Abstract：
BACKGROUND:The cardiovascular effects of sulfonylureas (SU) in diabetic patients are controversial and it has been suggested that diabetic patients with acute myocardial infarction while on SU were at increased risk. OBJECTIVES:To assess the in-hospital outcome of patients with acute myocardial infarction according to the use of SU at the time of the acute episode. METHODS:Of 443 intensive care units in France, 369 (83%) prospectively collected all cases of infarction admitted within 48 h of symptom onset in November 2000. RESULTS:Among the 2320 patients included in the registry, 487 (21%) had diabetes, of whom 215 (44%) were on SU. Patients on SU were older and had a more frequent history of hyperlipidemia than those not receiving SU. Type and location of infarction were similar in the two groups, and there was no difference in Killip class on admission. In-hospital mortality was lower in patients on SU (10.2%) than in those without SU (16.9%) (p = 0.035). There was a trend toward less frequent ventricular fibrillation (2.3% vs 5.9%, p = 0.052). In two models of multivariate analyses, SU therapy was associated with decreased in-hospital mortality (model 1: relative risk: 0.44, p = 0.012; model 2: relative risk: 0.37, p = 0.020). CONCLUSIONS:In this nationwide registry reflecting real-world practice, the use of sulfonylureas in diabetic patients was not associated with increased in-hospital mortality.
journal_name
Diabetes Metab Res Revjournal_title
Diabetes/metabolism research and reviewsauthors
Danchin N,Charpentier G,Ledru F,Vaur L,Guéret P,Hanania G,Blanchard D,Lablanche JM,Genès N,Cambou JPdoi
10.1002/dmrr.498keywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
143-9issue
2eissn
1520-7552issn
1520-7560journal_volume
21pub_type
杂志文章,多中心研究abstract：:In addition to reducing hyperglycaemia, the metabolic actions of TZDs (pioglitazone and rosiglitazone) in theory might improve the prognosis of patients with type 2 diabetes. However, it appears from recent data that pioglitazone and rosiglitazone have different cardiovascular risk profiles. The scope of this paper is...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.937
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND:Diabetes mellitus secondary to pancreatic diseases is a condition seldom thought of in clinical practice. Yet, a high percentage of exocrine pancreatic insufficiency has been reported for the general population and especially for diabetic subjects. Thus, we investigated the prevalence of diabetes mellitus du...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.2260
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:Current guidelines recommend screening the feet of diabetic subjects with a 10-g monofilament or tuning fork. We investigated which tests and locations on the feet have the best predictive value regarding 1-year ulcer-free survival in diabetic subjects participating in the prospective Rotterdam Diabetic Foot...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.3119
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:The importance of cytotoxic T lymphocyte antigen-4 (CTLA-4) in immune regulation is unquestioned, yet a precise understanding of which cells express it, and how it mediates immune inhibitory function, is lacking. Regulatory T cells are known to constitutively express CTLA-4 intracellularly, whereas conventio...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.1277
更新日期：2011-11-01 00:00:00
abstract：:Prevention of diabetic foot ulcers is important to reduce the burden of diabetic foot disease. However, we found that ulcer prevention is underexposed in research and clinical practice. Barriers to explain this are seen in patient's goal-setting; in the lack of interdisciplinary teams for ulcer prevention; in sample s...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.3234
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:Clinical studies have shown that proinsulin C-peptide exerts renoprotective effects in type 1 diabetes, although the underlying mechanisms are poorly understood. As C-peptide has been shown to induce several intracellular events and to localize to nuclei, we aimed to determine whether gene transcription is a...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.1220
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:Adenosine receptors denoted by A1 , A2A , A2B , and A3 and encoded by ADORA1, ADORA2A, ADORA2B, and ADORA3 genes, respectively, are adenosine-activated G-protein-coupled receptors that play an important role in obesity and type 2 diabetes mellitus. However, little is known about their significance in gestati...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.2446
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Both metabolic syndrome (MetS) and N-amino terminal fragment of the prohormone B-type natriuretic peptide (NT-proBNP) confer increased risk of cardiovascular diseases (CVD). We assessed if NT-proBNP levels were greater in people with uncomplicated MetS, who had neither CVD/chronic kidney disease (CKD) nor di...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.2616
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:To ascertain which demographic, clinical, and microbiological factors might affect clinical outcomes of patients with diabetic foot infections, excluding known osteomyelitis, by analysing Clinical Assessment Program and Teflaro® Utilization Registry study data of patients treated with ceftaroline fosamil. M...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,多中心研究
doi：10.1002/dmrr.2624
更新日期：2015-05-01 00:00:00
abstract：:Hypertension is a major modifiable risk factor for cardiovascular morbidity and mortality in diabetic patients. Guidelines recommend lowering blood pressure (BP) to less than 130/80 mmHg in diabetic patients. These recommendations are based on several studies in diabetic patients that showed the benefit of intensive B...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.2348
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Stable glucagon-like peptide-1 (GLP-1) mimetics, such as the GLP-1 analogue liraglutide, are approved for treatment of type 2 diabetes. GLP-1 has a spectrum of anti-diabetic effects that are of possible utility in the treatment of more severe forms of diabetes. METHODS:The present study has evaluated the ef...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.2608
更新日期：2015-03-01 00:00:00
abstract：AIMS:Insulin-like growth factor 1 receptor (IGF1R) is involved in cell growth and glucose homeostasis. In the current study, the IGF1R locus was analysed as a candidate gene for type 2 diabetes (T2D) in American Indians. MATERIALS AND METHODS:Whole genome sequence data from 335 American Indians identified 3 novel miss...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.2994
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:To investigate longitudinal associations of maternal glucose/HbA1c and insulin dose with birthweight-related outcomes in women with type 1 diabetes. METHODS:We performed a cohort study including 473 pregnant women with type 1 diabetes with singleton pregnancies. We investigated maternal self-monitored blood...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.3300
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVE:Increased plasma levels of plasminogen activator inhibitor-1 (PAI-1) have been suggested to be a part of the insulin resistance syndrome, and recent data suggest that adipose tissue participates in the production of PAI-1. We examined the expression and insulin regulation of subcutaneous adipose tissue PAI-1 ...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/1520-7560(2000)9999:9999<::aid-dmrr148>3.0
更新日期：2000-09-01 00:00:00
abstract：:The actual pathophysiology behind gestational diabetes mellitus (GDM) is still unclear, but a deterioration in insulin resistance beyond that induced by pregnancy, combined with beta cell dysfunction, plays a key role. Interventions that help improve glucose tolerance by attenuating pregnancy-induced insulin resistanc...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.2402
更新日期：2013-07-01 00:00:00
abstract：:Activation of self-reactive T cells that specifically destroy the pancreatic beta-cells is one of the hallmarks in the development of type 1 diabetes. Thus, for prevention and treatment of this autoimmune disease, approaches to induce and maintain T cell tolerance toward the beta-cells, especially in islet transplanta...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.345
更新日期：2003-05-01 00:00:00
abstract：BACKGROUND:Individuals with diabetes mellitus (DM) homozygous for the haptoglobin (Hp) 1 allele are at decreased risk of retinopathy as compared to DM individuals with the Hp 2 allele. We sought to recapitulate these findings in DM mice genetically modified at the Hp locus. METHODS:An early morphological characteristi...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.654
更新日期：2007-02-01 00:00:00
abstract：BACKGROUND:Hybrid closed-loop (HCL) therapy is rarely studied in pregnancy. We present three cases of women with type 1 diabetes who used the Medtronic 670G HCL system for most or all of gestation. METHODS:The Medtronic 670G system has a manual mode (no automated insulin delivery) and an auto mode (AM, HCL therapy). W...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.3248
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:In patients with type 1 diabetes, three main variables need to be assessed to optimize meal-related insulin boluses: pre-meal blood glucose (BG), insulin to carbohydrate ratio (I : C), and basal insulin. We are presenting data for a novel use of the hyperinsulinaemic-euglycaemic clamp (HEC) in patients with ...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.727
更新日期：2007-09-01 00:00:00
abstract：:Hepatic glycogen is replenished during the absorptive period postprandially. This repletion is prompted partly by an increased hepatic uptake of glucose by the liver, partly by metabolite and hormonal signals in the portal vein, and partly by an increased gluconeogenic flux to glycogen (glyconeogenesis). There is some...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.217
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:It has been shown that subjects with normal glucose tolerance (NGT), whose plasma glucose (PG) levels do not return to their fasting PG level within 2 h during an oral glucose tolerance test (OGTT) (Group I), have a significantly higher risk to develop type 2 diabetes than NGT subjects whose 2-h glucose retu...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.951
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND:We aimed to predict the incidence of obesity in a Korean population using a genetic risk score (GRS) constructed with obesity-related single nucleotide polymorphisms (SNPs) along with an oxidative stress score (OSS). METHODS:A total of 9460 Korean subjects and 356 974 SNPs were included. The GRS was constru...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.3230
更新日期：2020-02-01 00:00:00
abstract：AIM:We systematically review the available systems used to classify diabetic foot ulcers in order to synthesize their methodological qualitative issues and accuracy to predict lower extremity amputation, as this may represent a critical point in these patients' care. MATERIAL AND METHODS:Two investigators searched, in...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/dmrr.2535
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Platelet activation contributes to cardiovascular disease (CVD), the main complication of type 2 diabetes mellitus (T2DM) and pre-diabetic conditions. Mean platelet volume is an easy-to-measure platelet parameter that has been associated with CVD. We sought to assess mean platelet volume, platelet distributi...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/dmrr.2625
更新日期：2015-05-01 00:00:00
abstract：:Type 2 diabetes is responsible for the increased prevalence of ischaemic heart disease, generally related to coronary artery disease, which is associated with increased morbidity and death in diabetic patients. Epidermal growth factor receptor (EGFR) tyrosine kinase, one of the many factors involved in cell growth and...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.1050
更新日期：2010-01-01 00:00:00
abstract：:In Mediterranean countries, the incidence (per 100,000 per year) of Type 1 diabetes in children aged under 15 years shows wide variation from country to country, ranging from 2.45 in Macedonia to 34.4 in Sardinia. By interacting with environmental factors such as diet, toxins or viral infections, the HLA plus non-HLA ...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/(sici)1520-7560(199903/04)15:2<133::aid-dm
更新日期：1999-03-01 00:00:00
abstract：OBJECTIVE:Atherosclerosis is associated with insulin resistance (IR) and dyslipidaemia. Impaired glucose tolerance (IGT) is characterised by IR and is associated with a higher risk of atherosclerosis. The objective of the present study was to test whether early atherosclerosis indicated by intimal medial thickness (IMT...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.226
更新日期：2001-11-01 00:00:00
abstract：BACKGROUND:Studies have associated diabetes mellitus (DM) with the reduced risk of abdominal aortic aneurysm and thoracic aortic aneurysm and dissection. We used the national insurance data of Taiwan to examine these correlations for an Asian population. The association was also evaluated by DM severity. METHODS:We id...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.2585
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:Cross-sectional and family studies identified angiotensin-converting enzyme (ACE) gene as a risk factor for diabetic nephropathy (DN). The contribution of ACE gene variants to DN development and progression is controversial and varies among different ethnic/racial groups. METHODS:We investigated the associa...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.1006
更新日期：2009-11-01 00:00:00
abstract：:Patients with diabetes may undergo an approximately 24-h fast for a voluntary religious observance or in preparation for a medical procedure. Commonly, patients will manage their diabetes before and during such fasting without guidelines from their doctors, often because they did not ask for advice. The physician shou...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.1169
更新日期：2011-07-01 00:00:00
