Heparanase prevents the development of type 1 diabetes in non-obese diabetic mice by regulating T-cell activation and cytokines production.

abstract：BACKGROUND:Diabetes mellitus secondary to pancreatic diseases is a condition seldom thought of in clinical practice. Yet, a high percentage of exocrine pancreatic insufficiency has been reported for the general population and especially for diabetic subjects. Thus, we investigated the prevalence of diabetes mellitus du...

journal_title：Diabetes/metabolism research and reviews

authors： Ewald N,Kaufmann C,Raspe A,Kloer HU,Bretzel RG,Hardt PD

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:The prevalence of type 2 diabetes in China is increasing rapidly. Appropriate management of glycemia, blood pressure and dyslipidemia in this population is a major public health concern. OBJECTIVE:The aim of this study was to assess metabolic control including glycated hemoglobin A1c (HbA1c ), blood pressur...

journal_title：Diabetes/metabolism research and reviews

authors： Liu L,Lou Q,Guo X,Yuan L,Shen L,Sun Z,Zhao F,Dai X,Huang J,Yang H,Mordes JP,Chinese Diabetes Education Status Survey Study Group.

更新日期：2015-11-01 00:00:00

abstract：:Type 2 diabetes is responsible for the increased prevalence of ischaemic heart disease, generally related to coronary artery disease, which is associated with increased morbidity and death in diabetic patients. Epidermal growth factor receptor (EGFR) tyrosine kinase, one of the many factors involved in cell growth and...

journal_title：Diabetes/metabolism research and reviews

authors： Matrougui K

更新日期：2010-01-01 00:00:00

abstract：:There are a number of medical conditions such as growth failure in children, pregnancy, lipid abnormalities, and early complications that are improved by the meticulous glycemic control that can be achieved with insulin pump therapy (CSII). By using an insulin pump, many patients with severe hypoglycemia, the dawn phe...

journal_title：Diabetes/metabolism research and reviews

authors： Kaufman FR,Halvorson M,Miller D,Mackenzie M,Fisher LK,Pitukcheewanont P

更新日期：1999-09-01 00:00:00

abstract：:An appropriate diet represents the cornerstone for diabetes therapy. Diets that differ in their carbohydrate, lipid and protein content are used but the evidence of their effects on the long term is missing. Several confounding factors and compliance to diet render difficult the evaluation of the 'best diet' for diabe...

journal_title：Diabetes/metabolism research and reviews

authors： Pozzilli P,Fallucca F

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Lispro Mix 25% insulin lispro/75% insulin lispro protamine (LM25) and Lispro Mix 50% insulin lispro/50% insulin lispro protamine (LM50) were compared as starter insulins in East Asian patients with type 2 diabetes. METHODS:Phase 4, open-label, randomized trial conducted in China, Japan, Korea, and Turkey. S...

journal_title：Diabetes/metabolism research and reviews

authors： Watada H,Su Q,Li PF,Iwamoto N,Qian L,Yang WY

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing in developing countries, but its causes are not known. We aimed to ascertain the prevalence and determinants of NAFLD in a new largely unmedicated population-based cohort from the rapidly gentrifying region of Pinggu, China. METHODS:We ran...

journal_title：Diabetes/metabolism research and reviews

authors： Zhou X,Li Y,Zhang X,Guan YY,Puentes Y,Zhang F,Speliotes EK,Ji L

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Compare glycated hemoglobin (HbA1c ) diagnostic tests for prediabetes and diabetes with plasma glucose criteria and compare the metabolic profiles of people classified by HbA1c versus by glucose levels. METHODS:Participants were recruited for the San Juan Overweight Adults Longitudinal Study. The participan...

journal_title：Diabetes/metabolism research and reviews

authors： Vega-Vázquez MA,Ramírez-Vick M,Muñoz-Torres FJ,González-Rodríguez LA,Joshipura K

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:We have investigated the possible role of ACP1 (also known as cLMWPTP: cytosolic low molecular weight phosphotyrosine phosphatase), a highly polymorphic enzyme involved in signal transduction of T-cell receptor, insulin receptor and other growth factors in the relationship between maternal age at delivery an...

journal_title：Diabetes/metabolism research and reviews

authors： Bottini N,Meloni GF,Lucarelli P,Amante A,Saccucci P,Gloria-Bottini F,Bottini E

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Adenosine triphosphate (ATP) is a critical determinant of beta-cell insulin secretion in response to glucose. BHE/cdb rats have a mutation in ATP synthase that limits ATP production, yet develop mild diabetes only with ageing. We investigated the cellular basis for reduced insulin secretion and compensatory ...

journal_title：Diabetes/metabolism research and reviews

authors： Saleh MC,Fatehi-Hassanabad Z,Wang R,Nino-Fong R,Wadowska DW,Wright GM,Harper ME,Chan CB

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Malonyl-CoA, an allosteric inhibitor of carnitine palmitoyl transferase, controls the oxidation of fatty acids in muscle and other tissues by regulating their entrance into mitochondria. The level of malonyl-CoA in muscle is influenced by the uptake of energy substrates such as glucose, the precursor of its ...

journal_title：Diabetes/metabolism research and reviews

authors： Shafrir E,Ziv E,Saha AK,Ruderman NB

更新日期：2002-05-01 00:00:00

abstract：:Diabetic foot ulceration poses a heavy burden on the patient and the healthcare system, but prevention thereof receives little attention. For every euro spent on ulcer prevention, ten are spent on ulcer healing, and for every randomized controlled trial conducted on prevention, ten are conducted on healing. In this ar...

journal_title：Diabetes/metabolism research and reviews

authors： Bus SA,van Netten JJ

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:We conducted a meta-analysis to investigate the association of circulating tumor necrosis factor-1 (TNFR-1) and TNFR-2 with diabetic kidney disease (DKD) progression, which is the first-ever quantitative analysis of these associations thus far. Whether TNFRs were better than albumin-creatinine ratio (ACR) in...

journal_title：Diabetes/metabolism research and reviews

authors： Ye X,Luo T,Wang K,Wang Y,Yang S,Li Q,Hu J

更新日期：2019-11-01 00:00:00

abstract：:Diabetes foot infections are a common condition and a major causal pathway to lower extremity amputation. Identification of causative pathogens is vital in directing antimicrobial therapy. Historically, clinicians have relied upon culture-dependent techniques that are now acknowledged as both being selective for micro...

journal_title：Diabetes/metabolism research and reviews

authors： Malone M,Gosbell IB,Dickson HG,Vickery K,Espedido BA,Jensen SO

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Latent autoimmune diabetes in adults (LADA) exhibits significant clinical heterogeneity, but the underlying causes remain unclear. The aim of this study was to investigate whether age of onset of LADA contributes to the observed clinical heterogeneity by comparing the clinical, metabolic, and immunogenetic c...

journal_title：Diabetes/metabolism research and reviews

authors： Niu X,Luo S,Li X,Xie Z,Xiang Y,Huang G,Lin J,Yang L,Liu Z,Wang X,Leslie RD,Zhou Z

更新日期：2019-01-01 00:00:00

abstract：:Insulin resistance is characterized by hyperglycaemia, dyslipidaemia and oxidative stress prior to the development of type 2 diabetes mellitus. To date, a number of mechanisms have been proposed to link these syndromes together, but it remains unclear what the unifying condition that triggered these events in the prog...

journal_title：Diabetes/metabolism research and reviews

authors： Hafizi Abu Bakar M,Kian Kai C,Wan Hassan WN,Sarmidi MR,Yaakob H,Zaman Huri H

更新日期：2015-07-01 00:00:00

abstract：:The intestinal microbiota has come to be considered an additional risk factor for the development of metabolic diseases. Considering the potential role of antimicrobials as modulators of the intestinal microbiota, they have been investigated for use in the adjuvant treatment of obesity and insulin resistance (IR). In ...

journal_title：Diabetes/metabolism research and reviews

authors： Dos Reis SA,do Carmo Gouveia Peluzio M,Bressan J

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:To investigate longitudinal associations of maternal glucose/HbA1c and insulin dose with birthweight-related outcomes in women with type 1 diabetes. METHODS:We performed a cohort study including 473 pregnant women with type 1 diabetes with singleton pregnancies. We investigated maternal self-monitored blood...

journal_title：Diabetes/metabolism research and reviews

authors： García-Patterson A,Ovejero D,Miñambres I,Chico A,Gil PA,Martínez MJ,Adelantado JM,de Leiva A,Gich I,Desoye G,de Mouzon SH,Corcoy R

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Increased production of reactive oxygen species (ROS) in mitochondria has been proposed as the pathogenic mechanism for chronic complications of diabetes. Mitochondrial DNA (mtDNA) is more vulnerable to reactive oxygen species. However, there are few data on the mitochondrial DNA damage in diabetes and these...

journal_title：Diabetes/metabolism research and reviews

authors： Savu O,Sunkari VG,Botusan IR,Grünler J,Nikoshkov A,Catrina SB

更新日期：2011-07-01 00:00:00

abstract：:Patients with type 2 diabetes mellitus using sulfonylurea derivatives or insulin may experience hypoglycaemia. However, recent data regarding the incidence of hypoglycaemia are scarce. We conducted a systematic review and meta-analysis to determine the proportion of patients with type 2 diabetes mellitus that experien...

journal_title：Diabetes/metabolism research and reviews

authors： Schopman JE,Simon AC,Hoefnagel SJ,Hoekstra JB,Scholten RJ,Holleman F

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:There is conflicting information regarding the risk of gestational diabetes mellitus in twin pregnancies. This study was conducted to determine whether the risk of gestational diabetes mellitus is higher in pregnant Japanese women with twin versus singleton pregnancy. METHODS:The prevalence of gestational d...

journal_title：Diabetes/metabolism research and reviews

authors： Morikawa M,Yamada T,Akaishi R,Kojima T,Nishida R,Koyama T,Cho K,Minakami H

更新日期：2015-02-01 00:00:00

abstract：:Four kinds of subcutaneous continuous glucose monitoring (CGM) machines have been currently introduced in clinical practice. These machines exhibit real-time glucose on the monitor every 5 minutes and have alarms to indicate hypoglycaemia and hyperglycaemia. However, thus far, there is no clear consensus about the cli...

journal_title：Diabetes/metabolism research and reviews

authors： Kim HS,Shin JA,Chang JS,Cho JH,Son HY,Yoon KH

更新日期：2012-12-01 00:00:00

abstract：:Diabetes is a group of metabolic diseases characterized by elevated blood glucose levels that drive the development of life-threatening complications. Diabetes results from a situation of insufficient insulin action, either by deficient production of the hormone by the pancreas, or by the development of insulin resist...

journal_title：Diabetes/metabolism research and reviews

authors： Castaño C,Novials A,Párrizas M

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:The proposed 2015 US Preventive Services Task Force guidelines recommend diabetes screening for individuals ≥45 years or demonstrating other risk factors for dysglycemia. Still, many patients with dysglycemia remain undiagnosed, and opportunities for early intervention are lost. METHODS:To test novel approa...

journal_title：Diabetes/metabolism research and reviews

authors： Silverman RA,Schleicher MG,Valente CJ,Kim M,Romanenko Y,Schulman RC,Tiberio A,Greenblatt B,Rentala M,Salvador-Kelly AV,Kwon NS,Jornsay DL

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Mutating the insulin B:9-23 peptide prevents diabetes in NOD mice. Thus, the trimolecular complex of I-Ag7-insulin B:9-23 peptide-TCR may be essential for the development of spontaneous diabetes. Pathogenic T cells recognize the B:9-23 peptide presented by I-Ag7 in what is termed register 3, with the B22 bas...

journal_title：Diabetes/metabolism research and reviews

authors： Zhang L,Stadinski BD,Michels A,Kappler JW,Eisenbarth GS

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:The aim of the study is to assess the relationship between the shape of plasma glucose concentration during the OGTT and future risk for T2DM. METHODS:2445 non-diabetic subjects from the Botnia study received an OGTT at baseline and after 7-8 years of follow-up. RESULTS:NGT and IFG subjects who returned th...

journal_title：Diabetes/metabolism research and reviews

authors： Abdul-Ghani MA,Lyssenko V,Tuomi T,Defronzo RA,Groop L

更新日期：2010-05-01 00:00:00

abstract：:The prevalence of diabetes mellitus in primary hyperparathyroidism is approximately 8% and that of primary hyperparathyroidism in diabetic patients is approximately 1%. Both values are about three-fold higher than the respective expected prevalences in general populations. Patients with both disorders are over 40 year...

journal_title：Diabetes/metabolism research and reviews

authors： Taylor WH,Khaleeli AA

更新日期：2001-05-01 00:00:00

abstract：:There is strong evidence that the avoidance of hyperglycemia is essential inoptimizing pregnancy outcome in type 1 diabetes. The price to pay is a striking increase in severe hypoglycemia (SH), defined as episodes requiring help from another person. During type 1 diabetic pregnancy, occurrence rates of SH up to 15 tim...

journal_title：Diabetes/metabolism research and reviews

authors： ter Braak EW,Evers IM,Willem Erkelens D,Visser GH

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Sustained hyperglycaemia induces increased renal oxygen consumption resulting in reduced oxygen availability in the diabetic kidney. We investigated the roles of the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase and the neuronal nitric oxide synthase (nNOS) for the increased oxygen consumption ...

journal_title：Diabetes/metabolism research and reviews

authors： Edlund J,Fasching A,Liss P,Hansell P,Palm F

更新日期：2010-07-01 00:00:00

abstract：:Diabetic foot disease is an important complication of diabetes. The development and outcome of foot ulcers are related to the interplay between numerous diabetes-related factors such as nerve dysfunction, impaired wound healing and microvascular and/or macrovascular disease.The formation of advanced glycation end prod...

journal_title：Diabetes/metabolism research and reviews

authors： Huijberts MS,Schaper NC,Schalkwijk CG

更新日期：2008-05-01 00:00:00