Cataract development in diabetic sand rats treated with alpha-lipoic acid and its gamma-linolenic acid conjugate.


BACKGROUND:Diabetes commonly leads to long-term complications such as cataract. This study investigated the effects of alpha-lipoic acid (LPA) and its gamma-linolenic acid (GLA) conjugate on cataract development in diabetic sand rats. METHODS:Two separate experiments were conducted. In Experiment 1, sand rats were fed a "high-energy" diet (70% starch), an acute model of Type 2 diabetes, and injected with LPA. In Experiment 2, the animals received a "medium-energy" diet (59% starch), a chronic diabetic model, and were intubated with LPA or its GLA conjugate. Throughout the experiments, blood glucose levels and cataract development were measured. At the termination of the experiments, lens aldose reductase (AR) activity and lenticular reduced glutathione (GSH) levels were analyzed. RESULTS:LPA injection significantly inhibited cataract development and reduced blood glucose levels in rats fed the "high-energy" diet. Lens AR activity tended to be lower, while lenticular GSH levels increased. In sand rats fed a "medium-energy" diet (59% starch), LPA intubation had no effect on blood glucose levels and cataract development but GSH levels were increased. In contrast, sand rats intubated with GLA conjugate showed the highest blood glucose levels and accelerated cataract development. The conjugate treatment also decreased lenticular GSH content. CONCLUSIONS:The hypoglycemic effects of LPA are beneficial in the prevention of acute symptoms of Type 2 diabetes. It remains to be shown that the antioxidant activity of LPA is responsible for prevention or inhibition of cataract progression in sand rats.


Diabetes Metab Res Rev


Borenshtein D,Ofri R,Werman M,Stark A,Tritschler HJ,Moeller W,Madar Z





Has Abstract


2001-01-01 00:00:00














  • Association of ELMO1 gene polymorphism and diabetic nephropathy among Egyptian patients with type 2 diabetes mellitus.

    abstract:BACKGROUND AND OBJECTIVE:Diabetic nephropathy (DN) is the most common cause of end stage renal failure or even death among patients with type 2 diabetes mellitus. Genetic predisposition is widely studied among these patients to identify manageable aspects of the disease pathogenesis. This study was carried out to test ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Bayoumy NMK,El-Shabrawi MM,Leheta OF,Abo El-Ela AEM,Omar HH

    更新日期:2020-07-01 00:00:00

  • Leptin decreases apoptosis and alters BCL-2 : Bax ratio in clonal rodent pancreatic beta-cells.

    abstract:AIMS/HYPOTHESIS:The adipocyte derived peptide hormone leptin is known to regulate apoptosis and cell viability in several cells and tissues, as well as having several pancreatic islet beta-cell specific effects such as inhibition of glucose-stimulated insulin secretion. This study investigated the effects of leptin upo...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Brown JE,Dunmore SJ

    更新日期:2007-09-01 00:00:00

  • Normal renal function 8 to 13 years after cyclosporin A therapy in 285 diabetic patients.

    abstract:BACKGROUND:Cyclosporin A (CyA) may induce acute nephrotoxicity. The question has been raised of the possible long-term unfavorable course of CyA-induced lesions. Advantage was taken of a large cohort of diabetic patients treated for several months using moderate CyA dosage to evaluate the long-term evolution of renal f...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 临床试验,杂志文章


    authors: Assan R,Blanchet F,Feutren G,Timsit J,Larger E,Boitard C,Amiel C,Bach JF

    更新日期:2002-11-01 00:00:00

  • Basal insulin analogues in diabetic pregnancy: a literature review and baseline results of a randomised, controlled trial in type 1 diabetes.

    abstract::As basal insulin analogues are being used off-label, there is a need to evaluate their safety (maternal hypoglycaemia and fetal and perinatal outcomes) and efficacy [haemoglobin A1c(HbA1c), fasting plasma glucose, and maternal weight gain]. The aim of this review is to provide an overview of the current literature con...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,多中心研究,随机对照试验,评审


    authors: Mathiesen ER,Damm P,Jovanovic L,McCance DR,Thyregod C,Jensen AB,Hod M

    更新日期:2011-09-01 00:00:00

  • Overexpression of ZAC impairs glucose-stimulated insulin translation and secretion in clonal pancreatic beta-cells.

    abstract:BACKGROUND:ZAC (Zinc finger protein that regulates apoptosis and cell-cycle arrest) is a candidate gene for transient neonatal diabetes mellitus (TNDM). This condition involves severe insulin deficiency at birth that reverses over weeks or months but may relapse with diabetes recurring in later life. ZAC overexpression...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Du X,Ounissi-Benkalha H,Loder MK,Rutter GA,Polychronakos C

    更新日期:2012-11-01 00:00:00

  • Association of iron indices and type 2 diabetes: a meta-analysis of observational studies.

    abstract::The literature on the role of body iron status in the development of type 2 diabetes (T2D) in humans is inconsistent. We aimed to assess the association between iron indices and T2D by a meta-analysis of previously published studies. A systematic literature search was conducted in PubMed and EMBASE. Observational stud...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Orban E,Schwab S,Thorand B,Huth C

    更新日期:2014-07-01 00:00:00

  • Economic aspects of diabetic foot care in a multidisciplinary setting: a review.

    abstract:BACKGROUND:To evaluate the economic aspects of diabetic foot care in a multidisciplinary setting. METHOD:A review of the English language literature, published from 1966 to November 2005. RESULTS:The results of available studies on the cost-of-illness of diabetic foot problems are difficult to compare. Nevertheless t...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Matricali GA,Dereymaeker G,Muls E,Flour M,Mathieu C

    更新日期:2007-07-01 00:00:00

  • Differences in cardiovascular risk profile based on relationship between post-load plasma glucose and fasting plasma levels.

    abstract:BACKGROUND:It has been shown that subjects with normal glucose tolerance (NGT), whose plasma glucose (PG) levels do not return to their fasting PG level within 2 h during an oral glucose tolerance test (OGTT) (Group I), have a significantly higher risk to develop type 2 diabetes than NGT subjects whose 2-h glucose retu...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Succurro E,Marini MA,Grembiale A,Lugarà M,Andreozzi F,Sciacqua A,Hribal ML,Lauro R,Perticone F,Sesti G

    更新日期:2009-05-01 00:00:00

  • Role of vasoactive factors in the pathogenesis of early changes in diabetic retinopathy.

    abstract::Several interactive and mutually perpetuating abnormal biochemical pathways, such as protein kinase C (PKC) activation, augmented polyol pathway, and non-enzymatic glycation, may be activated as a result of sustained hyperglycemia in diabetes. These abnormal pathways may in turn influence several vasoactive factors, w...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Chakrabarti S,Cukiernik M,Hileeto D,Evans T,Chen S

    更新日期:2000-11-01 00:00:00

  • Advanced complicated diabetes mellitus is associated with a reduced risk of thoracic and abdominal aortic aneurysm rupture: a population-based cohort study.

    abstract:BACKGROUND:Studies have associated diabetes mellitus (DM) with the reduced risk of abdominal aortic aneurysm and thoracic aortic aneurysm and dissection. We used the national insurance data of Taiwan to examine these correlations for an Asian population. The association was also evaluated by DM severity. METHODS:We id...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Tsai CL,Lin CL,Wu YY,Shieh DC,Sung FC,Kao CH

    更新日期:2015-02-01 00:00:00

  • Periodontal risk markers in children and adolescents with type 1 diabetes: A systematic review and meta-analysis.

    abstract:BACKGROUND:Periodontal disease is a frequent complication of diabetes in adults, and both conditions are associated with systemic inflammatory states. This systematic review and meta-analysis was conducted to establish the relative severity of periodontal disease risk markers in children and adolescents with type 1 dia...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Jensen E,Allen G,Bednarz J,Couper J,Peña A

    更新日期:2021-01-01 00:00:00

  • Can molecular DNA-based techniques unravel the truth about diabetic foot infections?

    abstract::Diabetes foot infections are a common condition and a major causal pathway to lower extremity amputation. Identification of causative pathogens is vital in directing antimicrobial therapy. Historically, clinicians have relied upon culture-dependent techniques that are now acknowledged as both being selective for micro...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Malone M,Gosbell IB,Dickson HG,Vickery K,Espedido BA,Jensen SO

    更新日期:2017-01-01 00:00:00

  • Vitamin D deficiency is associated with painful diabetic neuropathy.

    abstract:BACKGROUND:The aetiology of painful diabetic neuropathy is unclear. We have evaluated vitamin D levels in diabetic patients with and without painful neuropathy. METHODS:Forty-three patients with type 1 diabetes and painless (DPN) (n = 20) or painful (PDN) (n = 23) neuropathy and 14 non-diabetic healthy control subject...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Alam U,Petropoulos IN,Ponirakis G,Ferdousi M,Asghar O,Jeziorska M,Marshall A,Boulton AJM,Efron N,Malik RA

    更新日期:2021-01-01 00:00:00

  • Serum IFN-gamma and IL-10 levels are associated with disease progression in non-obese diabetic mice.

    abstract:BACKGROUND:The goal of the present study was to determine whether cytokines in the peripheral blood of naive NOD mice correlate with the disease process and thereby would provide a marker for monitoring disease activity. METHODS:Female NOD mice (5, 10 and 14-16 weeks of age) were investigated in a cross-sectional stud...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Schloot NC,Hanifi-Moghaddam P,Goebel C,Shatavi SV,Flohé S,Kolb H,Rothe H

    更新日期:2002-01-01 00:00:00

  • Cardiovascular disease in patients with type 1 diabetes: Early evaluation, risk factors and possible relation with cardiac autoimmunity.

    abstract::Cardiovascular disease now is the leading cause of mortality among patients with type 1 diabetes (T1D). The risk of death from cardiovascular events in subjects with T1D is 2-10 times higher than the general population, depending on blood glucose control. Although complications of cardiovascular disease occur in middl...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Shi M,Tang R,Huang F,Zhong T,Chen Y,Li X,Zhou Z

    更新日期:2020-11-30 00:00:00

  • 24-Hour Fasting with Diabetes: guide to physicians advising patients on medication adjustments prior to religious observances (or outpatient surgical procedures).

    abstract::Patients with diabetes may undergo an approximately 24-h fast for a voluntary religious observance or in preparation for a medical procedure. Commonly, patients will manage their diabetes before and during such fasting without guidelines from their doctors, often because they did not ask for advice. The physician shou...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Grajower MM

    更新日期:2011-07-01 00:00:00

  • Identification of a distinct phenotype of elderly latent autoimmune diabetes in adults: LADA China Study 8.

    abstract:BACKGROUND:Latent autoimmune diabetes in adults (LADA) exhibits significant clinical heterogeneity, but the underlying causes remain unclear. The aim of this study was to investigate whether age of onset of LADA contributes to the observed clinical heterogeneity by comparing the clinical, metabolic, and immunogenetic c...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Niu X,Luo S,Li X,Xie Z,Xiang Y,Huang G,Lin J,Yang L,Liu Z,Wang X,Leslie RD,Zhou Z

    更新日期:2019-01-01 00:00:00

  • Levels of N-terminal pro brain natriuretic peptide are enhanced in people with the uncomplicated metabolic syndrome: a case-cohort analysis of the population-based Casale Monferrato study.

    abstract:BACKGROUND:Both metabolic syndrome (MetS) and N-amino terminal fragment of the prohormone B-type natriuretic peptide (NT-proBNP) confer increased risk of cardiovascular diseases (CVD). We assessed if NT-proBNP levels were greater in people with uncomplicated MetS, who had neither CVD/chronic kidney disease (CKD) nor di...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Bruno G,Barutta F,Landi A,Pinach S,Caropreso P,Mengozzi G,Baldassarre S,Fragapani S,Civera S,Cavallo Perin P,Gruden G

    更新日期:2015-05-01 00:00:00

  • Education programmes for persons with type 1 diabetes using an insulin pump: A systematic review.

    abstract::Education is essential in insulin pump therapy, but literature in the field is limited. We systematically reviewed insulin pump education programmes and their effects in two situations as follows: (1) basic education at the start of insulin pump therapy, providing the study design enabled us to separate the effects of...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Rytter K,Schmidt S,Rasmussen LN,Pedersen-Bjergaard U,Nørgaard K

    更新日期:2020-10-03 00:00:00

  • Programmed disorders of beta-cell development and function as one cause for type 2 diabetes? The GK rat paradigm.

    abstract::Now that the reduction in beta-mass has been clearly established in humans with type 2 diabetes mellitus (T2DM) 1-4, the debate focuses on the possible mechanisms responsible for decreased beta-cell number and impaired beta-cell function and their multifactorial etiology. Appropriate inbred rodent models are essential...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Portha B

    更新日期:2005-11-01 00:00:00

  • Anti-diabetic and neuroprotective effects of pancreatic islet transplantation into the central nervous system.

    abstract::During the last decades, the central nervous system (CNS) was intensively tested as a site for islet transplantation in different animal models of diabetes. Immunoprivilege properties of intracranial and intrathecal sites were found to delay and reduce rejection of transplanted allo-islets and xeno-islets, especially ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Lazard D,Vardi P,Bloch K

    更新日期:2016-01-01 00:00:00

  • Birth weight influences the clinical phenotype and the metabolic control of patients with type 1 diabetes (T1D).

    abstract:BACKGROUND:High birth weight has been related to an increased risk of type 1 diabetes (T1D), while suboptimal birth weight (both high and low) has been related to obesity, insulin resistance and type 2 diabetes. Insulin resistance, as a consequence of poor metabolic control, has been described in T1D patients. The aims...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Benevento D,Bizzarri C,Patera IP,Ravà L,Schiaffini R,Ciampalini P,Cianfarani S,Cappa M

    更新日期:2013-01-01 00:00:00

  • The changing world demography of type 2 diabetes.

    abstract::In recent years it has been estimated that the current global prevalence of type 2 diabetes amounts to about 150 million patients. Projections suggest that by the year 2025 the number of prevalent patients in the world will reach approximately 300 million. It is assumed that the increase in the number of patients will...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Green A,Christian Hirsch N,Pramming SK

    更新日期:2003-01-01 00:00:00

  • Fatty acid-induced effect on glucagon secretion is mediated via fatty acid oxidation.

    abstract:BACKGROUND:While the effect of fatty acids and ectopic triglyceride storage in pancreatic beta cells has been well-defined, only limited information is available on alpha cells. This study evaluates the long-term impact of fatty acids on alpha cell function and proliferation as well as fatty acid oxidation. METHODS:Cl...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Hong J,Jeppesen PB,Nordentoft I,Hermansen K

    更新日期:2007-03-01 00:00:00

  • Influence of diabetic metabolic state on fracture healing in spontaneously diabetic rats.

    abstract:BACKGROUND:Type 1 diabetes mellitus (DM) has been shown to alter the properties of bone and impair fracture healing in both humans and animals. The objective of this study was to examine changes in the histomorphometrical, histological and mechanical parameters of bone and remodeling during fracture healing, depending ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Follak N,Klöting I,Merk H

    更新日期:2005-05-01 00:00:00

  • Blood group AB is protective factor for gestational diabetes mellitus: a prospective population-based study in Tianjin, China.

    abstract:BACKGROUND:The ABO blood types are associated with cancers, cardiovascular diseases and type 2 diabetes mellitus but whether they are also associated with gestational diabetes mellitus (GDM) is unknown. We examined the relationship between the ABO blood types and the risk of GDM in a prospective population-based Chines...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Zhang C,Li Y,Wang L,Sun S,Liu G,Leng J,Guo J,Lv L,Li W,Zhang C,Hu G,Yu Z,Yang X

    更新日期:2015-09-01 00:00:00

  • Neuromuscular dysfunction in type 2 diabetes: underlying mechanisms and effect of resistance training.

    abstract::Diabetic patients are at higher risk of developing physical disabilities than non-diabetic subjects. Physical disability appears to be related, at least in part, to muscle dysfunction. Several studies have reported reduced muscle strength and power under dynamic and static conditions in both the upper and lower limbs ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Orlando G,Balducci S,Bazzucchi I,Pugliese G,Sacchetti M

    更新日期:2016-01-01 00:00:00

  • Stability of mitochondrial DNA against reactive oxygen species (ROS) generated in diabetes.

    abstract:BACKGROUND:Increased production of reactive oxygen species (ROS) in mitochondria has been proposed as the pathogenic mechanism for chronic complications of diabetes. Mitochondrial DNA (mtDNA) is more vulnerable to reactive oxygen species. However, there are few data on the mitochondrial DNA damage in diabetes and these...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Savu O,Sunkari VG,Botusan IR,Grünler J,Nikoshkov A,Catrina SB

    更新日期:2011-07-01 00:00:00

  • The 2015 IWGDF guidance documents on prevention and management of foot problems in diabetes: development of an evidence-based global consensus.

    abstract::Foot problems complicating diabetes are a source of major patient suffering and societal costs. Investing in evidence-based, internationally appropriate diabetic foot care guidance is likely among the most cost-effective forms of healthcare expenditure, provided it is goal-focused and properly implemented. The Interna...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Bakker K,Apelqvist J,Lipsky BA,Van Netten JJ,International Working Group on the Diabetic Foot.

    更新日期:2016-01-01 00:00:00

  • Sex and ethnic-origin specific BMI cut points improve prediction of 40-year mortality: the Israel GOH study.

    abstract:BACKGROUND:Although obesity has been associated with a higher risk for premature death, the sex and ethnic-origin specific body mass index (BMI) levels that are associated with increased mortality are controversial. We investigated the 40-year cumulative all-cause mortality, in relation to the BMI in adult life, among ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Dankner R,Shanik M,Roth J,Luski A,Lubin F,Chetrit A

    更新日期:2015-07-01 00:00:00