Cataract development in diabetic sand rats treated with alpha-lipoic acid and its gamma-linolenic acid conjugate.

abstract：:Common causes for non-healing of diabetic foot ulcers are infection and/or ischaemia. Diabetic patients are compromised hosts as far as wound healing is concerned. Diabetes mellitus is associated with a defective cellular and humoral immunity. In particular, decreased chemotaxis, decreased phagocytosis, impaired bacte...

journal_title：Diabetes/metabolism research and reviews

authors： Bakker DJ

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:This study aimed to investigate whether oestradiol differs between premenopausal women with and without type 1 diabetes and whether levels are associated with such factors as age, reproductive history or diabetes management. METHODS:Oestradiol in premenopausal women with type 1 diabetes (n = 89; age = 18-50...

journal_title：Diabetes/metabolism research and reviews

authors： Hassan LS,Monson RS,Danielson KK

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Malonyl-CoA, an allosteric inhibitor of carnitine palmitoyl transferase, controls the oxidation of fatty acids in muscle and other tissues by regulating their entrance into mitochondria. The level of malonyl-CoA in muscle is influenced by the uptake of energy substrates such as glucose, the precursor of its ...

journal_title：Diabetes/metabolism research and reviews

authors： Shafrir E,Ziv E,Saha AK,Ruderman NB

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:ZAC (Zinc finger protein that regulates apoptosis and cell-cycle arrest) is a candidate gene for transient neonatal diabetes mellitus (TNDM). This condition involves severe insulin deficiency at birth that reverses over weeks or months but may relapse with diabetes recurring in later life. ZAC overexpression...

journal_title：Diabetes/metabolism research and reviews

authors： Du X,Ounissi-Benkalha H,Loder MK,Rutter GA,Polychronakos C

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Body mass index (BMI) is associated with death in a V-shaped manner in general populations but it is unknown whether BMI or other risk factors also exhibit V-shaped relationships with death in type 2 diabetic patients. METHODS:A prospective cohort of 7534 Chinese, type 2 diabetic patients enrolled since 199...

journal_title：Diabetes/metabolism research and reviews

authors： So WY,Yang X,Ma RC,Kong AP,Lam CW,Ho CS,Cockram CS,Ko GT,Chow CC,Wong V,Tong PC,Chan JC

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Leptin's hematopoietic or proinflammatory role has been experimentally reported. We investigated whether serum leptin concentrations are associated with white blood cell (WBC) counts in humans. METHODS:Serum leptin concentrations of Japanese civil servants aged 40 to 59 years (1082 men and 200 women) were a...

journal_title：Diabetes/metabolism research and reviews

authors： Mabuchi T,Yatsuya H,Tamakoshi K,Otsuka R,Nagasawa N,Zhang H,Murata C,Wada K,Ishikawa M,Hori Y,Kondo T,Hashimoto S,Toyoshima H

更新日期：2005-09-01 00:00:00

abstract：:It is well established that hyperglycaemia is associated with many negative cardiovascular and immunological effects. Because of the high prevalence of underlying vascular disease along with associated infection, patients with diabetic foot ulcers are especially vulnerable to these adverse consequences. While studies ...

journal_title：Diabetes/metabolism research and reviews

authors： Egan AM,Dinneen SF

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Latent autoimmune diabetes in adults (LADA) exhibits significant clinical heterogeneity, but the underlying causes remain unclear. The aim of this study was to investigate whether age of onset of LADA contributes to the observed clinical heterogeneity by comparing the clinical, metabolic, and immunogenetic c...

journal_title：Diabetes/metabolism research and reviews

authors： Niu X,Luo S,Li X,Xie Z,Xiang Y,Huang G,Lin J,Yang L,Liu Z,Wang X,Leslie RD,Zhou Z

更新日期：2019-01-01 00:00:00

abstract：:During late gestation, although maternal adipose tissue lipolytic activity becomes enhanced, lipolytic products cross the placenta with difficulty. Under fasting conditions, free fatty acids (FFA) are used for ketogenesis by the mother, and ketone bodies are used as fuels and lipogenic substrates by the fetus. Materna...

journal_title：Diabetes/metabolism research and reviews

authors： Herrera E,Amusquivar E

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:To investigate longitudinal associations of maternal glucose/HbA1c and insulin dose with birthweight-related outcomes in women with type 1 diabetes. METHODS:We performed a cohort study including 473 pregnant women with type 1 diabetes with singleton pregnancies. We investigated maternal self-monitored blood...

journal_title：Diabetes/metabolism research and reviews

authors： García-Patterson A,Ovejero D,Miñambres I,Chico A,Gil PA,Martínez MJ,Adelantado JM,de Leiva A,Gich I,Desoye G,de Mouzon SH,Corcoy R

更新日期：2020-07-01 00:00:00

abstract：:During the last decades, the central nervous system (CNS) was intensively tested as a site for islet transplantation in different animal models of diabetes. Immunoprivilege properties of intracranial and intrathecal sites were found to delay and reduce rejection of transplanted allo-islets and xeno-islets, especially ...

journal_title：Diabetes/metabolism research and reviews

authors： Lazard D,Vardi P,Bloch K

更新日期：2016-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:In type 2 diabetes mellitus (T2DM), the abnormal protein and lipid composition of diabetic high-density lipoprotein (HDL) could impair its anti-inflammatory functions. Whether nonenzymatic glycation directly impaired the anti-inflammatory effects of HDL in innate immunity remained unclear. METHODS:Huma...

journal_title：Diabetes/metabolism research and reviews

authors： Liu D,Ji L,Zhang D,Tong X,Pan B,Liu P,Zhang Y,Huang Y,Su J,Willard B,Zheng L

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:The aim of the study is to assess the relationship between the shape of plasma glucose concentration during the OGTT and future risk for T2DM. METHODS:2445 non-diabetic subjects from the Botnia study received an OGTT at baseline and after 7-8 years of follow-up. RESULTS:NGT and IFG subjects who returned th...

journal_title：Diabetes/metabolism research and reviews

authors： Abdul-Ghani MA,Lyssenko V,Tuomi T,Defronzo RA,Groop L

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Adiponectin acts as an insulin sensitizer in rodent models. The direct effect of adiponectin in intact type 2 diabetic muscle is unknown. We examined whether adiponectin stimulates glucose transport in isolated skeletal muscle strips from type 2 diabetic men. METHODS:We obtained open muscle biopsies from 12...

journal_title：Diabetes/metabolism research and reviews

authors： Kuoppamaa H,Skrobuk P,Sihvo M,Hiukka A,Chibalin AV,Zierath JR,Koistinen HA

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:The possible effect of random intrasite placement on the outcome of the Semmes-Weinstein monofilament (SWF) test is not known. We sought to determine the significance of this variable in the diagnosis of loss of protective sensation (LOPS) in patients with diabetes. METHODS:Forty-five patients with diabetes...

journal_title：Diabetes/metabolism research and reviews

authors： Slater RA,Koren S,Ramot Y,Buchs A,Rapoport MJ

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Environmental factors such as nutrition or exposure to infections play a substantial role in the pathogenesis of type 1 diabetes (T1D). We have previously shown that gluten-free, non-purified diet largely prevented diabetes in non-obese diabetic (NOD) mice. In this study we tested hypothesis that early intro...

journal_title：Diabetes/metabolism research and reviews

authors： Funda DP,Kaas A,Tlaskalová-Hogenová H,Buschard K

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Studies have associated diabetes mellitus (DM) with the reduced risk of abdominal aortic aneurysm and thoracic aortic aneurysm and dissection. We used the national insurance data of Taiwan to examine these correlations for an Asian population. The association was also evaluated by DM severity. METHODS:We id...

journal_title：Diabetes/metabolism research and reviews

authors： Tsai CL,Lin CL,Wu YY,Shieh DC,Sung FC,Kao CH

更新日期：2015-02-01 00:00:00

abstract：:Every year, over 1 million people with diabetes lose a leg due to diabetic foot disease. Most amputations are preceded by a foot ulcer. Causes for the development of foot ulcers are generally multifactorial and may include neuropathy, peripheral vasculopathy, abnormal foot mechanics and infection. Multidisciplinary ap...

journal_title：Diabetes/metabolism research and reviews

authors： Cahn A,Elishuv O,Olshtain-Pops K

更新日期：2014-07-01 00:00:00

abstract：:Abstinence from food and liquid during daylight hours is observed by Muslim individuals during the month of Ramadan. Even though the Koran exempts the sick from fasting, many people with diabetes still fast during this religious period. It is essential for patients, family and healthcare professionals to be aware of t...

journal_title：Diabetes/metabolism research and reviews

authors： Hui E,Devendra D

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Vitamin D insufficiency and type 2 diabetes are both common in Finland, and low vitamin D status has been suggested as a risk factor for type 2 diabetes. Our aim was to study the associations between serum 25-hydroxyvitamin D [25(OH)D], a marker of vitamin D status, and glucose homeostasis and type 2 diabete...

journal_title：Diabetes/metabolism research and reviews

authors： Hurskainen AR,Virtanen JK,Tuomainen TP,Nurmi T,Voutilainen S

更新日期：2012-07-01 00:00:00

abstract：:Diabetes is an important cause of morbidity and mortality in Africa. Although a dramatic increase in disease burden is projected, it remains to be seen what effect the ongoing devastation of HIV disease will have on the epidemiology of such chronic diseases as diabetes. Recent data on type 2 diabetes prevalence indica...

journal_title：Diabetes/metabolism research and reviews

authors： Motala AA

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:There is conflicting information regarding the risk of gestational diabetes mellitus in twin pregnancies. This study was conducted to determine whether the risk of gestational diabetes mellitus is higher in pregnant Japanese women with twin versus singleton pregnancy. METHODS:The prevalence of gestational d...

journal_title：Diabetes/metabolism research and reviews

authors： Morikawa M,Yamada T,Akaishi R,Kojima T,Nishida R,Koyama T,Cho K,Minakami H

更新日期：2015-02-01 00:00:00

abstract：:Diabetes is a group of metabolic diseases characterized by elevated blood glucose levels that drive the development of life-threatening complications. Diabetes results from a situation of insufficient insulin action, either by deficient production of the hormone by the pancreas, or by the development of insulin resist...

journal_title：Diabetes/metabolism research and reviews

authors： Castaño C,Novials A,Párrizas M

更新日期：2019-03-01 00:00:00

abstract：AIMS:Diabetic neuropathy (DN) is a "Cinderella" complication, particularly in the Middle East. A high prevalence of undiagnosed DN and those at risk of diabetic foot ulceration (DFU) is a major concern. We have determined the prevalence of DN and its risk factors, DFU, and those at risk of DFU in patients with type 2 d...

journal_title：Diabetes/metabolism research and reviews

authors： Ponirakis G,Elhadd T,Chinnaiyan S,Dabbous Z,Siddiqui M,Al-Muhannadi H,Petropoulos IN,Khan A,Ashawesh KAE,Dukhan KMO,Mahfoud ZR,Murgatroyd C,Slevin M,Malik RA

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Intranasally applied insulin is one of the antigen-specific therapies currently tested in clinical type 1 diabetes prevention trials, for example, in the Type 1 Diabetes Prediction and Prevention Study (DIPP). The possibility that the therapy may cause hypoglycaemia or local irritation and the poorly known i...

journal_title：Diabetes/metabolism research and reviews

authors： Kupila A,Sipilä J,Keskinen P,Simell T,Knip M,Pulkki K,Simell O

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Physical exercise provides health benefits for people with type 2 diabetes mellitus, partly by enhancing skeletal muscle insulin action. We tested the hypothesis that changes in expression of key genes in skeletal muscles relate to exercise-induced improvements in type 2 diabetic patients. METHODS:We determ...

journal_title：Diabetes/metabolism research and reviews

authors： Fritz T,Krämer DK,Karlsson HK,Galuska D,Engfeldt P,Zierath JR,Krook A

更新日期：2006-11-01 00:00:00

abstract：:Several interactive and mutually perpetuating abnormal biochemical pathways, such as protein kinase C (PKC) activation, augmented polyol pathway, and non-enzymatic glycation, may be activated as a result of sustained hyperglycemia in diabetes. These abnormal pathways may in turn influence several vasoactive factors, w...

journal_title：Diabetes/metabolism research and reviews

authors： Chakrabarti S,Cukiernik M,Hileeto D,Evans T,Chen S

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Patients with impaired 50-g oral glucose challenge test (OGCT) have not been investigated for fetal anterior abdominal wall thickness until now. We aimed to investigate patients with impaired 50-g OGCT, but not gestational diabetes and match them with healthy uneventful pregnant participants for anterior abd...

journal_title：Diabetes/metabolism research and reviews

authors： Aksoy H,Aksoy U,Açmaz G,Tutuş S

更新日期：2014-10-01 00:00:00

abstract：:The prevalence of diabetes mellitus in primary hyperparathyroidism is approximately 8% and that of primary hyperparathyroidism in diabetic patients is approximately 1%. Both values are about three-fold higher than the respective expected prevalences in general populations. Patients with both disorders are over 40 year...

journal_title：Diabetes/metabolism research and reviews

authors： Taylor WH,Khaleeli AA

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:The present study was undertaken to determine whether there were changes evident in axonal membrane function prior to the onset of neuropathy in patients with type 1 and type 2 diabetes. METHODS:From a cohort of 110 consecutive referrals, nerve excitability was investigated in 40 diabetic patients without c...

journal_title：Diabetes/metabolism research and reviews

authors： Arnold R,Kwai N,Lin CS,Poynten AM,Kiernan MC,Krishnan AV

更新日期：2013-01-01 00:00:00