Cataract development in diabetic sand rats treated with alpha-lipoic acid and its gamma-linolenic acid conjugate.

abstract：BACKGROUND:To evaluate the association of statins and co-morbidities with new onset type 2 diabetes mellitus (T2DM) in patients 65 years and older. METHODS:This retrospective study used de-identified administrative healthcare claims and enrolment data from a Medicare Advantage Prescription Drug (MAPD) health plan offe...

journal_title：Diabetes/metabolism research and reviews

authors： Tangelloju S,Little BB,Esterhay RJ,Brock G,LaJoie S

更新日期：2020-09-01 00:00:00

abstract：:Rising rates of diabetes in pregnancy have led to an escalation in research in this area. As in any area of clinical research, definitions of outcomes vary from study to study, making it difficult to compare research findings and draw conclusions. Our aim was to compile and create a repository of definitions, which co...

journal_title：Diabetes/metabolism research and reviews

authors： International Association of Diabetes in Pregnancy Study Group (IADPSG) Working Group on Outcome Definitions.,Feig DS,Corcoy R,Jensen DM,Kautzky-Willer A,Nolan CJ,Oats JJ,Sacks DA,Caimari F,McIntyre HD

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Diabetic nephropathy (DN) is the most common cause of end stage renal failure or even death among patients with type 2 diabetes mellitus. Genetic predisposition is widely studied among these patients to identify manageable aspects of the disease pathogenesis. This study was carried out to test ...

journal_title：Diabetes/metabolism research and reviews

authors： Bayoumy NMK,El-Shabrawi MM,Leheta OF,Abo El-Ela AEM,Omar HH

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:The incidence of type 1 diabetes mellitus (T1DM) has increased in recent decades, as has the incidence of preterm births (<37 weeks). We aimed to evaluate and compare the prevalence of prematurity and early prematurity (<34 weeks) and birth season variability among T1DM and non-T1DM children. METHODS:A nati...

journal_title：Diabetes/metabolism research and reviews

authors： Adar A,Shalitin S,Eyal O,Loewenthal N,Pinhas-Hamiel O,Levy M,Dally-Gottfried O,Landau Z,Zung A,Levy-Khademi F,Zangen D,Tenenbaum-Rakover Y,Rachmiel M

更新日期：2018-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:The adipocyte derived peptide hormone leptin is known to regulate apoptosis and cell viability in several cells and tissues, as well as having several pancreatic islet beta-cell specific effects such as inhibition of glucose-stimulated insulin secretion. This study investigated the effects of leptin upo...

journal_title：Diabetes/metabolism research and reviews

authors： Brown JE,Dunmore SJ

更新日期：2007-09-01 00:00:00

abstract：:Now that the reduction in beta-mass has been clearly established in humans with type 2 diabetes mellitus (T2DM) 1-4, the debate focuses on the possible mechanisms responsible for decreased beta-cell number and impaired beta-cell function and their multifactorial etiology. Appropriate inbred rodent models are essential...

journal_title：Diabetes/metabolism research and reviews

authors： Portha B

更新日期：2005-11-01 00:00:00

abstract：:Neuropathy is a frequent complication in diabetes and most commonly seen as distal symmetrical sensorimotor polyneuropathy (PN). Involvement of the motor system is infrequently seen at the clinical examination. However, with the application of quantitative techniques, that is, isokinetic dynamometry, type 1 and type 2...

journal_title：Diabetes/metabolism research and reviews

authors： Andersen H

更新日期：2012-02-01 00:00:00

abstract：:Non-invasive tests for the detection of peripheral artery disease (PAD) among individuals with diabetes mellitus are important to estimate the risk of amputation, ulceration, wound healing and the presence of cardiovascular disease, yet there are no consensus recommendations to support a particular diagnostic modality...

journal_title：Diabetes/metabolism research and reviews

authors： Brownrigg JR,Hinchliffe RJ,Apelqvist J,Boyko EJ,Fitridge R,Mills JL,Reekers J,Shearman CP,Zierler RE,Schaper NC,International Working Group on the Diabetic Foot.

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Heparanase is an endo-beta-D-glucuronidase that cleaves heparan sulfate saccharide chains. The enzyme promotes cell adhesion, migration and invasion, and was shown to play a significant role in cancer metastasis and angiogenesis. METHODS:The present study focuses on the involvement of heparanase in autoimmu...

journal_title：Diabetes/metabolism research and reviews

authors： Bitan M,Weiss L,Zeira M,Reich S,Pappo O,Vlodavsky I,Slavin S

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Higher prothrombotic status and alterations in platelet function and thrombopoiesis are associated with diabetes mellitus (DM). We assessed the impact of diabetes and glucose control on the immature platelet fraction (IPF) and their relationship with prevalence and extent of coronary artery disease (CAD). M...

journal_title：Diabetes/metabolism research and reviews

authors： Verdoia M,Nardin M,Rolla R,Pergolini P,Suryapranata H,Kedhi E,Carriero A,De Luca G,Novara Atherosclerosis Study Group (NAS).

更新日期：2020-05-01 00:00:00

abstract：:Increasing coprevalence of diabetes mellitus (DM) and tuberculosis (TB) in low-income and middle-income countries (LMICs) indicates a rising threat to the decades of progress made against TB and requires global attention. This systematic review provides a summary of type 2 diabetes and tuberculosis coprevalence in var...

journal_title：Diabetes/metabolism research and reviews

authors： McMurry HS,Mendenhall E,Rajendrakumar A,Nambiar L,Satyanarayana S,Shivashankar R

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Data on the association between body iron and glucose homeostasis by the three glycaemic states are scarce. Thus, we investigated the association between body iron as assessed by a serum ferritin concentration and glucose homeostasis using homeostasis model assessment (HOMA) of insulin resistance (HOMA-IR) a...

journal_title：Diabetes/metabolism research and reviews

authors： Aregbesola A,Virtanen JK,Voutilainen S,Mursu J,Lagundoye A,Kauhanen J,Tuomainen TP

更新日期：2015-07-01 00:00:00

abstract：:Diabetes is an important cause of morbidity and mortality in Africa. Although a dramatic increase in disease burden is projected, it remains to be seen what effect the ongoing devastation of HIV disease will have on the epidemiology of such chronic diseases as diabetes. Recent data on type 2 diabetes prevalence indica...

journal_title：Diabetes/metabolism research and reviews

authors： Motala AA

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:Atherosclerosis is associated with insulin resistance (IR) and dyslipidaemia. Impaired glucose tolerance (IGT) is characterised by IR and is associated with a higher risk of atherosclerosis. The objective of the present study was to test whether early atherosclerosis indicated by intimal medial thickness (IMT...

journal_title：Diabetes/metabolism research and reviews

authors： Snehalatha C,Vijay V,Suresh Mohan R,Satyavani K,Sivasankari S,Megha T,Radhika S,Ramachandran A

更新日期：2001-11-01 00:00:00

abstract：:Hypoglycaemia is inevitable when striving for low HbA1c values. Nocturnal hypoglycaemia often occurs without symptoms, but results in diminished next day well-being and hypoglycaemia unawareness. Frequency of nocturnal hypoglycaemia was first assessed in research ward settings, but suffered from insufficient glucose s...

journal_title：Diabetes/metabolism research and reviews

authors： DeVries JH,Wentholt IM,Masurel N,Mantel I,Poscia A,Maran A,Heine RJ

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:Statins are one of the most widely prescribed medications in the United States; however, there is a concern that they are associated with new-onset-diabetes (NOD) development. We sought to understand the risk of dysglycemia and NOD for a cohort of individuals that reflect real-world physician prescribing patt...

journal_title：Diabetes/metabolism research and reviews

authors： Zigmont VA,Shoben AB,Lu B,Kaye GL,Clinton SK,Harris RE,Olivo-Marston SE

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Individuals with diabetes mellitus (DM) homozygous for the haptoglobin (Hp) 1 allele are at decreased risk of retinopathy as compared to DM individuals with the Hp 2 allele. We sought to recapitulate these findings in DM mice genetically modified at the Hp locus. METHODS:An early morphological characteristi...

journal_title：Diabetes/metabolism research and reviews

authors： Miller-Lotan R,Miller B,Nakhoul F,Aronson D,Asaf R,Levy AP

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Patients with impaired 50-g oral glucose challenge test (OGCT) have not been investigated for fetal anterior abdominal wall thickness until now. We aimed to investigate patients with impaired 50-g OGCT, but not gestational diabetes and match them with healthy uneventful pregnant participants for anterior abd...

journal_title：Diabetes/metabolism research and reviews

authors： Aksoy H,Aksoy U,Açmaz G,Tutuş S

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:We conducted this research in order to evaluate the prevalence of glutamic acid decarboxylase antibodies (GADA) in Korean women with gestational diabetes mellitus (GDM), to identify the clinical characteristics of these women, and to gauge the prevalence of diabetes among them after childbirth. METHODS:We s...

journal_title：Diabetes/metabolism research and reviews

authors： Yu SH,Park S,Kim HS,Park SY,Yim CH,Han KO,Yoon HK,Jang HC,Chung HY,Kim SH

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Current guidelines recommend screening the feet of diabetic subjects with a 10-g monofilament or tuning fork. We investigated which tests and locations on the feet have the best predictive value regarding 1-year ulcer-free survival in diabetic subjects participating in the prospective Rotterdam Diabetic Foot...

journal_title：Diabetes/metabolism research and reviews

authors： Rinkel WD,van der Oest MJW,Dijkstra DA,Castro Cabezas M,Coert JH

更新日期：2019-03-01 00:00:00

abstract：:Four kinds of subcutaneous continuous glucose monitoring (CGM) machines have been currently introduced in clinical practice. These machines exhibit real-time glucose on the monitor every 5 minutes and have alarms to indicate hypoglycaemia and hyperglycaemia. However, thus far, there is no clear consensus about the cli...

journal_title：Diabetes/metabolism research and reviews

authors： Kim HS,Shin JA,Chang JS,Cho JH,Son HY,Yoon KH

更新日期：2012-12-01 00:00:00

abstract：:This perspective covers a novel area of research describing the inadequacies of current approaches for diagnosing dysglycaemia and proposes that the 1-hour post-load glucose level during the 75-g oral glucose tolerance test may serve as a novel biomarker to detect dysglycaemia earlier than currently recommended screen...

journal_title：Diabetes/metabolism research and reviews

authors： Bergman M,Jagannathan R,Buysschaert M,Pareek M,Olsen MH,Nilsson PM,Medina JL,Roth J,Chetrit A,Groop L,Dankner R

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Cross-sectional and family studies identified angiotensin-converting enzyme (ACE) gene as a risk factor for diabetic nephropathy (DN). The contribution of ACE gene variants to DN development and progression is controversial and varies among different ethnic/racial groups. METHODS:We investigated the associa...

journal_title：Diabetes/metabolism research and reviews

authors： Ezzidi I,Mtiraoui N,Kacem M,Chaieb M,Mahjoub T,Almawi WY

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:A longitudinal study assessed serum paraoxonase 1 (PON1) activity and concentration as affected by age and as associated with the development of type 2 diabetes (T2D). PON1's recently established physiological function is the hydrolysis of lipolactones in oxidized LDL particles. METHODS:Serum samples and cl...

journal_title：Diabetes/metabolism research and reviews

authors： Crow JA,Meek EC,Wills RW,Chambers JE

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:HLA region is the major locus (IDDM1) of type 1 diabetes (T1D) susceptibility. It explains approximately 50% of the genetic background of T1D, indicating additional genetic determinants. Genome scans and candidate gene studies have generated several chromosomal candidate regions that may have a role in T1D d...

journal_title：Diabetes/metabolism research and reviews

authors： Laine AP,Nejentsev S,Veijola R,Korpinen E,Sjöroos M,Simell O,Knip M,Akerblom HK,Ilonen J

更新日期：2004-03-01 00:00:00

abstract：AIM:We systematically review the available systems used to classify diabetic foot ulcers in order to synthesize their methodological qualitative issues and accuracy to predict lower extremity amputation, as this may represent a critical point in these patients' care. MATERIAL AND METHODS:Two investigators searched, in...

journal_title：Diabetes/metabolism research and reviews

authors： Monteiro-Soares M,Martins-Mendes D,Vaz-Carneiro A,Sampaio S,Dinis-Ribeiro M

更新日期：2014-10-01 00:00:00

abstract：:In the last few years, there has been increasing focus on the impact of interventions on cardiovascular outcomes in patients with type 2 diabetes. Insulin resistance and hyperglycaemia often co-exist with a cluster of risk factors for coronary artery disease, but the underlying mechanisms leading to the development of...

journal_title：Diabetes/metabolism research and reviews

authors： Ceriello A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Intensive insulin therapy is the gold standard by which Type 1 diabetes is treated. In addition to this therapy, administration of nicotinamide (NA) can be beneficial. This concept is reinforced by the results of a recent meta-analysis of the use of NA in patients with recent-onset Type 1 diabetes. METHODS:...

journal_title：Diabetes/metabolism research and reviews

authors： Visalli N,Cavallo MG,Signore A,Baroni MG,Buzzetti R,Fioriti E,Mesturino C,Fiori R,Lucentini L,Matteoli MC,Crinò A,Corbi S,Spera S,Teodonio C,Paci F,Amoretti R,Pisano L,Suraci C,Multari G,Sulli N,Cervoni M,De Mat

更新日期：1999-05-01 00:00:00

abstract：:The prevalence of diabetes mellitus in primary hyperparathyroidism is approximately 8% and that of primary hyperparathyroidism in diabetic patients is approximately 1%. Both values are about three-fold higher than the respective expected prevalences in general populations. Patients with both disorders are over 40 year...

journal_title：Diabetes/metabolism research and reviews

authors： Taylor WH,Khaleeli AA

更新日期：2001-05-01 00:00:00

abstract：:Patients with diabetes may undergo an approximately 24-h fast for a voluntary religious observance or in preparation for a medical procedure. Commonly, patients will manage their diabetes before and during such fasting without guidelines from their doctors, often because they did not ask for advice. The physician shou...

journal_title：Diabetes/metabolism research and reviews

authors： Grajower MM

更新日期：2011-07-01 00:00:00