS neglected tropical diseases

authors： Gao X,Nasci R,Liang G

更新日期：2010-04-27 00:00:00

abstract：BACKGROUND:Massangam health district (HD), in the West Region of Cameroon, has received ivermectin mass drug administration (MDA) for 20 years, however there is evidence of continued high transmission of Onchocerca volvulus. In order to better understand the transmission dynamics in the HD and inform intervention strat...

journal_title：PLoS neglected tropical diseases

authors： Bakajika D,Senyonjo L,Enyong P,Oye J,Biholong B,Elhassan E,Boakye D,Dixon R,Schmidt E

更新日期：2018-11-14 00:00:00

abstract：BACKGROUND:Envenoming by viper snakes constitutes an important public health problem in Brazil and other developing countries. Local hemorrhage is an important symptom of these accidents and is correlated with the action of snake venom metalloproteinases (SVMPs). The degradation of vascular basement membrane has been p...

journal_title：PLoS neglected tropical diseases

authors： Baldo C,Jamora C,Yamanouye N,Zorn TM,Moura-da-Silva AM

更新日期：2010-06-29 00:00:00

abstract：BACKGROUND:Human African trypanosomiasis is a severely neglected vector-borne disease that is always fatal if untreated. In Tanzania it is highly focalised and of major socio-economic and public health importance in affected communities. OBJECTIVES:This study aimed to estimate the public health burden of rhodesiense H...

journal_title：PLoS neglected tropical diseases

authors： Matemba LE,Fèvre EM,Kibona SN,Picozzi K,Cleaveland S,Shaw AP,Welburn SC

更新日期：2010-11-02 00:00:00

abstract：BACKGROUND:Blindness is caused by eye pathogens that include a free-living protist (Acanthamoeba castellanii, A. byersi, and/or other Acanthamoeba spp.), a fungus (Fusarium solani), and a bacterium (Chlamydia trachomatis). Hand-eye contact is likely a contributor to the spread of these pathogens, and so hand washing wi...

journal_title：PLoS neglected tropical diseases

authors： Aqeel Y,Rodriguez R,Chatterjee A,Ingalls RR,Samuelson J

更新日期：2017-02-09 00:00:00

abstract：:Trypanosoma cruzi, the aetiological agent of Chagas disease possess extensive genetic diversity. This has led to the development of a plethora of molecular typing methods for the identification of both the known major genetic lineages and for more fine scale characterization of different multilocus genotypes within th...

journal_title：PLoS neglected tropical diseases

authors： Diosque P,Tomasini N,Lauthier JJ,Messenger LA,Monje Rumi MM,Ragone PG,Alberti-D'Amato AM,Pérez Brandán C,Barnabé C,Tibayrenc M,Lewis MD,Llewellyn MS,Miles MA,Yeo M

更新日期：2014-08-28 00:00:00

abstract：BACKGROUND:Since cholera appeared in Africa during the 1970s, cases have been reported on the continent every year. In Sub-Saharan Africa, cholera outbreaks primarily cluster at certain hotspots including the African Great Lakes Region and West Africa. METHODOLOGY/PRINCIPAL FINDINGS:In this study, we applied MLVA (Mul...

journal_title：PLoS neglected tropical diseases

authors： Moore S,Miwanda B,Sadji AY,Thefenne H,Jeddi F,Rebaudet S,de Boeck H,Bidjada B,Depina JJ,Bompangue D,Abedi AA,Koivogui L,Keita S,Garnotel E,Plisnier PD,Ruimy R,Thomson N,Muyembe JJ,Piarroux R

更新日期：2015-06-25 00:00:00

abstract：OBJECTIVE:We conducted a systematic literature review with indirect comparison of studies evaluating therapeutic efficacy and toxicity associated to visceral leishmaniasis (VL) therapy among HIV infected individuals. MAIN OUTCOME MEASUREMENTS:The outcomes of interest were clinical and parasitological cure, mortality, ...

journal_title：PLoS neglected tropical diseases

authors： Cota GF,de Sousa MR,Fereguetti TO,Rabello A

更新日期：2013-05-02 00:00:00

abstract：INTRODUCTION:Buruli Ulcer (BU) is caused by the environmental microbe Mycobacterium ulcerans. Despite unclear transmission, contact with a BU endemic region is the key known risk factor. In Victoria, Australia, where endemic areas have been carefully mapped, we aimed to estimate the Incubation Period (IP) of BU by inte...

journal_title：PLoS neglected tropical diseases

authors： Trubiano JA,Lavender CJ,Fyfe JA,Bittmann S,Johnson PD

更新日期：2013-10-03 00:00:00

abstract：BACKGROUND:During severe (pneumo)sepsis inflammatory and coagulation pathways become activated as part of the host immune response. Thrombomodulin (TM) is involved in a range of host defense mechanisms during infection and plays a pivotal role in activation of protein C (PC) into active protein C (APC). APC has both an...

journal_title：PLoS neglected tropical diseases

authors： Kager LM,Wiersinga WJ,Roelofs JJ,de Boer OJ,Weiler H,van 't Veer C,van der Poll T

更新日期：2014-04-24 00:00:00

abstract：:Dengue appears to be endemic in Africa with a number of reported outbreaks. In February 2013, several individuals with dengue-like illnesses and negative malaria blood smears were identified in Mombasa, Kenya. Dengue was laboratory confirmed and an investigation was conducted to estimate the magnitude of local transmi...

journal_title：PLoS neglected tropical diseases

authors： Ellis EM,Neatherlin JC,Delorey M,Ochieng M,Mohamed AH,Mogeni DO,Hunsperger E,Patta S,Gikunju S,Waiboic L,Fields B,Ofula V,Konongoi SL,Torres-Velasquez B,Marano N,Sang R,Margolis HS,Montgomery JM,Tomashek KM

更新日期：2015-04-29 00:00:00

abstract：BACKGROUND:Imported strongyloidiasis is increasingly being diagnosed in non-endemic areas. The aim of this study was to describe the epidemiological, clinical and microbiological characteristics of patients with imported strongyloidiasis in Spain. METHODOLOGY:This is an observational retrospective study that included ...

journal_title：PLoS neglected tropical diseases

authors： Salvador F,Treviño B,Chamorro-Tojeiro S,Sánchez-Montalvá A,Herrero-Martínez JM,Rodríguez-Guardado A,Serre-Delcor N,Torrús D,Goikoetxea J,Zubero Z,Velasco M,Sulleiro E,Molina I,López-Vélez R,Pérez-Molina JA,on behalf the +RE

更新日期：2019-05-16 00:00:00

abstract：BACKGROUND:Leishmania uses the amino acid L-arginine as a substrate for arginase, enzyme that produces urea and ornithine, last precursor of polyamine pathway. This pathway is used by the parasite to replicate and it is essential to establish the infection in the mammalian host. L-arginine is not synthesized by the par...

journal_title：PLoS neglected tropical diseases

authors： Aoki JI,Muxel SM,Zampieri RA,Acuña SM,Fernandes JCR,Vanderlinde RH,Sales MCOP,Floeter-Winter LM

更新日期：2017-10-26 00:00:00

abstract：:Rickettsia (R.) helvetica is the most prevalent rickettsia found in Ixodes ricinus ticks in Germany. Several studies reported antibodies against R. helvetica up to 12.5% in humans investigated, however, fulminant clinical cases are rare indicating a rather low pathogenicity compared to other rickettsiae. We investigat...

journal_title：PLoS neglected tropical diseases

authors： Speck S,Kern T,Aistleitner K,Dilcher M,Dobler G,Essbauer S

更新日期：2018-02-12 00:00:00

abstract：BACKGROUND:Cutaneous dirofilariosis is a canine mosquito-borne zoonosis that can cause larva migrans disease in humans. Dirofilaria repens is considered an emerging pathogen occurring with high prevalence in Mediterranean areas and many parts of tropical Asia. In Hong Kong, a second species, Candidatus Dirofilaria hong...

journal_title：PLoS neglected tropical diseases

authors： Yilmaz E,Fritzenwanker M,Pantchev N,Lendner M,Wongkamchai S,Otranto D,Kroidl I,Dennebaum M,Le TH,Anh Le T,Ramünke S,Schaper R,von Samson-Himmelstjerna G,Poppert S,Krücken J

更新日期：2016-10-11 00:00:00

abstract：:Schistosomes are parasitic platyhelminths that currently infect over 200 million people globally. The parasites can live for years in a putatively hostile environment - the blood of vertebrates. We have hypothesized that the unusual schistosome tegument (outer-covering) plays a role in protecting parasites in the bloo...

journal_title：PLoS neglected tropical diseases

authors： Bhardwaj R,Skelly PJ

更新日期：2011-04-05 00:00:00

abstract：BACKGROUND:In the Brazilian Amazon, clinical and epidemiological frameworks of Chagas disease are very dissimilar in relation to the endemic classical areas of transmission, possibly due to genetic and biological characteristics of the circulating Trypanosoma cruzi stocks. Twenty six T. cruzi stocks from Western Amazon...

journal_title：PLoS neglected tropical diseases

authors： Monteiro WM,Margioto Teston AP,Gruendling AP,dos Reis D,Gomes ML,de Araújo SM,Bahia MT,Magalhães LK,de Oliveira Guerra JA,Silveira H,Toledo MJ,Vale Barbosa Md

更新日期：2013-01-01 00:00:00