Toxin-based selection of insulin-producing cells with improved defense properties for islet cell transplantation.

abstract：BACKGROUND:Lispro Mix 25% insulin lispro/75% insulin lispro protamine (LM25) and Lispro Mix 50% insulin lispro/50% insulin lispro protamine (LM50) were compared as starter insulins in East Asian patients with type 2 diabetes. METHODS:Phase 4, open-label, randomized trial conducted in China, Japan, Korea, and Turkey. S...

journal_title：Diabetes/metabolism research and reviews

authors： Watada H,Su Q,Li PF,Iwamoto N,Qian L,Yang WY

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:This article aims to describe the implementation and initial results of an audit-feedback quality improvement initiative in Belgian diabetic foot clinics. METHODS:Using self-developed software and questionnaires, diabetic foot clinics collected data in 2005, 2008 and 2011, covering characteristics, history ...

journal_title：Diabetes/metabolism research and reviews

authors： Doggen K,Van Acker K,Beele H,Dumont I,Félix P,Lauwers P,Lavens A,Matricali GA,Randon C,Weber E,Van Casteren V,Nobels F,Initiative for Quality Improvement and Epidemiology in Diabetic Foot Clinics (IQED-Foot) Study Group.

更新日期：2014-07-01 00:00:00

abstract：:Whether diabetic foot ulcerations arise from an amalgam of neuro-ischemic factors or because of arterial occlusive disease alone, the arterial circulation must be thoroughly evaluated. Clinical evaluation is foremost, but numerous non-invasive diagnostic options such as duplex ultrasonography and MRA are often enliste...

journal_title：Diabetes/metabolism research and reviews

authors： Andros G

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Data on the association between body iron and glucose homeostasis by the three glycaemic states are scarce. Thus, we investigated the association between body iron as assessed by a serum ferritin concentration and glucose homeostasis using homeostasis model assessment (HOMA) of insulin resistance (HOMA-IR) a...

journal_title：Diabetes/metabolism research and reviews

authors： Aregbesola A,Virtanen JK,Voutilainen S,Mursu J,Lagundoye A,Kauhanen J,Tuomainen TP

更新日期：2015-07-01 00:00:00

abstract：:During the last decades, the central nervous system (CNS) was intensively tested as a site for islet transplantation in different animal models of diabetes. Immunoprivilege properties of intracranial and intrathecal sites were found to delay and reduce rejection of transplanted allo-islets and xeno-islets, especially ...

journal_title：Diabetes/metabolism research and reviews

authors： Lazard D,Vardi P,Bloch K

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Clinical studies have shown that proinsulin C-peptide exerts renoprotective effects in type 1 diabetes, although the underlying mechanisms are poorly understood. As C-peptide has been shown to induce several intracellular events and to localize to nuclei, we aimed to determine whether gene transcription is a...

journal_title：Diabetes/metabolism research and reviews

authors： Lindahl E,Nordquist L,Müller P,El Agha E,Friederich M,Dahlman-Wright K,Palm F,Jörnvall H

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Visceral adiposity index (VAI) is a novel marker of visceral adipose tissue accumulation and dysfunction. The study aim was to explore the association of VAI with the 10-year type 2 diabetes mellitus (T2DM) incidence in apparently healthy individuals and compare its T2DM predictive ability against common ant...

journal_title：Diabetes/metabolism research and reviews

authors： Koloverou E,Panagiotakos DB,Kyrou I,Stefanadis C,Chrysohoou C,Georgousopoulou EN,Skoumas I,Tousoulis D,Pitsavos C,ATTICA Study group.

更新日期：2019-09-01 00:00:00

abstract：:The exact cause of the obesity epidemic remains unknown; however, both environmental and genetic factors are involved. People at risk of developing obesity include children with type 1 diabetes mellitus (T1DM), which in turn increases their cardiovascular disease risk. Here, we discuss the clinical and genetic factors...

journal_title：Diabetes/metabolism research and reviews

authors： Łuczyński W,Głowińska-Olszewska B,Bossowski A

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Platelet activation contributes to cardiovascular disease (CVD), the main complication of type 2 diabetes mellitus (T2DM) and pre-diabetic conditions. Mean platelet volume is an easy-to-measure platelet parameter that has been associated with CVD. We sought to assess mean platelet volume, platelet distributi...

journal_title：Diabetes/metabolism research and reviews

authors： Zaccardi F,Rocca B,Pitocco D,Tanese L,Rizzi A,Ghirlanda G

更新日期：2015-05-01 00:00:00

abstract：:Rising experimental evidence suggests that thiazolidinediones (TZDs) exert a protective effect on breast cancer. However, studies concerning this issue were inconsistent and limited. Hence, we performed a meta-analysis with data from currently available studies to evaluate the effect of TZDs on breast cancer risk amon...

journal_title：Diabetes/metabolism research and reviews

authors： Du R,Lin L,Cheng D,Xu Y,Xu M,Chen Y,Wang W,Bi Y,Li D,Lu J

更新日期：2018-02-01 00:00:00

abstract：:Increasing coprevalence of diabetes mellitus (DM) and tuberculosis (TB) in low-income and middle-income countries (LMICs) indicates a rising threat to the decades of progress made against TB and requires global attention. This systematic review provides a summary of type 2 diabetes and tuberculosis coprevalence in var...

journal_title：Diabetes/metabolism research and reviews

authors： McMurry HS,Mendenhall E,Rajendrakumar A,Nambiar L,Satyanarayana S,Shivashankar R

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Women with obesity and type 2 diabetes (T2D) are at greater risk of dying from breast cancer than women without these conditions. Obesity and T2D are associated with insulin resistance and endogenous hyperinsulinemia and are more common in Black women. There is increasing disparity in breast cancer mortality...

journal_title：Diabetes/metabolism research and reviews

authors： Gallagher EJ,LeRoith D,Franco R,Antoniou IM,Nayak A,Livaudais-Toman J,Bickell NA

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:The proposed 2015 US Preventive Services Task Force guidelines recommend diabetes screening for individuals ≥45 years or demonstrating other risk factors for dysglycemia. Still, many patients with dysglycemia remain undiagnosed, and opportunities for early intervention are lost. METHODS:To test novel approa...

journal_title：Diabetes/metabolism research and reviews

authors： Silverman RA,Schleicher MG,Valente CJ,Kim M,Romanenko Y,Schulman RC,Tiberio A,Greenblatt B,Rentala M,Salvador-Kelly AV,Kwon NS,Jornsay DL

更新日期：2016-01-01 00:00:00

abstract：:There are a number of medical conditions such as growth failure in children, pregnancy, lipid abnormalities, and early complications that are improved by the meticulous glycemic control that can be achieved with insulin pump therapy (CSII). By using an insulin pump, many patients with severe hypoglycemia, the dawn phe...

journal_title：Diabetes/metabolism research and reviews

authors： Kaufman FR,Halvorson M,Miller D,Mackenzie M,Fisher LK,Pitukcheewanont P

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Increased production of reactive oxygen species (ROS) in mitochondria has been proposed as the pathogenic mechanism for chronic complications of diabetes. Mitochondrial DNA (mtDNA) is more vulnerable to reactive oxygen species. However, there are few data on the mitochondrial DNA damage in diabetes and these...

journal_title：Diabetes/metabolism research and reviews

authors： Savu O,Sunkari VG,Botusan IR,Grünler J,Nikoshkov A,Catrina SB

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Sustained hyperglycaemia induces increased renal oxygen consumption resulting in reduced oxygen availability in the diabetic kidney. We investigated the roles of the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase and the neuronal nitric oxide synthase (nNOS) for the increased oxygen consumption ...

journal_title：Diabetes/metabolism research and reviews

authors： Edlund J,Fasching A,Liss P,Hansell P,Palm F

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Recently, a genome-wide association study identified a strong association between the fat mass- and obesity-associated rs9939609 single nucleotide polymorphism (SNP) and the risk of obesity in European population. However, the results in Chinese population were reported to be contradictory. Therefore, our ai...

journal_title：Diabetes/metabolism research and reviews

authors： Li X,Song F,Jiang H,Zhang M,Lin J,Bao W,Yao P,Yang X,Hao L,Liu L

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:To evaluate the association between fasting plasma glucose (FPG) and mortality by gender. METHODS:A total of 17 248 eligible participants from a rural Chinese prospective cohort population were included. The same questionnaire interview and anthropometric and laboratory measurements were performed at both b...

journal_title：Diabetes/metabolism research and reviews

authors： Liu L,Chen X,Liu Y,Sun X,Yin Z,Li H,Zhang M,Wang B,Ren Y,Zhao Y,Liu D,Zhou J,Liu X,Zhang D,Cheng C,Liu F,Zhou Q,Xu Q,Xiong Y,Liu J,You Z,Hong S,Wang C,Hu D

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Diabetic nephropathy (DN) is the most common cause of end stage renal failure or even death among patients with type 2 diabetes mellitus. Genetic predisposition is widely studied among these patients to identify manageable aspects of the disease pathogenesis. This study was carried out to test ...

journal_title：Diabetes/metabolism research and reviews

authors： Bayoumy NMK,El-Shabrawi MM,Leheta OF,Abo El-Ela AEM,Omar HH

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Type 2 diabetes mellitus (DM) is associated with a decreased level of circulating endothelial progenitor cells (EPCs) and adiponectin. Experimental studies suggest a potential link between hypoadiponectinaemia and the depletion of the EPC level. This study investigated the relationships between adiponectin l...

journal_title：Diabetes/metabolism research and reviews

authors： Li M,Ho JC,Lai KW,Au KK,Xu A,Cheung BM,Lam KS,Tse HF

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Our previous studies showed that some Korean type 2 diabetic patients could maintain long-term normal blood glucose control without any medication, referred to as remission after a certain period of normalization of blood glucose level by continuous subcutaneous insulin infusion (CSII) treatment. In this stu...

journal_title：Diabetes/metabolism research and reviews

authors： Park S,Choi SB

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Human leukocyte antigen (HLA) genotypes associated with increased risk for type 1 diabetes mellitus (T1D) have been reported to be associated with increased birth weight. We set out to investigate the association between HLA haplotypes conferring risk for T1D and birth weight and search for possible differen...

journal_title：Diabetes/metabolism research and reviews

authors： Peet A,Kool P,Ilonen J,Knip M,Tillmann V,DIABIMMUNE Study Group.

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Childhood obesity is encouraged by low physical activity (PA), time spent using screens (screen time, ST), and by sugar-sweetened beverage consumption (SSBc). It is also influenced by unfavorable parents' characteristics, such as a high body mass index (BMI) and low education level (EL). Our aim was to evalu...

journal_title：Diabetes/metabolism research and reviews

authors： Vinciguerra F,Tumminia A,Roppolo F,Romeo LC,La Spina N,Baratta R,Parrino C,Sciacca L,Vigneri R,Frittitta L

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:The genetic basis of the autoimmune disease type 1 diabetes (T1D) has now been largely determined, so now we can compare these findings with emerging genetic knowledge of disorders and phenotypes that have been negatively or positively associated with T1D historically. Here, we assessed the role in T1D of va...

journal_title：Diabetes/metabolism research and reviews

authors： Saleh NM,Raj SM,Smyth DJ,Wallace C,Howson JM,Bell L,Walker NM,Stevens HE,Todd JA

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:The aetiology of painful diabetic neuropathy is unclear. We have evaluated vitamin D levels in diabetic patients with and without painful neuropathy. METHODS:Forty-three patients with type 1 diabetes and painless (DPN) (n = 20) or painful (PDN) (n = 23) neuropathy and 14 non-diabetic healthy control subject...

journal_title：Diabetes/metabolism research and reviews

authors： Alam U,Petropoulos IN,Ponirakis G,Ferdousi M,Asghar O,Jeziorska M,Marshall A,Boulton AJM,Efron N,Malik RA

更新日期：2021-01-01 00:00:00

abstract：:Non-invasive tests for the detection of peripheral artery disease (PAD) among individuals with diabetes mellitus are important to estimate the risk of amputation, ulceration, wound healing and the presence of cardiovascular disease, yet there are no consensus recommendations to support a particular diagnostic modality...

journal_title：Diabetes/metabolism research and reviews

authors： Brownrigg JR,Hinchliffe RJ,Apelqvist J,Boyko EJ,Fitridge R,Mills JL,Reekers J,Shearman CP,Zierler RE,Schaper NC,International Working Group on the Diabetic Foot.

更新日期：2016-01-01 00:00:00

abstract：:Insulin resistance is characterized by hyperglycaemia, dyslipidaemia and oxidative stress prior to the development of type 2 diabetes mellitus. To date, a number of mechanisms have been proposed to link these syndromes together, but it remains unclear what the unifying condition that triggered these events in the prog...

journal_title：Diabetes/metabolism research and reviews

authors： Hafizi Abu Bakar M,Kian Kai C,Wan Hassan WN,Sarmidi MR,Yaakob H,Zaman Huri H

更新日期：2015-07-01 00:00:00

abstract：:This perspective covers a novel area of research describing the inadequacies of current approaches for diagnosing dysglycaemia and proposes that the 1-hour post-load glucose level during the 75-g oral glucose tolerance test may serve as a novel biomarker to detect dysglycaemia earlier than currently recommended screen...

journal_title：Diabetes/metabolism research and reviews

authors： Bergman M,Jagannathan R,Buysschaert M,Pareek M,Olsen MH,Nilsson PM,Medina JL,Roth J,Chetrit A,Groop L,Dankner R

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:A nested case-control (NCC) design within a prospective cohort study can realize substantial benefits for biomarker studies. In this context, it is natural to consider the sample availability in the selection of controls to minimize data loss when implementing the design. However, this violates the randomnes...

journal_title：Diabetes/metabolism research and reviews

authors： Lee HS,Lynch KF,Krischer JP,TEDDY Study Group.

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Increased activity of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in enhanced adrenocorticotropin (ACTH) and serum glucocorticoid levels, has been described in patients with diabetes mellitus and in animal models of this disease; however, altered steroid production by adrenocortical cells could ...

journal_title：Diabetes/metabolism research and reviews

authors： Astort F,Repetto EM,Martínez Calejman C,Cipelli JM,Sánchez R,Di Gruccio JM,Mercau M,Pignataro OP,Arias P,Cymeryng CB

更新日期：2009-07-01 00:00:00