Overexpression of ZAC impairs glucose-stimulated insulin translation and secretion in clonal pancreatic beta-cells.

abstract：BACKGROUND:For cost-effective population-based diabetes prediction and confirmation, islet autoantibody assays must be made more economical. METHODS:We evaluated glutamic acid decarboxylase (GAD)-Ruc (renilla luciferase) and IA2ic (also known as ICA512ic)-Ruc (renilla luciferase) fusion protein constructs in high-thro...

journal_title：Diabetes/metabolism research and reviews

authors： Marcus P,Yan X,Bartley B,Hagopian W

更新日期：2011-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:In type 2 diabetes mellitus (T2DM), the abnormal protein and lipid composition of diabetic high-density lipoprotein (HDL) could impair its anti-inflammatory functions. Whether nonenzymatic glycation directly impaired the anti-inflammatory effects of HDL in innate immunity remained unclear. METHODS:Huma...

journal_title：Diabetes/metabolism research and reviews

authors： Liu D,Ji L,Zhang D,Tong X,Pan B,Liu P,Zhang Y,Huang Y,Su J,Willard B,Zheng L

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:High birth weight has been related to an increased risk of type 1 diabetes (T1D), while suboptimal birth weight (both high and low) has been related to obesity, insulin resistance and type 2 diabetes. Insulin resistance, as a consequence of poor metabolic control, has been described in T1D patients. The aims...

journal_title：Diabetes/metabolism research and reviews

authors： Benevento D,Bizzarri C,Patera IP,Ravà L,Schiaffini R,Ciampalini P,Cianfarani S,Cappa M

更新日期：2013-01-01 00:00:00

abstract：:Non-invasive tests for the detection of peripheral artery disease (PAD) among individuals with diabetes mellitus are important to estimate the risk of amputation, ulceration, wound healing and the presence of cardiovascular disease, yet there are no consensus recommendations to support a particular diagnostic modality...

journal_title：Diabetes/metabolism research and reviews

authors： Brownrigg JR,Hinchliffe RJ,Apelqvist J,Boyko EJ,Fitridge R,Mills JL,Reekers J,Shearman CP,Zierler RE,Schaper NC,International Working Group on the Diabetic Foot.

更新日期：2016-01-01 00:00:00

abstract：:Diabetes foot infections are a common condition and a major causal pathway to lower extremity amputation. Identification of causative pathogens is vital in directing antimicrobial therapy. Historically, clinicians have relied upon culture-dependent techniques that are now acknowledged as both being selective for micro...

journal_title：Diabetes/metabolism research and reviews

authors： Malone M,Gosbell IB,Dickson HG,Vickery K,Espedido BA,Jensen SO

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:Increased plasma levels of plasminogen activator inhibitor-1 (PAI-1) have been suggested to be a part of the insulin resistance syndrome, and recent data suggest that adipose tissue participates in the production of PAI-1. We examined the expression and insulin regulation of subcutaneous adipose tissue PAI-1 ...

journal_title：Diabetes/metabolism research and reviews

authors： Koistinen HA,Dusserre E,Ebeling P,Vallier P,Koivisto VA,Vidal H

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:In patients with type 1 diabetes, three main variables need to be assessed to optimize meal-related insulin boluses: pre-meal blood glucose (BG), insulin to carbohydrate ratio (I : C), and basal insulin. We are presenting data for a novel use of the hyperinsulinaemic-euglycaemic clamp (HEC) in patients with ...

journal_title：Diabetes/metabolism research and reviews

authors： Bevier WC,Zisser H,Palerm CC,Finan DA,Seborg DE,Doyle FJ,Wollitzer AO,Jovanovic L

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Adenosine receptors denoted by A1 , A2A , A2B , and A3 and encoded by ADORA1, ADORA2A, ADORA2B, and ADORA3 genes, respectively, are adenosine-activated G-protein-coupled receptors that play an important role in obesity and type 2 diabetes mellitus. However, little is known about their significance in gestati...

journal_title：Diabetes/metabolism research and reviews

authors： Wojcik M,Zieleniak A,Mac-Marcjanek K,Wozniak LA,Cypryk K

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Physical functioning may be an important pre-clinical marker of chronic disease, used as a tool to identify patients at risk for future cardiometabolic abnormalities. This study evaluated if self-reported physical functioning was associated with the development of cardiometabolic abnormalities or their clust...

journal_title：Diabetes/metabolism research and reviews

authors： Ylitalo KR,Karvonen-Gutierrez C,McClure C,El Khoudary SR,Jackson EA,Sternfeld B,Harlow SD

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:fulminant type 1 diabetes mellitus (T1DM) is characterized by abrupt onset of hyperglycemia and rapid progression to ketoacidosis. This study aimed at examining the clinical and autoimmunity features of fulminant T1DM in Chinese. METHODS:a total of 24 patients with fulminant T1DM and 48 classical autoimmune...

journal_title：Diabetes/metabolism research and reviews

authors： Zheng C,Zhou Z,Yang L,Lin J,Huang G,Li X,Zhou W,Wang X,Liu Z

更新日期：2011-01-01 00:00:00

abstract：:Ethnic minorities living in high-income countries usually exhibit a greater risk of developing diabetes along with higher morbidity and mortality rates. We evaluated the effectiveness of interventions to improve glycaemic control in ethnic minority groups. Results of major controlled trials, systematic reviews and met...

journal_title：Diabetes/metabolism research and reviews

authors： Lirussi F

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing in developing countries, but its causes are not known. We aimed to ascertain the prevalence and determinants of NAFLD in a new largely unmedicated population-based cohort from the rapidly gentrifying region of Pinggu, China. METHODS:We ran...

journal_title：Diabetes/metabolism research and reviews

authors： Zhou X,Li Y,Zhang X,Guan YY,Puentes Y,Zhang F,Speliotes EK,Ji L

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Clinical studies have shown that proinsulin C-peptide exerts renoprotective effects in type 1 diabetes, although the underlying mechanisms are poorly understood. As C-peptide has been shown to induce several intracellular events and to localize to nuclei, we aimed to determine whether gene transcription is a...

journal_title：Diabetes/metabolism research and reviews

authors： Lindahl E,Nordquist L,Müller P,El Agha E,Friederich M,Dahlman-Wright K,Palm F,Jörnvall H

更新日期：2011-10-01 00:00:00

abstract：:During the last decades, the central nervous system (CNS) was intensively tested as a site for islet transplantation in different animal models of diabetes. Immunoprivilege properties of intracranial and intrathecal sites were found to delay and reduce rejection of transplanted allo-islets and xeno-islets, especially ...

journal_title：Diabetes/metabolism research and reviews

authors： Lazard D,Vardi P,Bloch K

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:HLA region is the major locus (IDDM1) of type 1 diabetes (T1D) susceptibility. It explains approximately 50% of the genetic background of T1D, indicating additional genetic determinants. Genome scans and candidate gene studies have generated several chromosomal candidate regions that may have a role in T1D d...

journal_title：Diabetes/metabolism research and reviews

authors： Laine AP,Nejentsev S,Veijola R,Korpinen E,Sjöroos M,Simell O,Knip M,Akerblom HK,Ilonen J

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Latent autoimmune diabetes in adults (LADA) exhibits significant clinical heterogeneity, but the underlying causes remain unclear. The aim of this study was to investigate whether age of onset of LADA contributes to the observed clinical heterogeneity by comparing the clinical, metabolic, and immunogenetic c...

journal_title：Diabetes/metabolism research and reviews

authors： Niu X,Luo S,Li X,Xie Z,Xiang Y,Huang G,Lin J,Yang L,Liu Z,Wang X,Leslie RD,Zhou Z

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:We aimed to predict the incidence of obesity in a Korean population using a genetic risk score (GRS) constructed with obesity-related single nucleotide polymorphisms (SNPs) along with an oxidative stress score (OSS). METHODS:A total of 9460 Korean subjects and 356 974 SNPs were included. The GRS was constru...

journal_title：Diabetes/metabolism research and reviews

authors： Park S,Yoo HJ,Jee SH,Lee JH,Kim M

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:To evaluate the economic aspects of diabetic foot care in a multidisciplinary setting. METHOD:A review of the English language literature, published from 1966 to November 2005. RESULTS:The results of available studies on the cost-of-illness of diabetic foot problems are difficult to compare. Nevertheless t...

journal_title：Diabetes/metabolism research and reviews

authors： Matricali GA,Dereymaeker G,Muls E,Flour M,Mathieu C

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Smooth muscle cells proliferation and extracellular matrix (ECM) protein deposition are key features of diabetic macroangiopathy. In the present study, we have studied the role of endothelin(A) (ET(A)) receptor, the predominant receptor on smooth muscle cells, in diabetes-induced vascular hypertrophy and rem...

journal_title：Diabetes/metabolism research and reviews

authors： Fukuda G,Khan ZA,Barbin YP,Farhangkhoee H,Tilton RG,Chakrabarti S

更新日期：2005-07-01 00:00:00

abstract：AIM:We systematically review the available systems used to classify diabetic foot ulcers in order to synthesize their methodological qualitative issues and accuracy to predict lower extremity amputation, as this may represent a critical point in these patients' care. MATERIAL AND METHODS:Two investigators searched, in...

journal_title：Diabetes/metabolism research and reviews

authors： Monteiro-Soares M,Martins-Mendes D,Vaz-Carneiro A,Sampaio S,Dinis-Ribeiro M

更新日期：2014-10-01 00:00:00

abstract：:Studies on skeletal involvement in patients with diabetes mellitus have generated conflicting results, largely because of the pathogenetic complexity of the condition. Several mechanisms may contribute to skeletal damage, including the increased urinary excretion coupled with the lower intestinal absorption of calcium...

journal_title：Diabetes/metabolism research and reviews

authors： Carnevale V,Romagnoli E,D'Erasmo E

更新日期：2004-05-01 00:00:00

abstract：:It is well established that hyperglycaemia is associated with many negative cardiovascular and immunological effects. Because of the high prevalence of underlying vascular disease along with associated infection, patients with diabetic foot ulcers are especially vulnerable to these adverse consequences. While studies ...

journal_title：Diabetes/metabolism research and reviews

authors： Egan AM,Dinneen SF

更新日期：2016-01-01 00:00:00

abstract：:Rising rates of diabetes in pregnancy have led to an escalation in research in this area. As in any area of clinical research, definitions of outcomes vary from study to study, making it difficult to compare research findings and draw conclusions. Our aim was to compile and create a repository of definitions, which co...

journal_title：Diabetes/metabolism research and reviews

authors： International Association of Diabetes in Pregnancy Study Group (IADPSG) Working Group on Outcome Definitions.,Feig DS,Corcoy R,Jensen DM,Kautzky-Willer A,Nolan CJ,Oats JJ,Sacks DA,Caimari F,McIntyre HD

更新日期：2015-10-01 00:00:00

abstract：:Diabetes mellitus is one of the most challenging health concerns of the 21st century. With at least 30% of the diabetic population remaining undiagnosed, effective and early diagnosis is of critical concern. Development of a diagnostic test, more convenient and reliable than those currently used, would therefore be hi...

journal_title：Diabetes/metabolism research and reviews

authors： Matheson A,Willcox MD,Flanagan J,Walsh BJ

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Patients with impaired 50-g oral glucose challenge test (OGCT) have not been investigated for fetal anterior abdominal wall thickness until now. We aimed to investigate patients with impaired 50-g OGCT, but not gestational diabetes and match them with healthy uneventful pregnant participants for anterior abd...

journal_title：Diabetes/metabolism research and reviews

authors： Aksoy H,Aksoy U,Açmaz G,Tutuş S

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:Statins are one of the most widely prescribed medications in the United States; however, there is a concern that they are associated with new-onset-diabetes (NOD) development. We sought to understand the risk of dysglycemia and NOD for a cohort of individuals that reflect real-world physician prescribing patt...

journal_title：Diabetes/metabolism research and reviews

authors： Zigmont VA,Shoben AB,Lu B,Kaye GL,Clinton SK,Harris RE,Olivo-Marston SE

更新日期：2019-11-01 00:00:00

abstract：:There are a number of medical conditions such as growth failure in children, pregnancy, lipid abnormalities, and early complications that are improved by the meticulous glycemic control that can be achieved with insulin pump therapy (CSII). By using an insulin pump, many patients with severe hypoglycemia, the dawn phe...

journal_title：Diabetes/metabolism research and reviews

authors： Kaufman FR,Halvorson M,Miller D,Mackenzie M,Fisher LK,Pitukcheewanont P

更新日期：1999-09-01 00:00:00

abstract：AIMS:The Semmes-Weinstein monofilament is the most widely used test to diagnose the loss of protective sensation. The commonly used protocol of the International Consensus on the Diabetic Foot includes a 'sham' application that allows for false-positive answers. We sought to study the heretofore unexamined significance...

journal_title：Diabetes/metabolism research and reviews

authors： Slater RA,Koren S,Ramot Y,Buchs A,Rapoport MJ

更新日期：2014-01-01 00:00:00

abstract：:The International Working Group on the Diabetic Foot (IWGDF) has published evidence-based guidelines on the prevention and management of diabetic foot disease since 1999. In conjunction with advice from internal and external reviewers and expert consultants in the field, this update is based on a systematic review of ...

journal_title：Diabetes/metabolism research and reviews

authors： Rayman G,Vas P,Dhatariya K,Driver V,Hartemann A,Londahl M,Piaggesi A,Apelqvist J,Attinger C,Game F,International Working Group on the Diabetic Foot (IWGDF).

更新日期：2020-03-01 00:00:00

abstract：:Activation of self-reactive T cells that specifically destroy the pancreatic beta-cells is one of the hallmarks in the development of type 1 diabetes. Thus, for prevention and treatment of this autoimmune disease, approaches to induce and maintain T cell tolerance toward the beta-cells, especially in islet transplanta...

journal_title：Diabetes/metabolism research and reviews

authors： Gao W,Demirci G,Li XC

更新日期：2003-05-01 00:00:00