Abstract:
:In Mediterranean countries, the incidence (per 100,000 per year) of Type 1 diabetes in children aged under 15 years shows wide variation from country to country, ranging from 2.45 in Macedonia to 34.4 in Sardinia. By interacting with environmental factors such as diet, toxins or viral infections, the HLA plus non-HLA genes of susceptibility or resistance to Type 1 diabetes so far identified are the strongest determinants of the disease as far as incidence, age at onset and sex ratio are concerned. The distribution of these genes in the Mediterranean region is still not completely known. Sardinians are the most suitable population for studying such phenomena for three main reasons: their genetic features have been repeatedly analysed in depth; their incidence rate of Type 1 diabetes is by far the highest in the Mediterranean area; and considerable colonies of Sardinian emigrants settled in neighbouring low-incidence Italian regions. Studies on Spaniards and Jews have also contributed to a better understanding of the respective roles of genetic and environmental factors. From a body of research on the Mediterranean populations, it can be concluded that great genetic heterogeneity accounts for the wide variation in incidence of Type 1 diabetes, while rather ubiquitious environmental factors trigger the disease in genetically predisposed individuals.
journal_name
Diabetes Metab Res Revjournal_title
Diabetes/metabolism research and reviewsauthors
Muntoni S,Muntoni Sdoi
10.1002/(sici)1520-7560(199903/04)15:2<133::aid-dmkeywords:
subject
Has Abstractpub_date
1999-03-01 00:00:00pages
133-40issue
2eissn
1520-7552issn
1520-7560pii
10.1002/(SICI)1520-7560(199903/04)15:2<133::AID-DMjournal_volume
15pub_type
杂志文章,评审abstract:BACKGROUND:Malonyl-CoA, an allosteric inhibitor of carnitine palmitoyl transferase, controls the oxidation of fatty acids in muscle and other tissues by regulating their entrance into mitochondria. The level of malonyl-CoA in muscle is influenced by the uptake of energy substrates such as glucose, the precursor of its ...
journal_title:Diabetes/metabolism research and reviews
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doi:10.1002/dmrr.2652
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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abstract:OBJECTIVE:Increased plasma levels of plasminogen activator inhibitor-1 (PAI-1) have been suggested to be a part of the insulin resistance syndrome, and recent data suggest that adipose tissue participates in the production of PAI-1. We examined the expression and insulin regulation of subcutaneous adipose tissue PAI-1 ...
journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
doi:10.1002/1520-7560(2000)9999:9999<::aid-dmrr148>3.0
更新日期:2000-09-01 00:00:00
abstract::Four kinds of subcutaneous continuous glucose monitoring (CGM) machines have been currently introduced in clinical practice. These machines exhibit real-time glucose on the monitor every 5 minutes and have alarms to indicate hypoglycaemia and hyperglycaemia. However, thus far, there is no clear consensus about the cli...
journal_title:Diabetes/metabolism research and reviews
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
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更新日期:2011-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/dmrr.748
更新日期:2008-01-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,评审
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,评审
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更新日期:2012-12-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
doi:10.1002/dmrr.585
更新日期:2006-01-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
doi:10.1002/dmrr.3199
更新日期:2019-11-01 00:00:00