Abstract:
BACKGROUND:Vitamin D insufficiency and type 2 diabetes are both common in Finland, and low vitamin D status has been suggested as a risk factor for type 2 diabetes. Our aim was to study the associations between serum 25-hydroxyvitamin D [25(OH)D], a marker of vitamin D status, and glucose homeostasis and type 2 diabetes in a general population sample in Eastern Finland. METHODS:Cross-sectional analysis in the Kuopio Ischaemic Heart Disease Risk Factor Study. A total of 850 men and 906 women, aged 53-73 years, were analysed. Relative risk (RR) of prevalent diabetes was estimated as odds ratios by logistic regression. Associations between serum 25(OH)D and markers of impaired glucose metabolism in tertiles of serum 25(OH)D concentration were assessed by linear regression. RESULTS:The mean serum 25(OH)D concentration was 43.4 nmol/L (SD 17.6, range 8.5-122.8 nmol/L) in the study population. Serum 25(OH)D concentration <50 nmol/L were observed in 65.5% of the participants. Serum 25(OH)D was inversely associated with fasting serum insulin, fasting blood glucose and oral glucose tolerance test (OGTT) 2-h glucose levels after adjustment for age, gender and examination year. Association with the OGTT 2-h glucose remained statistically significant after multivariate adjustments. The RR (95% confidence interval) for type 2 diabetes in tertiles of serum 25(OH)D were 1, 1.26 (0.86, 1.85) and 1.44 (0.96, 2.15) after multivariate adjustments (p for trend = 0.08). CONCLUSIONS:Our results suggest that low serum 25(OH)D is associated with impaired glucose and insulin metabolism.
journal_name
Diabetes Metab Res Revjournal_title
Diabetes/metabolism research and reviewsauthors
Hurskainen AR,Virtanen JK,Tuomainen TP,Nurmi T,Voutilainen Sdoi
10.1002/dmrr.2286subject
Has Abstractpub_date
2012-07-01 00:00:00pages
418-23issue
5eissn
1520-7552issn
1520-7560journal_volume
28pub_type
杂志文章abstract::Diabetic foot ulceration poses a heavy burden on the patient and the healthcare system, but prevention thereof receives little attention. For every euro spent on ulcer prevention, ten are spent on ulcer healing, and for every randomized controlled trial conducted on prevention, ten are conducted on healing. In this ar...
journal_title:Diabetes/metabolism research and reviews
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abstract:BACKGROUND:Diabetes mellitus secondary to pancreatic diseases is a condition seldom thought of in clinical practice. Yet, a high percentage of exocrine pancreatic insufficiency has been reported for the general population and especially for diabetic subjects. Thus, we investigated the prevalence of diabetes mellitus du...
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journal_title:Diabetes/metabolism research and reviews
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journal_title:Diabetes/metabolism research and reviews
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journal_title:Diabetes/metabolism research and reviews
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journal_title:Diabetes/metabolism research and reviews
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journal_title:Diabetes/metabolism research and reviews
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doi:10.1002/dmrr.868
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,评审
doi:10.1002/dmrr.199
更新日期:2001-05-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,meta分析,评审
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
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doi:10.1002/dmrr.2381
更新日期:2012-12-05 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2002-01-01 00:00:00