Association of TCF7L2 SNPs with age at onset of type 2 diabetes and proinsulin/insulin ratio but not with glucagon-like peptide 1.

abstract：AIMS:Insulin-like growth factor 1 receptor (IGF1R) is involved in cell growth and glucose homeostasis. In the current study, the IGF1R locus was analysed as a candidate gene for type 2 diabetes (T2D) in American Indians. MATERIALS AND METHODS:Whole genome sequence data from 335 American Indians identified 3 novel miss...

journal_title：Diabetes/metabolism research and reviews

authors： Muller YL,Skelton G,Piaggi P,Chen P,Nair A,Kobes S,Hsueh WC,Knowler WC,Hanson RL,Baier LJ,Bogardus C

更新日期：2018-05-01 00:00:00

abstract：:A recent study from Gallagher et al. aimed to investigate the effect of a new depeptidyl-peptidase-4 inhibitor, MK-0626, on bone turnover in a mouse model developing insulin resistance and diabetes (MKR mice). Authors have found that treatment with MK-0626 did not affect either MKR mice fasting glucose or parameters o...

journal_title：Diabetes/metabolism research and reviews

authors： Napoli N

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:T1DM is a T-cell-mediated autoimmune disease targeting insulin-producing beta-cells. Multiple factors may contribute to the development of T1DM. Among these, the metabolic state of beta-cells and pro-inflammatory cytokines, produced by infiltrating immune cells, have been implicated in the precipitation of T...

journal_title：Diabetes/metabolism research and reviews

authors： Osterbye T,Funda DP,Fundová P,Månsson JE,Tlaskalová-Hogenová H,Buschard K

更新日期：2010-11-01 00:00:00

abstract：:As basal insulin analogues are being used off-label, there is a need to evaluate their safety (maternal hypoglycaemia and fetal and perinatal outcomes) and efficacy [haemoglobin A1c(HbA1c), fasting plasma glucose, and maternal weight gain]. The aim of this review is to provide an overview of the current literature con...

journal_title：Diabetes/metabolism research and reviews

authors： Mathiesen ER,Damm P,Jovanovic L,McCance DR,Thyregod C,Jensen AB,Hod M

更新日期：2011-09-01 00:00:00

abstract：:Rising rates of diabetes in pregnancy have led to an escalation in research in this area. As in any area of clinical research, definitions of outcomes vary from study to study, making it difficult to compare research findings and draw conclusions. Our aim was to compile and create a repository of definitions, which co...

journal_title：Diabetes/metabolism research and reviews

authors： International Association of Diabetes in Pregnancy Study Group (IADPSG) Working Group on Outcome Definitions.,Feig DS,Corcoy R,Jensen DM,Kautzky-Willer A,Nolan CJ,Oats JJ,Sacks DA,Caimari F,McIntyre HD

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Increased activity of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in enhanced adrenocorticotropin (ACTH) and serum glucocorticoid levels, has been described in patients with diabetes mellitus and in animal models of this disease; however, altered steroid production by adrenocortical cells could ...

journal_title：Diabetes/metabolism research and reviews

authors： Astort F,Repetto EM,Martínez Calejman C,Cipelli JM,Sánchez R,Di Gruccio JM,Mercau M,Pignataro OP,Arias P,Cymeryng CB

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:A nested case-control (NCC) design within a prospective cohort study can realize substantial benefits for biomarker studies. In this context, it is natural to consider the sample availability in the selection of controls to minimize data loss when implementing the design. However, this violates the randomnes...

journal_title：Diabetes/metabolism research and reviews

authors： Lee HS,Lynch KF,Krischer JP,TEDDY Study Group.

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Leptin's hematopoietic or proinflammatory role has been experimentally reported. We investigated whether serum leptin concentrations are associated with white blood cell (WBC) counts in humans. METHODS:Serum leptin concentrations of Japanese civil servants aged 40 to 59 years (1082 men and 200 women) were a...

journal_title：Diabetes/metabolism research and reviews

authors： Mabuchi T,Yatsuya H,Tamakoshi K,Otsuka R,Nagasawa N,Zhang H,Murata C,Wada K,Ishikawa M,Hori Y,Kondo T,Hashimoto S,Toyoshima H

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Clinical studies have shown that proinsulin C-peptide exerts renoprotective effects in type 1 diabetes, although the underlying mechanisms are poorly understood. As C-peptide has been shown to induce several intracellular events and to localize to nuclei, we aimed to determine whether gene transcription is a...

journal_title：Diabetes/metabolism research and reviews

authors： Lindahl E,Nordquist L,Müller P,El Agha E,Friederich M,Dahlman-Wright K,Palm F,Jörnvall H

更新日期：2011-10-01 00:00:00

abstract：:Cardiovascular disease now is the leading cause of mortality among patients with type 1 diabetes (T1D). The risk of death from cardiovascular events in subjects with T1D is 2-10 times higher than the general population, depending on blood glucose control. Although complications of cardiovascular disease occur in middl...

journal_title：Diabetes/metabolism research and reviews

authors： Shi M,Tang R,Huang F,Zhong T,Chen Y,Li X,Zhou Z

更新日期：2020-11-30 00:00:00

abstract：:In several large recent observational studies, peripheral arterial disease (PAD) was present in up to 50% of the patients with a diabetic foot ulcer and was an independent risk factor for amputation. The International Working Group on the Diabetic Foot therefore established a multidisciplinary working group to evaluat...

journal_title：Diabetes/metabolism research and reviews

authors： Hinchliffe RJ,Andros G,Apelqvist J,Bakker K,Friederichs S,Lammer J,Lepantalo M,Mills JL,Reekers J,Shearman CP,Valk G,Zierler RE,Schaper NC

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Cyclosporin A (CyA) may induce acute nephrotoxicity. The question has been raised of the possible long-term unfavorable course of CyA-induced lesions. Advantage was taken of a large cohort of diabetic patients treated for several months using moderate CyA dosage to evaluate the long-term evolution of renal f...

journal_title：Diabetes/metabolism research and reviews

authors： Assan R,Blanchet F,Feutren G,Timsit J,Larger E,Boitard C,Amiel C,Bach JF

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:This study aimed to investigate whether oestradiol differs between premenopausal women with and without type 1 diabetes and whether levels are associated with such factors as age, reproductive history or diabetes management. METHODS:Oestradiol in premenopausal women with type 1 diabetes (n = 89; age = 18-50...

journal_title：Diabetes/metabolism research and reviews

authors： Hassan LS,Monson RS,Danielson KK

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:In patients with type 1 diabetes, three main variables need to be assessed to optimize meal-related insulin boluses: pre-meal blood glucose (BG), insulin to carbohydrate ratio (I : C), and basal insulin. We are presenting data for a novel use of the hyperinsulinaemic-euglycaemic clamp (HEC) in patients with ...

journal_title：Diabetes/metabolism research and reviews

authors： Bevier WC,Zisser H,Palerm CC,Finan DA,Seborg DE,Doyle FJ,Wollitzer AO,Jovanovic L

更新日期：2007-09-01 00:00:00

abstract：:The role of peripheral arterial disease in ulcerated diabetic feet has long been underestimated. Progressive claudication, rest pain and the extent of irreversible tissue loss have frequently been indications for revascularization for neuroischaemic ulcers in diabetic patients. These typical ischaemic symptoms are war...

journal_title：Diabetes/metabolism research and reviews

authors： Apelqvist JA,Lepäntalo MJ

更新日期：2012-02-01 00:00:00

abstract：AIMS:This study was designed to investigate the association between pancreatic fat content (PFC) and insulin secretory capacity as well as glucose tolerance in Korean adults. MATERIALS:A total of 39 participants (mean age 49.9 years, 53% males) without a previous history of diabetes, or those previously diagnosed as h...

journal_title：Diabetes/metabolism research and reviews

authors： Chin SO,Hwang YC,Cho IJ,Jeong IK,Ahn KJ,Chung HY

更新日期：2020-11-30 00:00:00

abstract：:Small fibres constitute 70-90% of peripheral nerve fibres and regulate several key functions such as tissue blood flow, temperature and pain perception as well as sweating, all of which are highly relevant to the clinical presentation and adverse outcomes associated with foot ulcerations in patients with diabetes. Rec...

journal_title：Diabetes/metabolism research and reviews

authors： Malik RA,Veves A,Tesfaye S,Smith G,Cameron N,Zochodne D,Lauria G,Toronto Consensus Panel on Diabetic Neuropathy.

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Although obesity has been associated with a higher risk for premature death, the sex and ethnic-origin specific body mass index (BMI) levels that are associated with increased mortality are controversial. We investigated the 40-year cumulative all-cause mortality, in relation to the BMI in adult life, among ...

journal_title：Diabetes/metabolism research and reviews

authors： Dankner R,Shanik M,Roth J,Luski A,Lubin F,Chetrit A

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Intensive insulin therapy is the gold standard by which Type 1 diabetes is treated. In addition to this therapy, administration of nicotinamide (NA) can be beneficial. This concept is reinforced by the results of a recent meta-analysis of the use of NA in patients with recent-onset Type 1 diabetes. METHODS:...

journal_title：Diabetes/metabolism research and reviews

authors： Visalli N,Cavallo MG,Signore A,Baroni MG,Buzzetti R,Fioriti E,Mesturino C,Fiori R,Lucentini L,Matteoli MC,Crinò A,Corbi S,Spera S,Teodonio C,Paci F,Amoretti R,Pisano L,Suraci C,Multari G,Sulli N,Cervoni M,De Mat

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Type 2 diabetes mellitus (DM) is associated with a decreased level of circulating endothelial progenitor cells (EPCs) and adiponectin. Experimental studies suggest a potential link between hypoadiponectinaemia and the depletion of the EPC level. This study investigated the relationships between adiponectin l...

journal_title：Diabetes/metabolism research and reviews

authors： Li M,Ho JC,Lai KW,Au KK,Xu A,Cheung BM,Lam KS,Tse HF

更新日期：2011-02-01 00:00:00

abstract：:Several interactive and mutually perpetuating abnormal biochemical pathways, such as protein kinase C (PKC) activation, augmented polyol pathway, and non-enzymatic glycation, may be activated as a result of sustained hyperglycemia in diabetes. These abnormal pathways may in turn influence several vasoactive factors, w...

journal_title：Diabetes/metabolism research and reviews

authors： Chakrabarti S,Cukiernik M,Hileeto D,Evans T,Chen S

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Platelet activation contributes to cardiovascular disease (CVD), the main complication of type 2 diabetes mellitus (T2DM) and pre-diabetic conditions. Mean platelet volume is an easy-to-measure platelet parameter that has been associated with CVD. We sought to assess mean platelet volume, platelet distributi...

journal_title：Diabetes/metabolism research and reviews

authors： Zaccardi F,Rocca B,Pitocco D,Tanese L,Rizzi A,Ghirlanda G

更新日期：2015-05-01 00:00:00

abstract：:Whether diabetic foot ulcerations arise from an amalgam of neuro-ischemic factors or because of arterial occlusive disease alone, the arterial circulation must be thoroughly evaluated. Clinical evaluation is foremost, but numerous non-invasive diagnostic options such as duplex ultrasonography and MRA are often enliste...

journal_title：Diabetes/metabolism research and reviews

authors： Andros G

更新日期：2004-05-01 00:00:00

abstract：:Hyperglycemia unawareness is the term suggested to me (M. Muggeo, personal communication, 1997) to encompass very broadly all of the stages in diabetes mellitus from the onset of any degree of hyperglycemia until the diagnosis is actually made. Diabetes and its handmaiden, obesity, are growing in epidemic proportions ...

journal_title：Diabetes/metabolism research and reviews

authors： Roth J

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Hybrid closed-loop (HCL) therapy is rarely studied in pregnancy. We present three cases of women with type 1 diabetes who used the Medtronic 670G HCL system for most or all of gestation. METHODS:The Medtronic 670G system has a manual mode (no automated insulin delivery) and an auto mode (AM, HCL therapy). W...

journal_title：Diabetes/metabolism research and reviews

authors： Polsky S,Akturk HK

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:To evaluate possible differences in distal polyneuropathy (PN) characteristics and degree of abnormalities for various small and large fibre parameters in diabetes type 1 (DM1) and type 2 (DM2). METHODS:Sixty-six DM1 and 57 DM2 patients with or without PN symptoms were included. Nerve conduction studies (NC...

journal_title：Diabetes/metabolism research and reviews

authors： Løseth S,Mellgren SI,Jorde R,Lindal S,Stålberg E

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:This study assesses the autonomic function of patients who have regained awareness of hypoglycaemia following islet cell or whole pancreas transplant. METHODS:Five patients with type 1 diabetes and either islet cell (four patients) or whole pancreas (one patient) transplant were assessed. These patients wer...

journal_title：Diabetes/metabolism research and reviews

authors： Kamel JT,Goodman DJ,Howe K,Cook MJ,Ward GM,Roberts LJ

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between ankle-branchial index (ABI) and cardiovascular disease in type 2 diabetes patients. METHODS:A total of 634 inpatients with type 2 diabetes were recruited in this cross-sectional study. All patients were measured with ABI and computed tomography angiography (CTA) scan f...

journal_title：Diabetes/metabolism research and reviews

authors： Xu L,He R,Hua X,Zhao J,Zhao J,Zeng H,Li L,Liu F,Jia W

更新日期：2019-01-01 00:00:00

abstract：:Hypertension is a major modifiable risk factor for cardiovascular morbidity and mortality in diabetic patients. Guidelines recommend lowering blood pressure (BP) to less than 130/80 mmHg in diabetic patients. These recommendations are based on several studies in diabetic patients that showed the benefit of intensive B...

journal_title：Diabetes/metabolism research and reviews

authors： Shlomai G,Grossman E

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Diabetic wounds are refractory and very difficult to heal. We aimed to use miRNA to identify novel and specific molecular markers for diabetes mellitus (DM) diagnosis and treatment. METHODS:The expression level of miR-296-5p was determined in tissue samples of 12 DM patients. The effect of miR-296-5p on pro...

journal_title：Diabetes/metabolism research and reviews

authors： Liu X,Wang Y,Zhang X,Zhang X,Guo J,Zhou J,Chai Y,Ma ZL

更新日期：2019-02-01 00:00:00