Can we prevent beta cell apoptosis in type 2 diabetes?

abstract：BACKGROUND:While the effect of fatty acids and ectopic triglyceride storage in pancreatic beta cells has been well-defined, only limited information is available on alpha cells. This study evaluates the long-term impact of fatty acids on alpha cell function and proliferation as well as fatty acid oxidation. METHODS:Cl...

journal_title：Diabetes/metabolism research and reviews

authors： Hong J,Jeppesen PB,Nordentoft I,Hermansen K

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) can lead to cirrhosis and hepatocellular carcinoma and is strongly associated with obesity and insulin resistance. The aim of this study was to assess if plasma markers associated with NAFLD are increased in people with concomitant diabetes compared with those withou...

journal_title：Diabetes/metabolism research and reviews

authors： Sharma S,Barrett F,Adamson J,Todd A,Megson IL,Zentler-Munro PL,MacRury SM

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:In type 2 diabetes (T2D), copresence of low-density lipoprotein cholesterol (LDL-C) < 2.8 mmol/L with triglyceride < 1.7 mmol/L or with albuminuria synergistically increased cancer risk. We tested whether use of renin angiotensin system inhibitors attenuated the increased cancer risk associated with these tw...

journal_title：Diabetes/metabolism research and reviews

authors： Yang X,Ma RC,So WY,Wang Y,Kong AP,Ozaki R,Xu G,Chan JC

更新日期：2014-07-01 00:00:00

abstract：:Hypertension is a major modifiable risk factor for cardiovascular morbidity and mortality in diabetic patients. Guidelines recommend lowering blood pressure (BP) to less than 130/80 mmHg in diabetic patients. These recommendations are based on several studies in diabetic patients that showed the benefit of intensive B...

journal_title：Diabetes/metabolism research and reviews

authors： Shlomai G,Grossman E

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Brown adipose tissue (BAT) is important for energy expenditure through thermogenesis, although its regulatory factors are not well known in humans. There is evidence suggesting that thyroid hormones affect BAT functions in some mammals, but the effects of thyroid hormones on BAT activity in humans are still ...

journal_title：Diabetes/metabolism research and reviews

authors： Zhang Q,Miao Q,Ye H,Zhang Z,Zuo C,Hua F,Guan Y,Li Y

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus is an endocrine disorder which is characterized by the development of resistance to the cellular activity of insulin or inadequate insulin production. It leads to hyperglycemia, prolonged inflammation, and oxidative stress. Oxidative stress is assumed to play an important role in the develo...

journal_title：Diabetes/metabolism research and reviews

authors： Gurel-Gokmen B,Ipekci H,Oktay S,Alev B,Ustundag UV,Ak E,Akakın D,Sener G,Emekli-Alturfan E,Yarat A,Tunali-Akbay T

更新日期：2018-11-01 00:00:00

abstract：:The increasing global prevalence of type 2 diabetes mellitus (T2DM) requires the implementation of preventive strategies to halt this trend, tailored to the specific needs of individual regions. Risk factors for T2DM are among the main targets for improving health outcomes and curbing the development of diabetes; exce...

journal_title：Diabetes/metabolism research and reviews

authors： Palermo A,Maggi D,Maurizi AR,Pozzilli P,Buzzetti R

更新日期：2014-03-01 00:00:00

abstract：:Foot problems complicating diabetes are a source of major patient suffering and societal costs. Investing in evidence-based, internationally appropriate diabetic foot care guidance is likely among the most cost-effective forms of healthcare expenditure, provided it is goal-focused and properly implemented. The Interna...

journal_title：Diabetes/metabolism research and reviews

authors： Bakker K,Apelqvist J,Lipsky BA,Van Netten JJ,International Working Group on the Diabetic Foot.

更新日期：2016-01-01 00:00:00

abstract：:The prevalence of diabetes mellitus in primary hyperparathyroidism is approximately 8% and that of primary hyperparathyroidism in diabetic patients is approximately 1%. Both values are about three-fold higher than the respective expected prevalences in general populations. Patients with both disorders are over 40 year...

journal_title：Diabetes/metabolism research and reviews

authors： Taylor WH,Khaleeli AA

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Both metabolic syndrome (MetS) and N-amino terminal fragment of the prohormone B-type natriuretic peptide (NT-proBNP) confer increased risk of cardiovascular diseases (CVD). We assessed if NT-proBNP levels were greater in people with uncomplicated MetS, who had neither CVD/chronic kidney disease (CKD) nor di...

journal_title：Diabetes/metabolism research and reviews

authors： Bruno G,Barutta F,Landi A,Pinach S,Caropreso P,Mengozzi G,Baldassarre S,Fragapani S,Civera S,Cavallo Perin P,Gruden G

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing in developing countries, but its causes are not known. We aimed to ascertain the prevalence and determinants of NAFLD in a new largely unmedicated population-based cohort from the rapidly gentrifying region of Pinggu, China. METHODS:We ran...

journal_title：Diabetes/metabolism research and reviews

authors： Zhou X,Li Y,Zhang X,Guan YY,Puentes Y,Zhang F,Speliotes EK,Ji L

更新日期：2019-07-01 00:00:00

abstract：:Cardiorespiratory fitness, which is determined mainly by the level of physical activity, is inversely related to mortality in the general population as well as in subjects with diabetes, the incidence of which is also increased by low exercise capacity. Exercise is capable of promoting glucose utilization in normal su...

journal_title：Diabetes/metabolism research and reviews

authors： Pugliese G,Zanuso S,Alessi E,Simonelli P,Fallucca S,Fallucca F,Balducci S

更新日期：2009-09-01 00:00:00

abstract：:In the last few years, there has been increasing focus on the impact of interventions on cardiovascular outcomes in patients with type 2 diabetes. Insulin resistance and hyperglycaemia often co-exist with a cluster of risk factors for coronary artery disease, but the underlying mechanisms leading to the development of...

journal_title：Diabetes/metabolism research and reviews

authors： Ceriello A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Studies have associated diabetes mellitus (DM) with the reduced risk of abdominal aortic aneurysm and thoracic aortic aneurysm and dissection. We used the national insurance data of Taiwan to examine these correlations for an Asian population. The association was also evaluated by DM severity. METHODS:We id...

journal_title：Diabetes/metabolism research and reviews

authors： Tsai CL,Lin CL,Wu YY,Shieh DC,Sung FC,Kao CH

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:We evaluated whether global levels of DNA methylation status were associated with retinopathy as well as providing a predictive role of DNA methylation in developing retinopathy in a case-control study of 168 patients with type 2 diabetes. METHODS:The 5-methylcytosine content was assessed by reversed-phase ...

journal_title：Diabetes/metabolism research and reviews

authors： Maghbooli Z,Hossein-nezhad A,Larijani B,Amini M,Keshtkar A

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:We have investigated the possible role of ACP1 (also known as cLMWPTP: cytosolic low molecular weight phosphotyrosine phosphatase), a highly polymorphic enzyme involved in signal transduction of T-cell receptor, insulin receptor and other growth factors in the relationship between maternal age at delivery an...

journal_title：Diabetes/metabolism research and reviews

authors： Bottini N,Meloni GF,Lucarelli P,Amante A,Saccucci P,Gloria-Bottini F,Bottini E

更新日期：2005-07-01 00:00:00

abstract：:Diabetic foot disease is an important complication of diabetes. The development and outcome of foot ulcers are related to the interplay between numerous diabetes-related factors such as nerve dysfunction, impaired wound healing and microvascular and/or macrovascular disease.The formation of advanced glycation end prod...

journal_title：Diabetes/metabolism research and reviews

authors： Huijberts MS,Schaper NC,Schalkwijk CG

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:We conducted a meta-analysis to investigate the association of circulating tumor necrosis factor-1 (TNFR-1) and TNFR-2 with diabetic kidney disease (DKD) progression, which is the first-ever quantitative analysis of these associations thus far. Whether TNFRs were better than albumin-creatinine ratio (ACR) in...

journal_title：Diabetes/metabolism research and reviews

authors： Ye X,Luo T,Wang K,Wang Y,Yang S,Li Q,Hu J

更新日期：2019-11-01 00:00:00

abstract：:Small fibres constitute 70-90% of peripheral nerve fibres and regulate several key functions such as tissue blood flow, temperature and pain perception as well as sweating, all of which are highly relevant to the clinical presentation and adverse outcomes associated with foot ulcerations in patients with diabetes. Rec...

journal_title：Diabetes/metabolism research and reviews

authors： Malik RA,Veves A,Tesfaye S,Smith G,Cameron N,Zochodne D,Lauria G,Toronto Consensus Panel on Diabetic Neuropathy.

更新日期：2011-10-01 00:00:00

abstract：:Diabetic foot ulceration poses a heavy burden on the patient and the healthcare system, but prevention thereof receives little attention. For every euro spent on ulcer prevention, ten are spent on ulcer healing, and for every randomized controlled trial conducted on prevention, ten are conducted on healing. In this ar...

journal_title：Diabetes/metabolism research and reviews

authors： Bus SA,van Netten JJ

更新日期：2016-01-01 00:00:00

abstract：:Activation of self-reactive T cells that specifically destroy the pancreatic beta-cells is one of the hallmarks in the development of type 1 diabetes. Thus, for prevention and treatment of this autoimmune disease, approaches to induce and maintain T cell tolerance toward the beta-cells, especially in islet transplanta...

journal_title：Diabetes/metabolism research and reviews

authors： Gao W,Demirci G,Li XC

更新日期：2003-05-01 00:00:00

abstract：:Diabetes is an important cause of morbidity and mortality in Africa. Although a dramatic increase in disease burden is projected, it remains to be seen what effect the ongoing devastation of HIV disease will have on the epidemiology of such chronic diseases as diabetes. Recent data on type 2 diabetes prevalence indica...

journal_title：Diabetes/metabolism research and reviews

authors： Motala AA

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:There is a controversy about self-monitoring of blood glucose (SMBG) in patients with type 2 diabetes who are not using insulin. Randomized trials are limited in duration, size, and validity. METHODS:Systematic search for randomized trials and observational studies published since 1990. For inclusion studie...

journal_title：Diabetes/metabolism research and reviews

authors： McGeoch G,Derry S,Moore RA

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:For cost-effective population-based diabetes prediction and confirmation, islet autoantibody assays must be made more economical. METHODS:We evaluated glutamic acid decarboxylase (GAD)-Ruc (renilla luciferase) and IA2ic (also known as ICA512ic)-Ruc (renilla luciferase) fusion protein constructs in high-thro...

journal_title：Diabetes/metabolism research and reviews

authors： Marcus P,Yan X,Bartley B,Hagopian W

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Periodontal disease is a frequent complication of diabetes in adults, and both conditions are associated with systemic inflammatory states. This systematic review and meta-analysis was conducted to establish the relative severity of periodontal disease risk markers in children and adolescents with type 1 dia...

journal_title：Diabetes/metabolism research and reviews

authors： Jensen E,Allen G,Bednarz J,Couper J,Peña A

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Clinical studies have shown that proinsulin C-peptide exerts renoprotective effects in type 1 diabetes, although the underlying mechanisms are poorly understood. As C-peptide has been shown to induce several intracellular events and to localize to nuclei, we aimed to determine whether gene transcription is a...

journal_title：Diabetes/metabolism research and reviews

authors： Lindahl E,Nordquist L,Müller P,El Agha E,Friederich M,Dahlman-Wright K,Palm F,Jörnvall H

更新日期：2011-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:In type 2 diabetes mellitus (T2DM), the abnormal protein and lipid composition of diabetic high-density lipoprotein (HDL) could impair its anti-inflammatory functions. Whether nonenzymatic glycation directly impaired the anti-inflammatory effects of HDL in innate immunity remained unclear. METHODS:Huma...

journal_title：Diabetes/metabolism research and reviews

authors： Liu D,Ji L,Zhang D,Tong X,Pan B,Liu P,Zhang Y,Huang Y,Su J,Willard B,Zheng L

更新日期：2012-02-01 00:00:00

abstract：:Glucose can be extracted through intact skin by electro-osmotic flow (a process called 'reverse iontophoresis') upon the application of a low-level electrical current. Recently we have combined iontophoretic extraction with an in situ glucose sensor in a device called the GlucoWatch biographer. Clinical results with t...

journal_title：Diabetes/metabolism research and reviews

authors： Potts RO,Tamada JA,Tierney MJ

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:ZAC (Zinc finger protein that regulates apoptosis and cell-cycle arrest) is a candidate gene for transient neonatal diabetes mellitus (TNDM). This condition involves severe insulin deficiency at birth that reverses over weeks or months but may relapse with diabetes recurring in later life. ZAC overexpression...

journal_title：Diabetes/metabolism research and reviews

authors： Du X,Ounissi-Benkalha H,Loder MK,Rutter GA,Polychronakos C

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:To evaluate possible differences in distal polyneuropathy (PN) characteristics and degree of abnormalities for various small and large fibre parameters in diabetes type 1 (DM1) and type 2 (DM2). METHODS:Sixty-six DM1 and 57 DM2 patients with or without PN symptoms were included. Nerve conduction studies (NC...

journal_title：Diabetes/metabolism research and reviews

authors： Løseth S,Mellgren SI,Jorde R,Lindal S,Stålberg E

更新日期：2010-02-01 00:00:00